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AMERICAN COLLEGE OF INTEGRATIVE MEDICINE AND DENTISTRY
PRESENTS
OXYGEN/OZONE THERAPY IN
DENTISTRY
FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE
UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011
*DISINFECTION PROPERITES*NON-TOXIC WOUND CLEANING
*IMPROVED AND ACCERATED WOUND HEALING
FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE
UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011
+ACTIVATION OF RED BLOOD CELL METABOLISM WITH IMPROVED OXYGEN RELEASE
+ACTIVATION OF ENZYMATIC ANTIOXIDANTS AND RADICAL SCAVENGERS
FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE
*ACTIVATION OF IMMUNOCOMPETENT CELLS AND RELEASE OF CYTOKINES SUCH AS
INTERFERONES AND INTERLEUKINS. MODULATION OF THE IMMUNE SYSTEM
UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011
FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE
UNIVERSITY OF HAVANA, CUBA DEPARTMENT OF PHARMACOLOGY PROF. OLGA SONIA LEON FERNANDEZ VIENNA, OCT. 8 -10, 2011
*INCREASED ANTIOXIDANT CAPACITY THROUGH ACTIVATION OF CELLULAR
ANTIOXIDANT SYSTEMSCATALASE, SUPEROXIDE DISMUTATSE
CATALASE
FUNDAMENTAL SCIENTFIC FACTS ABOUT OXYGEN/OZONE
*ANTIINFLAMMATORY EFFECT*INCREASED CIRCULATION VIA NITRIC OXIDE
*HIGH REDOX POTENTIAL
WHAT IS
OZONE ?
• A chemical compound consisting of three oxygen atoms (O3).
• The elemental form of oxygen occurring naturally as a result of ultraviolet energy or lightning causing a temporary recombination of oxygen atoms into groups of three.
• The form of oxygen that is formed by an electric discharge field of a corona discharge generator (simulates lightning).
• Oxygen is the only gas that can accept and carry an
electrical charge. Remember, the terminal electron acceptor.
HOW IS OZONE CREATED?
OXYGEN AND A ENERGY SOURCE
A MEDICAL GRADE OXYGEN FED COLD CORONA DISCHARGE OZONE UNIT
AND SEARCH “OZONE DENTISTRY”PubMedUS National Library of Medicine National Institutes of Health Search term Search database All DatabasesPubMedProteinNucleotideGSSESTStructureGenomeBioProjectBioSampleBioSystemsBooksConserved DomainsClonedbGaPdbVarEpigenomicsGeneGEO DataSetsGEO ProfilesHomoloGeneMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMed
HealthSNPSRATaxonomyToolKitToolKit ozone dentistry Search RSSSave searchLimitsAdvanced Help Display Settings: Summary,20 per page,Sorted by Recently Added
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1. Treatment of Root Canal Biofilms of Enterococcus faecalis with Ozone Gas and Passive Ultrasound Activation. Case PD, Bird PS, Kahler WA, George R, Walsh LJ. J Endod. 2012 Apr;38(4):523-6. Epub 2012 Feb 2. PMID: 22414842 [PubMed - in process] Related citations
2. Ozone therapy in dentistry: A strategic review. Saini R. J Nat Sci Biol Med. 2011 Jul;2(2):151-3. PMID: 22346227 [PubMed - in process] Free PMC Article
191 articles
PRIMARY ISSUES IN DENTISTRY
• TRAUMA
• INFECTION
• BACTERIAL
• FUNGAL
• VIRAL
• PARASITIC
These infections can be:
• Acute• Chronic• Bacterial • Viral• Fungal• Parasitic• OR… A some combination of the above• And RESISTANT to current therapeutics
Integrative Treatment Regimens
• Antibiotics• Antifungals• Antivirals• Antiparasitics• Antiseptics• Essential Oils/Plant Extracts• Homeopathics• Lasers• Ultraviolet Light• Oxygen/Ozone
Therapies
All of these regimens have proven to be effective in the treatment of infections
BUT…
MOST OF THE REGIMENS HAVE SIGNIFICANT SIDE EFFECTS
EXCEPT…
OXYYGEN/OZONE THERAPY
Multitude of resources for use in human treatment.
When used at a therapeutic level
DOSE AND LANGUAGE USE FOR OZONE THERAPY IN DENTISTRY
• EXPRESSED AS MICROGRAMS PER MILLILITERS OF OXYGEN (mcg/ml)
• ALSO EXPRESSED AS “GAMMA”• INTERNAL USE RANGE: 6 - 30µg/ml (dependent on
application)
• EXTERNAL USE RANGE: 40- 50µg/ml (root canal therapy & caries)
• **START with a LOW dose and GO SLOW***
What Treatment Regimens willEffectively Eliminate:
• BACTERIA
• VIRUSES
• FUNGI
• PARASITES
1. Bacteria 2. Ozone contacts cell membrane 3. Ozone (peroxides) penetrates cell membrane 4. Rupture of cell membrane begins 5. Membrane loses integrity 6. Bacteria lyses due to ozone
OZONE IS PRODUCED BY ANTIBODIES DURING BACTERIAL KILLING IN INFLAMMATION
THE SCRIPPS RESEARCH INSTITUTE NOVEMBER 18, 2002
LERNER, WENTWORH ET AL. SCIENCE
WHITE BLOOD CELLS/ PLASMA CELLS/
ANTIBODIES
OXIDATION /BIOFILM
The cover story in “THE JOURNAL OF THE AMERICAN DENTAL ASSOCIATION,” Vol 140, No 8 978-986 is “Periodontitis: An Archetypical Biofilm Disease” It states that “Periodontitis is a classic example of biofilm-mediated diseases.” The article concluded that, “Periodontitis, like other biofilm infections, is refractory to antibiotic agents and host defenses because the causative microbes live in complex communities that persist despite challenges that range from targeted antibiotic agents to phagocytosis.” The clinical implications concluded that “The regular delivery of non targeted anti-biofilm agents may be an effective strategy for treating biofilms, especially if these agents include oxidative agents that dissolve the biofilm matrix.”
OZONE OXIDIZES / DESTROYS BIOFILM
BIOFILM DISEASES
• Periodontal Disease
• Carious Disease
• Endodontic Disease
• Post Extraction
• Implant Issues
Current Therapies in Dentistry
• Caries (tooth decay)
• Infection of head and neck
• Periodontal Disease
• Root Canal Therapy
• Enhanced wound healing (post-surgical)
• Soft tissue lesions
IS THIS A LOCAL OR SYSTEMIC PROBLEM?
BOTH!!!
Pulp Exposure?
Deep Caries?
What’s under sealants?
ARRESTMENT OF CARIES
THE CASE FOR PIT AND FISSUE SEALENTS WITH OXYGEN/OZONE
60 second exposure 46µg/cc
2 minutes post exposure
46 micrograms/cc – 60 second exposure
OZONE
ENDODONTIC REALITY
FUMIGATION PROCEDURE WITH 40 – 50 µg/cc EACH ROOT EXPOSURE TIME 40-60 SEC.
A “Dry Socket”?
Periodontal Problems?
CODE #162
TWO MONTHS OF TREATMENT DR. JOSE DE CASTRO-COIMBRA
History of Ozone
CHRISTIAN FREDRICH SCHONBEIN DISCOVERED OZONE IN 1840
• 1881- John Harvey Kellogg, MD, from Battle Creek, MI used ozone to treat diptheria.
• 1896- Nikola Tesla patented first O3 generator and sold them to doctors for medical use.
• 1898- Benedict Lust, MD, New York- Founder of Naturopathy, wrote about ozone therapy.
1885 Florida Medical AssociationPublished: Ozone
• Written by Charles J. Kenworthy M.D. • Practicing medicine in Jacksonville, Florida. • Proved that ozone was in regular medical usage
in the United States before 1885. • Therefore, it predates the 1906 Pure Food and
Drug Act and the FDA. • Ozone for medical usage is grandfathered in the
United States, and held perfectly legal for use without censure.
Ozone History in Dentistry
• 1932 - E.A. Fisch, a dentist uses ozonated water in dental procedures and pioneered its use in medicine. (1932-1998 rise and fall of antibiotics)
• 1998 - Edward Lynch publishes a series of articles investigating the efficacy of ozone on dental infection.
• 1998 – Mollica, Harris first introduced to oxygen/ozone therapy in dentistry to United States
• 2000 – Harris delivers first comprehensive oxygen/ozone lecture at Capital University of Integrative Medicine.
• 2000 – Oxygen/Ozone becomes curriculum based at CUIM. • 2000 – Oxygen/Ozone Therapy in Dentistry introduced in the
clinical setting at National Integrative Health Associates – CUIM clinic
• 2002 – Mollica, Harris Oxygen-Ozone Therapy “Applications in Biologic Dentistry”. Presented at first continuing education on oxygen/ozone in dentistry
• 2004 – Edward Lynch – chief editor – Ozone: The Revolution in Dentistry
• 2007 – Mollica, Harris Cyto-Immunologic Nutritional Supportive Therapies for Oxygen/Ozone Therapy
• 2008 – International Academy of Oral Medicine and Toxicology accepts Oxygen/Ozone Therapy in Dentistry as scientifically valid.
• 2008 – IAOMT scientifically validates endodontic therapy with oxygen/ozone (G. Cole)
• 2009 – IAOMT publishes Oxygen/Ozone in Dentistry • 2009 – Academy of General Dentistry introduces
subject code 162 – Ozone Therapy
THE SCIENCE
OF OZONE THERAPY
CORONADISCHARGE
Properties of Ozone
In Vitro (Ex Vivo) Powerful Oxidizer–Kills bacteria, fungi and viruses at lower concentrations than chlorine (1 molecule of ozone = 3,000 to 10,000 molecules of chlorine) AND kills 3500 times faster than chlorine.
●Also oxidizes phenolics (poisonous compounds of methanol and benzene), pesticides, detergents, chemical manufacturing wastes and aromatic compounds more rapidly and effectively than chlorine, yet WITHOUT chlorine’s harmful residues (Trihalomethanes, etc.).
Important Aspect to Consider *AGAIN*
Oxygen/Ozone can accept AND
Carry an electrical charge
Biofilm, Bacteria, Virus, Fungi, Parasites, Infection and
Inflammation all are positively charged
Ozone has a negatively
charged area
The In Vivo Therapeutic Oxidative
BURST
0Z0NE
PLASMA
REACTIVE OXYGEN SPECIES
ROS (early phase)
LIPID OXIDATION PRODUCTS
LOPs (late phase)
O3 H2O2
O1
–Ozonated Water: Ozone gas is bubbled through water, creating a solution that has a shelf life of 10 hours at room temperature and 5 days in the refrigerator. Ozonated water is used to treat:
• Wounds• Burns• Intestinal problems• Slow healing skin infections• Gynecological Infections• Also used for colonics• and enemas
– Ozonated Oil (primarily olive oil): Ozone is bubbled through oil until it forms a salve/balm type consistency. This is used to treat:
• Skin conditions, infections with bacteria, fungi and viruses.• Hemorrhoids• Vulvovaginitis• Insect bites/bee stings• Gingivitis• Placed on capsules and ingested to treat ulcers, gastritis and
giradiasis
TMD ApplicationsFOLLOW “Standard of Care Procedures”
IF symptoms fail to resolve
THEN consider ozone treatment due to the probability of an
infection/inflammation in the joint(s) or chronic inflammation of
ligaments, tendons, muscles or ganglia
THE SCIENCE/RESEARCH OF OXYGEN/OZONE ALLOWS FOR…….!!!
• NON-TOXIC SAFE AND EFFECTIVE APPLICATION
• TRUE BIOLOGIC AGENT
• MINIMAL TO NO SIDE EFFECTS
• ECONOMIC THERAPY
IN A BIOLOGIC SENSE…….
• THE CREATION OF A THERAPEUTIC OXYGEN/OXIDATIVE
“BURST” WHICH INDUCES A MULTI-FACTORIAL BIOCHEMICAL/
PHYSIOLOGIC RESPONSE THERE BY REVERSING A STATE OF
ANAEROBIOSIS CONTAINED WITHIN THE AFFLICTED
TISSUES….MOLLICA
OTTO WARBURG
INTEGRATION OF OZONE THERAPYINTO
DAILY BIOLOGIC DENTAL PRACTICE
NASAL INSUFFLATION
+O3 C10H18O3
TRIOZONIDE OF TRIOLEIN
NOT AN OXIDANT
OXIDATION OF OLIVE OIL SO WHAT’S THE POINT?
– Inhalation of Ozonides: An ozone/oxygen mixture is bubbled through olive oil and gaseous compounds are created that are a species of triozonides of triolein (C10H18O3) that are safe to inhale. These triozonides decompose at the aqueous level of the lung alveolus. The thereby create oxidative peroxides that are used to treat:
AllergiesAsthmaOther respiratory diseasesSinus infectionsFoundational procedure
THE CREATION OF AROMATIC TERPENES!
BIOFILMAn aggregate of microbes with a distinct
colonizing architecture.
LUNG ALVEOLUS WITH BIOFILM FORMATION
DYSFUNCTIONAL CILIA DUE TO MICROBIAL TOXINS FROM BIOFILM
EAR INSUFFLATION: THE OXYGEN/OZONE BEING DELIVERED TO THE TYMPANIC
MEMBRANE MUST BE MOISTENED PRIOR TO CONTACT!
MOISTURE CAN BE DELIVERED VIA BUBBLING OXYGEN/OZONE THROUGH THE OZONATED WATER SNAKE OR MOISTENED AT THE CUPS OF THE
STETHOSCOPE WITH WET GAUZE
(use a fan to blow the gas away from the face)
Ear Infections (German Research)
17 patients received 15 sessions of rectal ozone plus ozonized oil
drops for chronic suppurative O.M. 16 tested negative at the end of
two cycles, and 14 improved their hearing loss. Mastoid x-ray
improvement noted in 13. Another study remarked on the
improvement noted using O2/O3 irrigations of the TM.
This is the preferred therapy for recurrent otitis media as opposed to repeated and
prolonged use of antibiotics.
• Vestn Otorinolaringol. 2009;(3):34-5.
• [Treatment of patients with acute and chronic suppurative middle ear diseases using
ozone preparations].
• [Article in Russian]
• Sin'kov EV.
• Abstract
• Methods of clinical application of gaseous ozone and ozonated solutions are described
with special reference to the treatment of patients with acute and chronic suppurative
middle ear diseases. Results of otoscopy, microbiological and cytological studies confirm
therapeutic efficiency of the above techniques as accelerating recovery of patients with
this pathology. It is recommended to include ozonotherapy as an additional method in
the combined treatment of acute and chronic suppurative otitis media.
It is recommended to include ozonotherapy as an additional method in the combined treatment of acute
and chronic suppurative otitis media.
Vestn Otorinolaringol. 1999;(2):48-9. [Reasons for the application of medical ozone in the treatment of chronic purulent mesotympanitis]. [Article in Russian] Shakov VIu, Edeleva AN. Abstract Ozone-oxygen mixture (ozone concentration 600 microg/l) was used in irrigations of the tympanic cavity in 52 patients with chronic purulent mesotympanitis (CPM). The course of the treatment consisted of 5-7 procedures. 18 CPM controls received standard treatment without the irrigations. The course of the ozone-oxygen irrigations produced good results: ear discharge and tympanic mucosa inflammation stopped in 81% of the irrigated patients, levels of myeloperoxidase which marks inflammation reduced significantly, bactericidal effects of the mixture were observed for all the detected pathogens, antibiotic sensitivity of the bacteria rose. Fast antiinflammatory result of ozone therapy was due not only to its bactericidal effect but also via its antihypoxic and immunomodulating mechanisms
Fast antiinflammatory result of ozone therapy was due not only to its bactericidal effect but also via its antihypoxic
and immunomodulating mechanisms
MULTI-TONSILULAR FORMS
TONSIL-FASCIA SPACE INFUSION TECHNIQUE
• PRINCIPLE PART OF COMPREHENSIVE LYMPHATIC THERAPY • PURPOSE: TO DRAIN AND DISENFECT THE TONSILS,
SURROUNDING FASCIA AND SOFT TISSUE(RETRO-PHARYNGEAL SPACE)
• 6 TO 10µg/cc in syringe with 30g 1”needle • Insert needle up to hub through tonsil. • Slowing start infusion at the same time, slowly retract. This
will dispense oxygen/ozone throughout area. • Infusion a total of 1 – 2cc per side • Expectations: 24 – 72 hours drainage and possible outbreak
of pus-like lesions. This is good and will remediate within a few days.
ONE INFUSION 2-3CC AT 6 - 10µG/CC
QUESTIONS??