You‘ll find out…• What stem cells actually are.

• Which talents they have.

• Why you need them.

• How to become a millionaire.

• The last point was a lie (or not).

Stem cells ancient tribe?• are concerning each higher organism

• are „building stones“

• 1st stem cell fertilized ovum

• foundation for the whole organism

• via multiplication & differentiation of stem cells

• >200 different cell types

• formation of all tissues & organs

Have you ever met a stem cell?• 2 defining capabilities to know it‘s a stem cell indeed

1 Specialization

• after divison secondary cell specialized

• „choose if they want to be“ a neuron, blood- ,bone-,.. cell

• stem cells are universal cells

• not originally made as a certain type of cell

• fulfill important regeneration & reparation functions

Have you ever met a stem cell?• 2 defining capabilities to know it‘s a stem cell indeed

• by replication

• replacement is like a copy

• same properties

2 Self-Renewal

How can they help us?

• regenerative & general medicine

• drug development

• therapeutic use

• disease modelling

Stem cell = stem cell?• differentiate 2 central forms

• concerning their origin

1 Embryonic Stem Cells (ESCs)

• „mothers of all cells“

• can turn into any specific type of cell

• struggles:

• exist only for a short period of time

• medical use is ethically controversial

Stem cell = stem cell?• differentiate 2 central forms

2 Adult Stem Cells

• „knights in shining armour“

• create substitutes

• ensure to fix/replace destroyed cells

• cannot differentiate into all types of cells

• struggles:

• obtaining difficult, risky & expensive

Toti- pluri- what?!• distinguish them by their potency

• can differentiate into any kind of cell

• are able to give rise to an entirely functional organism

• example: fertilized ovums

1 Totipotent Stem Cells

2 Pluripotent Stem Cells

Toti- pluri- what?!• distinguish them by their potency

• are similar to totipotent stem cells

• can differentiate into any kind of cells

• are able to give rise to all tissue types

• but not to an entire organism

• example: embryonic stem cells

Toti- pluri- what?!• distinguish them by their potency

• can differentiate into different cell types within a tissue type

• example: adult stem cells

3 Multipotent Stem Cells

Research amazing – stem cells amazingInduced Pluripotent Stem Cells (iPSCs)

• are synthesized

• by adding gens to ordinary tissue cells

• leads to „reprogramming“

• manmade qualities similiar to embryonic stem cells

• medical use lesser ethical issue

Research amazing – stem cells amazingInduced Pluripotent Stem Cells (iPSCs)

• may be produced corresponding to a patient´s needs

• Problem of immune rejection solved?

• possibility to differentiate them into neurons

• huge potential in medical use

Multitalents heal, help & hypnotize• Just kidding, but who knows what research may find out?

• stem cells can replace damaged cells

• are used after heart attacks, burns, spinal cord injuries, strokes, …

1 Regenerative Medicine

Multitalents heal, help & hypnotize• Just kidding, but who knows what research may find out?

• used to create organs & tissues

• huge potential in medicine

2 Synthesis

Multitalents heal, help & hypnotize

• Just kidding, but who knows what research may find out?

• used to develop medicine

• prevent side effects

• reduce animal testing

3 Drug Development

Multitalents heal, help & hypnotize• Just kidding, but who knows what research may find out?

• used to model disease mechanisms

• in order to better understand illnesses

• to improve healing chances

4 Disease Modelling

How do we know?We just asked them

• https://www.vita34.at/stammzellen/• https://de.wikipedia.org/wiki/Stammzelle• http://www.planet-wissen.de/natur/forschung/stammzellen_die_alleskoenner_unter_den_zellen/• http://flexikon.doccheck.com/de/Stammzelle• http://www.oeaw.ac.at/oesterreichische-akademie-der-wissenschaften/die-oeaw/article/stammzellen-ersatzteile-aus-dem-la

bor/• http://www.forumgesundheit.at/portal27/forumgesundheitportal/content?contentid=10007.757033&viewmode=content&p

ortal:componentId=gtnddbb3089-5ab1-4bb1-b4b8-5b4d46e787b6• http://www.imabe.org/index.php?id=1737• http://www.wissensschau.de/stammzellen/ips_zellen.php• https://de.wikipedia.org/wiki/Induzierte_pluripotente_Stammzelle• https://www.welt.de/wissenschaft/article123838643/Stammzellen-helfen-bei-Arzneimittel-Entwicklung.html• http://www.wissensschau.de/stammzellen/embryonale_stammzellen.php• http://www.zellwerk.biz/serv_stemc.htm• http://www.ivf.at/BEHANDLUNG/K%C3%BCnstlicheBefruchtung.aspx• Drawings: Google Autodraw_by Isabell Aigner• http://www.planet-wissen.de/natur/forschung/stammzellen_die_alleskoenner_unter_den_zellen/

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