Embed Size (px)
Citation preview
Healthy Ageing through Technoculture
Marios Kyriazis
ELPIs Foundation for Indefinite Lifespans
www.elpisfil.org
How to conquer ageing
• Biotechnology?
• Drugs and supplements?
• Nanotechnology?
• Stem cells?
• Artificial Intelligence?
The fallacy of the longevity elixir
PROBLEMS:
• Stem cells: harvesting, delivery, compatibility, bone marrow transplants
• Tissue engineering: harvesting, surgical transplants
• Genetic therapies: technical issues, delivery, integration in the body
• Nano-medicine: unknown results, side effects
• Pharmacological therapies: compliance, interactions, polypharmacy
BIOLOGY OF AGEING
CELLS
DNA
LYSOSOMES
ABNORMAL PROTEINS
FREE RADICALS
MITOCHONDRIA
CROSS LINKS
A wider view of ageing
ELIMINATION OF AGEING
BIOLOGY
EPIGENETICS
LIFESTYLE
REPAIR
BIOMEDICINEREPRODUCTION
GENDER
EVOLUTION
CULTURE
ETHICS
CONFLICT RESOLUTION
RISKS
TECHNOLOGY
HYPER CONNECTION
GLOBAL BRAIN
COMPLEXITY SCIENCE
CYBERNETICS
SOCIETY
ENVIRONMENT
SMART CITIES
POLITICS
I concentrate on Technology and Culture
Technology Culture
Both concepts are based on INFORMATION
A meaningful set of data or patterns which influence the formation or transformation of other data or patterns, in order to reduce uncertainty
and help achieve a goal
Information
+ Complexity Functionality Fitness Survival
Organisation
How to increase information content
1. Enriched environment, hormetic challenges
2. Social hyper-connectivity (real and virtual/online)
3. Behavioural models: goal-seeking behavior, search for excellence, a bias for action
4. The pursuit of innovation, diversification, creativity, novelty, and the avoidance of routine.
HormesisAn adaptive response of cells and organisms to a moderate, intermittent, challenge.
Hormesis describes phenomena where there is low dose stimulation, high dose inhibition.
Nutritional, physical, mental and chemical challenges may result in mild damage which upregulates repair mechanisms. In an attempt to repair this damage, age-related damage is also repaired.
Examples of hormesisNutritional
Physical
Sexual
Social
Environmental Enrichment
Experimental animals are exposed to an enriched environment- a habitat augmentation. This has several positive effects on health, specifically on brain and immune function.
ChallengeHere, a challenge is defined as a situation that potentially carries
biological value for an organism, so that the organism is inclined to act. A challenge provokes action because it represents a situation in which
not acting will lead to an overall lower fitness than acting.
The balance between age-related degeneration and health depends on:
A. How well our repair processes are maintained through artificial (item-based) pharmacological, genetic, cellular, biotechnological and other physical interventions.
B. Through utilising challenging exposure to information with consequent improvement of function.
Use of internet and longevity
Global Brain
Internet connections
An Irregular, Useful Guest
Second, usefulness
• Humanity is not going to improve if its members don't make an effort to achieve something higher.
Third, quest
• Always seek novelty, never be satisfied, never sit quiet and 'relax' for long periods. Be inquisitive, always ask 'why' and don't take anything at face value.
• Try to get to the top but don't stop there. There is always something higher.
• Come up with new ideas, and then try to achieve them.
First, irregularity
We thrive on change, challenges and unexpected events.
A ‘power-law’ lifestyle: frequent low level activities, some medium level ones, and rare intense activities.
Ever-changing, imaginative and unpredictable activities improve immunity, reduce inflammation, improve nerve-growth factors, and many others.
The end?
ELPIs Foundation for Indefinite Lifespans
www.elpisfil.org
Meeting to discuss these concepts: 3rd
Symposium ‘Pathways to Indefinite Lifespans’
0n Saturday 23 May 2015, In Larnaca, Cyprus
