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蘇迎士

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蘇迎士

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Nature 517, 455–459 (22 January 2015)

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Kim LewisNortheastern University

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. Kaeberlein et al. Science 2002;296:1127-1129

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1 g soil from Maine

+

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One cell/20 μl of mediumSMS media

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Seawater

Appl. Environ. Microbiol. April 2010 vol. 76 no. 8

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Soil

Appl. Environ. Microbiol. April 2010 vol. 76 no. 8

B

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1 transfer, 26%

2 transfer, 13%

3 transfer, 22%

4 transfer , 13%

>4 transfer, 17%

unsustinable, 9%

Domestication

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Front. Microbiol., 08 July 2014

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Eleftheria terrae

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Structure of teixobactin

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Non-ribosomal peptide synthetase

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Bacteriacidal activity against S. aureus

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Fig. 5. Bacterial cell surface charge is regulated during growth.

Miki Matsuo et al. Microbiology 2011;157:1786-1797

©2011 by Society for General Microbiology

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Late exponential activity against VISA

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Bactericidal activity against VISA

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Lysis

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Low dose(4×MIC) for 27 days

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Teixobactin作用機轉示意圖圖/駱宛琳

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Thigh model

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結論

新思考方式突破過去困境

微生物世界仍有許多未知

人體實驗結果仍待觀察


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