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2. Presenter Disclosure Information for TCT 2007; October 20-25, 2007 Martin B. Leon, M.D. Scientific Advisory Board: Medtronic Vascular, Abbott Vascular, Cordis-JNJ, and Boston Scientific 3. Endeavor DES System PC Technology Drug: Zotarolimus Stent Delivery System Driver Cobalt Alloy Stent 4. Polymer and Drug Matrix Tissue Blood PC Basecoat( 1m thick) Drug Layer 90% Zotarolimus (10 g/mm) 10% PC ( 2-4m thick) PC Overspray( 0.1 m thick) Stent Strut 3.0 mm Stents 500x magnification Illustrative Not to Scale Taxus Cypher Endeavor 5. Porcine Drug Elution Kinetics and PK
Blood and Arterial Tissue Zotarolimus Concentration
Drug Elution by Recovered Drug from Stent Concentration (Blood) ng/ml Days Concentration (Tissue) ng/ml Blood Tissue % Drug Eluted Time (Days) 65 87 98 99 6. Biocompatibility (Inflammation Scores)
*CVPath, Dr Renu Virmani Inflammation Scores Inflammation Scores 1 28 to 180 days Inflammation Scores 1 28 to 180 days Inflammation Scores Days Days 1 Bare stent controls matched with test groups 2 Not Done *P