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causes, affects, treatment
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Presentation
“ALZHEIMER’S DISEASE”
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• Presented to:• Dr. N Khalid
Presented by:
Ayesha SadiqaReg # 1429-
313271B.S Biotech (3rd)
PRESTON UNIVERSITY
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Table of Contents• Definition• Causes• Affects• Age limit for this disease• Symptoms• Stages • Cure and Treatment
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Alzheimer’s• Alzheimer's is the most common form of
dementia.• It is a neurodegenerative disease that
occurs in the brain. • Alzheimer’s disease causes a deterioration
in the brain by destroying the nerve cells. • Once the nerve cells begin to deteriorate it
causes a reduction of responses to other nerve cells.
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• The condition spreads out causing 1. Chemical interruptions 2. Slow transmission of impulses3. Finally tissues in the brain begin to get worse.
• In Alzheimer’s disease, nerve cells in the brain die gradually which makes it increasingly difficult for your brain’s signals to be sent properly.
• There are 7 stages of Alzheimer's
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How you get the disease?
• It’s still unknown as how the Alzheimer’s disease process begins, it seems likely that damage to the brain starts a decade or more before problems become evident.
• People who have relatives with Alzheimer’s have a higher risk than the general population for developing the disease.
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• People who have a parent or sibling with Alzheimer's disease are 3.5 times as likely to develop it.
• This strong tendency of Alzheimer's disease to run in families is due, in part, to mutations in certain genes
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Alzheimer’s affect in body• Alzheimer’s affects the brain.
• Alzheimer's causes 1. Death of neurons 2. Shrinkage of brain. 3. Loss of functioning capabilities in almost all
parts of brain, not just the ones that affect memory.
4. Formation of clumps and tangles within the brain and all these at last OR
5. Eventually, leads to death.
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• In Alzheimer’s the cerebral cortex shrinks massively.
• (The cerebral cortex is the outer surface of the brain and it is responsible for all intellectual functioning.)
• The spaces in the folds of the brain (the sulci; singular sulcus) are grossly enlarged.
• You cannot catch or spread Alzheimer’s
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Chances of Alzheimer's• Alzheimer’s disease can occur at any age, even as
young as 40 years, but its occurrence is much more common as the years go by.
• Early Alzheimer's starts at 65 years of age or younger. Late Alzheimer's starts after age 65
• One in ten people over 65 years of age suffer from the disease, and over half the people over 85 have Alzheimer’s disease.
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• At first the symptoms are difficult to recognise.
• In the first 2 stages of Alzheimer's you cannot recognise that you have it.
• Often it is difficult to pinpoint when the Alzheimer’s disease actually began in a person
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Symptoms of Alzheimer's • Short term memory loss – forgetting recent events, names
and places • Difficulty performing familiar tasks • Disorientation especially away from your normal
surroundings• Increasing problems with planning and managing • Trouble with language • Rapid, unpredictable mood swings• Lack of motivation • Changes in sleep and confusion about the time of day• Reduced judgement e.g. being unaware of danger
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7 stages of Alzheimer’s• Stage 1: Normal• Stage 2: Normal aged forgetfulness• Stage 3: Mild cognitive impairment• Stage 4: Mild Alzheimer’s• Stage 5: Moderate Alzheimer’s disease• Stage 6: Moderately severe Alzheimer's disease• Stage 7: Severe Alzheimer's disease
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Cure and Treatment• Currently there is no cure for Alzheimer’s.
• However there are several drugs that may be prescribed to help people with Alzheimer’s. They are not a cure, but can help with some of the symptoms of the disease.
• Drugs such as:1. Donepezil (Aricept)2. Rivastigmine (Exelon)3. Galantamine (Reminyl)
• These are used to treat symptoms in Alzheimer's disease.
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• Antidepressants• Anti-anxiety medications• Antipsychotics are used to treat the
symptoms of • Depression, Anxiety, Agitation, and the
Hallucinations and Delusions that may occur in Alzheimer's disease patients
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Thank you….