Decolonization MRSA•Evidence supporting is

strong.•Efficacy studies needed for

different treatments.•Cost analysis needed.

Nutritional OptimizationLymphocyte Cnt > 1500

Albumin > 3.5 g/dlZinc > 5 mcg/dl

Transferrin > 200 mg/dl

High Risk: Increased Contamination

•Revision•OR > 150 min

•Prior joint infection

High Risk: Decreased Immunity

•Rheum Arthritis•Diabetes Mellitis•Organ Transplant

•Hemophilia

DiabetesDM: 3.43% vs 0.87%Mraovic et al 2011:

Blood glucose levels before surgery and POD#1 were

significantly correlated with infection.

Obesity•Independently assoc c

Infection•Inceased risk of other

comorbidities (*diabetes, CV disease)

Postoperative Optimization•Post op antibiotics•Blood Transfusion

Hematoma and Drainage•Duration of hospital stay

•Invasive procedures (including dental)