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An Unusual Mitral Regurgitation
David Messika-Zeitoun MD, PhD and Claire Cimadevilla MDBichat Hospital, Paris, France
Medical History
• 49 years-old lady• Past medical history
• Hodgkin disease : radiotherapy + chemotherapy in 1993
• Cardiovascular risk factors: none• Symptoms:
• Palpitations• Shortness of breath (NYHA II)
Medical History
• First visit (outpatient clinic) in November 2008• 3/6 systolic murmur• ECG: Sinus rhythm, left bundle block branch • Transthoracic echocardiography
• Severe mitral regurgitation• Systolic pulmonary artery pressure: 50 mm hg
Transthoracic Echocardiography a few days after
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Etiology
Hering American Journal of Cardiology 2003
Calcifications of the aortic-mitral aponevrosis highly suggestive of post-radiation valvular heart disease
Quantification: Vena Contracta
3 mm 7 mm
Mild MR Severe MRGray zone
Quantification: PISA
Aliasing velocity (Va)
R
ERO = 0.17 cm²RVOL = 37 ml
TTE Conclusions
- Post-radiation moderate organic mitral regurgitation- Moderate left enlargement- Normal systolic pulmonary artery pressure
What to do next to explain discrepancies between outpatient and inpatient echocardiographies
• Nothing
• Transesophageal echocardiography
• Exercise echocardiography
• Other ?
What to do next to explain discrepancies between outpatient and inpatient echocardiographies
• Nothing
• Transesophageal echocardiography
• Exercise echocardiography
• Other ?
Transesophageal Echocardiography: beginning of the examination
Severe mitral regurgitation with complete lack of coaptation
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Transesophageal Echocardiography: Few minutes later
Almost disappearance of the mitral regurgitation
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3D Transesophageal Echocardiography
3D TEE nicely showing the conformational changes of the aortic annulus and absence of leaflet coaptation
Beginning of the examination Few minutes later
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Diagnosis
Severe MR ParoxysmalFunctional called “eclipsed MR”
Coronary Angiography
Normal coronary angiography
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Exercise Echocardiography
• Under beta-blocker therapy• 60 W, 82% maximal predicted heart rate• Stop because of fatigue• No change in left ventricular ejection
fraction• No change in the degree and mechanism of
mitral regurgitation• Systolic pulmonary artery pressure:
progressive raise from 30 to 60 mm Hg
At 5 years, our patient remains moderately symptomatic and never experienced any acute complication such as pulmonary edema
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