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1
Detoxing Heavy MetalsIntegrative Approaches in Medicine
Detoxing Heavy MetalsIntegrative Approaches in Medicine
Harold Ravins, DDSHarold Ravins, DDSThe Center for Holistic DentistryThe Center for Holistic Dentistry
Harold Ravins, DDSHarold Ravins, DDSThe Center for Holistic DentistryThe Center for Holistic Dentistry
2
Advances in Holistic Advances in Holistic DentistryDentistry
Find hidden infections in the mouth– Not considered usual dental problems– Not the primary indicator of a health problem
How?– Good quality X-rays Bite analysis T-scan– Comprehensive exam Bio-electrical Impedance– Dental acupuncture Heavy metal fecal test– Energetic testing Other detection methods
Find hidden infections in the mouth– Not considered usual dental problems– Not the primary indicator of a health problem
How?– Good quality X-rays Bite analysis T-scan– Comprehensive exam Bio-electrical Impedance– Dental acupuncture Heavy metal fecal test– Energetic testing Other detection methods
3
Determination of Hg ToxicityDetermination of Hg Toxicity
Practical experience– 200 patients tested for heavy metals – 99% showed toxic levels of Hg
Discuss harmful effects of Hg to patients Give them educational literature Recommend fecal test Patients usually decide for themselves to have
amalgams removed
Practical experience– 200 patients tested for heavy metals – 99% showed toxic levels of Hg
Discuss harmful effects of Hg to patients Give them educational literature Recommend fecal test Patients usually decide for themselves to have
amalgams removed
4
Mercury Situation in Mercury Situation in DentistryDentistry ADA claims no scientific proof of leakage into
the body
However:– FDA agrees that Hg is very toxic– Dentists are required comply with hazardous
waste remove for Hg– Test show high levels with amalgams– Amalgams banned in Europe– $2500 fine by EPA if office windows are opened
ADA claims no scientific proof of leakage into the body
However:– FDA agrees that Hg is very toxic– Dentists are required comply with hazardous
waste remove for Hg– Test show high levels with amalgams– Amalgams banned in Europe– $2500 fine by EPA if office windows are opened
5
Shouldn’t we be concerned about the established relationship between toxins, cancer, heart disease, and other chronic illnesses?... Especially now that cancer is the #1 cause of death and the #1 cause of death among our children ages 1-15!
Why are we not addressing TOXINS!
Shouldn’t we be concerned about the established relationship between toxins, cancer, heart disease, and other chronic illnesses?... Especially now that cancer is the #1 cause of death and the #1 cause of death among our children ages 1-15!
Why are we not addressing TOXINS!
Toxins?Toxins?
6
What can we do?What can we do? Inform ourselves as health care providers what
toxins are and how they damage biological systems
Develop ways to evaluate, measure and inform our patients
Develop simple, safe and effective means to do this
Let’s practice healing …Not Medicating
Inform ourselves as health care providers what toxins are and how they damage biological systems
Develop ways to evaluate, measure and inform our patients
Develop simple, safe and effective means to do this
Let’s practice healing …Not Medicating
7
In the NewsIn the News 45 States Have Issued Mercury Advisories: coal-fired
power plants– Source: News-Leader.com – Quoted from the EPA and Department of
Natural Resources
Mercury and Fish Advisories Issued for Nine More Waterways– Source: De Ridder Beauregard Daily News –Quoted from The Louisiana
Department of Health and Hospitals Environmental Quality
Dangerous Lead Levels Found in More Homes– Source: Cincinnati Enquirer – Quoted from the EPA
Lead Linked to Premature Deaths in Adults: Early Exposure = 46% Higher Mortality– Source: The Baltimore Sun – Quoted from the CDC
45 States Have Issued Mercury Advisories: coal-fired power plants– Source: News-Leader.com – Quoted from the EPA and Department of
Natural Resources
Mercury and Fish Advisories Issued for Nine More Waterways– Source: De Ridder Beauregard Daily News –Quoted from The Louisiana
Department of Health and Hospitals Environmental Quality
Dangerous Lead Levels Found in More Homes– Source: Cincinnati Enquirer – Quoted from the EPA
Lead Linked to Premature Deaths in Adults: Early Exposure = 46% Higher Mortality– Source: The Baltimore Sun – Quoted from the CDC
8
In the News In the News (Cont’d)(Cont’d)
California Sues Over Heavy-Metal Fish– Source: Business Report – Quoted from the California Attorney General
Lead Poisoning Alert– Source: pediatrics.about.com – Quoted from the FDA
Mercury Air Level is Worry for Ohio– Source: Akron Beacon Journal – Quoted from the EPA
EPA Doubles Estimates of Children with Mercury in Blood
– Source: Access North Georgia – Quoted from the EPA
Mercury List Longer Each Year– Source: The News-Press – Quoted from Dept. of Environmental Protection
California Sues Over Heavy-Metal Fish– Source: Business Report – Quoted from the California Attorney General
Lead Poisoning Alert– Source: pediatrics.about.com – Quoted from the FDA
Mercury Air Level is Worry for Ohio– Source: Akron Beacon Journal – Quoted from the EPA
EPA Doubles Estimates of Children with Mercury in Blood
– Source: Access North Georgia – Quoted from the EPA
Mercury List Longer Each Year– Source: The News-Press – Quoted from Dept. of Environmental Protection
9
In the News In the News (Cont’d)(Cont’d)
CDC Vaccine Data Leads Scientists to Shocking Discovery: Possible Autism/Neurological Link– Source: Yahoo News – Quoted from the CDC
Chromated Copper Arsenate: CCA-Treated Lumber Poses Danger from Arsenic– Toxicol Sci. 2004 Jun;79(2):287-95
EPA: Amount of Toxins in Air, Water and Land Increased at Record Rate…– Source: Axis of Logic – Quoted from the EPA
FDA Warns Pregnant Women to Limit Tuna– Richard Simmons -Los Angeles Times 3/2004
CDC Vaccine Data Leads Scientists to Shocking Discovery: Possible Autism/Neurological Link– Source: Yahoo News – Quoted from the CDC
Chromated Copper Arsenate: CCA-Treated Lumber Poses Danger from Arsenic– Toxicol Sci. 2004 Jun;79(2):287-95
EPA: Amount of Toxins in Air, Water and Land Increased at Record Rate…– Source: Axis of Logic – Quoted from the EPA
FDA Warns Pregnant Women to Limit Tuna– Richard Simmons -Los Angeles Times 3/2004
10
Major Heavy Metal ToxinsMajor Heavy Metal Toxins
MercuryLeadCadmiumAluminumArsenicNickel
MercuryLeadCadmiumAluminumArsenicNickel
11
Metal Toxicity MechanismsMetal Toxicity Mechanisms
Neurotoxic: damage brain structures; lower IQ; down-regulates dopamine activity
Nephrotoxic Immune dysregulation Cardiovascular Bone & tissue deposits Dysbiosis; fungal mycotoxins Endocrine disruption; thyroid, adrenal, sex h Cognitive problems; ADHD, Alz, depression Metabolic dysregulation; energy decline, etc
Neurotoxic: damage brain structures; lower IQ; down-regulates dopamine activity
Nephrotoxic Immune dysregulation Cardiovascular Bone & tissue deposits Dysbiosis; fungal mycotoxins Endocrine disruption; thyroid, adrenal, sex h Cognitive problems; ADHD, Alz, depression Metabolic dysregulation; energy decline, etc
12
Health Care Health Care ProfessionalsProfessionals Education for your patients’ sake
– A plea to stay abreast of new modalities for patient care
• Be informed of what our industrialized society is doing to our patients’ health
• Be open to complementary treatments
• New diagnostic tests to assess toxicity
• Know that your patients are more informed and asking for our help for treatment and prevention of toxic pollutants
• Look toward innovation, science, research and validation of the best methods
to give your patients what they demand
Education for your patients’ sake
– A plea to stay abreast of new modalities for patient care
• Be informed of what our industrialized society is doing to our patients’ health
• Be open to complementary treatments
• New diagnostic tests to assess toxicity
• Know that your patients are more informed and asking for our help for treatment and prevention of toxic pollutants
• Look toward innovation, science, research and validation of the best methods
to give your patients what they demand
13
Time-Lapse Microphotography of Toxic Time-Lapse Microphotography of Toxic Effects on Human CellsEffects on Human CellsTime-Lapse Microphotography of Toxic Time-Lapse Microphotography of Toxic Effects on Human CellsEffects on Human Cells
Normal Cell GrowthNormal Cell GrowthNormal Cell GrowthNormal Cell Growth Toxic Cell Damage and DeathToxic Cell Damage and DeathToxic Cell Damage and DeathToxic Cell Damage and Death
14
Lead-induced Hypertension: Lead-induced Hypertension: Role of Oxidative StressRole of Oxidative Stress
Chronic, low-level lead exposure causes hypertension in both animals and humans
Inactivation of endogenous nitric oxide Reactive oxygen species (ROS) lowers enzyme activity Functional deficiency in nitric oxide Increase sympathetic activity & plasma norepinephrine Lead-induced inhibition of vascular smooth muscle ACE, angiotensin II, aldosterone, thromboxane
Chronic, low-level lead exposure causes hypertension in both animals and humans
Inactivation of endogenous nitric oxide Reactive oxygen species (ROS) lowers enzyme activity Functional deficiency in nitric oxide Increase sympathetic activity & plasma norepinephrine Lead-induced inhibition of vascular smooth muscle ACE, angiotensin II, aldosterone, thromboxane
Ref: Vaziri ND, “Lead-induced Hypertension: Role of Oxidative Stress,” Ref: Vaziri ND, “Lead-induced Hypertension: Role of Oxidative Stress,” Curr Hypertens Rep. 2004 Aug;6(4):314-20Curr Hypertens Rep. 2004 Aug;6(4):314-20Ref: Vaziri ND, “Lead-induced Hypertension: Role of Oxidative Stress,” Ref: Vaziri ND, “Lead-induced Hypertension: Role of Oxidative Stress,” Curr Hypertens Rep. 2004 Aug;6(4):314-20Curr Hypertens Rep. 2004 Aug;6(4):314-20
15
Random Blood Sampling of Dr. Ellithorpe’s Random Blood Sampling of Dr. Ellithorpe’s Patients: Presence Excessively High Heavy Patients: Presence Excessively High Heavy MetalsMetals
Per
cent
of
Pat
ient
sP
erce
nt o
f P
atie
nts
N=251N=251100
2217
0
25
50
75
100
Presence of Heavy Metals
Elevated Heavy Metals
Potentially Toxic Heavy Metals
100
2217
0
25
50
75
100
Presence of Heavy Metals
Elevated Heavy Metals
Potentially Toxic Heavy Metals
16
Sources of Toxic Metals - Sources of Toxic Metals - AluminumAluminumSources of Toxic Metals - Sources of Toxic Metals - AluminumAluminum
Eating small amounts of aluminum in food Breathing aluminum dust in air Drinking contaminated water near:
– Waste Sites– Manufacturing plants– Areas naturally high in aluminum
Antacids Cooking utensils - minimal
Eating small amounts of aluminum in food Breathing aluminum dust in air Drinking contaminated water near:
– Waste Sites– Manufacturing plants– Areas naturally high in aluminum
Antacids Cooking utensils - minimal
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
17
Sources of Toxic Metals - Sources of Toxic Metals - ArsenicArsenic
Eating food, drinking water or breathing air containing arsenic
Breathing contaminated air Breathing sawdust, burning smoke Living near hazardous waste sites Living near high levels of arsenic in rock
Eating food, drinking water or breathing air containing arsenic
Breathing contaminated air Breathing sawdust, burning smoke Living near hazardous waste sites Living near high levels of arsenic in rock
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
18
Sources of Toxic Metals - Sources of Toxic Metals - CadmiumCadmium Breathing contaminated air
– Battery manufacturing– Metal soldering or welding
Eating foods containing cadmium:– Shellfish, Liver, Kidney meats
Breathing cigarette smoke Drinking contaminated water Breathing contaminated air
– Burning of fossil fuels, municipal waste
Breathing contaminated air– Battery manufacturing– Metal soldering or welding
Eating foods containing cadmium:– Shellfish, Liver, Kidney meats
Breathing cigarette smoke Drinking contaminated water Breathing contaminated air
– Burning of fossil fuels, municipal waste
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
19
Sources of Toxic Metals - Sources of Toxic Metals - MercuryMercury
Eating fish or shellfish Breathing vapors from:
– Spills, incinerators, industryDental work, medical treatmentsBreathing contaminated air or skin contact:
– Dental, health services, chemical, other industries using mercury
Eating fish or shellfish Breathing vapors from:
– Spills, incinerators, industryDental work, medical treatmentsBreathing contaminated air or skin contact:
– Dental, health services, chemical, other industries using mercury
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
20
Sources of Toxic Metals - Sources of Toxic Metals - LeadLead
Eating food, drinking water that contains leadLead base paintsWorking where lead is usedHealth care products containing leadHobbies which lead is used:
– Glass staining
Eating food, drinking water that contains leadLead base paintsWorking where lead is usedHealth care products containing leadHobbies which lead is used:
– Glass staining
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
21
Global Chronic Low Level Metal Global Chronic Low Level Metal ToxicityToxicity
Recognized by:– US Environmental Protection Agency (EPA)– Food & Drug Administration (FDA)– Centers for Disease Control (CDC)– State Health Departments
Treatment standards are needed– Preventative measures– Comprehensive medicine with proven results– Reduction of crisis management
Recognized by:– US Environmental Protection Agency (EPA)– Food & Drug Administration (FDA)– Centers for Disease Control (CDC)– State Health Departments
Treatment standards are needed– Preventative measures– Comprehensive medicine with proven results– Reduction of crisis management
22
There are NO Safe Levels of There are NO Safe Levels of Heavy MetalsHeavy Metals
Low levels are becoming dangerousLow levels accumulate Low levels become storedLow levels become higherMultiple toxins compound the danger
Low levels are becoming dangerousLow levels accumulate Low levels become storedLow levels become higherMultiple toxins compound the danger
23
Death Rates of Participants with Death Rates of Participants with Low Pb Levels in NHANES III Low Pb Levels in NHANES III
SurveySurvey
17
39
46
68
46
0
10
20
30
40
50
60
70
80
10 20 30
All CausesCardiovascular Diseases Cancer
17
39
46
68
46
0
10
20
30
40
50
60
70
80
10 20 30
All CausesCardiovascular Diseases Cancer
Per
cent
Inc
reas
e in
Mor
talit
yP
erce
nt I
ncre
ase
in M
orta
lity
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern Med, 2002, 162: 2443-2449Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern Med, 2002, 162: 2443-2449
Blood Lead Levels (µg/dL)Blood Lead Levels (µg/dL)
24
NHANES-III Survey ResultsNHANES-III Survey Results
Estimated 29 million people (15% of adult population over age 20) had Pb levels of at least 20 µg/dL from 1976-1980.
30 µg/dL Pb is considered toxic
Estimated 29 million people (15% of adult population over age 20) had Pb levels of at least 20 µg/dL from 1976-1980.
30 µg/dL Pb is considered toxic
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality.Arch Intern Med, 2002, 162: 2443-2449. Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality.Arch Intern Med, 2002, 162: 2443-2449.
25
Heavy MetalsHeavy Metals
Heavy metals and other toxins cause cell membrane damage through the production of free radicals and oxidative stress.
Heavy metals and other toxins cause cell membrane damage through the production of free radicals and oxidative stress.
26
Human Cell SchematicHuman Cell SchematicHuman Cell SchematicHuman Cell Schematic
Cell Membrane
Mitochondria
Nucleus
Cytoplasm
27
The cell contains all of Life’s processes. Of particular importanceIs the mitochondria, which are the sites of energy production
28
The Cell and Mitochondria Membrane
29
Cell MembraneCell Membrane
Mitochondria MembraneMitochondria Membrane(Outer)
Mitochondria MembraneMitochondria Membrane(Inner)
30
Oxidative DamageOxidative DamageOxidative DamageOxidative Damage
31
Oxidative Damage to Cell Oxidative Damage to Cell MembranesMembranes
Healthy MembraneHealthy Membrane Oxidative Stress DamageOxidative Stress Damage
32
Lipid layer repaired
33
Chelation TherapyChelation Therapy
Modes– DMPS; IV, transdermal– DMSA; oral– Penicillinamine– EDTA
• IV• Oral• Rectal Suppositories
– Others • Oral supplements
Modes– DMPS; IV, transdermal– DMSA; oral– Penicillinamine– EDTA
• IV• Oral• Rectal Suppositories
– Others • Oral supplements
34
Recommended ModalityRecommended Modality
CaNa2 EDTA Chelation Suppositories CaNa2 EDTA Chelation Suppositories
35
DetoxaminDetoxamin®® CaNa CaNa2 2 EDTA EDTA SuppositoriesSuppositories
36
Why CaNaWhy CaNa2 2 EDTA EDTA Suppositories?Suppositories?
Non-invasive Safe Broad specificity metal chelation Easy to use Low cost Less time consuming Convenient
Non-invasive Safe Broad specificity metal chelation Easy to use Low cost Less time consuming Convenient
37
CaNaCaNa22 EDTA Chelation EDTA Chelation (Detoxamin)(Detoxamin)
FDA approved for lead detoxificationAlso chelates other metals
– Suppository form• Can be used in combination with IV, oral,
transdermal, topical or as stand alone therapy
– IV Chelation• Expensive• Time consuming – 3-5 hours• Invasive• Greater risk
FDA approved for lead detoxificationAlso chelates other metals
– Suppository form• Can be used in combination with IV, oral,
transdermal, topical or as stand alone therapy
– IV Chelation• Expensive• Time consuming – 3-5 hours• Invasive• Greater risk
38
Pharmacokinetic Pre-clinical Pharmacokinetic Pre-clinical ResultsResults
IntravenousIntravenous Rectal Rectal (Suppositories)(Suppositories)
Absolute Absolute Bioavailability Bioavailability
100%100% 36.3 %36.3 %
Blood to Blood to Tissue RatioTissue Ratio
3.73.7 13.613.6
Half-LifeHalf-Life 1.5 hours1.5 hours Over 8 hoursOver 8 hours
39
Specimen Collection Specimen Collection SummarySummary
Pre-Detoxamin CaNa2-EDTA Suppositories– Comprehensive stool analysis with Fecal Metals analysis
Post-Detoxamin CaNa2-EDTA Suppositories– Comprehensive Stool Analysis with Fecal Metals analysis
after the 90th suppository
Pre-Detoxamin CaNa2-EDTA Suppositories– Comprehensive stool analysis with Fecal Metals analysis
Post-Detoxamin CaNa2-EDTA Suppositories– Comprehensive Stool Analysis with Fecal Metals analysis
after the 90th suppository
40
ProtocolProtocol
Challenge for Heavy Metals– 1.5 gm CaNa2 EDTA Detoxamin suppositories
• 2 - 750 mg suppositories at night
– Fecal test - send to Doctors Data, St Charles, Illinois, (800-323-2784)
Typically several heavy metals are present– Average 6-12– Elevated 1-4
Recommend Detoxamin suppositories at bedtime– Monday through Thursday nights x 90 suppositories– Consistently used – will be finished in 6 months
Challenge for Heavy Metals– 1.5 gm CaNa2 EDTA Detoxamin suppositories
• 2 - 750 mg suppositories at night
– Fecal test - send to Doctors Data, St Charles, Illinois, (800-323-2784)
Typically several heavy metals are present– Average 6-12– Elevated 1-4
Recommend Detoxamin suppositories at bedtime– Monday through Thursday nights x 90 suppositories– Consistently used – will be finished in 6 months
41
Protocol (Cont’d)Protocol (Cont’d)
Repeat the same challenge and compare results
Maintenance – 1 suppository last 5 nights of each month
Recommend Vitamin/mineral supplement– RepairACell or one of your choice
Repeat the same challenge and compare results
Maintenance – 1 suppository last 5 nights of each month
Recommend Vitamin/mineral supplement– RepairACell or one of your choice
42
Why Detoxamin: CaNaWhy Detoxamin: CaNa2 2 EDTA EDTA Suppositories?Suppositories?
Clinically proven Unparalleled safety EDTA - US FDA approved for Pb detox Consumer friendly Low cost Can treat large patient population, home use Less time consuming than IV chelation Broad specificity metal chelation Easy to use and convenient Effective in children, adolescents and adults
Clinically proven Unparalleled safety EDTA - US FDA approved for Pb detox Consumer friendly Low cost Can treat large patient population, home use Less time consuming than IV chelation Broad specificity metal chelation Easy to use and convenient Effective in children, adolescents and adults
43
Comparison of IV Chelation Comparison of IV Chelation and Detoxaminand Detoxamin
IV Chelation Detoxamin
Invasive Yes No
Time consuming Yes No
Expensive Yes No
Greater risk Yes No
Easy to administer Yes No
Clinically proven Yes Yes
44
Detoxamin SafetyDetoxamin Safety
Comprehensive Metabolic Panel– Albumin - Total Protein– Total Bilirubin - Sodium – Calcium - AST (SGOT)– Chloride - Urea Nitrogen (BUN)
– Creatinine, Serum - Bicarbonate (CO2)
– Glucose - ALT (SGPT)– Alkaline Phosphatase - C-Reactive Protein– Potassium
No statistical difference in above lab parameters between pre and post treatment with Detoxamin in all subjects
Comprehensive Metabolic Panel– Albumin - Total Protein– Total Bilirubin - Sodium – Calcium - AST (SGOT)– Chloride - Urea Nitrogen (BUN)
– Creatinine, Serum - Bicarbonate (CO2)
– Glucose - ALT (SGPT)– Alkaline Phosphatase - C-Reactive Protein– Potassium
No statistical difference in above lab parameters between pre and post treatment with Detoxamin in all subjects
45
Practical Clinical Case StudyPractical Clinical Case Study
Date Cd Hg Pb Ni
5/03 1.7 30 43 9.5
2/04 1.0 2.6 27 17
2/05 1.0 18 27 13
55 y/o 55 y/o • • W • F • 131 lbs. • School Teacher • Chronic LBP • Fatigue • HypothyroidW • F • 131 lbs. • School Teacher • Chronic LBP • Fatigue • Hypothyroid
Outcome: 7/04 – Excellent energy • Exercise 3x/day – water Outcome: 7/04 – Excellent energy • Exercise 3x/day – water aerobics • Back pain stable • Reduced need for medications.aerobics • Back pain stable • Reduced need for medications.
Patient K.MPatient K.M..
46
Practical Clinical Case StudyPractical Clinical Case StudyPractical Clinical Case StudyPractical Clinical Case Study
42 y/o 42 y/o • W • W •• F • 145 lbs. • Photographer • Fibromyalgia • Chronic Fatigue F • 145 lbs. • Photographer • Fibromyalgia • Chronic Fatigue •• HypothyroidHypothyroid
Outcome: 11/04 – Energy good • Exercises daily (45 min.) with Outcome: 11/04 – Energy good • Exercises daily (45 min.) with mild to moderate pain of fibromyalgia • Increased daily activitiesmild to moderate pain of fibromyalgia • Increased daily activities
Date Ar Cd Pb Hg Ni
8/02 220 2.5 20 24 49
12/02 4.5 2.1 7.4 15 25
5/03 45 3.2 12 8.9 18
F.K.F.K.
47
Practical Clinical Case StudyPractical Clinical Case Study
Date Cd Hg Pb Ni
10/02 1.2 5.2 27 8.4
2/03 0.9 4.4 18 3.6
10/03 1.4 9.8 20 1.6
5/04 0.7 3.8 16 7.7
12/04 1.0 1.6 12 12
52 y/o 52 y/o • • M • 175 lbs. • Electrician • Chronic Anxiety Panic Attacks • Hypertension • LBPM • 175 lbs. • Electrician • Chronic Anxiety Panic Attacks • Hypertension • LBP
Outcome: 10/04 – Anxiety greatly improved • Reduced need for Outcome: 10/04 – Anxiety greatly improved • Reduced need for auxiolytic medication • Improved BP • Reduced anti-hypertensive auxiolytic medication • Improved BP • Reduced anti-hypertensive medication • LBP improved • Exercises daily (30 min.)medication • LBP improved • Exercises daily (30 min.)
Patient M.O.Patient M.O.
48
Detoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in FecesFecesDetoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in FecesFeces
.1
.5
.31
.37
.15 .16
.72*
.56
.93*
.44*
0
0.2
0.4
0.6
0.8
1
Arsenic Lead Mercury Cadmium Uranium
Day 0 Cumulative Day 3 + Day 90
.1
.5
.31
.37
.15 .16
.72*
.56
.93*
.44*
0
0.2
0.4
0.6
0.8
1
Arsenic Lead Mercury Cadmium Uranium
Day 0 Cumulative Day 3 + Day 90
*Significantly different from Day 0 (p<0.05)*Significantly different from Day 0 (p<0.05)
Mea
n V
alue
sm
g/kg
Mea
n V
alue
sm
g/kg
49
Detoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in FecesFeces (Cont’d)(Cont’d)
Detoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in FecesFeces (Cont’d)(Cont’d)
6.2
12.7*
0
2
4
6
8
10
12
14 Day 0
Cumulative Day 3 + Day 90
6.2
12.7*
0
2
4
6
8
10
12
14 Day 0
Cumulative Day 3 + Day 90
Mea
n V
alue
mg/
kgM
ean
Val
uem
g/kg
*Significantly different from Day 0 (p<0.05)*Significantly different from Day 0 (p<0.05)
NickelNickelNickelNickel
50
Detoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in UrineUrineDetoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in UrineUrine
5.5
15.6
1.8 1.73.6
5.84.9
1.3.5
10.1
13.5
36.6
0
5
10
15
20
25
30
35
40
Aluminum Arsenic Lead Mercury Cadmium Nickel
Day 0
Cumulative Day 3 + Day 90
5.5
15.6
1.8 1.73.6
5.84.9
1.3.5
10.1
13.5
36.6
0
5
10
15
20
25
30
35
40
Aluminum Arsenic Lead Mercury Cadmium Nickel
Day 0
Cumulative Day 3 + Day 90
Mea
n V
alue
sµ
g/g
crea
tinin
eM
ean
Val
ues
µg/
g cr
eatin
ine
*Significantly different from Day 0 (p<0.05)*Significantly different from Day 0 (p<0.05)
*
**
* *
*
51
Detoxamin SafetyDetoxamin Safety
Comprehensive Metabolic Panel– Albumin - Total Protein– Total Bilirubin - Sodium – Calcium - AST (SGOT)– Chloride - Urea Nitrogen (BUN)
– Creatinine, Serum - Bicarbonate (CO2)
– Glucose - ALT (SGPT)– Alkaline Phosphatase - C-Reactive Protein– Potassium
No statistical difference in above lab parameters No statistical difference in above lab parameters between pre and post treatment with Detoxamin between pre and post treatment with Detoxamin in all subjectsin all subjects
Comprehensive Metabolic Panel– Albumin - Total Protein– Total Bilirubin - Sodium – Calcium - AST (SGOT)– Chloride - Urea Nitrogen (BUN)
– Creatinine, Serum - Bicarbonate (CO2)
– Glucose - ALT (SGPT)– Alkaline Phosphatase - C-Reactive Protein– Potassium
No statistical difference in above lab parameters No statistical difference in above lab parameters between pre and post treatment with Detoxamin between pre and post treatment with Detoxamin in all subjectsin all subjects
52
Detoxamin Safety Detoxamin Safety (Cont’d)(Cont’d)
Observations within study– Dosage form is gentle– Little biological burden– In general, very well tolerated
Historical events– Over 450,000 doses administered within the past
five years• Minor complaints with first few applications
– Loose stools– Rectal gas – Headache – Lethargy– Joint pain
Observations within study– Dosage form is gentle– Little biological burden– In general, very well tolerated
Historical events– Over 450,000 doses administered within the past
five years• Minor complaints with first few applications
– Loose stools– Rectal gas – Headache – Lethargy– Joint pain
53
Detoxamin Clinical Pilot Study Detoxamin Clinical Pilot Study SummarySummary
Significant excretions observed– Fecal
• Ar, Pb, Cd, Ni
– Urine• Ar, Pb, Hg, Cd, Ni
Average change in pre and post DMSA– Fifty percent for Al, Ar, Pb, Hg, Ni – No difference with Cd
Significant excretions observed– Fecal
• Ar, Pb, Cd, Ni
– Urine• Ar, Pb, Hg, Cd, Ni
Average change in pre and post DMSA– Fifty percent for Al, Ar, Pb, Hg, Ni – No difference with Cd
54
NHANES-III Survey ResultsNHANES-III Survey Results
Estimated 29 million people (15% of adult population over age 20) had Pb levels of at least 20 µg/dL from 1976-1980.
30 µg/dL Pb is considered toxic
Estimated 29 million people (15% of adult population over age 20) had Pb levels of at least 20 µg/dL from 1976-1980.
30 µg/dL Pb is considered toxic
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality.Arch Intern Med, 2002, 162: 2443-2449. Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality.Arch Intern Med, 2002, 162: 2443-2449.
55
Effects of Detoxamin on Effects of Detoxamin on Elevated Lead Urine Levels in Elevated Lead Urine Levels in ChildrenChildren
In connection with Columbia and Fordham U Purpose: To demonstrate gradual lead reduction
in blood and urine Conducted in Dominican Republic
– Residential neighborhood near battery recycling plant– 20 children identified with blood levels over 10 µg/dL– Initial mean blood determination of 66.6 µg/dL Pb– Note: Blood levels of > 10 µg/dL are of CDC concern– Treatment with 1000mg Detoxamin suppositories
In connection with Columbia and Fordham U Purpose: To demonstrate gradual lead reduction
in blood and urine Conducted in Dominican Republic
– Residential neighborhood near battery recycling plant– 20 children identified with blood levels over 10 µg/dL– Initial mean blood determination of 66.6 µg/dL Pb– Note: Blood levels of > 10 µg/dL are of CDC concern– Treatment with 1000mg Detoxamin suppositories
56
Effects of Detoxamin on Elevated Effects of Detoxamin on Elevated Lead Urine Levels in ChildrenLead Urine Levels in Children
4.2
61.45
9
22.7
0
20
40
60
80
100
0 1 10 20 30
Pre-Treatment Baseline
After 1st Suppository
10 Days of Suppository
10 Days After Suppository
10 Days Additional Suppository
4.2
61.45
9
22.7
0
20
40
60
80
100
0 1 10 20 30
Pre-Treatment Baseline
After 1st Suppository
10 Days of Suppository
10 Days After Suppository
10 Days Additional Suppository
325.6325.6
µg/
dLµ
g/dL
Treatment DayTreatment Day
N=20N=20
57
Effects of Detoxamin on Elevated Effects of Detoxamin on Elevated Lead Urine Levels in Children - Lead Urine Levels in Children - SummarySummary
Significant excretion of Pb was observed after only one initial dose of Detoxamin (325.6µg/dL or 78 times more Pb excreted above baseline of 4.2µg/dL)
Gradual Pb excretion occurred continually of a 30 day period
Significant excretion of Pb was observed after only one initial dose of Detoxamin (325.6µg/dL or 78 times more Pb excreted above baseline of 4.2µg/dL)
Gradual Pb excretion occurred continually of a 30 day period
58
Detoxamin Instructions for Detoxamin Instructions for useuse
Administration– Self application rectal suppository– One per evening or one every other evening– Evacuate bowels before application– Three to six months duration
Recommendations– Eat evening meals 3-4 hours prior to Detoxtamin
• Protein rich with low sugar content– Take quality multi-vitamin/mineral supplement in AM
Maintenance– Six Detoxamin suppositories per month
Administration– Self application rectal suppository– One per evening or one every other evening– Evacuate bowels before application– Three to six months duration
Recommendations– Eat evening meals 3-4 hours prior to Detoxtamin
• Protein rich with low sugar content– Take quality multi-vitamin/mineral supplement in AM
Maintenance– Six Detoxamin suppositories per month
For more information call 1-877-656-4553 – www.Detoxamin.comFor more information call 1-877-656-4553 – www.Detoxamin.com
59
Effects of Detoxamin on Effects of Detoxamin on Elevated Lead Urine Levels in Elevated Lead Urine Levels in
ChildrenChildren In connection with Columbia and Fordham U Purpose: To demonstrate gradual lead
reduction in blood and urine Conducted in Dominican Republic
– Residential neighborhood near battery recycling plant
– 20 children identified with blood levels over 10 µg/dL– Initial mean blood determination of 66.6 µg/dL Pb– Note: Blood levels of > 10 µg/dL are of CDC
concern– Treatment with 1000mg Detoxamin suppositories
In connection with Columbia and Fordham U Purpose: To demonstrate gradual lead
reduction in blood and urine Conducted in Dominican Republic
– Residential neighborhood near battery recycling plant
– 20 children identified with blood levels over 10 µg/dL– Initial mean blood determination of 66.6 µg/dL Pb– Note: Blood levels of > 10 µg/dL are of CDC
concern– Treatment with 1000mg Detoxamin suppositories
60
Comparison of IV Chelation and CaNaComparison of IV Chelation and CaNa2 2
EDTA SuppositoriesEDTA Suppositories
IV
Chelation
Rectal
Suppositories
Non-Invasive No Yes
Quick and easy to use No Yes
Inexpensive No Yes
Increased safety No Yes
Broad spectrum metal removal Yes Yes
FDA approved Yes Yes
Clinically proven Yes Yes