Case capsule

Dr. Zeeshan

• 40 / M

• No comorbidities

• Epigastric pain associated with epigastric fullness• Dysphagia to solids for 1 month• Cough after food intake• Dyspnoea on exertion

• ? Relevant H/O

NO SIGNIFICANT FINDINGS ON EXAMINATION

DIFFERENTIALS

• Esophageal pathology- Intraluminal: Benign : GERD, Esophageal webs, rings , Zencker’s

diverticulum

Malignant : Ca esophagus

- Extrinsic compression

BLOOD INVESTIGATIONS WITHIN NORMAL LIMITS

HOW WOULD YOU LIKE TO PROCEED?

WHAT NEXT?

• UGI scopy

• Barium swallow

• ? Importance of order

WHAT NEXT?

CT report A well defined, thin walled, large, nonenhancing, fluid density

lesion, measuring 13 mm x 11 mm x 9.1 mm in the middle and posterior mediastinum, extending from T4 to T9 vertebrae and predominantly on the right.

The lesion is displacing the trachea anteriorly, the lower two third of the esophagus to the ipsilateral side, and causing splaying of the carina, main bronchi and right pulmonary artery

The lesion is seen compressing upon the esophageal lumen; fat planes between the lesion and the esophageal wall is indistinct. The lesion causes compression of the left atrium and the pulmonary veins are stretched over the anterior surface of the lesion, however the fat plane is preserved

Approach to a mediastinal mass

Mediastinum

Compartments

• Anterior

• Middle

• Posterior

Anterior compartment

• Between sternum and anterior aspect of pericardium

• Contents:- Thymus- Internal mammary A.- Lymph node- Connective tissue - Fat

Anomalies of Ant. Compartment

• Terrible T’s

- Thymoma- Teratoma- (Terrible) lymphoma- Thyroid tissue

Middle compartment

• Ant: Pericardium• Posteriorly : Ventral surface of thoracic spineContents:- Heart- Airway- Pericardium- Ascending thoracic aorta- SVC with azygos vein

Anomalies of middle compartment

• Lymphadenopathy : MC cause- Sarcoidosis- Lymphoma- Metastatic lung malignancy

Posterior mediastinum

• Artery– Thoracic part of descending Aorta

• Veins– Azygos vein– Hemiazygos, accessory hemiazygos veins

• Nerves– Vagus nerve– Splanchnic nerve

• Esophagus• Thoracic duct

Anomalies of Post. Mediastinum

• Mass arising from Esophagus

• Aneurysms of descending aorta

• Neurogenic tumors

Importance of H/O

• Age

• Anatomic location

• Associated symptoms

Why age?

• Adults :- Thymomas

- Lymphomas

- Germ cell tumors

- Only 1/3rd lesion are symptomatic

• Children:

- Post. Neurogenic tumors

- Lymphomas

- Germ cell tumors

- 2/3rd symptomatic

Anatomic location

• Chest X-ray- AP- Lateral

• CT thorax

WHICH PART OF MEDIASTINUM IS THE MASS ARISING FROM??

Posterior mediastinum

• Differentials for a cystic mass in posterior mediastinum:

- Bronchogenic cyst

- Esophageal duplication cyst

Bronchogenic cyst

• MC cystic lesion

• Abnormal budding of the lungs

• MC in men/ right paratracheal location

• Symptoms of cough, substernal pain, recurrent infections, dyspnoea

Esophageal duplication cysts

• Third most common benign esophageal mass• MC – Leiomyoma• 2nd MC – Polyp

• Three criteria to establish diagnosis:1.Esophageal attachment2.Presence of 2 layers of muscularis propria3.Epithelium characteristic of GI tract

HOW WOULD YOU LIKE TO PROCEED

• EUS

• Preoperative biopsy : debatable Not recommended

• Pt was posted for Thoracotomy proceed

• He underwent excision of posterior mediastinal tumor with resection of thoracic esophagus + stomach pullup.

Findings

• 15 x 25x12 cm sized mass arising from the posterior mediastinum ? site of origin with the oesophagus stretched over it laterally and the tumour was crossing the midline.

• The lower limit was about 4 cm from the oesophageal hiatus.

• The tumour contained jelly like material and was infiltrating the posterior pericardium.

• There were few enlarged nodes in relation to the tumour.

• The tumour was very vascular.

Biopsy

• Smooth muscle tumor probably benign

• Leiomyoma

• Maximum tumor size – 11.2cm

• Tumor was adherent to wall of esophagus

Leiomyoma of esophagus

Incidence

• Most common benign tumors of the esophagus

• 90% occur in the lower/middle third

• Arise from muscularis mucosa

• Male predominance

• Most lesion are intramural/submucosal

• Solitary

• Size : 2-8cm

• Slow growing tumors

• 50% patients asymptomatic

Symptoms

• Dysphagia – Most common symptom

• Retrosternal pain/discomfort

• Heart burn

• Weight loss

Diagnosis

• UGI scopy : Submucosal mass lesion

• Barium swallow : Smooth filling defect in the esophageal lumen without a mucosal abnormality

• CT Thorax: Well defined eccentric intramural mass with homogenous enhancement after administration of IV contrast

• EUS : Homogenous and hypoechoic lesion with clear margins with surrounding hyperechoic area

• Biopsy : To be avoided

- Cause scarring and hampers extramucosal excision of tumor

- Usually non diagnostic

Management

• Asymptomatic/ small leiomyomas

• Monitor periodically using UGI scopy, EUS and CT thorax

• Risk of malignant transformation < 1%

Indication for surgery

• Symptomatic leiomyomas

• Leiomyomas > 5cm

Modes of excision

• Thoracoscopic excision of lesion

• Open surgery

Open approach

• Middle third of esophagus – Right thoracotomy

• Lower third of esophagus - Left thoracotomy/ Left thoraco-abdominal / Transhiatal approach

Summary

• Leiomyomas are rare tumors of esophagus

• If <5cm patient usually kept on follow-up

• Large leiomyomas are excised with segmental esophageal resections

• Malignant potential <1%