By: Juan Felipe González Franco

Medicine student

Faculty of health sciences UPB

2015

BIBLIOGRAPHY

-Centro Nacional de Investigaciones Oncológicas (CNIO). (2015, July 15). Defective telomeres are now being linked to dozens of diseases, including many types of cancer. ScienceDaily. Retrieved august 2, 2015 from www.sciencedaily.com/releases/2015/07/150715130828.htm

-The University of Texas Health Science Center at San Antonio. (2015, May 4). Revolutionary method of making RNAs. ScienceDaily. Retrieve august 2, 2015 fromwww.sciencedaily.com/releases/2015/05/150504121041.htm

MEDICAL UTILITY

These researches are very important in my opinion because of

the clinical application:The first one talks about

investigating the telomeres and understanding these complex

structures may help future medicine with new treatments for diseases

like cancer.

The second one Dr. Sousa thinks this new method to

make RNA molecules that are chemically diverse will speed up

research exponentially.In my humble opinion Dr. Sousa is

too optimistic but, if he is right, biological sciences will benefit

most. Until now make RNAs to develop diagnostics and therapeutics has

been limited by existing technology.The interest in this is because RNAs

are molecules that can be used to make therapeutics, sensors and

diagnostics.

GENETIC MATERIAL REPLICATION

By: J. Felipe Gonzalez F.

MOLECULAR BIOLOGY

Teacher: Lina Martínez

Defective telomeres are now being linked to dozens of diseases, including many types of cancer:Telomeres are the structures that prevent the DNA strands makes chemically bonds to other strands, i.e. the chromosomes would merge and that would be lethal for the cell.The researchers are amazed about how complex is the biology of telomeres, and the high number of factors “they are finding that are essential to the preservation of telomeres and, above all, the precise coordination that is required between them all.”

STUDENT OBSERVATIONIn my opinion what they are investigating is very important and will be will be a key issue in the future research, because they talk about topics of great interest for modern science like are cancer therapy and ageing.

INTRODUTION

In recent years not only their relation to ageing has been confirmed; also defective telomeres seem to be linked to a lot of diseases even with some types of cancer, this is very important for the future medicine. The importance of investigating these structures is to improve diagnoses and develop possible treatments for many diseases. Telomeres, in the opinion of these researchers, will become increasingly important in clinical studies.

Different types of RNAs perform different functions, such as silencing a gene or regulating a plethora of processes in cells.

The new method described by Dr. Sousa and his colleagues in Nature, which includes robotics, will speed up research exponentially.

This is desirable for studies of RNA structure and function, and for design of applications that could be used to diagnose and treat diseases. This new technique allows the researcher make RNA molecules that are chemically diverse.

Revolutionary method of making RNAs:

Rui Sousa, Ph.D., professor of biochemistry in the School of Medicine at the Health Science Center is a co-author on the paper with colleagues from the National Institutes of Health, the University of Colorado, said that “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics, for which there is a growing market”.

He and his colleagues describes a new, more efficient method of making ribonucleic acids (RNAs).

"This new technique allows a researcher to make RNA molecules that are chemically diverse,“ and they think this new method, will speed up research exponentially.

STUDENT OBSERVATION

Dr. Sousa and his collages propose a new method for making RNA in a more effective way, that will help a lot in my opinion because of what the told us at the beginning “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics“.

INTRODUCCION

Telomeres are the structures that protect the ends of chromosomes.

The genetic information of DNA is copied into molecules called messenger RNAs, which are basically the manufacturing instructions for

proteins.

Defective telomeres are now being linked to dozens of diseases, including many types of cancer:

Centro Nacional de Investigaciones Oncológicas (CNIO).

Defective telomeres are now being linked to dozens of diseases, including many types of cancer:Telomeres are the structures that prevent the DNA strands makes chemically bonds to other strands, i.e. the chromosomes would merge and that would be lethal for the cell.The researchers are amazed about how complex is the biology of telomeres, and the high number of factors “they are finding that are essential to the preservation of telomeres and, above all, the precise coordination that is required between them all.”

STUDENT OBSERVATIONIn my opinion what they are investigating is very important and will be a key issue in the future research, because they talk about topics of great interest for modern science like are cancer therapy and ageing.

TELOMESRES

Telomeres are the ending regions of a chromatid, their presence protects the genes

before them on the chromosome from being

truncated instead.

Defective telomeres are now being linked to dozens of diseases, including many types of cancer:

The researchers investigate telomeres, this structures are being linked to diseases like

cancer, this show us the great importance of telomeres and their function in the prevalence

of the chromosome structure.

telomeres have been tightly preserved throughout the evolution in all cell lines,

that indicates its importance.

They prevent the fusion of chromosomes and the loss of genetic information each

time a cell divides.

Defective telomeres are now being linked to dozens of diseases, including many types of cancer:

Student observation:

In my opinion what they are investigating is very important and will be a key issue in the future research, because they

talk about topics of great interest for modern science like are cancer therapy and ageing.

Revolutionary method of making RNAs:

Rui Sousa, Ph.D., professor of biochemistry in the School of Medicine at the Health Science Center is a co-author on the paper with colleagues from the National Institutes of Health, the University of Colorado, said that “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics, for which there is a growing market”.

He and his colleagues describes a new, more efficient method of making ribonucleic acids (RNAs).

"This new technique allows a researcher to make RNA molecules that are chemically diverse,“ and they think this new method, will speed up research exponentially.

STUDENT OBSERVATION

Dr. Sousa and his collages propose a new method for making RNA in a more effective way, that will help a lot in my opinion because of what the told us at the beginning “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics“.

Revolutionary method of making

RNAs:

Revolutionary method of making RNAs:

Dr. Sousa and his colleagues talk us about a

new method that includes robotics, and

they think will speed up research exponentially.

Revolutionary method of making RNAs:

Dr. Sousa mentioned this new technique and he said it allows a researcher to make RNA molecules that are chemically diverse, and can reduce the time it takes to make those molecules.

Revolutionary method of making RNAs:

The great importance of thesemolecules regarding medicine, in words of Dr. Sousa is that “RNAs are molecules that can be used to make therapeutics, sensors and diagnostics”.

Dr. Sousa and his collages propose a new method for

making RNA in a more effective way, that will help a lot in my opinion because of

what the told us at the beginning “RNAs are molecules

that can be used to make therapeutics, sensors and

diagnostics“.

Revolutionary method of making RNAs:Student observation

MEDICAL UTILITY

MEDICAL UTILITY

Both researches allow to genetic replication and each one have a medical application, however one of theme were focused in the importance of telomeres like structures that protect the endings of the chromatids, and the other one in a new more efficient method to make RNA using robotics .

MEDICAL UTILITY

The research About telomeres has increasing because now the investigations are considering

The Importance of These not very simple structures in topics like conserving the genetic material in each chromatid. this have a close

relationship With the mutations and degeneration of the genetic code, with Cancer

and aging.

MEDICAL UTILITY

Until now make RNAs to Develop diagnostics and therapeutics has-been limited by Existing

technology .

As Dr. Sousa Said RNAs are molecules that can be used to make therapeutics , sensors and

diagnostics, for that reason it has an Important clinical application improving the method to

make DNA.

Centro Nacional de Investigaciones Oncológicas (CNIO). (2015, july 15). Defective telomeres are now being linked to dozens of diseases, including many types of cancer.

ScienceDaily. Retrieved august 2, 2015 from www.sciencedaily.com/releases/2015/07/150715130828.htm

The University of Texas Health Science Center at San Antonio. (2015, May 4). Revolutionary method of making RNAs. ScienceDaily. Retrieve august 2, 2015 from

www.sciencedaily.com/releases/2015/05/150504121041.htm

Martínez Sánchez, Lina María. Biología molecular.8.ed.Medellin: UPB. Fac. Medicina.

BIBLIOGRAPHY