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UVRI-IAVIHIV Vaccine Programme
Sustaining community involvement in HIV prevention research:
Experiences from the UVRI-IAVI HIV Vaccine Program
William KidegaUVRI-IAVI HIV Vaccine Program
UVRI-IAVIHIV Vaccine Programme
Presentation Layout
- Introduction - About UVRI-IAVI- Why community engagement?- Community engagement activities- Lessons learnt- Conclusion
UVRI-IAVIHIV Vaccine Programme
Introduction
• Despite the known prevention options (ABC strategy), new infections still occur.
• Annual HIV incidence in Uganda reached 132,500 new cases in 2005. This includes 25,000 mother-to-child transmissions.
• Uganda has a population of 28 million people, with an HIV prevalence of about 6.4% and 0.7% adults and children respectively.
270,000 people eligible for treatment in 2007, but only 140,000 (52%) accessing it. Women infected more than men across the age
spectrum from birth to age 45-49 years. (Source: NSP 2007/8-20011/12)
UVRI-IAVIHIV Vaccine Programme
Introduction cont….
• Because of the above, the importance of sustaining community involvement in HIV prevention research cannot be understated.
• Amidst all the existing prevention options, an effective, affordable, accessible HIV vaccine may be the best hope to eradicate the epidemic.
• The Uganda Virus Research Institute-International AIDS Vaccine Initiative (UVRI-IAVI) HIV Vaccine Program works closely with communities at grassroots and national levels in order to engage a wide range of stakeholders.
UVRI-IAVIHIV Vaccine Programme
UVRI-IAVIHIV Vaccine Programme
About UVRI-IAVI HIV Vaccine Program
IAVI MOU with GOU 2001
Mission: To support the conduct of HIV vaccine trials, and also create a conducive environment by working with communities, policy makers and other partners.
• Based at the Uganda Virus Research Institute.
• Two HIV vaccine trials conducted so far (2003 & 2006), third expected to begin in 2009.
• Large number of upstream research activities that will eventually feed into the HIV vaccine R & D process (e.g Bill & Melinda Gates foundation-central lab standardizing assays, epidemiological and feasibility studies).
• Strategic partnerships and outreach at local and national levels.
UVRI-IAVIHIV Vaccine Programme
Why community engagement?
• To elicit understanding and support for HIV vaccine research and development
• To eventually recruit informed participants into trials
• To prepare communities for speedy access to an HIV vaccine once developed
UVRI-IAVIHIV Vaccine Programme
Support to clinical trials and studies
Paving way for vaccine trials through:• Community outreach and community advisory board
(CAB) activities• Collaborations with other HIV prevention researchers• Social science research• Building capacity around services informed by
assessments, e.g. family planning• Working to ensure that communities hosting HIV
vaccine research have access to adequate voluntary counselling & testing, and healthcare services
UVRI-IAVIHIV Vaccine Programme
Community information seminars
UVRI-IAVIHIV Vaccine Programme
Community Advisory Board
UVRI-IAVIHIV Vaccine Programme
Peer Leaders
UVRI-IAVIHIV Vaccine Programme
Support to fishing communities
UVRI-IAVIHIV Vaccine Programme
Healthcare and VCT strengthening
UVRI-IAVIHIV Vaccine Programme
Supportive environment
“Not all can participate as study volunteers, but can provide support in different ways…”
• Policy makers, Government Ministries• Civil society e.g the AIDS Information Centre• Media• Healthcare professionals• Gender Advisory Committee to address inadequate female
participation in HIV Vaccine Trials
Note: The 1st HIV vaccine trial conducted by IAVI in Uganda (2003-2005) enrolled 1 female for every 5.25 males; the 2nd trial (2006-2007) enrolled 1 female for every 1.7 males)
UVRI-IAVIHIV Vaccine Programme
www.iavi.or.ug
IEC Materials and Tools
UVRI-IAVIHIV Vaccine Programme
World AIDS Vaccine Awareness Day
UVRI-IAVIHIV Vaccine Programme
Lessons Learnt
• The continuous engagement of different stakeholders has provided sustained commitment and support.
• Sustained outreach to policy makers has ensured continued support for HIV prevention research.
• The complicated concepts related to HIV Vaccine research require correct messaging.
• Vaccine development timelines are long-term, thus important to manage community expectations.
UVRI-IAVIHIV Vaccine Programme
To create a Vaccine: Takes years, sometimes Decades
Most licensed vaccines took at least several decades to develop, the world still awaits other vaccines
Infectious agent (disease) Agent linked to disease
Vaccine licensed in U.S.
Years elapsed
Bordetella pertussis (Whooping cough) 1906 1948 42
Poliovirus (polio) 1908 1955 47
Measles virus (measles) 1953 1963 10
Hepatitis B virus (hepatitis) 1965 1981 16
Heamophilus influenza (meningitis) 1889 1981 92
Salmonella Typhi (typhoid fever) 1884 1989 105
Vericella zoster (chickenpox) 1953 1995 42
Rotavirus (diarrheal disease) 1973 2006 33
Human papillomavirus (cervical cancer) 1981 2006 25
HIV (AIDS) 1983 - 25+
Human cytomegalovirus (birth defects, mononucleosis)
1960 - 48+
Mycobacterium tuberculosis (TB) 1982 * (not so effective vs adult TB
126+
Plasmodium spp (malaria) 1880 - 128+
UVRI-IAVIHIV Vaccine Programme
Conclusion
• Strategic and sustained community engagement is vital in eliciting support and enhancing ownership of HIV prevention research activities.
• Research teams should work with communities as allies from the outset.
UVRI-IAVIHIV Vaccine Programme
Imagine a vaccine against HIV ………..
…………Now imagine you could make it happen
UVRI-IAVIHIV Vaccine Programme
Acknowledgements
The UVRI-IAVI HIV Vaccine Program would like to thank The International AIDS Vaccine Initiative
for their generous support
UVRI-IAVIHIV Vaccine Programme
Government of Uganda