Alz-50 PHF-1

Silver Thioflavine S

PHF-1 PHF-1

Clif Saper

EM:

Sheep Human

Humans – NFTs

Rhesus monkeys – No NFTs

Artiodacytla (sheep, goats, cows) – NFTs

Mice and rats – No NFTs-Add human tau gene: NFTs

Is this informative in a clinico-biologic sense?

NFT in cow (Bos taurus)

PHF-1

A-Ab pathologyB-Braak NFT stagesC-CERAD Neuritic Amyloid plaques