Sheehan's syndrome and simmond's syndrome

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<ul><li> 1. By;WARDA SHAKIL</li></ul> <p> 2. Other Names for this Disease:-Postpartum hypopituitarismPostpartumpanhypopituitarismPostpartum panhypopituitarysyndromePostpartum pituitary necrosisSimmond's disease 3. DEFINATION:-Characteristically caused by ischemic necrosis ofmost of the anterior pituitary gland which resultsfrom spasm in its arterioles, occurring at the time ofsevere hemorrhage or shock (usually postpartum)complicating child birth.4% of women who loose large amount of bloodsuffer some degree of damage to Anterior PituitaryGland.8% suffer moderately50% suffer severely ; having postpartumhypopituitarism ending up in shock. 4. CAUSES:-Sheehan syndrome is caused by severe blood lossduring or after childbirth. Blood loss at that time canbe particularly damaging to the pituitary gland(which enlarges during pregnancy), destroyinghormone-producing tissue so that the gland cannotfunction properly. 5. CLINICS:-In the fully developed syndrome; which is only seenwhen 95% of the Anterior Pituitary Gland isdestroyed, all functions:-LactogenicThyrotropicCorticotropicSomatotropic are IMPAIRED 6. SIGNS:-Agalactia is the first and foremost most signAmenorrheaEvidence of HypothyroidismDecreased insulin tolerance- HypoglycemiaSigns of Adreno-cortical failure:-(axillary sweating absent, loss of axillary and pubic hair, decrease inskin pigmentation)WeaknessFatigueDizzinessOligomenorrhea (infrequent menstrual periods)Hot flashesDecreased libidoLow blood pressureSlowed mental functioningWeight gainDifficulty staying warm 7. These women also have moderate anemia- by lack of pituitaryerytropoetic factorSevere atrophy of all genital organs including reproductive organsLoss of breast tissueDry vaginal mucousAtrophy of subcutaneous fatPremature Aging 8. DIAGNOSE:-Clinical Signs And Patient HistoryLab Analysis of various hormonal levelsCT-Scan/ MRI of Brain (targeting Pituitary Gland) 9. TREATMENT:-Treatment involved lifelong estrogen andprogesterone hormone replacement therapy. Thyroidand adrenal hormones also must be taken. 10. By;WARDA SHAKIL 11. Simmonds Syndrome and Sheehans Syndrome arequite similar and according to various literaturethere is no such difference between the two but inreality they do have few differences which goes asfollows:-SIMMONDS SYNDROME:- Etiology:-Inflammatory disease of Brain or Pituitary Tumor Clinical Sign:-Significant weight loss (Hypophyseal Cachexia) Treatment:-Antibiotic Therapy or Surgery</p>


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