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Revision questions 1.3. Membrane structure
Understandings, Applications and Skills
Understandings:• Phospholipids form bilayers in water due to the amphipathic
properties of phospholipid molecules.• Membrane proteins are diverse in terms of structure, position in the
membrane and function.• Cholesterol is a component of animal cell membranes.•Applications and skills:• Application: Cholesterol in mammalian membranes reduces
membrane fluidity and permeability to some solutes.• Skill: Drawing of the fluid mosaic model.• Skill: Analysis of evidence from electron microscopy that led to the
proposal of the Davson-Danielli model.• Skill: Analysis of the falsification of the Davson-Danielli model that led
to the Singer-Nicolson model.
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
1. Draw and label a diagram of a single phospholipid molecule.
2. Draw and label a phospholipid monolayer and a bilayer.
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
3. Draw and label a diagram of the plasma membrane.
4. Outline the structure of the Davson-Danielli model of the cell membrane. Outline the evidence used to support it.
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5. Outline the main points of the freeze-fracture technique and explain how
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
evidence from this method, like this micrograph, were used to refute the Davson-Danielli model
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6. Improvements in biochemical techniques allowed proteins to be extracted from membranes. Outline how evidence from these methods were used to refute the Davson-Danielli model?
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Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
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7. In the following image you may see two integral proteins and some notes on their affinity with water. This evidence falsifies the Davson-Danielli model. Explain how
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Hydrophilic region
Hydrophobic region
Revision questions 1.3. Membrane structure
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8. Outline the Singer-Nicholson fluid mosaic model of the cell membrane.
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http://www.ib.bioninja.com.au/_Media/tracie_med.jpeg
9. List the six main functions of the membrane proteins.
T :Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
R :A :C :I :E :
10.Outline the functions of glycoproteins found in the plasma membrane
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Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
11.Cholesterol is a type of lipid, but it is not a fat or oil. What group does it belong to?
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12.Outline the structure of cholesterol and its position in the membrane. You may sketch the relative position if you wish.
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13.Explain how cholesterol affects the fluidity of the membrane.
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Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
Revision questions 1.3. Membrane structure
References:
Allott, Andrew. Biology: Course Companion. S.l.: Oxford UP, 2014. Print.
Paine, Chris . “BioKnowledgy DP Notes 1.3 - Membrane structure” <
http://www.slideshare.net/diverzippy/bioknowledgy-dp-notes-13-membrane-structure?ref=http://www.bioknowledgy.info/13-membrane-structure.html> Web. 25 Sep 2016.
Dr. Miltiadis Kitsos, DP Biology, Platon School, mailto:[email protected]
