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NMDP and Be The Match Registry™ Overview
John P. Miller, MDPhD Cord Blood Symposium, San Francisco
June 5, 2013
About Transplant
A marrow or umbilical cord blood transplant is often the best or only hope of a cure for many patients with leukemia, lymphoma and other life-threatening diseases.
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70% of all patients who need a transplant do not have a matching donor in their family. They turn to the NMDP’s Be The Match Registry® to find an unrelated donor.
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National Marrow Donor Program is a nonprofit organization dedicated to creating an opportunity for all patients to receive the marrow or umbilical cord blood transplant they need, when they need it.
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Overview of Our Work
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Support Patients
Conduct & Support Research
Manage the Be The Match
Registry®
Educate Doctors
Facilitate Transplants
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NMDP Network
174 Transplant Centers (36 International)
100 Apheresis Centers (15 International)
44 Recruitment Centers
92 Collection Centers (15 International)
49 Donor Centers (8 International)
25 Cord Blood Banks (5 International)
1 Sample Repository 26 Testing
Laboratories
40 Cooperative Registries
Cord Blood Bank Network Membership Types US Number International
Number
NMDP Member Cord Blood Banks 19 NA
NMDP Affiliated Listing CBBs 1 (has own IND)
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CBBs Qualified under NMDP IND 19 63
Total CBBs accessible through NMDP
20 63
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International Activity
• 45% of transplants we facilitate have either an international donor or recipient
• More than 18.5 million potential adult donors and more than 590,000 cord blood units available worldwide
FY 2011
Be The Match Registry 2012 A
dult
Don
ors C
ord Blood U
nits
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Growth of Cord Blood Units on the Be The Match Registry®
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Diversity of Adult Donors on the Be The Match Registry® 2012
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Diversity of Cord Blood Units on the Be The Match Registry® 2012
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Transplants by Cell Source
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Transplants – Distribution of Cell Source
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Minority includes those patients with race of CAU, DEC, OTH, and UNK in combination with Hispanic ethnicity.
NMDP Transplants for Minority and Caucasian Patients
Transplants for Minority Patients by Cell Source
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Role of Cord Blood in Transplants by Patient Race
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Meeting Need of Minority Patients
• 44% of CBUs on the registry are from a minority donor (compared to 27% of adult donors)
• Over last 5-6 years cord blood has been product source for ~20% of all transplants • In 2012 thirty-nine percent of minority patients who received a transplant used cord blood • In 2012, 33 percent of cord blood transplants were for minority patients
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Transplants by Recipient Age
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Overall Survival, 3-year
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45 (42-48)%
55 (52-58)%
Malignant diseases, age <18 yrs
Non-malignant diseases Malignant diseases, age ≥ 60 yrs
Malignant diseases, age 18-59 yrs
P<0.001 P<0.001
25 (21-30)%
35 (33-37)%
60 (55-64)%
69 (66-72)%
P<0.001
2000-2004
2005-2009
Access to Transplant
• With expanded indications and age ranges, the calculated “need” for unrelated transplant has increased by 25%
• NMDP facilitated transplants have grown by 200% overall and 250% for minorities during that same timeframe
• Challenge – Meeting only 25% of the need in Minority communities and 50% of the need in the Caucasian population
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Access has improved since 2006
We advance transplant science through our research partner, CIBMTR®
(Center for International Blood and Marrow Transplant Research)
• Improved matching: making
it easier and faster to find the best donor or cord blood unit
• Improved timing: earlier
transplant is leading to better outcomes
• Advances in treatment:
making transplant a better option for patients 51-75 years old.
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We will continue to:
• Increase recruitment and availability of adult donors, cord blood and new cell sources.
• Help all patients get the
transplant they need, when they need it.
• Improve outcomes
through advances in research and clinical practice.
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Future Goals
• Join the Be The Match Registry®
• Make a donation to: - grow the registry - help patients cover uninsured costs - advance research • Spread the word about
the opportunity to help save a life
• Help collect high quality cord blood units (CBUs)
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You Can Help
The NATIONAL
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