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Immune transcriptional responses to viral infections nacho caballero

Immune transcriptional responses to viral infections

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Using changes in gene expression to diagnose different types of viral diseases (lassa virus, marburg virus) Image credit Monkey by Christy Presler from The Noun Project Megaphone by Mister Pixel from The Noun Project Drop by matthew hall from The Noun Project

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Page 1: Immune transcriptional responses to viral infections

Immune transcriptional

responses to viral infections

nacho caballero

Page 2: Immune transcriptional responses to viral infections

marburg lassa

Page 3: Immune transcriptional responses to viral infections

macaque

read count 42

rnaimmune cellsblood sample

sequence

Page 4: Immune transcriptional responses to viral infections

IFIT1

Page 5: Immune transcriptional responses to viral infections

vs.

direct infection

distress signal

Page 6: Immune transcriptional responses to viral infections

interferon

ISGs

Page 7: Immune transcriptional responses to viral infections

IFIT1

Page 8: Immune transcriptional responses to viral infections

Fold

cha

nge

(log

2)

Days post-infection

Lassa Marburg

Common response

Page 9: Immune transcriptional responses to viral infections

Unique response

Page 10: Immune transcriptional responses to viral infections

Candidate biomarkers

Page 11: Immune transcriptional responses to viral infections

Microarray validationco

mp

onen

t 1

component 2

M1

M3M5

L6

L3

Page 12: Immune transcriptional responses to viral infections

Compare additional viruses

Analyze human samples

Page 13: Immune transcriptional responses to viral infections

rclickme.com

Page 14: Immune transcriptional responses to viral infections

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