Non-steroidal anti-inflammatory drug NimesulideNimesuilde is a pain killer Non-steroidal medicinal drug (NSAIDs)with a complex mode of action, characterized by a quick onset of analgesic activity.The anti-inflammatory drug mechanism ofNimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patients overall risks.Main purpose of using this drug is to treat acute pain, to treat degenerative joint disease, to treat primary dysmenorrhoea in adolescents and adults above 12 years old, it is used for treatment of all types of pains resulting from sports injury, depression etc.Additionally it helps in increasing energy, improve skin tone, and to cure Heart diseases, and also helpful for dry skin and is usually recommended for the shortest period necessary to control symptoms in patients with painNimesulide has superior gastrointestinal safety as compared to other NSAIDs.
Its multifactorial mode of action gives a unique and broad action on inflammatory processes.Nimesulide is also offered in the form of gell, powder which is now available in worldwide of more than 50 countries. It also available in different trademarks like Nimesil, Nimulid, Nise e.t.c.The solubility enhancement of 4 cox-2 inhibitors, celecoxib, rofecoxib, meloxicam, and nimesulide, using a series of pure solvents and solvent mixtures. Water, alcohols, glycols, glycerol, and polyethylene glycol 400 (PEG 400) were used as solvents and water-ethanol, glycerol-ethanol, and polyethylene glycol-ethanol were used as mixed-solvent systems. A pH-solubility profile of drugs was obtained in the pH range 7.0 to 10.9 using 0.05M glycine-sodium hydroxide buffer solutions. Lower alcohols, higher glycols, and PEG 400 were found to be good solvents for these drugs. The aqueous solubility of celecoxib, rofecoxib, and nimesulide could be enhanced significantly by using ethanol as the second solvent. Among the mixed-solvent systems, PEG 400-ethanol system had highest solubilization potential. In the case of meloxicam and nimesulide, solubility increased significantly with increase in pH value. Physico-chemical properties of the solvent such as polarity, intermolecular interactions, and the ability of the solvent to form a hydrogen bond with the drug molecules were found to be the major factors involved in the dissolution of drugs by pure solvents. The greater the difference in the polarity of the 2 solvents in a given mixed solvent, the greater was the solubilization power. However, in a given mixed-solvent system, the solubilization power could not be related to the polarity of the drugs.Assessment of nimesulide solubility: Solubility of nimesulide in phosphate buffer pH 6.8 in presence of different 323 concentrations 2-10% (v/v or w/v) of some selected cosolvents was investigated. The selected cosolvents were: formamide, DMF, DMA, DMSO, ethanol, propanol, isopropanol, glycerol, EG, PG, PEG 200, PEG 300, PEG 400 and PEG 600. In addition, the solubility in presence of different concentrations 2-10% (w/v) of different nonionic surfactants (tween 20, tween 40, tween 80, myrj 52, myrj 53, brij 35 and brij 58) was also studied. An excess amount of nimesulide was added to 50-ml stoppered glass bottles containing 10 ml cosolvent solutions or surfactant solutions. The bottles were shaken in a mechanical shaking water bath previously equilibrated at 32C. Aliquots were withdrawn after three hours (equilibrium time), filtered using a 0.45 m membrane disc filter and assayed spectrophotometrically at max 392 nm (max was determined practically) after appropriate dilution employing the same concentration of the cosolvent or surfactant as a blank. The results are the mean values of three determinations.