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METABOLISM OF PURINE NUCLEOTIDES
Origin of the ring atoms of purine
Purine bases are recycled from Salvage Path way
Adenine + PRPP AMP+ PPi
Guanine + PRPP GMP+Ppi
Hypoxanthine+ PRPP IMP+PPi
APRT
HGPRT
HGPRT
GOUT Primary Gout: Enzyme defect Secondary Gout 1.Over production of Uric acid (Cancer,
Starvation,alcohol) 2.Decreased excretion of uric acid (renal failure,
Lactic acidosis, alcohol)
GOUTSymptoms: Arthritis of Metatarsophalangeal jointPrecipatated by high purine diet & alcoholTophi – chronic cases Treatment:Decreased purine intake Allopurinol- xanthine oxidase inhibitorProbenacid – uricosuricsColchicine – anti inflammatory
LESCH- NYHAN SYNDROMEX – linked disorderHGPRTase deficiencySelf mutilation, mental retardation,
nephrolithiasis
PURINE NUCLEOTIDE ANALOGSUsed as Anti cancer agents:MercaptopurineMethotrexateAzaserine 6-TG (thioguanine)8 AG (Azaguanine)