Trinity Centre for Bioengineering Regenerating Damaged Bones and Joints Prof. Daniel J. Kelly Dept of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland. Trinity Centre for Bioengineering, Trinity Biomedical Science Institute, Trinity College Dublin, Ireland. AMBER (Advanced Materials and Bioengineering Research Centre), Trinity College Dublin, Ireland.
1. Trinity Centre for Bioengineering Regenerating Damaged Bones
and Joints Prof. Daniel J. Kelly Dept of Mechanical and
Manufacturing Engineering, School of Engineering, Trinity College
Dublin, Ireland. Trinity Centre for Bioengineering, Trinity
Biomedical Science Institute, Trinity College Dublin, Ireland.
AMBER (Advanced Materials and Bioengineering Research Centre),
Trinity College Dublin, Ireland.
2. Trinity Centre for Bioengineering Research Interests:
Mechanobiology How do adult stem cells respond to biophysical cues?
Tissue Engineering and Regenerative Medicine Adult Stem Cell /
Biomaterial based therapies for musculoskeletal tissue
regeneration. Funding: European Research Council Starter Grant
(1.5m)/Consolidator Grant (2m) SFI PIYRA (1.3m) / IvP Award (1.7m)
/ SFI US Ireland Fund AO Foundation; Enterprise Ireland; Irish
Research Council. Lab Overview
3. Trinity Centre for Bioengineering Core
technologies/expertise Hydrogels for tissue regeneration
Mesenchymal stem cells (esp. Infrapatellar fat pad) ECM derived
scaffolds Bioreactors Electrospinning 3D Bioprinting Application
areas Focal cartilage & osteochondral defect repair Large bone
defect healing Whole bone and joint regeneration Ligament
regeneration Interface tissue engineering Lab Overview
4. Trinity Centre for Bioengineering Osteoarthritis A major
clinical problem Adopted from Aigner et al. (2006)
5. Trinity Centre for Bioengineering Whole Bone and Joint
Regeneration Thompson et al, 2015
6. Trinity Centre for Bioengineering Mesenchymal Stem Cells
(MSCs) Adapted from Caplan (1989; 1994)
7. Trinity Centre for Bioengineering Endochondral Bone Tissue
Engineering Sheehy et al, Acta Biomaterilia, 2015.
8. Trinity Centre for Bioengineering Endochondral Bone Tissue
Engineering Sheehy et al, 2015.
9. Trinity Centre for Bioengineering 100m Enhanced Bone
Formation In-Vivo 2. PCL Deposition 3. MSC laden Alginate
Deposition 4. Hybrid Scaffold Channelled Hybrid Scaffold 1. Stem
Cell Expansion 3D Bioprinting For Endochondral Bone
Regeneration
10. Trinity Centre for Bioengineering 3D Bioprinting For
Endochondral Bone Regeneration
11. Trinity Centre for Bioengineering Whole Bone Regeneration
Sheehy et al, Bioresearch Open Access, 2015.
12. Trinity Centre for Bioengineering Whole Bone Regeneration
Sheehy et al, Bioresearch Open Access, 2015.
13. Trinity Centre for Bioengineering Joint Regeneration
14. Trinity Centre for Bioengineering Joint Regeneration
15. Trinity Centre for Bioengineering Current lab members: Dr
Grainne Cunniffe Dr Binulal Sathy Dr John Mulvihill Dr Sara
Romanazzo Dr David Browe Simon Carroll Lu Luo Henrique Almeida Adam
OReilly Alan Irvine Susan Critchley Rukmani Sridharan Andrew Daly
Tomas Gonzalez Fernandez Pedro Daz Payno Dinorath Olvera Paola
Aprile Johnnie Chu Acknowledgements Funding: Science Foundation
Ireland (President of Ireland Young Researcher Award, Research
Frontiers Programme) European Research Council Enterprise Ireland
Irish Research Council Past lab members: Dr Conor Buckley Dr Eric
Meyer Dr Mathew Haugh Dr Yurong Liu Dr Rajalakshmanan Eswaramoorthy
Dr Michael Sawkins Dr Tariq Mesallati Dr Alanna Gannon Dr Eamon
Sheehy Dr Andrew Steward Dr Darren Burke Dr Thomas Nagel Dr Stephen
Thorpe Dr Eoghan Maher Dr Tatiana Vinardel Dr Michael Early Edoardo
DellAmico Peter Kearney Collaborators: Prof. Fergal OBrien (Royal
College of Surgeons in Ireland) Prof Cathal Moran (Trinity College
Dublin) Prof. Veronica Campbell (Trinity College Dublin) Prof.
Paula Murphy (Trinity College Dublin) Prof. Conor Buckley (Trinity
College Dublin) Prof. Pieter Brama (University College Dublin) Dr.
Garry Duffy (Royal College of Surgeons in Ireland) Prof. Kevin
Mulhall, (Consultant Orthopaedic Surgeon, Mater University
Hospital). Dr. Mary Murphy (NUI Galway) Dr. David Hoey (University
of Limerick) Prof. Dennis McGonagle (University of Leeds) Prof.
Chris Jacobs (Columbia University) Prof. Diane Wagner (University
of Notre Dame) Prof. Kurt Hankenson (University of Pennsylvania
School of Veterinary Medicine) Prof. Miguel Angel Martnez
(University of Zaragoza) Prof. Tammy Donahue (Colorado State
University) Dr. Nicholas Dunne (Queens University Belfast) Prof.
Eben Alsberg (Case Western Reserve University) Prof Joel Boerckel
(University of Notre Dame)