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Androgenetic Alopecia and Cardiovascular Risk
FactorsGretel S. Montañez
RISE Program- Fall 2011
What is alopecia?
(Nordqvist, 2009) ( Mosby, 2009) Illustration copyright 2000 by Nucleus Communications, Inc. All rights reserved. http://www.nucleusinc.com
Types of alopecia Areata Totalis Universalis Barbae Mucinosa Androgenetic
(Nordqvist, 2007) Illustration (Breeling, 2008)
What is Androgenetic Alopecia?
(Nordqvist, 2007) (Berman, Zieve, 2011)
Diagnosis Eliminating other
causes of baldness
Trichonoscopy Biopsy
Treatments Finasteride Minoxidil Laser
phototherapy Dermabrasion gel
(Nordqvist, 2007)
Baldness could be a signal of other diseases prostatic cancer heart problems emotional problems
Relations between baldness and cardiovascular risk factors
(Arias, 2009)
Androgenetic alopecia and cardiovascular risk factors in men and
women: A comparative study
Present the relations between the androgenic alopecia and cardiovascular risk factors
Objectives: analyze the presence of cardiovascular risk factors and find the cardiovascular risk in Adult Panel III for metabolic factors, hormonal factors Comparison between genres
Use 154 Caucasian participants, 77 early-onset AGA and 77 healthy controls
Results: diagnosed metabolic syndrome in 60% males and 48.6% woman with AGA
(Arias, Gutiérrez, Castellote, Buendía, Naranjo, 2009)
Results: Diagnosed metabolic syndrome in 60% males
and 48.6% woman with AGA Carotic atheroma plaques in 29.9% in patients
with AGA and 7.8% in the control group High levels of aldosterone and insulin in males
and woman with AGA
Conclusion: Using ultrasound would be useful to find
methods to detect cardiovascular risks with early-onset AGA and find an early preventive treatment
(Arias, Gutiérrez, Castellote, Buendía, Naranjo, 2009)
Baldness and coronary heart disease risk factors
Study the relation between the prevalence of baldness and coronary risks factors in male workers
3 periods of examination (1987-1980)
Participants: 872 males 280 fronto-occipital baldness 273 frontal baldness 231 no baldness
MAHADEVIA, 2011
(Trevisan, Farinaro, Krogh, Joss, Giumfxti, Fusco, Panico, Mellone, Frascatore, Scottoni, Mancini , 1993)
Method Make a personal profile that include
Resting electrocardiogram Blood pressure measurement Height and weight measurements Blood sample for cholesterol and triglycerides
Results: 38% participants not present signs of hair loss 31.3% had slow frontal baldness 31.9% had fronto-occipital baldness Baldness was associated with high levels of cholesterol and blood
pressure
(Trevisan, Farinaro, Krogh, Joss, Giumfxti, Fusco, Panico, Mellone, Frascatore, Scottoni, Mancini , 1993)
Baldness and Myocardial Infarction in Men
The Atherosclerosis Risk in Communities Study
Examined the associations between baldness and myocardial infarction and the risk of atherosclerosis
Method: Blood sample took from National Heart Lung Two groups: Experimental= risk of atherosclerosis and Control=
free baldness Classified the baldness by the Hamilton/Norwood scale Technician observed the patient head from side and top and
compared with normal hair Organized in 5 groups
No baldness moderate vertex baldness Frontal baldness alone severe vertex baldness Mild vertex baldness skip
(Shahar, Heiss, Rosamond, Szklo et al , 2007)
back
2008 DermaGenoma Inc, all rights reserved.
Method (cont.) Distribution of baldness pattern by myocardial infarction status and the
relations of baldness in several risk factors for coronary heart disease. The relations of baldness patterns in a carotid thickness The subject were 5,056 men (52-75 years)
767 had history of myocardial infarctions Results:
.28 (frontal baldness), 1.02 (mild vertex baldness) 1.40 (moderate vertex baldness) 1.18 (severe vertex baldness) Baldness patterns were not an important risk factor for myocardial
infarction or atherosclerosis
(Shahar, Heiss, Rosamond, Szklo et al , 2007)
Discussion First study
Confirms the association between early-onset Androgenetic alopecia and a higher cardiovascular risk
Prevalence of carotid atheromatosis in patients with AGA
Second study Pattern of male baldness were associated with increased levels of
serum total cholesterol and high blood pressure
Third study No evidence of an association between baldness and carotid
thickness
Conclusion 2/3 studies reviewed sustain my statement
Contributions to science Lead to future studies about the relations of alopecia with other
diseases Informs society