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A supplement for lowering blood sugar
A supplement for lowering cholesterol
A supplement to lower blood
pressure
A supplement for the
treatment of asthma
o Global prevalence of raised cholesterol among adults (≥ 5.0 mmol/l) was 39% (2008).
o One third of ischaemic heart disease is attributable to high cholesterol.
o Estimated to cause 2.6 milliondeaths (4.5% of total).
o 29.7 million (2%) of disability adjusted life years (DALYS).
o A 10% reduction in serum cholesterol in men aged 40 can reduce heart disease by 50% within 5 years.
o In high-income countries, over 50% of adults had raised total cholesterol.
Source: W HO estimates Global Health Observatory,
Pipeline – Large Addressable Markets
o 300 million asthma sufferers worldwide.
o Number of asthmatics will grow by more than 100 million by 2025.
o 250,000 annual deaths – almost all are avoidable.
o 70% of asthmatics also haveallergies.
o World-wide, the economic costs associated with asthma are estimated to exceed those of TB and HIV/AIDS combined.
Source: W orld Health Organization. Globalsurveillance…,
o Globally, nearly one billion people have high blood pressure (hypertension).
o Raised blood pressure causes 7.5 million deaths (12.8% of total deaths).
o Accounts for 57 million (3.7%) disability adjusted life years (DALYS).
o Blood pressure levels are shown to be positively and continuously. related to the risk for stroke and coronary heart disease.
o Globally, raised blood pressure inadults 25+ is around 40% (2008)
Source: W HO estimates Global Health Observatory,W orld Heart Federation
Product Information
CuraLin - Product Efficacyo Within 3-5 days users can expect to see a dramatic change in blood sugar
levels. After just one month we expect to see a significant reduction as well as an improvement in the overall health of users.
o Results showed the product was successful in improving glycemic control inpatients.
o Recognizable ingredients with evidence of blood sugar reduction properties.
o 100% natural product including vegetarian capsules.
Patient Impacto The application of Ayurvedic practice combined with the scientific knowledge of 21st
Century medicine creates a dramatic impact on the reduction of sugar levels produced in the body.
o The formula reactivates and strengthens the pancreas which is responsible for theproduction of insulin in the body.
o Blood sugar levels reduced with attention given to the overall balance of the body.
o Clear Benefits:o Helps lower and control blood sugar levels o
Reactivates and strengthens the pancreas o
Helps with blurred visiono Removes any tingling sensationo Boosts energy levelso Reduces dependency on allopathic
medicationo Completely herbal
Customer Feedback (1)A customer survey was conducted by phone in April 2014 with data from an uncontrolled sample group of 50 product users.
o Average age 61
o Male 66% : Female 34%
o Average length of product use 3.1 years
o 44% take no other form of diabetic treatment
% reduction after 3 monthsuse
% reduction till today
Users 6 - 7.9 mmol/l 8.5% 10.7%
Users 8+ mmol/l 18.6% 24.4%
Total 13.3% 17.3%
Survey results
Customer Feedback (2)How satisfied are you with the
performance of the Supplement?I am confident in my ability to manage my
blood sugar levels?
How big an impact has it had on your lifestyle?
Some Impact 14%
Would you recommend the supplement to anyone else?
Big Impact 84%%
Neutral2%
Confident13%
Very Confident 84%
Neutral 3%
Yes 100%
Very Satisfied 94%
Satisfied 6%
CuraLin Ingredients profile
- Momordica Charantia - Bitter Melon
Bitter Melon grows in tropical areas such as the Far East, the Caribbean and EastAfrica.
This plant is traditionally used in Asia as a treatment for diabetes mainly at earlystages and also to lower blood lipid levels.
Among the active ingredients are vicine, charantin, triterpenoids and anti-oxidants which reduce the level of free radicals. Its active ingredients preform the following:
o regeneration of the hysiological function of damaged pancreatic cells and improvement of theirefficiency
o reduce glucose absorptiono increase sensitivity of the muscle cells to insulin.o reduction of gluconeogenesis activity (which converts glucose reserves in the liver to available
glucose)
A study examined the effect of the substance on 42 Taiwanese men and women with a mean age of 45.7 + 11.4. The study demonstrated a statistically significant decrease (p=0.021) of 19% in the labeled cases of the syndrome (after only three months of treatment)Wild bitter gourd improves metabolic syndrome: a preliminary dietary supplementation trial. Nutrition Journal, vol. 11, no. 1, article
4,2012.C. Tsai, E. C. Chen et al.
Gymnema Sylvestre Gymenema is known for its ability to decrease the craving for the
characteristic sweet taste of carbohydrates. The active substance aponin connects to receptors for the sweet taste
found on the tongue and prevents their activity, thereby lowering the strong craving for sweet foods.
The substance hastens the release of insulin from the pancreatic cells, slows the absorption rate of carbohydrates from the digestive system (which contributes to the feeling of satiety for a longer period of time and indirectly to weight loss).
A study published in 2001 examined how continuous daily consumption (90 days) of the substance affected the fasting blood glucose level; glucose measured two hours after a meal and the level of HbAiC.
www.diabetesincontrol.com/articles/uncategorized/10355-effect-of-extended-release-gymnema-sylvestre-leaf-extract-beta-fast-gxr
A study conducted in India in 1990 included 22 volunteers. Aged 40-62 they had been diagnosed with the disease for duration of between 1-12 years and had used he substance for a period of 18-20 months. A mean decrease of approximately 28% was seen in fasting blood glucose levels, and 21 volunteers reduced the levels of conventional drug treatment with five volunteers stopping altogether.
www.diabeteslibrary.org/View.aspx?url=Gymnema_sylvestre.
Trigonella Foenum Graecm
Also known as Fenugreek contains a high amount of fiber and alkaloids, which improve the ability of the pancreas to produce and release insulin mainly due to the presence of the amino acid 4- hydroxylisoleucine which regulates the release rate of insulin, so it is compatible with blood glucose levels.
Fenugreek seeds have also been attributed with the property of slowing down the absorption rate of carbohydrates from the digestive system.
A study has shown that a 60 day usage term of the supplement slows down the carbohydrates absorption rate in the digestion system as well as the fasting blood glucose levels.
Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India. 2001 Nov;49:1057- 61.Gupta A et al.
Curcuma Longa
Turmeric is known for its culinary properties and has been used for thousands of years in Indian and Chinese medicine for the treatment of diabetes.
The active substance in turmeric, curcumin, is known for its ability toreduce glucose levels and treat complications of diabetes.
The active mechanism of the substance is linked to its ability to moderate immune activity, that is, reduce the level of substances secreted from the immune system. These substances are also responsible, for raising insulin resistance.
Another property includes raising sensitivity to insulin by the enzymatic activity,of PPAR in muscle cells and fat.
A research conducted for 9 months on 120 patients indicated a 16% decrease of blood sugar levels in the group using the supplement compared to the control group.
Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med. 2013 Nov 24.Zhang DW et
al. Curcumin extract for prevention of type 2 diabetes: Diabetes Care. 2012 Nov;35(11):2121-7. Chuengsamarn S
et al.
Syzygum Cumini
Syzygium grows in tropical areas such as South America and Australia. There are over 100 different species of the plan ranging across Africa, South East Asia, the pacific ocean and Madagascar.
It’s pharmacological mechanism is tied to the delaying of the processof transforming starch to available glucose in the body.
Inhibitory potential of traditional herbs on α-amylase activity. Pharm Biol. 2012 Mar;50(3):326-31. doi: 10.3109/13880209.2011.608075. Epub 2011 Dec 2.Saha S1, Verma R.
A study published in 2014 has shows that the supplement supports reduction of fasting blood glucose levels with in 3 weeks, on diabetic induced mousses.
Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats.JComplement Integr Med. 2014 Jun;11(2):71-81.
Emblica officinalis
The active ingredient in the plant is tannoid whose properties work to restore the function of pancreatic cells.
A study from 2012 examined 42 mice in which type-II diabetes was induced (by way of pharmacological treatment). The mice were divided into seven groups, where each group was given the plant in various doses for a period of 45 days. Afterwards, the plasmatic glucose level and insulin level were examined and a significant statistical increase was found to be dependent on the dose amount. A histological change in the pancreatic tissue which demonstrated its restoration was also observed.
ANTIDIABETIC ACTIVITY OF EMBLICA OFFICINALIS SEED EXTRACT IN STREPTOZOTOCIN INDUCED TYPE-2 DIABETES MELLITUS IN RAT.Parminder N. et al. International Journal of Natural Product Science 2012: Spl Issue 1:135.
A study published in 2009, examined in a similar model tested on mice, saw a decrease in fasting glucose levels and three hours after the glucose loading test. For mice who were treated with the plant, a decrease was observed of 25% and 41.6% respectively for each of the measures.
Anti-diabetic activity of Emblica Officinalis in animal models. November 2009, Vol. 47, No. 11, Pages 1050-1055. Shikha Mehta et al.
Swertia Chirata This plant grows mainly in the Himalayas and contains a
number of active ingredients including chirtin, ophelic acid and mangiferin.
Their properties include: Direct activation of pancreatic cells to release insulin Reduction of glucose absorption from the digestive
system Improvement of the break-down process of cellular glucose
(process of glycolysis) Increase in the peripheral use of glucose by skeletal
muscles and its storage in the liver and muscles.
A study done on mousses and published at 2007 indicated a reduction of up to 30% in glucose levels approximately 3-4 hours after a meal in the group using the supplement. www.academia.edu/465211/BLOOD_SUGAR_LOWERING_ACTIVITY_OF_SWERTIA_CHIRAYITA_ROXB._EX._FLEM_KARST_IN_DIFFERENT_EXPERI
MENTAL_RAT_MODELS.
Picrorhiza Kurroa
This plant grows mainly in the Himalayas and Nepal.
The plant has a long history of use inIndian Ayurvedic medicine for the treatment ofdigestive problems.
Eugenia Jambolana
This plant is an evergreen tropical tree in the floweringplant family Myrtaceae
The plant is native to is nativeto Bangladesh, India, Nepal,Pakistan, Sri Lanka, Malaysia,the Philippines, and Indonesia.
The seed is also used in various alternative healing systems like Ayurveda (to control diabetes), Unani and Chinese medicine for digestive ailments.
The pulp of the fruit, extracts from the bark and seeds is of greatbenefit when it comes to lowering of blood glucose level.
Tinospora Cordifolia Tinospora cordifolia, which is known by the common
names Guduchi and Giloy, is an herbaceous vine of the family Menispermaceae indigenous to the tropical areas of India, Myanmarand Sri Lanka.
The plant has a long history of use in India as a medicine.
A study aiming at investigating the chronic (100 days) antihyperglycemic effect of the extract was conducted and demonstrated the effect of the supplement. Fasting blood glucose, glycosylated hemoglobin (HBA1C) and serum insulin levels were evaluated in normal, diabetic and treated rats.
The extract significantly reduces the fasting blood glucose level, glycosylated hemoglobin level as compare to diabetic control (p<0.001), the insulin and C-peptide levels were improved which shows the regeneration of cell which secretes insulin
Melia Azadirachta Also known as Neem, Nimtree, and Indian Lilac is a tree in
the mahogany family Meliaceae. It is one of two species in thegenus Azadirachta, and is native to India and the Indian subcontinent.
Products made from neem trees have been used in India for over twomillennia for their medicinal properties. Neem products are usedby Ayurvedic practitioners for anthelmintic,antifungal, antidiabetic, antibacterial, antiviral, contraceptive and sedative.
A study conducted on human patients have shown the efficacy of Azadirachta in the treatment of type 2 diabetes. Based on results obtained it was found that Azadirachta indica has significant hypoglycemic activity.
CuraLin - Pharmacological PathWays
FDA compliance
DOSAGE & WARNINGS :
The recommended dosage for Diagnosed Diabetic people is up to 6 capsules aday.
Not for use under the age of 18
Pregnant women, nursing mothers, people with hypoglycemic history, pleaseadvice your physician before use.
For prevention purposes, for people with high glycemic levels who were not diagnosed yet ( pre – diabetic ),start using 1 capsule after breakfast and lunch and increase this amount, according to the results of the test in fasting .
Please store in a cool and dry environment.
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Channels To Market – Initial Thoughts
Awareness and trust among clients to supportsales and client adaption
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Advertising on & off
line
PublicRelations
Marketing Key Channels - Supporting Measures
• Designated sale team to retail shops, specialized shops, and organizations.
• Distribution by wholesalers to pharmacies and natural products stores
The wholesaler must have the capacities of reaching the maximum number of sales points, as well as, the financial possibilities to invest at the promotion in the sale points, using propagandists as needed.
• Distribution by wholesalers to para medical professionals.
Usually based on some opinion leaders coming from this sector, who can organize somemeetings & professional seminars, where they can promote their sales
• Distribution by Dieticians
Same like 2 for this specific profession
• Distribution by independent distributors, some of them who can introduce the product to targeted market potential (elderlies houses) .
Organize and recruit a group of direct sales agents and preparing a compensation plan accordingly that will be based on a monthly parameters.
• On line shop
Cross advertising with insurance companies and government bodies, for diabeticpeople.
Note : the decisions regarding the pricing is related to the different ways that will bechosen .
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