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A Patient’s Guide to Treatment

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The BOTOX® Cosmetic “WOW” Commercial

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BOTOX® Cosmetic Overview

History of BOTOX® Cosmetic

How lines and wrinkles can form

How BOTOX® Cosmetic works

What to expect from a BOTOX® Cosmetic procedure

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BOTOX® Cosmetic Overview [cont’d]

Dramatic results with no downtime

Dramatic results within a week

Dramatic results that people notice

Dramatic results that look natural

BOTOX® Cosmetic safety

Summary

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BOTOX® (Botulinum Toxin Type A)—10 Years of Success BOTOX® is the only one of its type with over 10 years

of success in treating patients with a variety of conditions

Approved in 70 countries for a broad range of conditions

Currently being investigated in the US for the treatment of many medical conditions

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BOTOX® Cosmetic—NOW FDA APPROVED!

With dosing specific to treat frown lines, BOTOX® is now available as BOTOX® Cosmetic

BOTOX® Cosmetic is a highly effective procedure that can dramatically reduce wrinkles between your brows

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How Lines and Wrinkles Can Form

Movement of brow muscles causes the skin to crease

corrugator muscles corrugator muscles

procerus muscle

As skin becomes less elastic over time, repeated frowning creates visible lines and wrinkles

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Ricki

“My daughter said that I was looking older and that I looked unhappy—even when I was smiling. I realized that I was looking older because of the frown lines that were developing between my brows.”

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How BOTOX® Cosmetic Works BOTOX® Cosmetic is a natural and purified protein that

relaxes the muscles by blocking nerve impulses

With a few tiny injections, BOTOX® Cosmetic blocks the release of acetylcholine, the chemical thatcauses muscles to contract.

Once the muscles are at rest, the skin becomes smoother, creating a more natural and relaxed appearance

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What to Expect From a BOTOX® Cosmetic Procedure This simple 10-minute procedure consists of a few

tiny injections No anesthesia is required, although you may be advised

to numb the area with a cold pack or anesthetic cream prior to injecting

Discomfort is minimal and brief—most patients compared the sensation to a bug bite

There may be slight temporary bruising at the injection site, which can easily be covered up with makeup

Advance to Video Advance to Next Slide

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Injection Video

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Dramatic Results… With No Downtime

before after

Unretouched clinical photos taken at maximum frown before BOTOX® Cosmetic and 30 days after BOTOX® Cosmetic treatment.

After the procedure, you can resume normal activity immediately

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You’ll see a marked improvement within days that may continue to improve for as long as a week

In clinical studies, the majority of people (82.5%) reported an improvement in the lines between their brows after a week (n=405)

The effects of BOTOX® Cosmetic last up to 4 months

before after

Dramatic Results… Within a Week

Unretouched clinical photos taken at maximum frown before BOTOX® Cosmetic and 30 days after BOTOX® Cosmetic treatment.

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Donna

“I would definitely do it again. I make sure to schedule treatments every 3 to 4 months. I’m pretty diligent about it because I feel like it makes a difference.”

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Dramatic Results… That People Notice

After 30 days, nearly 90% of BOTOX® Cosmetic patients surveyed rated the improvement in their brow lines as moderate to better

For many patients, BOTOX® Cosmetic virtually “erases” these lines

Unretouched clinical photos taken at maximum frown before BOTOX® Cosmetic and 30 days after BOTOX® Cosmetic treatment.

before after

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Ricki

“The results have been terrific. [BOTOX® Cosmetic] has virtually removed the frown lines between my brows.”

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Dramatic Results… That Look Natural

With BOTOX® Cosmetic, you will not look “like you’ve had work done.” You can still frown, smile, or look surprised without the wrinkles and creases

Donna

“I get compliments on my appearance, but nobody can pinpoint exactly what I’ve done. I feel good about not doing something that’s very obvious, because I like appearing natural. That’s important to me.”

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BOTOX® Cosmetic Safety

Contraindicated in the presence of infection at the proposed injection site(s) and in individuals with known hypersensitivity to any ingredient in the formulation

Safe and effective. The most common side effects are headache, respiratory infection, flu syndrome, temporary eyelid droop, and nausea

Administered at very low doses, and the effects are usually confined to the injected area; it does not travel throughout the body

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BOTOX® Cosmetic Safety

Less frequently occurring (<3%) adverse reactions included pain

in the face, redness at the injection site, and muscle weakness

These events are thought to be associated with the injection and occurred within the first week

Full prescribing information has been provided to your doctor

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BOTOX® Cosmetic—Summary

BOTOX® Cosmetic is a simple, 10-minute procedure that can dramatically reduce your frown lines

No recuperation time is required You’ll see a marked improvement within days, and effects last up

to 4 months Treatment is safe and effective. The most common side effects

are headache, respiratory infection, flu syndrome, temporary eyelid droop, and nausea

Questions to ask your doctor: Am I a good candidate for BOTOX® Cosmetic treatment? What is your experience in using BOTOX® Cosmetic for

frown lines? When can I expect to see results and how long will they last?