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PREOPERATIVE SEDATION AND PREMEDICATION IN PEDIATRICS
DR NIDA FATIMAJAWAHARLAL NEHRU MEDICAL
COLLEGE,AMU ALIGARH
objectives
• Sedation and premedication• Why? --Aims of premedication!• When?• How?• Drugs for premedication!• Routes for administration!• Side effects & complications!
• Whole family is under Stress.• Parental Anxiety• SEPARATION ANXIETY• <6m- no separation anxiety• 6m- 5yrs -more regression after separation• 2-6years -↑ in anxiety than older child-5X
Introduction
Kids not small adults • Respiratory functions• Hepatic functions poorly developed• Renal functions• Cardiovascular-heart rate dependent • Apnoeic events related to Gestational age.• ANS and reflexes – poorly developed
•Great variation in recommendations.•Sedative -omitted for neonates and sick infants.•child's age, body weight, drug history, allergic status and medical or surgical conditions •Avoid needles!!•Oral premedication ≠ risk of aspiration pneumonia
Pediatric consideration
What does “put to sleep” really meanWill I be awaken during operation?Will I move during Operation?Am I going to die?Will I be naked totally.Concerns of mutilation and tortureNeedle phobia
Fear of Unknown-older kids
1. Narrative information 2. Orientation tour to O.T’s3. Role rehearsal using dolls 4. Puppet shows/ Videos of O.R5. Communication 6. Consent
Pre-op preparation programs
• Allay Anxiety & fear.• Reduce saliva and airway secretions.• Enhance the hypnotic effects of general
anaesthesia.• Reduce postoperative nausea & vomiting.
AIMS OF PREMEDICATION
• Attenuate vagal reflexes.• Produce amnesia.• ↓ volume & ↑pH of gastric contents.• Attenuate sympathoadrenal responses. • ↓amount of drug produce-unconsciousness.• Provide analgesia before surgery.
• Untreated severe GERD • Recent apnea history• Congenital airway anomalies -macroglossia,
micronathia, etc.• Extreme Tonsillar hypertrophy• Mitochondrial or metabolic disease
Specific risks
Greater risk for aspiration Low gastric pH High residual volumes
Type Fasting time (hrs)Clear liquids 2Breast milk 4
Infant formula 6Solid (fatty or fried) foods 8
Preoperative fasting
• Vital signs –H.R, R.R, B.P, temperature• Pulse oximetry• ETCO2 • Accurate weight• Focused physical exam-ECG, rate & rhythym.• Renal or hepatic functions.
Pre-sedation assessment
Drugs options for sedation
• Narcotics: Morphine, fentanyl• Benzodiazpines: Diazepam, Midazolam• Ketamine• Barbiturate: Thiopentone, Methohexital• Propofol• Clonidine, Dexmedetomidine• Chloral hydrate
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. Advantages Disadvantages
Oral painless slow onset
IM reliable painful, threatening, sterile abscess
Rapid onset
Rectal rapid, reliable painful defaecation
Irregular/delayed Absorption
Nasal reliable uncomfortable,Desaturation
Transoral,
Muco oral reliable slow onset, nauseaVomiting, desaturation
IV most reliable Painful, threatening
Routes of administration Route of administration Advantages Disadvantages
Oral painless slow onset
IM
Rapid onsetreliable
painful, threatening, sterile abscess
Rectal rapid, reliable painful defaecationIrregular / delayed absorption
Route of administration
Advantages Disadvantages
Nasal reliable uncomfortable, Desaturation
Transoral,
Muco oral reliable slow onset, nausea,Vomiting,
desaturation
IV
most reliable Painful, threatening
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Doses of drugs commonly used:
Drug Dose mgm/kg. Route
Barbiturates
• Methohexital 20-30 10% rectal, • Thiopentone 20-30 rectal
Doses of drugs commonly used
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Benzodiazepines
Diazepam oral 0.1-0.3 Iv 0.1-0.3 Im not recommended Rectal 0.2-0.3
Midazolam oral 0.5-0.75 Iv 0.05-0.15 Im
0.05-0.15 Rectal 0.5-0.75 Nasal 0.2-0.5 Sublingual 0.2-0.5
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• KETAMINE Oral 6-10 mgs Iv 1-3 Im 2-8 Rectal 10-15 Nasal 3-5
Sublingual 3-5
•1.PATIENT• Age, sex, body wt, physical condition, psychological status.
•2.PROPOSED SURGERY• Nature of op. , site of op., posture during surgery, duration of Op ,etc
FACTORS AFFECTING CHOICE OF PREMEDICANT DRUG
• 3. Availability- adequate preoperative and postoperative nursing care
• 4. Surgical and anaesthetic management available
FACTORS AFFECTING CHOICE OF PREMEDICANT DRUG
IDEAL STRATEGY• eliminates the pain, discomfort,& physiologic
abnormalities,• helps intubation expeditiously, • minimizes traumatic injury to the newborn,• Complete Cardiopulmonary stability• has no adverse effects• Rapid induction and emergence
• Midazolam - 0.3–0.5 mg/kg, 15 mg maximum• oral route-preferred-less traumatic than i.m• requires 20–45 min for effect, bitter • Smaller doses of midazolam in combination with oral ketamine (4–6 mg/kg)• Chloral hydrate 20 to 75 mg/kg max 2 g
Oral gastric/sublingual/transmucosalsedatives
• uncooperative patients, intramuscular Midazolam-0.1–0.15 mg/kg, 10 mg maximum or Ketamine (2–3 mg/kg) with Atropine (0.02 mg/kg) may be helpful.
Intramuscular sedatives
• Rectal midazolam- 0.5–1 mg/kg, 20 mg max• Rectal methohexital-25–30 mg/kg of 10% sol
administered in cases while the child is in the parent’s arms.
Rectal sedatives
• Sufentanil 1-2 µgkg-1 ,• midazolam 0.2-0.3 mgkg-1 • Ketamine 2-3mgkg-1
• unpleasant,• potential neurotoxicity of nasal midazolam.• Nasal dexmedetomidine has also been used by
some clinicians.
Nasal sedatives
• Use of topical analgesia if possible– EMLA, LMX, Synera (>3 years)-use care to follow
age and duration guidelines– New product on market called Zingo (>3 as well)
being trialed at several pediatric institutions• Take time to find best site• Secure well!
IV access
• Lollipop: Fentanyl-Actiq, 5–15 mcg/kg• Fentanyl levels continue to rise intraop and
contribute to postoperative analgesia.
Other routes:
Sedation Scoring Scale Description
1 Awake
2 Awake, Calm and quiet
3 Drowsy, readily responds to verbal gentle stimuli
4 Asleep, slowly responds to verbal/gentle stimuli
5 Asleep, not readily arousable.
SCORING SYSTEMS OF EFFICIENCY OF PREMEDICATION
• Reduces- bradycardia during induction. • reduces-hypotension in neonates and infants <3m• prevent secretions –bronchial and salivary. • Secretions-patients with URIs or ketamine. • Atropine orally (0.05 mg/kg), i.m, rectally.
Anticholinergics
• Atropine, 0.01-0.02 mg/kg i.m or i.v• Glycopyrollate ,0.01mg/kg i.m/i.v-does not cross
BBB, no confusion • Scopolamine (0.005-0.01 mg/kg)-sedating effect
of 5 to 15 times> atropine• adjuvant to ketamine anesthesia-antisialagogue
and central sedative effects
Analgesics
• Pain alleviation -goal of all caregivers.• Pain at intubation -disturbs physiologic homeostasis• analgesic reduces the pain and discomfort of
intubation.• Ideally - rapid onset, short duration, no adverse effects on respiratory mechanics, and predictable pharmacokinetic properties.
• Neonates-very sensitive to respiratory depressant effects of opioids-rarely used.
• Opioids-Used in children.• Opioids + sedatives , dose adjusted to avoid
serious respiratory depression. • Other analgesics:• Acetaminophen, tramadol, butorphanol,
codeine, pentazocine.
• Opioids-m/c used → Fentanyl• Oral-10 to 15 μg/kg. = 1-2 μg/kg i.v / nasal• children blunts physiologic disturbances-
endotracheal suctioning, ↓pulmonary arterial pressure & systemic hypertension.
• Remifentanil-rapid onset of action and an ultrashort duration of action
Antihistaminics
• Central antiemetic action • Sedation • Anxiolysis • H2 receptor antagonism• ά – adrenergic anatagonism • Anticholenergic properties • Potentiation of opiod analgesia
•
• Antihistamine, antiemetic, and sedative activity,• Weaker sedative than Diazepam• Best premedication for Ketamine• Competes for H1 receptor sites on effector cells• Prevents histamine-mediated responses• preoperative sedation and as an analgesic
adjunct
Promethazine
ANTI-EMETICS
1.Metoclopramide–0.15-0.20 mg/kg iv2.Ondansetron-0.10-0.12 mg/kg iv3. Droperidol 0.05-0.075 mg/kg.4. Dexamethasone 0.1-0.2 mg/kgCombination of metocopramide, ondansetron,
dexamethasone etc.
α2 Agonist
• dose-related sedation • attenuates the hemodynamic response to
intubation in combination with atropine.• Clonidine oral 3-4 µg/kg • Dexmedetomidine-safety not established in
pediatric age group.
Suppress cardiovascular system
Respiratory side effects (decreased ventilation)
Hard to monitor effects
Side effects of individual drugs
DISADVANTAGES OF PREMEDICATION
Adverse effects • Opioids- acute chest wall rigidity-preterm and
term infants, nausea and vomiting • Midazolam- intranasal-potential neurotoxicity• cardiovascular collapse after regional anesthesia
toxicity• paradoxical effect with behavioral changes and
agitation and hiccups
• Methohexital- hiccups, apnea, airway obstruction, laryngospasm , cardio-respiratory arrest
• Chloral hydrate- metabolic acidosis, renal failure, and hypotonia
• Phenothiazines- dystonic reactions • Ketamine- hallucinations, nightmares, and
delirium • Codeine-seizure
No premedication• Intubation without premedication may• be acceptable during :• infants with upper airway anomalies such as
Pierre Robin sequence.• during resuscitation• after acute deterioration or critical illness
Thanks!!