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ARTHRITIS and FOOT Catherine Cyteval
Montpellier
Montpellier
Mr L 54 years old
Bulk centered on the head of the second metatarsal bone and inter osseous space of metatarsus of the left foot Synovial sarcoma?
Patient referred for biopsy under US
2nd metatarsal bone neck erosion
X rays
US
Toute lésion para articulaire est d’origine articulaire jusqu’à preuve histologique du contraire
Inflammatory joint +
Normal joint space +
Soft tissu bulke
Gout
Diagnostic issues with Gout Differential diagnosis: Arthritis Tumor Puncture-aspiration Negative in 25% of the cases -Thick content, challenging Suction -Fast routing in the laboratory: change of environment crystals of monosodium urate => solubilization of the crystals, risk of false negatives
Swan A, Amer H, Dieppe P. The value of synovial fluid assays in the diagnosis of joint disease: a literature survey. Ann Rheum Dis 2002
Crystals of sodium urate negatively birefringent. polarizing Microscope
• 10! / 1 "
• primitive forms (genetic): 90 %
• secondary forms: hyperuricemic patients • Metatarsophalangeal joint of the hallux +++
• No joint narowing • Erosions and
metaphyseal notches on cookie cutter
• Marginal osteophytes gives an aspect bristling
• Periosteal reaction
• High density of the bulck++++
MTP
Fin hyperechoïc border at the surface of cartilage (refractive micro crystals)
SA Wright Ann Rheum Dis 2007
T2 T1
T1 gado
Non specific MRI
Ct scan
Spectral CT
Urique Ac (HAP)
HAP (urique Ac )
Ca (urique Ac)
Fusion Urique Ac (Ca)
Two beams of different energy (80 et 140kV) , a difference in attenuation is characteristic of a given element (attenuation profile)
gouty tophus with gouty arthropathy of the 2nd MTP
No biopsy Favorable evolution with drug treatment
Mr C 78 years old
Mr C 73 years old
Painful inflammatory joints for less than 1 year
chondrocalcinosis • Quick severe destruction • Non-bearing joint • Few osteophytosis
• Subchondral sclerosis with clear limit
• many souschondrale erosions • Crenellated meshed articular
surfaces
Chondrocalcinosis
• Extremely common condition • 5% in adults • 27.6% for elderly
• Ca pyrophosphate crystal deposition ++ • articular structures • cartilages • fibro-cartilage
Cartilage cell
Pseudo osteo arthritis (70 %)
Gouty like (24 %) Arthritis like (6 %)
Ca++
PYROPHOSPHATE CRYSTALS
Calcic deposition - within cartilages
- tendons - Se 96,4% ; Sp 86,7% - PPV 92% ; NPV 93%
G Filippou Ann Rheum Dis 2007
Nrl
Gout
CCA
Mr H 48 years old
Acute Painful hallux
Hydroxyapatite
Take Home Message microcristals arthritis
Apatitis Periarticular
Chondrocalcinosis Sharpe dense bone surface
Gout Para articular dense bulk
Rheumatoid Arthritis (RA) • Affects appendicular skeleton particularly the small joints
of hands and feet
Spondylarthropathies
• Asymetric oligoarthritis • Abnormalities in cartilaginous joints (Spine discs,
sacroiliac joints) • HLA-B27 often present
Rheumatoid Arthritis 0.5% in the population - Foot involvement 90%
Spondylarthropathies • Ankylosing spondylitis : mainly affects axial skeleton
0.2% in the population – 40% joint and 30% foot involvement
• Psoriatic arthritis : skin involvement 0.2% in the population -70% joint and 60% foot involvement
• Reiter’s syndrome :urethritis, conjontivitis and arthritis
<0.1% in the population - 70% joint and foot involvement
INFLAMMATORY JOINT DISEASES have many characteristics in common
• They lead to inflammation in – Synovium-lined joints – Bursae and tendon sheaths – Tendinous attachment to bones – Soft tissues – Bones.
• However the distribution and extent of abnormalities at specific target vary among the disorder
FOUR FEATURES TO BE SEEK FOR
ENTHESITIS
ARTHRITIS
TENOSYNOVITIS
PERIOSTITIS Modalities X Rays MRI Ultra Sonography
ENTHESITIS
1)ARTHRITIS
TENOSYNOVITIS
PERIOSTITIS
1) Inflammatory Arthritis Synovitis
Synovium is the first inflammatory location in the joint
Bone edema Erosions
Joint space narrowing
US and synovitis
Normal=0
2
1
3
MTP
3
2
1
Doppler activity differentiates active from inactive synovium 0
T1 TIRM T2 fat sat
T1 gado fat sat
IRM et Synovite Epaissisement synovial
Hypersignal T2 et réhaussement après injection de gadolinium
MRI and Synovitis Dynamic MRI directly reflects the synovial inflammation
Dec
Feb April
The straight line of early enhancement rate reflects the increase of the vx number and of their permeability
Allows to follow the evolution of inflammation
1)Inflammatory arthritis • Synovitis
• Bone edema
• Erosions • Space joint narrowing
Lesion of high signal intensity on T2 images has ill defined margins Reversible bone lesion before the irreversible erosion Only seen with MRI
1) Inflammatory arthritis
• Synovitis
• Bone edema
• Erosions
US-Erosions
Sagittal Axial
MTP
US allows to see the erosions 2 years before XRay but doesn’t allow an exhaustive approach
Sharply marginated bone lesion with juxta articular localisation Visible in two planes with a cortical break seen in at least one plane.
MRI - Erosions Early RA – 6 month prevalence
X Ray : 8 to 40 % MRI : 45 to 72 %
ENTHESITIS
ARTHRITIS
TENOSYNOVITIS
PERIOSTITIS Localisation in • Rheumatoid arthritis • Spondylarthropathy
(Psoriatic arthritis)
Christian Buchbender Rheumatol Int 2013
Rheumatoid Arthritis Forefoot 90% of the patients will have a foot involvment during the disease Commonly an initial manifestation of RA Lesions predominate :
on the medial aspect of metatarsal head except for that in the fifth (lateral)
on the proximal and plantar aspect of the MTP joints
Bilateral and symetric lesions
Rheumatoid arthritis Forefoot
The lateral aspect of the fifth MTP is a very early and important finding of the disease
Bone edema Demineralisation
Erosion
Rheumatoid arthritis Forefoot
• With progression the MTP are affected in a relatively symetric fashion in both feet.
– Osteopenia – Erosion at the lateral aspect of joints
– Joint narrowing
Rheumatoid arthritis forefoot : later evolution
• Joints narrowing • Deformations : hallux valgus, spraid of MTP joints
with fibular deviation of the toes (except the fifth) Due to destruction of tendons and ligaments
©van der Heijde
Erosions
Narrowing
Score 7
Simple Erosion Narrowing Score (SENS)
Rheumatoid arthritis midfoot • Diffuse joint space loss, focal sclerosis and osteophytosis. • Erosions are infrequent and small
Rheumatoid arthritis midfoot
Osseous fusion can occasionally be seen In later evolution
PSORIATIC ARTHRITIS forefoot (up to 60 %)
• Bilateral, asymetric changes • predominating at MTP and IP (50%) • Extensive destruction of the IP great toe is characteristic
2/3 with skin psoriasis prior to joint lesions
PSORIATIC ARTHRITIS forefoot
Joint widening (pencil and cup)
Joint ankylosis
ENTHESITIS
1) ARTHRITIS
TENOSYNOVITIS
2) PERIOSTITIS and bone shaft edema
In addition to arthritis, spondylarthopathies show adjacent osseous abnormalities
2) PERIOSTITIS in Psoriatic arthritis • In phalangeal tufts and diaphysis
2) PERIOSTITIS in Psoriatic arthritis • Bone construction in phalangeal tufts and diaphysis
Psoriatic arthritis forefoot : later evolution
• Deformations with asymetric lesion associating joint fusions and widening
FOUR FEATURES TO BE SEEK FOR
ENTHESITIS
1) ARTHRITIS
3) TENOSYNOVITIS
2) PERIOSTITIS
3) Tenosynovitis
rupture of an inflammed tendon (posterior tibialis) can lead to
flat feet with talonavicular malalignment
4) ENTHESITIS
1) ARTHRITIS
3) TENOSYNOVITIS
2) PERIOSTITIS
RA 38%
Spondylarthropathies 45% (Genc 2005)
Location on the heels ++
Can appear at any point of osseous attachment of a tendon, ligament…
4) Enthesitis • 1rst phase : Inflammation
thickening of the tendon,
Plantar apeunevrosis Normal Enthesopathy < 4,4 mm
< 6,1 mm
Achilles tendon
Normal Enthesopathy
Doppler or MR T2 hypersignal
4) Enthesitis • 2nd phase : Destruction =Erosions
4) Enthesitis • 3rd phase : Bony construction = enthesophyte formation
ENTHESITIS
ARTHRITIS
TENOSYNOVITIS
PERIOSTITIS
RA
Bilateral symetric Destruction MTP
Spondylarthropathies
Bilateral Asymetric Destruction and construction IP
Take home message
ENTHESITIS
ARTHRITIS
TENOSYNOVITIS
PERIOSTITIS RA
MTP 90% Midfoot
Sporiatic A
A spondyl
Reiter syndrome
Forefoot Heel
15%
70%
30%
50% MTP –IP-tufts 60%
Take home message