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RED GROUP.• Ali H. 201110680• Khoza M.C 201304139 • Bopape M.S 201417054• Malatji T.O 201414940• Mabika N.P 201407212• Mahlane K 201410009• Mashaba T.L 201000285• Madali N 2014 20006• Mahlatji M.D. 201400934• Marima R.C. 201323610• Seepe M.E 201307066• Swana M 201307253
Route of administration
Oral, Topical, Rectal and Parenteral.
Oral route of administration
Types of oral dosage forms • Solutions• Syrups• Suspensions• Emulsions
• tablets• Capsules• Granules• Powders
Method of administration
• Ingestion of a drug by mouth and into the GI tract
• Drug mouth esophagus GIT• Most medicines administered by the oral route provide
“immediate-release” drug delivery or “convenience” drug delivery.
Oral administration
Tablets and capsules
Advantages • Convenient .• Easy to handle and identify.
Disadvantages • Slow onset of action.• Difficulty in swallowing in children.
Solutions
Advantages • Easy to swallow.• Medicament is dispersed
homogeneously throughout the preparation.
Disadvantages • Bulky ( not convenient to carry).• Less microbiological and chemically
stable.
Suspensions
Advantages • It is most suitable for drugs having
unpleasant taste and odor.• Exhibits a high rate of bioavailability.
Disadvantages• Since it is a bulky product ,
transportation cost is high.• Microbial contamination easily takes
place.
Powders and granules
Advantages • It has a fast dissolution ability and
absorption.• Manufacturing is cheap.
Disadvantages • Dose inaccuracy.• It has an undesirable taste.
Emulsions
Advantages • Increased route of absorption• It is possible to include two
incompatible ingredients one in each phase of the emulsion.
Disadvantages • Preparation needs to be shaken well
before use.• Bulky(difficult to transport and
pronged to container breakage).
Application of suspensions
• Used in patients with difficulty in swallowing solid dosage forms.
• Used for conversion of soluble drug to insoluble form with pleasant taste.
• It is also applied for the process of prolonging drug action.
Applications of emulsions
• They are used in formulations of oil and water soluble drugs together.
• Used to increase the absorption of oils and oil soluble drugs through intestinal walls
• They enhance palatability of oils when given orally by distinguishing both taste and oiliness
• Used in TPN that help in delivering oily nutrients
Applications
• Can also be used in patients who are allergic to topical dosage forms, such as creams etc.
Topical administration• Application of the drug to the surface of the skin includes
administration of the drug to the mucus membrane of the eye, vagina, nose and ears.
Topical route: Dosage Forms• Ointments • Creams• Gels (Jellies)• Poultice• Pastes• Dusting powders• Transdermal patch:• Plasters• Liniments• Lotions• Paints• Pressurized dispensers (aerosol sprays)
Ointment Ointments are semi-solid, greasy preparations for application to the skin, rectum or nasal mucosa.Application: Ointments – bacterial skin infections. E.g. fucidin.
Advantages • Prolonged contact time between
the drug and the affected area• Odourless
Disadvantages• Bulkier than solid dosage forms• Greasy
Gels
Gels are semisolid emulsions in an alcohol base . Some will melt in body temperature and they tend to be drying Application:Gels (Jellies)-pain reliever e.g diclofenec sodium .
Advantages • Less greasy• Maximum absorption
Disadvantages • Not for drugs with larger particle
size.
Lotions
Are fluid preparations (aqueous) for external application without friction. They are usually oil mixed with water .Application: Lotions- skin rash. e.g. calamine.
Advantages• Compliance• No first-pass metabolism
Disadvantages• Denatured by dermis enzymes• Poor permeability of the drug to
deeper skin layers
Creams
Creams are semi-solid emulsions, that is mixtures of oil and water. They are divided into two types: oil- in- water (O/W) and water-in-oil (W/O).Application: Creams- vaginal candidiasis e.g. clotrimazole.
Advantages• Cost effective• Non invasive
Disadvantages• Easily contaminated• Reduced compliance due to
increased frequency of application
Paints
Paints are liquids for application to the skin or mucous membranes.Application: Paints- skin & nail infections. e.g. phenol 4.5%.
Advantages• Evaporates quickly to leave a dry
resinous film of medicament • High content of glycerol for
prolonged contact of the drug and the affected site
Disadvantages• Stains• Frequent application
Transdermal patch
A medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream.Application: Transdermal patch- contraceptives e.g. norgestrel.
Advantages • No pH variation, which seen in
GIT transit.• Can be removed easily and
quickly in cases of adverse reaction.
• Increased compliance.
Disadvantages • Leaves adhesive residue on the
skin surface.• Can be irritating to the skin as it
may be placed for up to 7 days.
Aerosols
Pressurised dosage form in which a drug is dissolved, dispersed or suspended in compressed or liquified gas to expel the drug from the container in a spray form.Application: Pressurized dispensers (aerosol sprays)- Pain: sunburn. Lidocaine.
Advantages • Readily absorbed• Dose can be removed without
contamination
Disadvantages• Flammable• Reduced effectiveness with
incorrect use
Application of other Topical dosage forms• Poultice- inflammation e.g. Kaolin poultice• Pastes - minor skin irritation. i.e. cuts and burns. e.g. zinc oxide.• Dusting powders- cutaneous candidiasis. e.g. fluconazole• Plasters – s.t corns and warts. e.g. salicylic acid. • Liniments- muscle or joint pain- chilli.
Method of administration
• Clean the affected area well
• Pat skin dry
• Apply thinly and evenly to the affected area
• Gently massage / rub formulation into the skin until it has disappeared
• With lotions one can use a cotton to apply the medication, this is to avoid
bruising the skin
• Aerosol are sprayed evenly and thinly to the surface of the skin
Rectal route of administration
suppository
• A solid medical preparation in a roughly conical or cylindrical shape, designed to be inserted into the rectum or vagina,where it melts at body temperature and dissolves.
• E.g Dulcolax suppository
Applications
• Used in instances where the patient is unable to swallow oral dosage forms such as unconscious patients, young children, geriatrics, mentally disturbed patients and patients with dysphagia.
• Also used in cases when administrated orally, causes nausea and vomiting.
• GIT obstruction and impaired absorption
Method of administration
• The drug preparation is inserted into the rectum, which is the site of drug release, where it either brings about a local effect or is absorbed to act systemically.
• Remove suppository from its package.• Insert small tapered end first with index finger for the full
length of the finger. • May need to be lubricated with a water-soluble gel to ease
insertion.
Cont’d
Suppository
Advantages• Can be used for systemic
absorption of drugs and avoid first-pass metabolism
• When oral administration of a drug is not suitable as in infants or patients suffering from nausea, vomiting and gastrointestinal disturbances.
Disadvantages• Suppositories are not suitable for
patients suffering from diarrhoea• Incomplete absorption may be
obtained because suppository usually promotes evacuation of the bowel.
• Can cause local irritation on rectal mucosa
Enema
• An enema is the procedure of introducing liquids into the rectum and colon via the anus.
• There four types enema commonly administered: cleansing, return flow, medicated and oil retention.
• E.g. Neomycin enemaHydrocortisone enema
applications
• Constipation• Inflammatory bowel disease• Rehydration therapy in patients for whom intravenous therapy
is not applicable• To cleanse the colon before a surgical procedure or colon
examination.
Method of application
• Before administering the enema, position the patient on their left side and flex their right knee.
• The tube is then inserted into the rectum and the liquid is administered in small increments.
Enema
Advantages• Can be used when a local effect is
desired. • Can be used to bring about a
systemic effect, thus little to no first pass metabolism of the drug occurs.
Disadvantages• Barium enema generally is not as
accurate as colonoscopy or virtual colonoscopy
• Tap water, used in cleansing enemas, is hypotonic therefore causing electrolyte imbalance.
• Disliked by patients.
Parenteral Route of Administration
Parenteral Route of Administration
• They include dosage forms that are implanted, injected or infused directly into vessels, tissues, tissue spaces or body compartments.
• It is often used for drugs that cannot be given orally due to: Patient intolerance. Instability of the drug. Poor absorption if taken orally.
Pros and Cons
Advantages • Rapid onset of action. • No first pass metabolism. • Drug delivery to unconscious patients. Disadvantages • Irritation to site of administration. • Reduced patient compliance.
Route of Administration Definition Application
Intravenous They are administered into easily accessible veins near the surface of the skin.
Promethazine hydrochloride in acute anaphylaxis
Intramuscular They are administered directly into the muscles.
Adrenaline in Asthma attack
Intra-arterial Intra-arterial injections are administered into arteries
Streptokinase for Embolism
Subcutaneous They are administered into the fat layer directly beneath the skin.
Insulin for diabetic patients
Intradermal Drug is given within the skin layers. Drug sensitivity testing, e.g. penicillin
Intrathecal Injection of a drug into the spinal canal to reach the cerebrospinal fluid.
Methotrexate for Cancer
Dosage Forms
• Implants • Solutions
Dosage Forms cont’
• Suspensions • Emulsions
Dosage Forms cont’
• Dry powder
Dosage form Advantages Disadvantages
Dry powders • Easy formulation and development • Not marketed as ready-to-use
Suspensions • suitable for insoluble drugs• increase chemical stability
• Drug release is based on viscosity and solubility
• Difficult formulation and manufacture
Solutions • Used for rapid correction of electrolyte imbalance
• Reduced drug stability
Implants • Drug release can be traced and predictable
• Area of implantation can be infected
• Insertion requires specialized knowledge
emulsions • A vehicle for drugs intended for prolonged release
• Used to provide a concentrated source of calories and essential oil
• Liable to microbial contamination which can lead to cracking
• Storage conditions may affect stability
Method of Administration Wash your hands with a soap Wear sterile gloves Select and cleanse target area with an alcohol swab and allow alcohol to dry Prepare the syringe -remove needle guard -express any air bubbles from syringe -check amount of solution in the syringe Inject -place the needle close to the skin with the hole facing up -insert the needle at proper angle -slowly administer the medication Withdraw needle -place cotton above puncture site(not on the needle) -slowly remove the needle
References• Aulton M.E.2007.Pharmaceutics:The design and manufacture of
medicines.3rd Ed.Church Hill Livingstone.Elsevier:USA.• Aulton,M.E & Taylor,K.M.G,.2013.Pharmaceutics:The design and
manufacture of medicines.4th Ed.ChurchHill Livingstone.Elsevier.USA• Bentz,P.M.& Euis,J.R.2007.Modules for basic nursing skills.7th
Ed.Philadelphia:Lippincott williams&Wilkins.• Winfield A.J. Rees A.J. Smith I. 2009. Pharmaceutical practice. 4th Ed.
Churchill Livingstone: USA