Sara Castrillón CorreaDNA REPAIR

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The DNA repair mechanism has an importan rol in mantein fidelity of DNA, avoiding lessons and mutations

SCANNER OF HEREDITARY DEFECTSScience news

(January 24,2013)

XPD protein is involved in transcription-couple nucleotide excision repair

XPD protein can function like a scanner that pass arround DNA doublé hélix, trying to find signs of damage.when it does XPD stops and

mark DN,because the cell need to fix it

• DNA Repair affect the treatmet agains cancer,with XPDand damage recognition , the treatments will improve, especially with chemotherapy

XPD protein will be the solution in a long term for an appropriate treatment in cáncer diseases,because this protein will help the researchers to find a specific way to use chemotherapy that will work decreasing the actual risk that has this invasive treatment and increase the survival of the patient.

OBSERVATION

DNA- REPAIRING PROTEIN MAY BE THE KEY TO PREVENTING RECURRENCE OF SOME CANCERS

Science News(January 28, 2013)

• Jihe Zhao found a protein present in some cancer KLF8, that determined the possibility of recurrence of the tumor,because KLF8 help the tumor to regenerate.

KLF8 is present in Breast and Ovarian cancer

The test was with an specific treatment of breast cancer( doxorrubicin) and the

result show that this protein increase cell resistance

In pathologies like breast and ovarían cáncer the probality of recurrence is hight, and the best oportunitty to change it is try to stop the KLF8 as a part of regular therapy. That therapy would help a lot of women to improve quality of life.

OBSERVATION

MEDICAL UTILITY

Locate DNA damage

CAUSES

Disease, UV light, radiation and metabolic processes

Correct Treatment and diagnosis specific to ADN damage

For us medical students this approximation will

help us in a correct diagnosis and therapy,

that reflected in our patient.

REFERENCES

– MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p.

– FRIEDBERG,Errol; WALKER,Graham; SIEDE;Wolfram. DNA Repair and mutagenesis. American Society for microbiology. 1995. 2-31 p.

CIBERGRAFIA

• http://www.sciencedaily.com/releases/2013/01/130124133952.htm. Science Daily: News & Article in Science, Health,Enviroment & Technology. A Scanner for hereditary defects: New possibilities in genetic damage recognition for improving cáncer treatment

• • http://www.youtube.com/watch?feature=player_embedded&v=cOkWG85ReT4. Repairing

DNA: Our best defense against cáncer• • http://www.sciencedaily.com/releases/2013/01/130128104626.htm. Science Daily: News &

Article in Science, Health,Enviroment & Technology. DNA Repairing protein may be the key to preventing recurrence of some cancers.