Minoxidil - Translation from Hypertension ingredient to Hair Growth Stimulant

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MINOXIDIL - Translation from Hypertension ingredient to Hair Growth Stimulant

Minoxidil is an additional popular ingredient for well-known products in the hair loss prevention and hair regrowth industry. This was an interesting find because the original use for Minoxidil was for treatment of high blood pressure.

Molecular formula

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History:

Minoxidil was originally developed in the early 1970’s as a treatment for hypertension. Its use for treating thinning hair was originally discovered when it was noted to cause increased hair growth as a side effect of this treatment. Since 1998, Topical Minoxidil is the most widely recommended treatment for androgenetic alopecia. Minoxidil works to relieve hypertension by acting as a vasodilator. This means that it opens and relaxes blood vessels enough to reduce the force with which blood is pumped through them. This same vasodilatory property is responsible for the effectiveness of Minoxidil in stimulating hair re-growth. It causes vasodilation of the blood vessel by releasing nitric oxide which is known to widen the diameter of the vessels. As an antihypertensive, Minoxidil (sold as Loniten) is not the first-line drug in the management of high blood pressure. Because of its systemic side effects, when it was formulated for hair loss treatment, Minoxidil was presented in topical preparations to be applied directly to the hair.


Minoxidil and Hair Growth

Before Minoxidil was available as a topical hair loss solution, it caused the fortunate side-effect of new hair growth in those taking Loniten for hypertension. Minoxidil also caused the darkening of fine hair all over the body. These effects are, however, not long-lasting. To stimulate hair growth, topical Minoxidil preparations are mostly effective in people under 40 years and who have just recently started losing hair. Furthermore, Minoxidil is more effective when used on small areas rather than large areas of hair loss. 2% solution of the medication is found to be effective in reversing hair loss in 30% of male patients. Female patients, however, have much success with this concentration. 5% Minoxidil preparations produce a higher success rate, and is currently the preferred formulation for men. Apart from stimulating new hair growth, Minoxidil thickens existing hair shafts making even sparse hair look thicker. While the exact mechanism of Minoxidil role in hair loss reversal is not completely clear, two possible pathways have been proposed for its activity on the hair. First, Minoxidil releases nitric oxide which is a known vasodilator in the body. This effect is further helped by the drug’s action on the potassium channels of the cell.

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Facts:

There are a few basic things to know about this blood pressure medication turned hair growth stimulant. •The reason for the ability to cause or stimulate hair growth in users is actually unknown.

•Minoxidil contains moiety, which is a nitric oxide. •Minoxidil is designed for topical use for treatment of baldness or hair loss. •For men the products that contain Minoxidil generally use five percent, while women's products use less at around two percent.


Minoxidil Formulations

Minoxidil is available both in 2% and 5% topical solutions. While the 2% solution stops hair loss and encourage hair regrowth in 30% of men using it, the 5% solution has a success rate of 65%. The 2% solution is prepared with alcohol while the 5% solution uses propylene glycol as solvent. Therefore, some may find out that the higher concentration makes their hair sticky and irritates the scalp.

The scalp has at an average 100,000 hairs. A healthy scalp sheds hair continuously and new hair replaces them. Hair growth follows a series of cycle. Each cycle includes a growth phase (anagen), a transitional phase (catagen), and a resting phase (telogen).

Therefore, Minoxidil causes the blood vessels to dilate and transport a greater volume of oxygen and nutrient-rich blood to hair cells. On the other hand, it opens the potassium channels in cell membranes.For hair follicle cells this means that they are perfused with more blood rich in oxygen and nutrients, and these nutrients can easily flow into the cells. The combination of the two effects increases hair follicle cell metabolism which leads to an increase in the production of new hair.Secondly, Minoxidil directly stimulates the hair follicle growth through a pathway involving prostaglandins. It also produces an increase in the number of dermal papilla cells.These two pathways combine to shorten the telogen phase and prolong the anagen phase of the hair growth cycle. The net effects are increased hair growth and thicker hair strands.


Many Forms of Minoxidil

Loniten - An oral antihypertensive drug with a side effect of stimulating hair loss. Loniten is not recommended for long-term hair loss treatment 2% Topical Solution - The first liquid Minoxidil formulation introduced as Rogaine. No longer recommended for men but still used by women to reverse hair loss 5% Topical Solution - A newer formulation of Minoxidil recommended for men. It has twice the success rate of the 2% solution 5% Aerosol Foam - Newest formulation of Minoxidil introduced for men who develop contact dermatitis to Minoxidil liquid preparation. Has a success rate of 85% in men. Higher than 5% Formulations - Do not provide significantly more hair re-growth compared to the 5% formulations but produce more side effects of Minoxidil.

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Before Use

After Use

Recommended dosage The usual topical dosage of Minoxidil is 1ML and has to be used twice a day. Generally Minoxidil 5% is used in the treatment of Male Androgenetic alopecia and Minoxidil 2% is used in the treatment of Female Androgenetic alopecia. Applications -Hair Tonic -Hair Ampoules-Hair Lotion -Hair Cream-Hair styling gel -Hair shampoo & conditioner

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Efficacy :

Minoxidil visibly increases the hair density by 54% in comparison with placebo.

+66%

Minoxidil stimulates hair growth with higher activity than the control. There is significant increase in hair growth in Month 5 by 66% compared to baseline.

Significant increase in Anangen / Telogen ratio indicates reduction in hair loss and stimulating hair growth property.


Features Benefits

Resets follicle "biological clock" to anagen growth phase Converts telogen follicles to

anagen phase Extends duration of anagen

growth phase Significantly increases A/T

Reverses the hair loss process and helps hair re-growth

Increases matrix cell proliferation Works on Front of the Scalp and the Crown

No miniaturization of hair follicles Protects and nourishes hair during natural seasonal hair shedding

Induces cell growth factors such as VEGF,HGF,IGF-1

Optimizes hair growth cycle

Inhibits negative factor Stable and easy to implement in the formulations.

Known for its efficacy Safe and Effective for Both Men and Women

Conclusion : Minoxidil (Kopdil) is the only FDA approved and clinically proven drug for treating hair loss & facilitate new hair growth. It is widely used in OTC formulations across the globe for both men & women.


Thank You!


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Minoxidil - Translation from Hypertension ingredient to Hair Growth Stimulant