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80 slides about Ohio's bioscience Industry
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BioOhio Update
Name or Date
An Ohio Thomas Edison Center
© 2009 BioOhio
hallo
bonjour
shalom
konnichiwa
Nihao
Anyohaseo
päivää
Fáilte
Hola
© 2009 BioOhio
Ohio More than you know…
• 7th largest state with 11.4 million people
• 4th in the nation for biotech Industry strength
• Within 1 day drive of 61% of USA, 50% Canada
• Highly educated workforce
> 130 colleges and universities
© 2009 BioOhio
The Original Biotechnologies
© 2009 BioOhio
What is Bioscience?
…a broad sector, including:
•Pharmaceuticals•Genomics •Diagnostics •Medical devices & equipment•Bioinformatics•Biomedical imaging•Biomaterials•Clinical Research Organizations•Environmental•Regenerative medicine•Research and development & Testing Labs•Agricultural bioproducts•Healthcare Informatics•Nutraceutical/Food
© 2009 BioOhio
AgriculturalFeedstock & Chemicals
Agricultural processing
Basic organic chemicals
Ethyl alcohol mfg.
Organic fiber mfg.
Fertilizers
Pesticides and other agricultural chemicals
Medicinal & botanicals
Pharma-ceutical preparations
Diagnostic substances
Biological products
Drugs & Pharmaceuticals
Medical Devices & Equipment
Laboratory apparatus & furniture
Surgical, medical, dental, ophthalmic & analytical instruments & equipment
Irradiation apparatus & electromedical equipment
Hospitals
Specialty hospitals
University medical
research hospitals
Clinical research institutions
Research, Testing, &Medical Laboratories
Biological research
Commercial medical
research
Testing laboratories
Medical laboratories & diagnostic imaging centers
Product-Oriented Service -Oriented
Bioscience Subsectors
© 2009 BioOhio
Why Listen to me?
• We want to give you > business, help create regional jobs, give you all > visibility, > bio linkages with rest of the state, more wins– but we need your help!!!
• Licensed attorney in Ohio 1987• 18 years international and TBED experience• Lived in 3 countries, traveled to >50
– VC in Caribbean, Medical/Pharma/Opto Asia
• Started offices, JV’s in Korea & China, closed one in PRC
• Since 2001 been with BioOhio– Helped raised more than $1 billion
© 2009 BioOhio
Our History
• 1987 Edison BioTechnology Center (EBTC)
• 2001 Moved HQS to Columbus
• 2002 Omeris
• 2007 BioOhio
© 2009 BioOhio
Our History
• Founded in 1987 as the Edison BioTechnology Center, BioOhio (formerly Omeris) is a non-profit organization designed to build and accelerate bioscience industry, research, and education in Ohio
• Headquartered in Columbus, with affiliates around the state
© 2009 BioOhio
Be Proud…Be Strategic
“Ohio is one of the best places in the world to optimize the growth of your bioscience company because we can imbed you in an asset base, 1141 companies and growing; We are a partner that allows you to maximize any or all phases of your business strategy”
© 2009 BioOhio
*Total Ohio bioscience establishments are 1141 (March 1, 2009)
© 2009 BioOhio
© 2009 BioOhio
Large Ohio Bioscience Companies
• Procter & Gamble Pharmaceuticals www.pgpharma.com
• Ethicon Endo-Surgery (J&J)www.ethiconendo.com
• Cardinal Health www.Cardinal.com
• Battelle Memorial Institute www.battelle.org
• STERIS www.steris.com
• Philips Medical Systems www.medical.philips.com
• Abbott Nutrition (Ross Laboratories) http://abbottnutrition.com/
• Chemical Abstracts www.cas.org
• Mettler-Toledowww.mt.com
• Invacarewww.invacare.com
…and lots of emerging and mid sized companies
© 2009 BioOhio
3 cities in the top 40 Biotech locations in USA
#4 in biotechnology industry strength 2008State City Rank
OH Cleveland-Akron 20
Columbus 22
Cincinnati 28
All three cities rank higher than the 100 city average in Research grant awards in Bio-
Sciences
$630 Million in NIH Awards in 2008!
© 2009 BioOhio
© 2009 BioOhio
© 2009 BioOhio
© 2009 BioOhio
© 2009 BioOhio
© 2009 BioOhio
© 2009 BioOhio
Direct Commercial Bioscience Economic Impact Summary
© 2009 BioOhio
Central Ohio Regional Impact
© 2009 BioOhio
Northeast Ohio Regional Impact
© 2009 BioOhio
Southwest Ohio Regional Impact
© 2009 BioOhio
West Central Ohio Regional Impact
© 2009 BioOhio
Southeast Ohio Regional Impact
© 2009 BioOhio
Northwest Ohio Regional Impact
© 2009 BioOhio
© 2009 BioOhio
© 2009 BioOhio
Total Bioscience Funding 2004-2007
© 2009 BioOhio
© 2009 BioOhio
Top Employers
© 2009 BioOhio
Top Employers
© 2009 BioOhio
Top Employers
© 2009 BioOhio
NAICS
© 2009 BioOhio
NAICS
© 2009 BioOhio
Ohio is ranked 8th nationally in total patents issued and has more than every country in the world except for Japan, Germany, and the UK
© 2009 BioOhio
Fantastic Hospitals
• 2008 US News and World Report found 14 top hospitals in Ohio– Cleveland Clinic 4th best hospital in the nation and Top Heart
Center in the country for 14 straight years– Rainbow Babies Children’s Hospital (Cleveland) 2nd in neonatal care– 4 pediatric hospitals ranked in the Top 15– 6 of the top 50 Endocrinology Centers, most in the nation– 6 top 50 Orthopedic centers– 3 top 50 adult cancer centers,
• Child Magazine ranked Nationwide Children’s Hospital (Columbus) as the #1 facility for pediatric emergency care in 2007
• Thomson Reuters National Top 100, which measures hospital reliability, ranked 14 Ohio hospitals, tied for most in the nation in 2007– Most ranked facilities in the nation over the last four years
© 2009 BioOhio
© 2009 BioOhio
16% of all clinical trials in the US are conducted in Ohio
© 2009 BioOhio
Distribution of Active Clinical Trials
by Disease
As of November 4, 2008
© 2009 BioOhio
Now 63 Ohio Health Care Venture Funds…More than 100 have invested
into Ohio bioscience companies
1. Adena Ventures
2. Akron ArchAngels Network
3. Alpha Capital Partners
4. Arboretum Ventures
5. Athenian Ventures
6. Battelle Ventures
7. Blue Chip Venture Company
8. Blue Point Capital
9. Bridge Investment Fund
10.Case Technology Ventures
11.Charter Life Sciences
12.Chrysalis Ventures
13.CID Equity Partners
14.Cincinnati Children's Tomorrow Fund
15.CincyTech Ventures
16.Cleveland Clinic Innovations
17.Core Network
18.Draper Triangle Ventures
19.Early Stage Partners
20.Edgewater Capital
21.Entrepreneurs “E” Fund
22.Everett Partners
23.Fletecher Spaght
24.Fort Washington Capital
25. Foundation Medical Partners
26. Frantz Medical Ventures
27. Glengary Ventures
28. GLIDE Fund
29. iNetwork BioOpportunity
30. Innovation Fund of LCCC
31. Isabella Capital
32. JumpStart
33. Kadima Partners
34. Miami Valley Ventures
35. Morgenthaler Ventures
36. Mutual Capital
37. NCIC Capital
38. NCT Ventures
39. North Coast Angels
40. Oakwood Medical
41. Ohio Tech Angels I, II & III
42. Primus Capital
43. Queen City Angels
44. Radius Ventures
45. Redwood Holdings
46. Reservoir Ventures
47. River Cities Capital Funds
48. Riverside Capital
49. Rivervest Ventures
50. Scius (Spire Capital)
51. Soin International
52. RMS Investments
53. Rocket Ventures
54. Southern Ohio Creates Capital
55. Summit Health Ventures
56. Sycamore Partners
57. Talisman Capital
58. TechColumbus TechGenesis
59. TechColumbus RCF
60. Teton Capital
61. Triathlon Medical Ventures
© 2009 BioOhio
Business Climate Improved
• Jobs and Progress Plan
• 10-year, $5 billion investment in Ohio’s highways
• Tax Reform 21 percent income tax reduction Eliminating property taxes on investments in
machinery and equipment No business tax on products exported out of Ohio First $1 million of gross receipts tax-free
• Lawsuit Reform
• Third Frontier $1.6 billion
• Ohio’s Bipartisan Jobs Stimulus Plan $1.57 billion ($100 million, $50 million, $250 million)
© 2009 BioOhio
Tax Reform
© 2009 BioOhio
• Cardiovascular
• BioPharma
• BioPolymers
• Biomedical Imaging
• AgBio
© 2009 BioOhio
Ohio Ranks 4th in the Nation in Biotech Strength in the latest
report
© 2009 BioOhio
Ohio – National Top 10
AdvaMed
© 2009 BioOhio
Ohio claims its third Governor's Cup in a row, 06-08, for the most new or expanded capital projects, thanks
to the Strickland Administration's focus on taking steps necessary to be competitive, even in a
challenging economic environment.
© 2009 BioOhio
BioOhio’s Balanced Strategyindustry growth, resource optimization, community
building
Company & Capital
Formation
Company Attraction & Expansion
Member / Trade
Association Industry Function
Bioscience Workforce & Education
© 2009 BioOhio
BioOhio Strategic Elements
1. Industry Function:• Membership• Fact Sourcing• Networking • Branding• Advocacy
2. Asset-based Company Attraction & Expansion
3. Workforce & Education
4. Company & Capital Formation
© 2009 BioOhio
BioOhio Statewide Board• John A Bantle, II, PhD, Vice President - Research, Wright State University• Timothy G. Biro, CEO - MORK Process; Partner, Ohio Innovation Fund & Reservoir Ventures• Greg Blackmore, Sr. Vice President and Group President, Life Sciences - STERIS• Rathindra Bose, PhD, Vice President for Research & Creative Activity - Ohio University• Mark A. Collar, Chairman - Third Frontier Advisory Board• Mark J. Coticchia, VP Research and Technology Management - Case Western Reserve• Sandra J. Degen, PhD, Vice President for Research - University of Cincinnati• Anthony J. Dennis, PhD, President & CEO - BioOhio• Paul DiCorletto, Chairman - Lerner Research Institute (Cleveland Clinic)• Kevin Driscoll, PhD, Exec Director, Global Health Care Connect & Develop-Procter & Gamble• John Fisher, Executive Vice President - Ohio Farm Bureau Federation• Mike Hooven, President & CEO - Enable Medical Technologies• Peter G. Kleinhenz, General Partner - CID Equity Partners• Barbara Kunz, President - Health & Life Science Global Division Battelle• Thomas J. Murphy, President & COO - Ben Venue Laboratories• John M. Rice, PhD, Managing Partner - Triathlon Medical Ventures• David R. Scholl, PhD, President & CEO - Diagnostic Hybrids• James A. Scozzie, PhD, Senior Vice President - BioEnterprise• Arnold W. Strauss, MD, Director - Cincinnati Children’s Research Foundation• Caroline Whitacre, PhD, Senior Vice President for Research - The Ohio State University
© 2009 BioOhio
By-The Numbers, then & nowYear 1991 2001 2008/2009
Number of bio entities in Ohio
170 352 1141 (3.2X) 2009
University R&D expenditures
$285 million
$481 million
$1.1 billion (2.3X)
New Company starts ≈12 12 65 per year (5.4X) 2004-08
Private capital raised for new starts
Unknown $14 million
$189 million (13.5X)
$473 million
IPO/Acquisitions 2008
Bioscience Capital sources (in State)
4 8 63 (7.9) 2009
BioOhio (EBTC) membership
52 86 280 (3.3X) 2009
© 2009 BioOhio
Your Member OrganizationYour Trade Association / Your Bioscience
Chamber• Marketing Ohio’s Collaboration & Partnership
Opportunities• New Website launched July 2008• Trade Missions (Japan, Taiwan, China, USA, Germany, Israel)• Various Publications• LinkedIn• News Ticker, Webinars, Newsletters and much more
• Networking• BioOhio• BIO Mid America Venture Forum• PhRMA events• AdvaMed events• AgBio events• National BIO events• Regional Affiliate events
• Advocacy (National & Ohio)• SBIR Legislation, Patent Reform• Drug Pricing and importation• Stem cell research / Human Cloning• Bioscience workforce training• Third Frontier funding strategies
© 2009 BioOhio
Ohio Bioscience Growth Report & Magazines
Company & Capital Formation
www.biostart.org
www.bioenterprise.com
www.techcolumbus.org
www.ohiou.edu/biotech
www.rgp.org
www.ci.akron.oh.us
© 2009 BioOhio
What do our Incubators / Accelerators do?
• Collaborations with universities, established companies, and start-up companies; national and international collaborations
• Business development to help established and startup companies make contacts and pursue success
• Management support for startup companies, “portable executives,” “entrepreneurs in residence” until the company operates on its own
• Professional Services referrals to attorneys, accountants, regulatory expertise and others who understand the technology, the startup company environment, international business
• Access to Capital helping startups find investors, and helping investors find companies to invest in
© 2009 BioOhio
Attraction & Expansion• Regional Partners – more than 50
– Monthly phone calls and e-mail updates
• Program Operations– Finished an attraction brochure– Workforce/Talent recruitment remains #1 issue
• Global Cardiovascular Innovation Center (GCIC)– Relationship and Partnership growing and functioning well– Supply Chain directory
• Expansions– Site Selection Magazine “Governor’s Cup” 3 years in a row– Area Development Magazine Silver Shovel Award– 119 Bioscience expansions or new facilities 05-07
• OEDA/TeamOhio relationship • Israel, Taiwan, Finland, Ireland, Hungary, China, Germany
© 2009 BioOhio
Workforce & Education
• Community College Partnerships. Coordinating the efforts of Ohio’s 2 year college’s to provide comprehensive programs in support of bioscience industry expansion, e.g. introduction of manufacturing content
• Proposals Submitted. Submitted NSF & DOL proposals seeking additional funding in support of biomanufacturing industry expansion
• Blue Ribbon Panel. Invited participant on national 50 member NSF panel to set standards for education bio-technicians. Report published August 2008; www.aacc.nche.edu/ateprogram
• Career Fairs. Held 3rd annual Ohio Bioscience Career Fair in November 2008, and rolling out regional events during 2009
• Job awareness & Community Outreach. Entered into partnership with the Society for Manufacturing Engineers Educational Foundation to address improving bio-manufacturing image
© 2009 BioOhio
Workforce & EducationIn Progress & Planned
• Proposals. – Will submit BioOhio led NSF-ATE proposal, and partner in Lakeland CC led NSF-ATE proposal focused on
outreach and awareness in northeast Ohio. – Engage consulting group to secure additional federal funds– Continue to push proposal to develop a comprehensive workforce strategy for Bio in Ohio
• Job Awareness & Community Outreach. Work with SME Educational Foundation and others (Indianapolis WIB, MichBio) to implement a comprehensive plan for Ohio/Indiana/Michigan then expand to midwest, and possibly nationally
• Career Fairs. Hold annual Ohio Bioscience Career Fair, and support/initiate others. Lakeland CC will hold NE Ohio bioscience career fair November 5, sponsored by BioOhio.
• Community College Partnerships. Continue to enhance and roll out bioscience workforce support program in partnership with OBOR
• Strategy. Continue working with State (OBOR, ODOD, ODE) to develop comprehensive biosciences “Industry Sector” workforce strategy
© 2009 BioOhio
Bioscience Jobs
Agricultural Feedstock & ChemicalsDrugs & PharmaceuticalsMedical Devices & EquipmentResearch, Testing, & Medical Laboratories
33%
25%
8%
33%
Distribution of Bioscience Employment by Subsector
Source: Battelle calculations based on Bureau of Labor Statistics, QCEW program data from the Minnesota Implan Group. Data include Puerto Rico.
• Research & Testing 20,565 companies
• Medical Devices 15,190 companies
• Drugs & Pharmaceuticals 2,589 companies
• Ag Feedstock & Chemicals 2,111 companies
© 2009 BioOhio
Bioscience Wage Trends
• The biosciences offer high-paying, quality jobs across a range of occupations
• Bioscience workers earn $26,772 more than the average U.S. private sector wage, with all four subsectors above the national average
• Since 2001, real (inflation-adjusted) earnings are up 6.4% for bioscience workers, compared to just a 1.4% increase for private sector
Drugs & Pharmaceuticals 79,303$ Finance & Insurance 69,889$ Total Biosciences 65,775$ Research, Testing, & Medical Laboratories 65,414$ Agricultural Feedstock & Chemicals 63,383$ Professional, Scientific, & Technical Services 62,411$ Information 60,530$ Medical Devices & Equipment 56,449$ Manufacturing 47,705$ Construction 40,297$ U.S. Total Private Sector 39,003$ Transportation & Warehousing 38,758$ Real Estate & Rental & Leasing 37,167$ Health Care & Social Assistance 36,606$ Retail Trade 24,337$ Source: Battelle calculations based on Bureau of Labor Statistics, QCEW
program data from the Minnesota Implan Group.
Data include Puerto Rico.
U.S. Average Annual Wages per Employee, 2004
© 2009 BioOhio
AgBio• Ohio is home to the world’s largest soup factory (Campbell’s)
• Ohio is home to the world’s largest ketchup factory (Heinz)
• Ohio is home to the world’s largest pizza plant (Pillsbury)
• Ohio is home to the world’s largest yogurt plant (Dannon)
• Ohio is home to the country’s largest fructose plant (Cargill)
• More Swiss cheese is produced in Ohio than in Wisconsin
• Center for Innovative Food Technology • 935 food processing facilities 935 • Ohio Agricultural Research & Development Center
© 2009 BioOhio
Ohio’s Agricultural
Output
$79.6 Billion
Ohio’s Chemicals,
Plastics, Rubber
Materials Output $49
Billion
Ohio BioProducts Innovation Center
© 2009 BioOhio
Ohio BioProducts Innovation Center
Bio-Derived Feedstocks
Monomers and Resins
Bio-Polymers andBio-Product System
Solutions
• Soybean Oils
• Next Gen Soybean OilsSoy Proteins
• Corn based carbohydrates/sugars
• Polyacids
• Polyols
• Monomers
• Oligomers and Resins
• Specialty Compounds
• Coatings, Binders, Toners• Adhesives and Sealants• Composites • Solvents, Plasticizers• Lubricants • Surfactants, Cleaners• Fertilizer Systems
© 2009 BioOhio
Impact of the Human Genome Project
© 2009 BioOhio
Bio-Informatics
• Genechips (shown)
• Genetic Databases
• Tissue Databases
• www.osc.edu
• www.daytaohio.com
© 2009 BioOhio
Nanotechnology / BioMEMS
• Carbon Nanotube
© 2009 BioOhio
Human/Computer
• Implantable Biochips
• Glucose monitoring
• Identification
Retinal implant (shown)
© 2009 BioOhio
3-D Bioreactor - Mass Production of Embryonic
Stem • Problem: • Limited ES cell lines and
supplies for regenerative medicine and other biomedical applications
• Solution: in vitro expansion
• 2-D Cell culture: labor intensive (frequent sub culturing) and expensive (growth factors; surface coating)
• Need: Better and cheaper 3-D culturing method in bioreactor with controlled environment
© 2009 BioOhio
Genetically Modified Organisms
• Opportunity
– Improved pest and disease resistance
– Better economics
– Less use of chemicals Challenge
• Challenges– Fear of the unknown
– Misunderstanding
– Scientists not attending to social issues
© 2009 BioOhio
Third Frontier Network (OSCnet)The most advanced IT research network in
USA
© 2009 BioOhio
Technology Innovation Cycle
ADVANCED RESEARCH(8-15 years)
PRODUCT CYCLE(1-3 years)
BREAKTHROUGH(5-8 years)
v:
Discovery Development Application
t
er
CrossIndustrySources
FederalResearch
CollaborativeResearch
ResearchUniversities
GlobalSourcing
CorporateLabs
InternationalSources
Integration
Sense &Locate
GapAssessment
Assess
ProductPlatform
Produc
CustomDrives
UnmetNeeds
Develop
Product Development Involves the “Application” of Technology
© 2009 BioOhio
Medical DeviceCommercialization Pathway
Concept Development and Initial Research
Company Formation / Project Team
Secure IP Portfolio
Product Engineering and Prototype Development
Pre-Clinical and Clinical Studies
Manufacturing Development/ expansion for clinical trials
Clinical Trials/Outcomes
FDA Approval and Market Launch
Expansion/ Investment in Working Capital
$A
B
© 2009 BioOhio
Typical Product Development Process
Source: PTRM
© 2009 BioOhio
Critical Success Factors
• Differentiated, superior product/technology • Sharp, early product definition • Quality of pre-development activities• Strong market orientation• Reduced cost / drives revenue• Customers willing to pay $• Effective organizational structure• Engaged Partners• Quality of execution
– Technical, Business
© 2009 BioOhio
77
Sources of Capital
• Bootstrapping– Who will benefit from
your success? • FF&F
– Find enthusiastic supporters in your personal network
– Put your own money in (investors want to see this commitment)
• Angels– Looking to make money,
but also hope to get involved and add value
• Grants – Lots of free and cheap
money out there
• Venture / Private Equity– Care about making a
return on investment– Often do not have time or
ambition to get to involved
• SBA / Banks – Always take debt before
equity, but often difficult as they require security (receivables, assets…)
© 2009 BioOhio
Pitching
• 10 slides, 20 minutes, 30 Point font
• Differentiate for different audiences
• Investor
• Sales Prospect
• Partner Prospect
• B to B
• Problem• Solution• Business Model• Your Magic• Mktg/Sales• Competition• Mgmt Team• Financial Projections• Current Status – The
Ask
© 2009 BioOhio
Medical Product Development each step has defined Work Processes
Product Requirements(User Functional, Environmental,Physical, Manufacturing, Safety)
Design ValidationPlan
ProductSpecification
DesignVerification Plan
Product ArchitecturalDesign
(Spec allocation,Theory of operation)
SoftwareRequirementsSpecification
SoftwareVerificat./Validat.
Plan
SoftwareSubsystem(s)
Design
Design Transfer
Software SourceCode
SoftwareVerificat./Validat.
Procedures
DesignVerification
Results
SoftwareVerificat./Validat.
Results
DesignVerificationProcedures
Software Develop Plan(QA, Life Cycle, CodingStds., Tools, Environ.)
Initial HazardAnalysis
(Top Down)
Critical Element Flow Diagram (Complex Products with Software)
HardwareSubsystem(s)
Design(Electr. / Mech.)
DesignValidation
Procedures
DesignValidation Results
Hazard Analysis(Cumulative)
Operator Interface
Detailed DesignHazard
Assessment(Bottom Up)
MasterVerificat./Validat.
Plan
Risk/Safety Verification/ValidationDesign/Development
Product Definition(User Needs, Human Factors)
An Ohio Thomas Edison Center
Let me know how we can help you!
John F. Lewis Jr.Vice President