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Hypolipidemic DrugsHypolipidemic Drugs
Statins:Statins:Simvastatin, Atorvastatin, Simvastatin, Atorvastatin,
Bile Acid BindingBile Acid Binding Resins:Resins: Cholestyramine, Colestipol, Cholestyramine, Colestipol,
Nicotinic acidNicotinic acid NiacinNiacin Fibric Acid Derivatives Fibric Acid Derivatives GemfibrozilGemfibrozil and Fenofibrateand FenofibrateEzetimibeEzetimibe
Statins
HMG-CoA Reductase InhibitorsHMG-CoA Reductase Inhibitors
HMG-CoA HMG-CoA Cholesterol Cholesterol bile bile acidsacids
___
HMG-CoA Reductase
Statins
StatinsStatinsSide Effects:
Elevations of serum aminotransferase level ( liver enzymes)
Myositis (muscle pain), rhabdomyolysis, myoglobinemia, acute renal failure
Headache, nausea, bowel upset
Uses of statins Uses of statins
Familial hypercholestrolemiaFamilial hypercholestrolemia
Familial combined hyperlipidemia Familial combined hyperlipidemia
EZETIMIBE EZETIMIBE
Decreases GI Uptake of cholesterolSynergistic action with statin
Statin decreased synthesis of cholesterol in liver +Ezetimibe absorption from intestine
NiacinNiacin
Side EffectsSide Effects
FlushingFlushing, tachycardia, dry skin, , tachycardia, dry skin, nausea, nausea,
Fibric Acid DerivativesFibric Acid Derivatives
Gemfibrozil and FenofibrateGemfibrozil and Fenofibrate
Lower triglycerides and raise Lower triglycerides and raise HDL HDL
Fibric Acid Derivatives Fibric Acid Derivatives
Side EffectsSide EffectsRash, GI symptoms, Rash, GI symptoms, myopathy,myopathy, high high
aminotransferaseaminotransferase
Sites of Action for HypolipidemicsSites of Action for Hypolipidemics