Pattern diagnostics 2015

InnVentis

Pattern Diagnostics & Precision Medicine Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease Committee on a Framework for Development a New Taxonomy of Disease; National Research Council Preparing for Precision Medicine World Economic Forum November 2012

The precision medicine revolution: Targeted treatment zeros in on disease; GE Look ahead 2013

R&D Ecosystem of the Future 2011: By 2020, four out of every five drugs launched will be Precision Medicine drugs.

Precision Medicine © Dr. Thomas Wilckens, InnVentis

InnVentis

Precision Medicine - Paradigm Shift

Symptom-based Cohort-based Algorithm-based

Yesterday

Intuition Medicine

Today

Evidence-based Medicine

Tomorrow

Precision Medicine

DA

TA

AC

TIO

NS

Application of rules, algorithms and reference databases enables ACTIONABLE clinical decision support & PRECISE/EFFICIENT care

Reference Databases (Rules &

Algorithms)

Personal Molecular

Profiles (PMP, multi-omics)

Molecular Imaging

Non-molecular content (waveforms)

Precision Medicine

(prevention,

diagnosis, treatment)

Mobile Information

Communication Technologies

Big Data Analytics


InnVentis PRECISION MEDICINE: Integrating multi-omics, clinical and real world data

Eric Topol, CELL,Volume 157, Issue 1, 27 March 2014, Pages 241–253

‘‘omic’’ Latin suffix ‘‘ome’’ = mass or many.

Creation of topological maps

of health/disease

InnVentis

Convergence of diagnostics with Big-Data & AI: Multi-omics create Personal Molecular Profile, PMP

Genome 25.000 genes

Proteome 1 million

Metabolome > 6000 SM

Microbiom 1-3 % of

body mass

Existing knowledge ?


Big DATA

Pattern Discovery Reference Database Machine learning Algorithms

Personal Molecular

Profile

InnVentis

Pattern discovery & machine learning: All human senses use this principle

Pattern recognition: • Hearing (Music, Voices,…)

• Odors

• Taste

• Vision

• ……….


InnVentis Patter recognition is an archaic principle Application of pattern discovery to identify hidden disturbances

Pattern diagnostics:

• Host defence and immunity

• Enables greater flexibility

• Follows evolutionary principles

• Artificial Immune Systems in Computing, Fraud analysis etc.


InnVentis

Disease is a cuckoo‘s egg Application of Pattern discovery to identify hidden disturbances

Pattern recognition algorithm reveals how birds evolve individual egg pattern signatures Nature Communications 2014/5, Article number: 4117

Pattern diagnostics: • Invented by nature

• Enables dynamic differentiation

• Appreciates individuality


InnVentis

Pattern diagnostics: • Dynamic models

• Identifies „minor“ changes

• Flexible viewpoints

The tools are there: Facebooks deep learning face recognition


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Pattern-diagnostics: • Is independent from baselines

• Reveals “hidden” disturbances

• The more data the better the analysis;

i.e. precise patter recognition from “different angles”

• Machine learning recognizes “fragments” of a pattern

Molecular patterns are like memorable „skylines“

Pattern discovery, Machine Learning in Precision Medicine: Pattern-diagnostics enables flexible, precise diagnostics


InnVentis

child

Pattern diagnostics: • Lifetime monitoring

• Prevention

• Early intervention

• What‘s needed? DATA

Patterns are dynamic and flexible: Personal molecular pattern evolution over time

adult


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Detecting criminal organizations in mobile phone networks. Expert Systems with Applications 41(13):5733-5750, 2014

Disrupting biomedical R&D: Machine learning, pattern discovery and algorithm-based analytics

Paradigm shift: • Social networks are like biological

organisms

• There are tools to analyze social networks – user friendly

• Detecting pathologies with machine learning and algorithms in real-time: the future of diagnostics


InnVentis POC: Classification for childhood arthritis with pattern recognition: Relationship between the clusters and ILAR subtypes

The biological basis for clinical heterogeneity in childhood arthritis. Arthritis Rheumatol. 2014 Sep 8

Pattern diagnostics: • ILAR knows 6 (clinical) groups

• 152 and 102 patients

• Multiple molecular analytes

• New: 11 molecular clusters


InnVentis

Fully automated pattern discovery and classification

Resulting predictive model has an overall accuracy of 92.4%

In cross-validation, 88.4% of never before seen individuals could be assigned the correct class

Pattern discovery & machine learning Facilitating Big DATA management & analytics

Data of 1209 metabolites from 132 patients assigned to three groups: Healthy controls, low risk patients and high risk patients.

InnVentis‘solution reduceds the time for analysis from:

1day to 1min Scalable for Big DATA


InnVentis

New data and standardized processes (SOP) Essential prerequisites for success and value creation:

Nature 03 April 2013 If a job is worth doing, it is worth doing twice Researchers and funding agencies need to put a premium on ensuring that results are reproducible

Garbage in

Garbage out


How much existing „knowledge“ can be used, how?

InnVentis

Standards and SOPs on the horizon to secure value today? The case for vertically integrated lean and fast pilot projects

Launch of a Transformative Health Care Initiative: The National Biomarker Development Alliance (NBDA) 1/2014

Problems with scientific research How science goes wrong Scientific research has changed the world. Now it needs to change itself 10/2013

A sea of standards for omics data: sink or swim? JD Tenenbaum et. al. Am Med Inform Assoc, 09/2013

SOPs

= Value


Establishing data bases and algorithms requires highest comparability, validity & reliability

InnVentis Challenges: Pros should pave the way

Most biomarker discovery still takes place in government-funded university laboratories that are ill equipped to undertake the myriad procedures required for stringent biomarker profiling on the scale required to achieve the evidence needed to attract larger investment in clinical trials.

National Biomarker Development Alliance 9/2014


InnVentis

Precision Medicine & Big DATA

[email protected]

InnVentis enabling

PRECISION MEDICINE

Disclaimer: This presentation is for educational purposes only. No copyright violations are intended. Distribution, also in part, for commercial purpose is illigal


Health & Medicine

Pattern diagnostics 2015