Recent advances in tablet copy

May 3, 2023May 3, 2023 etn ashtami semwaletn ashtami semwal 11

Recent advances in Recent advances in tablettablet


Recent advances inRecent advances in Tablet formulationTablet formulation New techniquesNew techniques Recent equipmentsRecent equipments New polymersNew polymers


Tablet FormulationTablet Formulation Mouth Dissolving TabletMouth Dissolving Tablet MicrotabletMicrotablet Fast-melting Tablets Based On Highly Plastic Fast-melting Tablets Based On Highly Plastic

GranulesGranules 3-dimensional Printing Technology In Tablet3-dimensional Printing Technology In Tablet


Mouth dissolving tabletMouth dissolving tabletChatap V.K ,gupta R.D ,jaiswal N.R, M.P India oct 2007Chatap V.K ,gupta R.D ,jaiswal N.R, M.P India oct 2007.. This tablet fast disintegrates when placed on This tablet fast disintegrates when placed on

tongue.release the drug that dissolve in tongue.release the drug that dissolve in salivasaliva..

Also known as orodispersible,fastAlso known as orodispersible,fast disintegrating,rapiment,porous tablet.disintegrating,rapiment,porous tablet.


Mouth dissolving tabletMouth dissolving tablet

Techniques:Techniques: Freeze dryingFreeze drying MouldingMoulding SublimationSublimation Spray dryingSpray drying Direct compressionDirect compression Wet granulationWet granulation Dry granulationDry granulation


Mouth dissolving tablet:Mouth dissolving tablet:

Patented technology:Patented technology:

Zydus technologyZydus technology Durasolve technology Durasolve technology Orasolve technologyOrasolve technology Flash dose technologyFlash dose technology Sheaform technologySheaform technology

Ceform technologyCeform technology Wowtab technologyWowtab technology Flashtab technologyFlashtab technology Cotton candy Cotton candy

technologytechnology


MicrotabletMicrotablet Gul Majid khan ,DOP ,Pakistan.Gul Majid khan ,DOP ,Pakistan. Prepared by wet granulation method.Prepared by wet granulation method. Hydrophillic matrix was formed with xanthin Hydrophillic matrix was formed with xanthin

gum,karaya gum,HPMC together with a gum,karaya gum,HPMC together with a choice of additives from Lactose,avicel PH choice of additives from Lactose,avicel PH 101,Talc & Lubritab.101,Talc & Lubritab.

Multiunit dosage form obtained by Multiunit dosage form obtained by encapsulating the mini matrix tablet into hard encapsulating the mini matrix tablet into hard gelatin capsule.gelatin capsule.


Fast-melting tabletsFast-melting tablets Yourong Fua, Seong Hoon Jeongb and Kinam Parkb, aAkina Inc., 1291 Yourong Fua, Seong Hoon Jeongb and Kinam Parkb, aAkina Inc., 1291

Cumberland Ave., West Lafayette, IN 47906, USA, 2 November 2005Cumberland Ave., West Lafayette, IN 47906, USA, 2 November 2005. . Highly plastic granules that can be compressed into tablets at Highly plastic granules that can be compressed into tablets at

low pressure were developed to make fast-melting tablets low pressure were developed to make fast-melting tablets (FMTs) by compression method. (FMTs) by compression method.

The highly plastic granules are composed of three componentsThe highly plastic granules are composed of three components

highly plastichighly plasticgranulesgranules

plastic materialplastic material material enhancingmaterial enhancing water penetrationwater penetration Wet binderWet binder


3-Dimensional Printing technology in 3-Dimensional Printing technology in tablettablet

Chee Kong Lai,1 Wendy E. Katstra,1Department of Materials Science and Chee Kong Lai,1 Wendy E. Katstra,1Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139: Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139: January 27, 2004January 27, 2004

A system using light-induced fluorescence (LIF) A system using light-induced fluorescence (LIF) technology was developed for rapid and nondestructive technology was developed for rapid and nondestructive analysis of active pharmaceutical ingredients on tablet analysis of active pharmaceutical ingredients on tablet surfaces.surfaces.

Non homogeneous tablets with defined layer of active Non homogeneous tablets with defined layer of active ingredients were made by 3-Dimensional Printing ingredients were made by 3-Dimensional Printing technology to determine penetration depths of the light technology to determine penetration depths of the light source and the resultant fluorescence responses. source and the resultant fluorescence responses.

The LIF method of analysis showed penetration to The LIF method of analysis showed penetration to depths of up to 3 mm into tablets. depths of up to 3 mm into tablets.


3-Dimensional Printing technology in 3-Dimensional Printing technology in tablettablet

A correlation between A correlation between LIF signals from analysisLIF signals from analysis of of tablet surfacestablet surfaces and the and the total drug contenttotal drug content of the of the respective tablets was established. respective tablets was established.

This method of surface analysis was verified with UV This method of surface analysis was verified with UV spectrometric methods.spectrometric methods.

The use of on-line monitoring of the individual tablet The use of on-line monitoring of the individual tablet for surface content up to 3000 tablets a minute. for surface content up to 3000 tablets a minute.


Recent Advancement in Recent Advancement in GranulationsGranulations

http//www.pharmapedia.comhttp//www.pharmapedia.com Steam GranulationSteam Granulation Melt GranulationMelt Granulation Moisture Activated Dry GranulationMoisture Activated Dry Granulation Thermal Adhesion Granulation ProcessThermal Adhesion Granulation Process Foam GranulationFoam Granulation


Steam GranulationSteam Granulation

It is modification of wet granulation. Here steam is It is modification of wet granulation. Here steam is used as a binder instead of water. used as a binder instead of water.

Its several benefits includes higher distribution Its several benefits includes higher distribution uniformity, higher diffusion rate into powders, more uniformity, higher diffusion rate into powders, more favourable thermal balance during drying step.favourable thermal balance during drying step.

Processing time is shorter therefore more number of Processing time is shorter therefore more number of tablets are produced per batch. tablets are produced per batch.


Melt Granulation / Melt Granulation / Thermoplastic GranulationThermoplastic Granulation

Here granulation is achieved by the addition of Here granulation is achieved by the addition of meltable binder. meltable binder.

That is binder is in solid state at room temperature but That is binder is in solid state at room temperature but melts in the temperature range of 50 – 80˚C. melts in the temperature range of 50 – 80˚C.

There is no need of drying phase.There is no need of drying phase. Producing SR granulation or solid dispersion.Producing SR granulation or solid dispersion. Polyethylene Glycol (PEG) is used as melting Polyethylene Glycol (PEG) is used as melting

binders. When water insoluble binders are needed.binders. When water insoluble binders are needed.


Moisture Activated Dry Granulation Moisture Activated Dry Granulation (MADG)(MADG)

It involves minimal moisture addition, distribution and It involves minimal moisture addition, distribution and agglomeration. agglomeration.

No drying step is required. No drying step is required. Water distribution is via high shear mixer, or low-shear mixer Water distribution is via high shear mixer, or low-shear mixer

with highly atomized water spray. with highly atomized water spray. Better content uniformity than direct compression.Better content uniformity than direct compression. Excess moisture is absorbed by hydrophilic polymers such as Excess moisture is absorbed by hydrophilic polymers such as

cellulose or silica added to the moist pre-blend. cellulose or silica added to the moist pre-blend. Applicable to controlled release.Applicable to controlled release.


Thermal Adhesion Granulation Thermal Adhesion Granulation Process (TAGP)Process (TAGP)

It is applicable for preparing direct tableting It is applicable for preparing direct tableting formulations. formulations.

TAGP is performed by subjecting a mixture TAGP is performed by subjecting a mixture containing excipients to heating at a temperature in containing excipients to heating at a temperature in the range from about 30ºC to about 130ºC in a closed the range from about 30ºC to about 130ºC in a closed system under mixing by tumble rotation until the system under mixing by tumble rotation until the formation of granules. formation of granules.

It provides granules with good flow properties and It provides granules with good flow properties and binding capacity to form tablets of low friability, binding capacity to form tablets of low friability, adequate hardness and have a high uptake capacity adequate hardness and have a high uptake capacity for active substances whose tableting is poor.for active substances whose tableting is poor.


Foam GranulationFoam Granulation

Here liquid binders are added as aqueous foam. Here liquid binders are added as aqueous foam. useful for granulating water sensitive formulations,useful for granulating water sensitive formulations, Reduces drying time Reduces drying time Reduce manufacturing time, less binder required for Reduce manufacturing time, less binder required for

Immediate Release (IR) and Controlled Release (CR) Immediate Release (IR) and Controlled Release (CR) formulations.formulations.


Recent Coating TechniquesRecent Coating Techniques

Dry coatingElectrostatic coating


Electrostatic dry powder coating for Electrostatic dry powder coating for Immediate releaseImmediate release

Eur J Pharm Biopharm. 2010 Jun 19. Qiao M ,Zhang L, Ma Y,Zhu J ,Chow K. University Eur J Pharm Biopharm. 2010 Jun 19. Qiao M ,Zhang L, Ma Y,Zhu J ,Chow K. University of Western Ontario, canada of Western Ontario, canada

Developed electrostatic dry powder coating in a pan Developed electrostatic dry powder coating in a pan coater system. coater system.

Two immediate release coating compositions Two immediate release coating compositions Opadry(R) AMB and Eudragit(R) EPO were Opadry(R) AMB and Eudragit(R) EPO were

successfully applied using this process. successfully applied using this process. A liquid plasticizer was sprayed onto the surface of A liquid plasticizer was sprayed onto the surface of

the tablet cores to increase the conductivity of tablet the tablet cores to increase the conductivity of tablet cores to enhance particle deposition,cores to enhance particle deposition,


Electrostatic dry powder coating for Electrostatic dry powder coating for Immediate releaseImmediate release

The application of liquid plasticizer was followed by The application of liquid plasticizer was followed by spraying charged coating particles using an spraying charged coating particles using an electrostatic charging gun to enhance the uniform electrostatic charging gun to enhance the uniform deposition on tablet surface. deposition on tablet surface.

The coating particles were coalesced into a thin film The coating particles were coalesced into a thin film by acceptable processing temperature as formation by acceptable processing temperature as formation was confirmed by SEM micrographs. was confirmed by SEM micrographs.

The results also show coating process produces The results also show coating process produces tablets with smooth surface. tablets with smooth surface.


Dry coating in a rotary fluid bedDry coating in a rotary fluid bed

Caroline Désirée Kablitz , a, Kim Hardera, and Nora Anne Urbanetza Caroline Désirée Kablitz , a, Kim Hardera, and Nora Anne Urbanetza a Institute of Pharmaceutics, Germany 14 November 2005 a Institute of Pharmaceutics, Germany 14 November 2005. .

A highly efficient dry coating process was developed A highly efficient dry coating process was developed to obtain an enteric film avoiding completely the use to obtain an enteric film avoiding completely the use of organic solvents and water. of organic solvents and water.

Using hydroxypropyl methylcellulose acetate Using hydroxypropyl methylcellulose acetate succinate (HPMCAS) an enteric coat should be succinate (HPMCAS) an enteric coat should be obtained without adding talc as anti-tacking agent obtained without adding talc as anti-tacking agent because of problems arising from microbiological because of problems arising from microbiological contamination..contamination..

The process was conducted in the rotary fluid bed .The process was conducted in the rotary fluid bed .


Dry coating in a rotary fluid bedDry coating in a rotary fluid bed

The determined coating efficiency of the talc-The determined coating efficiency of the talc-free formulation was high with 94% and free formulation was high with 94% and storage stability regarding tacking could be storage stability regarding tacking could be achieved using colloidal silicon dioxide as top achieved using colloidal silicon dioxide as top powder. powder.

coating process in rotary fluid bed. serious coating process in rotary fluid bed. serious alternative to conventional solvent or water alternative to conventional solvent or water based coating processes.based coating processes.


Automated EquipmentAutomated Equipment Currently several supplier of equipment are develop Currently several supplier of equipment are develop

and introducing automated system which not only and introducing automated system which not only monitor & control each important parameter but monitor & control each important parameter but integrate the controls so that a change in one integrate the controls so that a change in one condition cause a corrective or compensating action condition cause a corrective or compensating action in the system.in the system.

If change is critical the system shut itself down.If change is critical the system shut itself down.

Automated EquipmentAutomated Equipment

RMGRMG

SIFTERSIFTER

CO-MILLCO-MILL

DISCHARGE BOWL/FBD DISCHARGE BOWL/FBD BOWLBOWL

Automated Equipment attached to each other.Automated Equipment attached to each other.

AUTOMATIAUTOMATICC


FBD FBD

FBD BOWLFBD BOWL

{{RECIPE RECIPE SET}SET}

BLENDERBLENDER

COMPRESSION COMPRESSION MACHINEMACHINE

MANUALMANUAL

AUTOMATIAUTOMATICC


COMPRESSION MACHINECOMPRESSION MACHINE

BLISTER/STRIP MACHINEBLISTER/STRIP MACHINE

CARTON CARTON AUTOFILLAUTOFILL

SHIPPERSHIPPERMANUAMANUALL

AUTOMATIAUTOMATICC




New non contact firm grip handler new New non contact firm grip handler new tablet printing machinetablet printing machine

Purto rico,Purto rico,NYNY javits apr 2007 newyork javits apr 2007 newyork Its capable printing of clear quality character Its capable printing of clear quality character

number,bar codes,logos ,data on tablet.number,bar codes,logos ,data on tablet. Its capable of 250-750,000 tablets per hour.Its capable of 250-750,000 tablets per hour. 100% vision product verification camera 100% vision product verification camera

station is an automated.station is an automated. Computerized control is integrated with a 21 Computerized control is integrated with a 21

CFR part 11.CFR part 11.


NEW POLYMERSNEW POLYMERS AQUA ZEIN AQUA ZEIN HYDROXYPROPYL HYDROXYPROPYL

DERIVATIVEDERIVATIVE FG 90 CHITOSANFG 90 CHITOSAN EUDRAGITEUDRAGIT International Journal of PharmaceuticsInternational Journal of Pharmaceutics

Volume 377, Issues 1-2Volume 377, Issues 1-2, 30 July 2009, Pages 120-127 , 30 July 2009, Pages 120-127

Disintegrating materialDisintegrating material CYCLODEXTRINCYCLODEXTRIN MALTODEXTRINMALTODEXTRIN CORNSTARCH CORNSTARCH ALGINIC ACIDALGINIC ACID METHOCEL®METHOCEL® STARCH-AGAR STARCH-AGAR

MIXTUREMIXTURE VEEGUM® HVVEEGUM® HV

http://www.sciencedirect.com/science/journal/03785173

http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235069%232009%23996229998%231288054%23FLA%23&_cdi=5069&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d4eb01aa890c00a474fda0130b7eba2e


Health & Medicine

Recent advances in tablet copy