1. Clinical evaluation of Fx 05 with regard to GME handling Marx
Runge Peadiatric Perfusion Division Lund, Sweden 2. Disclosure
Terumo Europe has arranged my travel here and covered the expenses.
The GAMPT BCC 200 which we have used in this evaluation was made
available to us by Terumo Europe 3. Sknes University hospital, Lund
4. Children's hospital, cardiac One of two centers in the country,
with a population of about 10 million All cardiac surgery patients
up to 18 years 271 cardiac procedures in 2013, 218 on pump Full VAD
program ECMO, Berlin heart, Heartware Heart transplantation 5.
Background Depend on how you classify, up to 50% of pediatric
cardiac patients suffer some sort of neurological deficit after
surgery, (Chen J et all 2009) There are many contributing factors
Gaseous micro emboli are considered to have a major impact on
patient outcome (Barak M et all 2005) 6. From out of the blue?
Perfusionist interventions (Ruth L et all 1999) Low level reservoir
operation (Nielsen PF et all 2008) Anesthesia Venous line air
Temperature gradients (Geissler HJ et all 1997) Suction and venting
Equipment design (LaPietra et al, 2000) 7. Muth C M, New England
Journal of Medicine,2000 - 8. Bubbles are trouble Mechanical damage
of Endothelial fluid leakage Complement activation-C3 and C5 rise,
histamine release Inflammatory response End organ ischemia
Reperfusion injury Cognitive impairment 9. Methods 20 Patients <
8 kg First time, elective cardiac surgery Gampt BCC 200 messurement
points before and after the oxygenator Purgeline open at all times
Sampleline returns to venous reservoir Perfusion/anesthesia and
surgery were performed according to local protocol 10. Set up 11.
Demographic data 12. Screenshot after a AVSD 13. Screenshot after a
AVSD 14. Results GME Number Median Range % Mean ( SD) Number V
282799,5 (16416-849595) Number A 23171 (817-145040) Reduction 87,29
( 6,9) 15. GME No 0 100000 200000 300000 400000 500000 600000
700000 800000 900000 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
19 20 % Reduction Mean 87,3 SD 6,9 16. Results GME Volumen Median
Range % Mean ( SD) Volumen V 659,6 (4,9-3080) Volumen A 0,23
(0,013-3,8) Reduction 99,8 ( 0,1) 17. GME Vol 0 500 1000 1500 2000
2500 3000 3500 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 %
Reduction Mean 99,8 SD 0,1 18. In sumary Bobbles are trouble, but
how many ? When some is bad the goal must be to eliminate as much
as possible This is a common road, for perfusion, surgeon and
anesthesia Future research should aim at identifying the threshold
for what that is tolerated 19. In summary The Fx 05 eliminate
almost all air Others have showed have samme(Lin J,et all) The
GAMPHT BCC200 is a useful tool for research and product evaluation
20. Sustainability 21. Thanks to my colleagues Ann katrin Krokstrm
Thomas Hansson And all the staff at our unit.
