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+BACTERIAL
INFECTION AND IMMUNE SYSTEM
RESPONSE
DIANA AGUDELO JARAMILLO
MEDICINE STUDENT
+FOLDING
+FOLDING
+
INTRODUCTION
+ TYPHOID FEVER: A RACE AGAINST TIME
Constantly the body is trying to protect himself of the pathogenic microorganism that can affect significantly.
+
TYPHOID FEVER: A RACE AGAINST
TIME
Neutrophils and monocytes enclose the bacteria to form abscess. But some of them can escape and continue infecting.
+TYPHOID FEVER: A RACE
AGAINST TIME
Although the immune cells kill a lot of bacteria Salmonella, there are others that evade that abscess and escape, guaranteed his survival and his replicates in all the body.
+ TYPHOID FEVER: A RACE AGAINST TIME
+STUDENT OBSERVATION
It is important to further scientific development in these areas to achieve eradicate Salmonella, who generate resistance even faster than the creation of new antibiotics.
+Steps leading to necrotizing fasciitis revealed, opening
way to possible new treatments for bacterial
infections
Group A Streptococcus (GAS) or S. Pyogenes, is a silent bacteria that colonize the body without produce any symptoms and can be mortal in a lot of cases such as toxic shock syndrome and streptococcal necrotizing fasciitis (flesh-eating disease)
+ STEPS LEADING TO NECROTIZING FASCIITIS REVEALED, OPENING WAY TO
POSSIBLE NEW TREATMENTS FOR BACTERIAL INFECTIONS
Once the bacteria enter to the cell, liberates two streptolysins that inhibit the synthesis of proteins in the cytoplasm.
BACTERIA
CELL
STREPTOLYSINS
mRNA
+ STEPS LEADING TO NECROTIZING FASCIITIS REVEALED, OPENING WAY TO
POSSIBLE NEW TREATMENTS FOR BACTERIAL INFECTIONS
The human cells increases the production of the amino acid asparagine as a method of defence that alters gene expression of GAS and increases his virulence.
ASPARAGINE
+STEPS LEADING TO
NECROTIZING FASCIITIS REVEALED, OPENING
WAY TO POSSIBLE NEW TREATMENTS FOR
BACTERIAL INFECTIONS
Asparaginase degrades asparagina. Thats why they use it to reduce the growth of GAS in human blood and mouse models of human infection.
+
Asparaginase has never before used to treat GAS infections. Knowing the metabolic changes occurring between the pathogen and its host´s infection can lead to develop a few of effective treatment against infection diseases.
STUDENT OBSERVATION
+MEDICAL UTILITY
The doctors, food distributors, among many other companies, are straining to maintain the necessary hygiene for disease control in clients, workers or patients.
+MEDICAL UTILITY
As health workers, we should alert people about this kind of diseases that are so contagious and how they can prevent them.
+
Some examples can be taking care of his own body, washing hands with a very good disinfectant and not consuming food which has expired date of caducity, also prevent the transmission, trying to cover the mouth when sneezing, or not share stuff that can have contact with fluids or blood of our body.
MEDICAL UTILITY
+
With the development of the studies about the virulence of those bacterias and how can they affect us, we can investigate more about a lot treatments that can helps to control the early effects that cause a lot of damage even if we don't feel any symptom, reducing the annual number of deaths.
MEDICAL UTILITY
+
REFERENCES
1. 1. MARTÍNEZ SANCHEZ, Lina María; et alt. Biología molecular. 7th
ed. Medellín, Col: Universidad Pontificia Bolivariana; 2012.
2. BROOKS, GF; CARROLL, KAREN; BUTEL, JANET; MORSE, STEPHEN; MIETZNER, TIMOTHY. Jawetz, Melnick y Adelberg, Microbiología Médica. (2010). 25 Edición. Mc Graw Hill. Mexico, DF. PP: 145,147,159,160.
3. niversität Basel (2014, January 16). Typhoid fever: A race against time. ScienceDaily. Retrieved January 25, 2014, from http://www.sciencedaily.com /releases/2014/01/140116085053.htm.
4. The Hebrew University of Jerusalem. (2014, January 20). "Steps leading to necrotizing fasciitis revealed, opening way to possible new treatments for bacterial infections." Medical News Today. Retrieved fromhttp://www.medicalnewstoday.com/releases/271385
+
“As we look higher, we get higher”
