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NeuroborreliosisName: Khalid Al-Kuwity
ID:213119354
Tutor: DR. Ansari
Objectives
• Neuroborreliosis • Epidemiology • Complication • Multiple Sclerosis • Neuroborreliosis v.s M.S• Diagnosis• Clinical features • Treatment• Prevention
Neuroborreliosis
Lyme disease (Neuroborreliosis ) is an infectious disease caused by the bacterium Borrelia burgdorferi .
Lyme disease can be transmitted to humans by the bite of an infected tick.
What is Borreliosis?
• The genus Borrelia is a member of the larger family of spiral-shaped bacteria called Spirochaetes and the bacteria can be termed as a Borreliosis.
Cont…
• There are many species of Borrelia bacteria worldwide, but not all of them cause the disease.
• There are only 3 species that known to cause the disease:
1- Borrelia burgdorferi.
2- Borrelia afzelii.
3- Borrelia garinii.
Symptoms
• Flu-like.• Erythema migrans (EM)
Rash.• Headache.• Stiff neck.• Muscle pain.• Tender glands • sensitivity to temperature
,sound and light levels
Con…
• Extreme tiredness.• Muscle weakness.• Joint pain.• Upset digestive system.• Disturbances of the central nervous
system• Sleep problems.
Con…
Epidemiology
Risk Factors
• Spending time in wooded or grassy areas.
• Having exposed skin.• Not removing ticks promptly or properly.
Complications
• Chronic joint inflammation (Lyme arthritis) commonly in the knee.
• Neurological symptoms, such as facial palsy and neuropathy.
• Cognitive defects, such as impaired memory.
• Heart rhythm irregularities
Multiple Sclerosis
Neuroborreliosis v.s M.S
*Golden Key
Mutable Sclerosis Lyme Disease
Effect only the CNS UMN
IgG oligoclonal band in the CSF
Parathesia (transit) not sever pain and not persist
Effect the CNS,PNS UMN, LMN
Present with organism antibody ( IgM, IgG) in the
CSF
Sever burning pain
Diagnosis
• Clinical features.• IgM antibodies detected in the 1st
month.• IgG late in the disease.• Enzyme-linked immunosorbent assay
(ELISA).• CSF (cerebrospinal fluid). • Polymerase chain reaction (PCR).
Clinical Features
Skin stage :present with erythmea
migrans. Associate with fever and
headache
Neurologic and cardiac
stage
Chronic Arthritis stage
Several day to weeks or months
If not treated
Treatment
• Antibacterial tablet ( Amoxicillin, doxycycline)
• Intravenous administration of ceftriaxone, cefotaxim or benzyl-pienicillin.
Prevention
• Wear long pants and long sleeves.• Use insect repellents.• Do your best to tick-proof your yard. • Check yourself, your children and your
pets for ticks.• Don't assume you're immune.• Remove a tick as soon as possible.
References
• 111-120, 130 1478-1481 352
156-161• http://www.mayoclinic.org/diseases-conditi
ons/lyme-disease/basics.
• http://www.lymediseaseaction.org.uk
Thank You