Atul Butte, MD, PhD

Principal Investigator, CIAPM

www.ciapm.org

#CIAPM16

• Launched by Governor Edmund G. Brown Jr. in April 2015

• California-wide initiative, hosted by UCSF & UC Health

• $3 million initial investment from California government

• $10 million appropriated in FY 2016 / 17 budget

Population Individual characteristicsand circumstances

- Diseases affect individuals differently- People have different responses to

same treatment- Some people get conditions such as

diabetes or heart disease despite a healthy life style

Precision Medicine: toward tailored approaches to health and disease

Stratified population

More precise - Prevention- Diagnoses- Treatments

• Building a California precision medicine asset inventory– We want to know what you are doing to advance precision medicine and if

you have resources to share!– Contact us at ciapm@ucsf.edu

• Two funded demonstration projects– Started 10 months ago

Demonstration ProjectCalifornia Kids Cancer Comparison

David Haussler, PhD, UC Santa Cruz

Demonstration ProjectCalifornia Kids Cancer Comparison

David Haussler, PhD, UC Santa Cruz

Data of more than 80 kids with cancer have been analyzed under CKCC – to date… this will double by the end of the project

These kids’ data against a compendium of over 10,000 tumors

Project indicators are highly encouraging: in all cases presented to live Tumor Boards, CKCC has identified new therapeutic options

Academic PartnersIndustry and

Nonprofit Partners Advocacy Partners

Demonstration Project: California Kids Cancer ComparisonProject Partners

Demonstration ProjectPrecision Diagnosis of Acute Infectious Diseases

Charles Chiu, MD, PhD, UC San Francisco

Demonstration ProjectPrecision Diagnosis of Acute Infectious Diseases

Charles Chiu, MD, PhD, UC San Francisco

Validation in UCSF CLIA-certified clinical microbiology laboratory (ended May 2016)

Clinical trial (began June 2016)300 CSF samples for acute meningitis / encephalitis dx35 patients enrolled to dateComparison with conventional testingOutcomes and cost-effectiveness measures

Clinical Microbial Sequencing Board (CMSB)Weekly online case discussion w/ multiple specialties

Demonstration ProjectPrecision Diagnosis of Acute Infectious Diseases

Project Partners

Academic PartnersNonprofit / Government

Partners Industry Partners

• Building a California precision medicine asset inventory– We want to know what you are doing to advance precision medicine and

if you have resources to share!– Contact us at ciapm@ucsf.edu

• Two funded demonstration projects– Started 10 months ago

• Six additional demonstration projects– 29 proposals under review right now

Selection Committee Institution ExpertiseNancy Cox - Chair Vanderbilt University Genomics / StatisticsElaine Mardis Washington University Genomics / CancerMarylyn Ritchie Geisinger Health System Genomics / BioinformaticsIsaac Kohane Harvard University Statistics / ComputationEric Hekler Arizona State University Digital HealthStanley Shaw Harvard University Digital HealthShawneequa Callier George Washington University Health Disparities / EthicsAkinlolu Ojo University of Arizona Health Disparities / Global HealthRachel Ceballos Fred Hutchinson Cancer Research Ctr Health Disparities / Behavioral HealthJeffrey Kahn Johns Hopkins University EthicsYa Chen Tina Shih MD Anderson Cancer Center Health EconomicsTimothy Coetzee National Multiple Sclerosis Society Patient EngagementMargaret Anderson Faster Cures Patient Engagement

Agenda

9:45 Panel Discussion: NGS-Based Molecular Diagnostics11:15 Break/Networking11:45 Panel Discussion: Big Data Progress and Challenges1:00 Lunch Break/Networking2:00 RFP 2 Applications: Speed Presentations

• Centennial Hall A• Centennial Hall C/D

4:00 Elevator Pitches/Reception • Centennial Hall C/D

Steven DubinettEsther FlattoDan GeschwindUta GrieshammerDeborah HermanIndia Hook-Barnard

Iman HussainTheresa O’BrienAnne SkinnerLinda TabaKeith Yamamoto

Thanks

Thank you to UCLA!

Uta Grieshammer, PhD, Program Director

www.ciapm.org

#CIAPM16