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Easy descriptions of tablet coating defects with pictures ..
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Tablet Coating Defetcs
By –Anika Tabassum BristyB.Pharm StudentNorth South University
Tablet coating :
Tablet coating is defined as “ covering the tablets with one or more layers of mixture of various substances such as natural or synthetic resins ,gums ,inactive and insoluble filler, sugar, plasticizer, polyhydric alcohol ,waxes , authorized color and some times flavor .’’
Aspects of tablet coating : Avoid irritation of stomach Avoid bad taste Avoid inactivation of drug in the stomach Improve drug effectiveness Reduce influence of moisture Improve drug stability Improve product identity Improve appearance and acceptability
Coating defects :
An ideal coated tablet should be free from any visual defect or functional defect. But some imperfections are seen in the tablet coating for different kinds of reasons .
The imperfections found in tablets coating are known as tablet coating defects .
Some coating defects -
• Blistering
• Bridging• Cracking• Picking• Capping• Pitting
• Twinning• Color variation• Orange peel• Roughness• Agglomeratio
n• Chipping
• Splitting• Flaking• Mottled
color• Erosion• Blushing
Twinning
Two tablets stick together. Most common in capsule
shaped tablets .
Cause –Coating suspension can not be evaporated.
Remedy – Reducing spray rate Increasing pan speed
Cracking Small, fine cracks observed on
the upper and lower central surface of tablets, or very rarely on the sidewall are referred to as ‘Cracks’.
Cause –• Use of higher
molecular weight polymers or polymeric blends
• Higher internal stresses in the film ( more than tensile strength of the film )
Remedy –• Use low molecular weight polymer• Adjust the plasticizer & pigment types and
concentration to minimize internal stresses
Sticking & picking
It is defect where isolated areas of film are pulled away from the surface when the tablet sticks together and then part.
Picking does not occur alone it must have another tablet to be stuck with which called sticking .
Sticking
Picking
Sticking & picking
Cause : Inefficient drying. Higher rate of application of
coating solution Over wetting Excessive film thickness
Remedy : • Reduce liquid
application rate. • Increase in drying air
temperature and air volume.
Blistering It is local detachment of film from the
substrate forming a blister .Cause :Over heating during spraying coating solution
Remedy : use mild drying condition .
Chippingo It is the defect where film become chipped and dented , usually at the edges of tablet .
Cause :• Excessive attrition
during coating process
Remedy : Increase hardness of the film .
Orange peel effects It refers to a coating texture that
resembles the surface of an orange .Cause :• Rapid Drying• High solution viscosity
Remedy :• Use mild drying conditions• Use additional solvents to
decrease viscosity of solution.
Roughness :The surface becomes rough and no glossy .
Remedy:Reduce the degree of atomization
Bridging Coating fills in the letter or logo
on the tablet .
Cause :• Improper formulation• Poor logo design• Improper application of
coating solution• Improper atomization
pressure• High percentage of solid
in coating solution• High coating viscosity
Remedy :• Increase plasticizer contents or change
plasticizer concentration• Reduce viscosity of coating solution
Filling The monogram or bisect is filled
and become narrow .Cause :• Applying too much
solution• Higher solution
applying rate Remedy - Control fluid application rate
Blooming (Hazing/dull film)• Coating becomes dull immediately
or after a prolonged storage . Normally it occurs together with surface roughness.
Cause - using low molecular weight plastisizer .
Remedy - increase MW & concentration of plastisizer .
Erosion
Cause :• Over-wetted
tablet surface• Inadequate drying• Lack of tablet
surface strength
Remedy – Control drying rate & temparature
PittingIt is defect whereby pits occur in the surface of tablet coreCause • Incontinuous spreading of film• temperature of the tablet core is greater than
the melting point of the materials used in tablet formulation
Remedy - control drying temperature
Color variation
Cause : improper mixing, uneven spray pattern, insufficient coating migration of soluble
dyes , plasticizer and other additives during drying.
Remedy :• Use of lake dyes eliminates dye
migration. • A reformulation with different plasticizer
and additives is the best way to solve film instability.
Two types of color variation –• Individual Tablet Color
variation,• Whole Batch Color
Variation
Cratering
It is the defect of film coating whereby volcanic-like craters appears exposing the tablet surface .Cause –• Penetration of the coating solution into the
surface of the tablet
Remedy –• Decrease in spray application rate• Use of optimum and efficient drying
Blushing (whitish specks) The defect best described as whitish specks
or haziness of the film .It is characterized by precipitation of polymer exacerbated by the use of high coating temperature at or above the thermal gelation temperature of the polymers.
Agglomeration
Agglomeration caused by coating suspension cannot be evaporated as soon as it reach the tablet which may be caused from too much inlet coating suspension or too less inlet heat and the unevaporated suspension glue the tablets together. The amount of excess unevaporated suspension is much more than twinning.
Sometimes it can cause by the leaking of coating suspension into the chamber, or too close spraying distance or too low atomizing pressure.
References :
Pharmainfo.netOnimax.netTechceuticals.comPharmaceutical Dosage Forms –
Tablets - Larry L. Augsburger, Stephen W. Hoag Tablet Coating by Air Suspension - Clarence James Endicott