Defining PersonalizedCancer Care

© 2016 Critical Outcome Technologies Inc. All rights reserved.

When it comes to

cancer chemotherapy,

“one size does not fit all.”

Ideally, an individual’s

chemotherapy should be

tailored to the gene mutation

of the tumor in question

There are billions of

mutation profiles

There are hundreds of cancer drugs

and hundreds of thousands of drug

combinations

Too much for any doctor, or

team of doctors, to consider

Developed to determine better

personalized treatment options

based on a patient’s genetic profile

ROSALINDTM

a smart

data

platform

The ROSALINDTM

platform is powered by

a dynamic computer

simulation of human

cancer cell signaling

Our visionMore personalized

cancer treatments

Higher remission

rates + lower cost

of cancer therapy

ROSALIND’s scientific premise

Gene mutations found in a tumor

lead to mutations in proteins

Mutated proteins result in abnormal

cell signaling and can lead to cancer

To be effective cancer therapy must

aim to restore normal cell signaling

ROSALIND evaluates data

from a tumor’s gene

mutation profile and

recommends treatments

most likely to restore

normal cell signaling

1

2

3

An input vector composed of the genetic

profile of the tumor to be simulated

A dynamic representation of positive &

negative interactions between cell

signaling proteins

An output vector identifying potential

remission inducing drug combinations

3 basic components to ROSALIND

Step 1: Obtain a gene mutation

profile from a biopsy of the patient’s

tumor

Step 2: A physician must send a

confidential copy of the gene

mutation profile to COTI*

Our 5 step process

* Critical Outcome Technologies Inc.

Step 3: COTI programs ROSALIND

with the gene mutation profile and

runs the simulation

Step 4: COTI reviews and interprets

the simulation output

Step 5: COTI sends the simulation

output to the ordering physician for

treatment consideration

NOTE: The simulation output drug combinations only include drugs currently approved or in clinical trials

If you have cancer, you want the best

treatment for your specific tumor.

Ask your doctor about

ROSALIND today

Visit our website

www.ROSALINDonline.com

Share our story online:

Follow ROSALINDonline

on Facebook and

Twitter

#ROSALIND

#Personalized

CancerCare

Disclaimer:

ROSALIND is a patent pending computational research and personalized cancer caretool that continues to undergo development and real world validation.

ROSALIND is not intended to replace or supersede the assessments or decisions ofany experienced physician or group of physicians.

The ROSALIND information is NOT a prescription for any treatment(s) and in no wayobligates any physician or group of physicians to use any part of the informationprovided in any way.

The sole purpose of ROSALIND is to provide information only regarding treatmentoptions that might otherwise not have been considered.

ROSALIND only considers drugs that have been approved for the treatment of cancer.

ROSALIND should not be used without the express and informed consent of thepatient. By using ROSALIND, the physician acknowledges that he or she has obtainedthis consent.

ROSALIND does not warrant or guarantee the effectiveness of its informational outputto the physician.

Defining PersonalizedCancer Care

© 2016 Critical Outcome Technologies Inc. All rights reserved.