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From Nuclear Energy to New Clear Energy Liberating Energy Copyright © 2011Henry Norman Mind Over Matter Really Tiny Stuff in Perspective Capturing Energy Life’s Leading Ladder The Ultimate Building Blocks Cell Power Plant ATP Production Sites Cell Membranes: Living Walls Popular Prominent Patterns “Lifelines” In Perspective Our Solar System In Perspective Distances In Perspectyive ATP Generator (Principles) Cytoskeleton: Myosin Filaments Cytoskeleton: Microtubules Cytoskeleton: Collagen Light and Dark Reactions Marvelous Molecular Motors Huffing, Puffing… World Wide Web Exercise? More Recycling! Gaian Symbiosis or Single Entity? Flower Power Life Loves Looping-the-Loop Email Author Credits Electronic Energy Exchange Cytoskeleton: Actin Filaments Mighty Muscle Movement Skeletal Muscle Structure No Waste: Recycling The World’s Smallest Motor Electron & Proton Translocation Electron Transport “Staircase” DNA: Digitally Numbered Aminoacids Some Really Close Relatives Our Distingushed Ancestors Forever Fanning Features

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This slide collection is intended as illustrations to the (work in progress) book "Life? The Universe! Almost Everything..." Some animations require PowerPoint 7.

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  • 1. Popular Prominent Distances In Our Solar System InLifelines In PatternsPerspectyive PerspectivePerspective Really Tiny Stuff inCell Membranes:ATP Production Sites Cell Power PlantPerspectiveLiving WallsThe Ultimate Lifes LeadingCapturing Energy Liberating Energy Building Blocks LadderNo Waste:Electron TransportElectron & Proton The Worlds SmallestRecycling StaircaseTranslocation Motor ATP Generator Cytoskeleton: Cytoskeleton: Cytoskeleton: Myosin(Principles) CollagenMicrotubules FilamentsCytoskeleton: Skeletal MuscleMighty Muscle Marvelous Molecular Actin Filaments StructureMovement MotorsLight and Dark Huffing, PuffingFrom Nuclear Energy Mind Over MatterReactions to New Clear EnergyWorld Wide Web Flower PowerGaian Symbiosis orExercise? Single Entity?More Recycling! DNA: DigitallyForever Fanning Our DistingushedSome Really CloseNumbered Aminoacids FeaturesAncestors Relatives Life Loves Looping- Electronic EnergyCredits Email Author the-Loop ExchangeCopyright 2011Henry Norman

2. Prominent Patterns Brain Cell Tree at Sunset Lena River Delta Courtesy Alan Opsahl, Pfizer Courtesy Kevin Schofelt (goo.gl/P0aIb)Courtesy NASA (Landsat 7)Colorado River Delta Fan Coral Purkinje SaguaroCourtesy Google Earth (Digital Globe) Courtesy Denis in Minneapolis ([email protected])Courtesy Anita Gould (Flickr) 3. Distances in PerspectiveScanning Electron Microscope RangeOptical (Light) Microscope Range10-1110-1010-910-810-710-6 10-5 10-4 10-310-210-1 10010 pm 11 nm 10 nm 100 nm 1 m10 m 100 m1 mm 1 cm1 dm1m Human Eye Range AtomLipid Virus Bacterium Cell HumanNucleon MoleculeProtein Mitochondrion 10-14 m ScaleAn atom is to one meter what one meter is to the Earth-Sun distance!Human Eye Range 100 101102 103 104 105 106 107 108 109 10101011 1m10 m100 m1 km 10 km 100 km 1 Mm10 Mm 100 Mm 1 Gm 10 Gm 100 Gm 300 Mm = 300 000 km = 1 light second150 Gm = 1 Astronomical Unit (AU) = Mean distance Earth-Sun = 150 000 000 km = 8.3 light minutes 4. Solar System Bodies (Except Pluto):Relative Sizes/DistancesDistance Sol Tellus = 150 Gm (Gigameter) =150 million kilometer = One Astronomical Unit:With a solar diameter of 32 cm (as in this slide), Earth diameter = 2.9 mm, 34.5 meter removedTellus Sol (Sun) Mercury Venus Mars Jupiter Saturn Uranus Neptune (Earth)Mass 333 000 0.05 0.8 10.1317.595 14.5 17.2 Diameter1090.4 0.91 0.5 11.29.5 43.9Diameter (km1,000) 1,390 4.912.1 12.6 6.8 143120.5 51.2 49.5Distance to Sol (AU) 0.4 0.71 1.55.29.519.230 5. Lifelines in Perspective Multi-Celled Life Forms Relative Organizational Complexity Ten Million Centuries Three Thousand Million Years Mostly Single-Cell Organisms Evolved Single-Celled Life Forms?4 000 3 500 3 0002 500 2 000 1 500 1 000 500 Now Past Time (Million Years Ago) Multi-CelledEukaryaSingle-Celled ArchaeaLUCA (?) ProkaryaBacteriaLUCA = Last Universal Common Ancestor (of all current Earth Life) 6. Features Forever Fanning OutYears Ago Prokaryotes Eukaryotes( 109)Bacteria Archaea ProtistsPlants Fungi Animals0 0.4 One Thousand Hard bodiesMillion Years 0.8 Soft bodies 1.2 Multi-celled organisms 1.6 Eukaryotes with organelles Chloroplast assimilation (?)2 Eukaryotes (DNA in nucleus) Mitochondrion assimilation (?) 2.4Three ThousandMillion Years 2.8 3.2 3.6 Prokaryotes (no nucleus, free DNA) Last Universal Common Ancestor (LUCA) of all current Earth Life4 7. Distinguished Ancestors(3 800 Million Years Ago) Prokaryotes (free DNA)(3 500) Archaea, bacteria Photosynthesis Begins Archaeozoic Era(2 200) Eukaryotes (DNA in nucleus)Three Thousand(1 700) Eukaryotes with organelles Two HundredMillion Years (1 300) Metazoan (multi-celled) organisms(1 200) PlantsProterozoic Era(1 100) Fungi (650) Cnidarians Ediacaran & Vendian fossils (610 MYA) (550) Fishes Cambrian Hard-body Radiation (550 MYA) Ordovician Radiation (500 MYA) Ordovician Extinction (440 MYA) (400) AmphibiansDevonian Extinction (370 MYA) Paleozoic Era (300) Reptiles, Birds Permian Extinction (260 MYA) (250) Mammals Six Hundred Triassic Extinction (210 MYA) Million Years (185) PlacentalsMesozoic EraCretaceous/Tertiary Extinction (65 MYA) (60) Primates(7.5) Gorilla gorilla Cenozoic Era(6) Pan troglodyte (Chimpanzee)(2.5) Homo habilis 8. Atoms, Molecules, and Energy 9. Atomic Distances in Perspective Micro Meter Prefixes: Zepto- Atto-Femto-Pico-10-21 10-2010-19 10-18 10-17 10-16 10-15 10-1410-13 10-12 10-1110-101 zm10 zm 100 zm 1 am10 am 100 am1 fm10 fm 100 fm 1 pm10 pm 100 pmSize-wise, an electron is to an atom, what an atom is to a human! NucleusNucleons(Proton, Neutron) Atom Electron333 zm 1 fm10 fm 100 pm < 10-18 m10-15 m10-14 m10-10 m (1 ) 10. About the really tiny stuff On the quantum level a peculiar dualistic nature hasbeen observed: curiously, quantum size stuff appearsto be both particles and waves, at the same time!The following few slides are misleading: Atoms, andwhat theyre made of, are not things in any ordinarysense. An electron, for example, is not a little sphereorbiting a nucleus, but rather something, vibrating innothing: like a misty cloud, it is smeared out as astanding waveand the particle aspect of this wave may be located anywhere within the cloud. Note also that so far, this is theory only: Nobody hasever directly seen anything as small as an atom. 11. Powerful Peculiar ParticlesHydrogen (1H (Protium)) Fundamental part, and motive force, for Life? The Universe! Almost Everything1 Electron 1 Protoncharge 1 charge +1 (+ )1H has no neutronsUp Quarks charge +u u1 fm Down Quarkd 10-15 m charge 100 000 fm2H (Deuterium) has one neutron 10-10 m (1 )3H (Tritium) has two neutrons 12. Curiously Commingling Courier100 000 fm10 fm 10-10 m (1 )10-15 m Carbon (12C)Electron Cloud Nucleus u d d6 Neutrons charge 0 ( +) Up Quark6 Electronscharge +u u 6 Protonscharge 6*(+ ) (inner shell: 2, outer shell: 4)charge (1*6)Down Quark charge d 13. Electron: Energy Exchanger Excited State(absorbed photon energy)Photon Emission Type PgUp (or right click/previous) to reset,Energy Quantum(spontaneous or facilitated) then PgDn (or left click) to restart!(massless photon)Quantum Leap Lifes Energy (no transitional states!) SourceLow EnergyEnergyHigh(unstable)(stable)Ground StateSecond Law of Thermodynamics implies:Low probability (close to 0) for spontaneous leap to higher state,High probability (close to 1) for spontaneous leap to lower state 14. DNA: Lifes Linear Ladder5 end 3 end Nitrogenous H C C BricksC ONucleobasesCarbonHC C C C TAC O C H C O H Pyrimidines O O P O (one carbon ring)Hydrogen O P O ~21 OOxygen O H C O C CThymineT H C CGC CCHPhosphorus C C OO H CO P O O C CytosineNitrogen O P OO O HC C Purines C O (two carbon rings) H C C C G C O C C HBackbone C C H O O O O P O~3 O P OAdenine A OO P OO H C O C C GGuanineOPhosphate H C C C C ATC O C C H O H OCovalent Bonds: 5H O P OOxygen C O 1O P O ONitrogenHydrogen H C C O H C C C C C O3Deoxyribose H C C C C G C C O C H C H (sugar) 3 end~11 5 end 15. DNA Nucleobase Triplets Encoded in Decimal & Quaternal Number Bases (In RNA, T = U (Uracil))4First quaternal (triplet) symbol position01 2 3TC A G0 000 TTT16 100 CTT32 200 ATT 48 300 GTT T0 Phe F1 001 TTC17 101 CTC33 201 ATC Ile I 49 301 GTC C1 0T LeuL Val V2 002 TTA18 102 CTA34 202 ATA 50 302 GTA A2 Leu LSecond quaternal (triplet) symbol position3 003 TTG19 103 CTG35 203 ATG Met2 M3 51 303 GTG G3Third quaternal (triplet) symbol position4 010 TCT20 110 CCT36 210 ACT 52 310 GCT T05 011 TCC21 111 CCC37 211 ACC 53 311 GCC C1 1CSer SProPThr TAla A6 012 TCA22 112 CCA38 212 ACA 54 312 GCA A27 013 TCG23 113 CCG39 213 ACG 55 313 GCG G38 020 TAT24 120 CAT40 220 AAT 56 320 GAT T0 Tyr Y His HAsn NAsp D9 021 TAC25 121 CAC41 221 AAC 57 321 GAC C1 2A10 022 TAA 26 122 CAA42 222 AAA 58 322 GAA A2Stop1 GlnQLys KGlu E11 023 TAG 27 123 CAG43 223 AAG 59 323 GAG G312 030 TGT 28 130 CGT44 230 AGT 60 330 GGT T0 Cys CSer S13 031 TGC 29 131 CGC45 231 AGC 61 331 GGC C1 3G ArgR Gly G14 032 TGA Stop1 30 132 CGA46 232 AGA 62 332 GGA A2Arg R15 033 TGG Trp2 W31 133 CGG47 233 AGG 63 333 GGG G31) Triplets 10, 11, & 14 serve only as stop codes (no amino acid encodings) 2) Triplets 15 & 35 encode amino acids W and M, respectively3) Triplet 35 does double duty as the universal start transcription" code 4) Amino acid names shown in their standard 3- and 1-letter codesNote also that the sum of triplet values 10+11+14 (the stop codes) equals 35 (the start code)! 16. This slide is an adaptation of an idea originated with Dr. LeeSpetner, from his book Not By ChanceRoom for Evolution: The DNA Condominium View DNA Triplet = Binary Sextet = "Room Address" Value (Base 2 (Binary) = Base 4 = DNA Nucleobase)Binary Digit #0 1st ndrd1 = "Floor"2= "Condo" 3 = "Room"1Lower UpperFloor0 = 00 = T0 = 00 = T (North)2EvenOdd3North South1 = 01 = C1 = 01 = C (East) "Condo"4EastWest2 = 10 = A 2 = 10 = A (South)5North South Room3 = 11 = G3 = 11 = G (West) 6EastWestNorth (DNA) T = 00G = 11C = 01TGC A = 10 3 = G = 110 A 00 2 = A = 10WestEast(Base 4)31 11 01(Base 2) 1 = C = 01 210 0 = T = 00SouthFour floors, four "condos/floor, four rooms/condo = 444 = 64. 64 triplets thus uniquely addresses all 64 DNA "condo rooms.For example: ATG = 2034 = 1000112 = 2nd Floor (102), North Condo (002), West Room (112) 17. ADP-ATP Phosphorylation ATP Inorganic Phosphorus (Pi) + Adenosine diphosphate (ADP) + Energy Tiny amount of heat (Increased entropy)H N HN CO O O C NH C H OP O H H OPO P O N C CC O NH C CO H O H O HC CH O O H Water (H2O) + Adenosine triphosphate ( ATP )(energy stored in oxygen-phosphorus phosphoranhydride bond)F0F1 ATP Synthase(ATP generator) Type PgUp (or right click/previous) to reset! To animate, type PgDn (or left click)! 18. H ATP -ADP Hydrolysis Adenosine triphosphate ( ATP ) + Water (H2O)H N HN CO O O C NH C H H H OPH OP O P O C N C CO NO H C CO H O H O HC CH O O HInorganic Phosphorus (Pi) + Adenosine diphosphate (ADP) + Energy Energy released: 30.5 kJ (7.3 kcal) / molTo animate, type PgDn (or left click)! Type PgUp (or right click/previous) to reset! 19. Energy Conversion and Entropy The Pendulum:Potential EnergySimple Energy Converter Kinetic Energy MaxMax MinMinCell metabolic processes, monitoredAs heat energy ( ) from frictionby the brain, maintain a continuousin the hinge and against the airsupply of potential energy, keepingdissipates, the pendulum swingsthe system alive, far from equilibrium slow down, and eventually stops 20. Lifes Primus Motor:Photosynthesis,Origin of most Earthly Life fuel! 21. Assimilated Bacterium: ChloroplastN Imports: Photon Energy + 6 H2O + 6 CO2Light Reactions: Photosystem II Dark Reactions: Electron Transport Calvin-Benson Cycle Photo System I (Reductive Pentose Electron TransportPhosphate Cycle)Exports: 6 O2 + C6H12O6 (Glucose) 22. Why (Most) Plants Are Green100Reflected GreenWhite Light(all wavelengths)C CC N N C % absorbtionMgC N N CC CAbsorbed Wavelengths(aided by chlorophyll, kinetic light energy is converted to Transmitted Greenpotential energy, stored in carbohydrate chemical bonds)0 400 450500 550 600 650700 UltravioletWavelength (nm)Infrared 23. Flower PowerPhotosynthesisPhoton hits chlorophyll molecule Chloroplasts: 6 H2O + 6 CO2 + thylakoid = C6H12O6 (Glucose) + 6 O2 (located inside Energy grana)Carbon dioxide (from airCandy Factoriesvia stomata) to chloroplast Chlorophyll captures energy, used to split H2O and to drivecyclic reactions inside stroma,building various carbohydrates StromaThylakoid Thylakoid Lumen (PS I/II) membrane H H H O H H HGrana (Thyla- H O C C C C C C H koid stacks) O Glucose O O H O H H HInner (C6H12O6) Outermembrane membrane Manufactured carbohydrates are transported to where they are needed by the plant (organism) 24. Thylakoid (Light) ReactionsPhotons PhotophosphorylationPhotosystem IIPhotosystem IExcited Energy LevelsFrom/ToFd (Ferredoxin) StromapQ(Dark)(Plastoquinone) Fd bound Reactions Cytochrome C C FADC CpCC N N C(Fd Soluble)C N N C Mg (Plastocyanine)MgDepletedC N N C C N N CC CC COxygenChlorophyll Molecule (only porphyrin ring shown, and move-(to air) ment added to visualize how electrons get excited to higher energy levels). ATP is synthesized by F0F1 ATP Synthase, driven by hydrogen protons, descending a pH gradient. 25. Stroma (Dark) Reactions CO2From AirCarbohydrate Synthesis Regeneration Glyceraldehyde- RibuloseReductive Pentose3-Phosphate Phosphate CycleBisphosphateFrom/To Also known as named after its discoverers,Thylakoid (Light) Calvin-Benson CycleReactions ReductionCarboxylation Rubisco(Ribulose Bisphosphate Carboxylase-Oxidase)3-Phospho- Glycerate From Roots 26. Microbiology,Cell Chemistry 27. Cell MembranesLiving WallsHOH Pi ADPATP Polar (hydrophilic, attracts water) headsform phospholipid bilayersNon-polar (hydrophobic, repels water) tailswith embedded transport proteinsNa+K+ ATPase Gated (Ion Pump) UniportSymportAntiport ChannelExtracellular matrix+ Non-polar interior ~60 mVCotransportsCytosol _Passive (down hill ion gradients), require no Active (against ion gradients),additional energy (facilitated diffusion) require additional energy (ATP)Channel gate on/off action may beelectrically or chemically controlled 28. MitochondrionCell PowerhouseGlycolysisCO2Inter-membrane SpaceHigh H+ concentration (Acidic, low pH)Pyruvate InorganicOuter MembranePhosphorusTCA Cycle(PI) AdenosineTriPhosphate(ATP) AdenosineDiPhosphate (ADP) Cristae Matrix Inner MembraneLow H+ concentration (Alkaline (base), high pH) Nucleoids in matrix has unique circular mitochondrial DNA,predominantly (1 000:1) inherited from the female egg cell 29. ATP Production SitesEnergy Source:Electrochemical Charge (pH) Gradient, created byHigh Energy Free Electrons ADP and Pi(Phosphorus,Inorganic)TCA Electron Transport,(Krebs) Oxidative Phosphorylation, CycleF0F1 ATP SynthaseGlycolysis:Glucose toPyruvic Acid MitochondrionATP ATPATP Energy stored in chemical bonds (oxygen-phosphorus) 30. The Citric Acid (TCA) CycleNAD+HH OATP H OH ATPOHHNAD+ NAD+O C O O C OO C OH+ H+Cell CytoplasmH2O Pyruvate AcetateCO2 + CitrateIsocitrateNAD+GlycolysisH2OInter-membrane spaceNADHCO2 NAD+OxaloacetateComplex I-ketoglutarate+NADNADH NAD+ NADHH+CO2 NADH Malate FADComplex IISuccinateGDP ADPO C O Lungs GTP ATPH2O FumarateCell EnergyMitochondrial Matrix 31. H2OElectron Transport Staircase High energy freeelectrons (from food)e Energy level differences used to pumpe hydrogen protons (H+) against a charge H++gradient, maintaining an ion pressure which in turn is used to synthesize ATP from ADP spontaneous energy flowsInner Membrane Complex I Mitochondrial are coupled to forced energy flows. Complex II Complex III_ At end of transport chain, now lowComplex IVenergy electrons, with one O- andtwo H+ ions, form H2O (pure water)+ 32. H+H+H+H+H+ H+ H+ e-e- e- e- e-Electron & Proton TransportInter-membrane Space (+ side) H+H+H+ H+H+ H+ H+H+ H+H+H+ H+H+H+H+H+ H+ H+H+ H+ H+ H+ H+ H+H+H+H+Complex IComplex IIComplex IIIComplex IV CH+ e-e- H+Fe S- e- e- H+H+ - Fe Se- e-QH+H+ e-e-H+H+ QH2e- e- Qe- e- Q- Fe SCu+ Cu2+ FADH2 FMNH2 QH2 QH2e- e- FAD e- e-FMN H+ H+H+ H+H+H+H+ H O OSuccinate Fumarate+2H+H+H+ H NAD+(FAD from Citric Acid Cycle)NADH+ H+ H+ H+FromTo H+Citric Acid CycleH+ H+ Mitochondrial Matrix (- side) 33. H+ H+ H+F0F1 ATP Synthase (Nano Motor)Inter-membrane Space H+H+High H+ concentration (Acidic, low pH)H+H+H+ H+ H+ H+H+H+ H+ H+ H+ H+25 nmH+ H+ H+H+H+H+ H+ H+ H+ H+RotorH+ H+ H+H+ H+H+H+ F0: Motor, H+ proton fuel StatorProtein shaftF1: Generator,Reaction siteCatalytic sitesADP + Pi H+ H+H+H+ H+ATP + H2O H+H+H+Mitochondrial MatrixH+ H+H+Low H+ concentration (Alkaline (base), high pH) 34. F0F1 ATP Synthase (Principle)Transmembrane Hydrogen protonstransporter protein(three for each ATP)falling down thecharge gradientOpenADP/Pi/ATPantiportF1 generatorTorque pumping up Stator catalytic sitesenergy to activation phosphorylationconformation level (stored in ATP) reaction site changesTightLooseHydrogen protons are Note: Turbine shovels exist only in this pumped back up by slide (only to represent the F0 protein rotor) complexes I, II, and IV 35. Structural StrengthCollagens EndoplasmicFibre ( < 1 mm) tensile strength ~ 9 000 gReticulum (stronger than reinforced concrete) (ER) LumenCollagen FibreThree precursor -chains (bundle of fibrils)~ 70 nm (loose terminal propeptides) Procollagen ~1 mm Self-assemblyCollagen Fibril(bundle of ~300 molecules) Collagen also contains:Glycine HydroxylysineHydroxyproline Self-assembly ~300 nm ~1.5 nm Procollagen peptidase Secreted enzyme removesCollagen Molecule out of cell propeptides (triple helix -domains) 36. Cytoskeleton: Actin Filaments3 4 Mg++G-Actin monomer, ATP and Mg++ + ATPsitting in the gap between 2 and 41 2~5 nmActin monomer gaps align toward the negative end of the fila-ment, spiraling along the long axis (thirteen monomer units perfull helical turn), growing faster at the positive end. ~35 nm + ~7 nm 37. Cytoskeleton Microtubules andtubulin, equal polarity, with a3-D structure, form heterodimers: + Non-covalently bonded into a linear array, with-tubulin at negative, -tubulin at positive end,with the end growing slower than end,forming sheets, which curl up into tubules. 25 nm 8 nm 15 nm + Again, 13 units per helical turn 38. Cytoskeleton: Myosin Filaments Actinbinding sites Myosin bundles up into filaments:Myosin II protein structure Bi-polar thick Myosin filament in muscle cell Sarcomere: 39. H Marvelous Molecular Motors HOHOHADPPiPi ADPATPATPKinesin payload examples: Payload vesicleKinesin Structure(membrane bound) Organelles (Mitochondria)Vesicle Acetylcholin (Nerve Cells) binding -tubulin binding Chromosomes (at Mitosis)sitessites Much more_+ Walks toward negative, 8 nm steps Other Important Motor Protein FamiliesDynein (also walks on microtubules, from negative to positive)Myosin (binds to Actin filaments, paramount in muscle cells) Myosin Muscle Cell Muscle CellATP GeneratorMicrotubules Actin FilamentsFilamentsStructurePower Cycle 40. Skeletal Muscle Structure Attached Muscleto Tendon(bundle of(collagen) Cells)Cell (Fibre),10-100 mbundle ofMyofibrilsMore than one nucleus Isolated MyofibrilSarcomere2.5 m(contraction unit) 1.5 mThick (myosin) filamentSliding Actin andMyosinThin (actin) filamentfilaments 41. ADPMuscle Cell Power Cycle ADP PiPiATPATPHOHHOHRelaxed muscle myosin cannot bind to actin, as the bindingsites are blockedby protein tropomysinand must first beunblocked (accomplished by the regulator protein troponin).Signal receptor molecules open Ca+ ion channels, resulting introponin release, which exposes the actin binding sites.Myosin now binds to actin, and the myosin head bends (byspending ATP ), and the attached actin filament slides along!Relax signals close the Ca+ ion channels, resulting in removalof troponin, allowing tropomysin to reblock the actin bindingsites. The myosin heads retract, and the cycle may repeat.Bi-polar thick Myosin filament (in muscle cell Sarcomere) Actin filaments attached to and pulled back by very strong titin protein springs 42. Life: Mind Over MatterPhysiology Energy ATP Cell ChemistryBrain (conscious Liver convertsActin and myosin mind) willinglactate (from muscles)filaments separatedmuscle to contractto glucose (stored)and relaxedNerve action (electric)Liver releases Na+/K+ ion flowpotential moves fromglucose into bloodacross axon (nerve brain to muscleto muscle cellscell) membranes Nerve signalMuscle cell convertsRelease oftransmission glucose to pyruvateneurotransmitter (via synapses)(through glycolysis)(acetylcholin) Muscle cell Mitochondria uses Muscle receptor membrane pyruvate (TCA cycle), molecules (proteins)depolarizationconverts ADP to ATP. open Ca+ ion channels SarcomereATP hydrolized to ADP, Myosin binds to actin, contractionreleasing work energyperforms work by commences and lactate (to liver) pulling actin filament 43. Cycles, CyclesEverywhere! 44. A World Wide Web Mammals,Birds, Fishes InsectsCarnivorousInsects, SpidersCarnivorous Mites, SpidersCarnivorous CarnivorousOligochaetaeSpringtails Roundworms (Earthworms)CollembolaNematodaProtista,Acari (Mites) (Springtails)(Roundworms)ProtozoaFungi (Mildew, Bacteria Mushrooms)Interdependencies, anyone?Plants, Roots,Organic Waste 45. NuclearNew Clear Energy FusionEnergy Recycled: H2O, CO2, O2 (low energy: high entropy) MitochondrionChloroplastPlant Manufacture:Vegetabilia evolvingCyanobacteria evolvingCarbohydratesinto animalia (high energy: low entropy) into vegetabiliaSimultaneous Independent Co-dependency Evolution! 46. Symbiosis or Single Entity?Photosynthesis RespirationCO2 + H2O O2 + CarbohydratesCarbohydrates + O2H2O + CO2InputH2O OutputWater O2OutputInputCarbohydratesInputCO2 OutputCarbon dioxideOxygen Plants, Carbohydrates, Most algae, other organicother livingEnergyOutput Inputsome bacteriamolecules organismsSurvival, Chemical Nuclear fusion energyPropagation,bond energy (See Matter/Energy Cycle) Useful (?) WorkPhotosynthesis 47. Glucose/Lactic Acid Cycle O2 CO2glucose glucose Lungs glucose-6P glucose-6PglycogenNADH ATPglycogen NADH ATPpyruvate pyruvateLiver, Muscles lactatelactateLiver Blood Muscles 48. A-Huffin and a-Puffin Oxygen O2 Inhaled gases exchanged in alveoli Exhaled From Plants C NCFe C N CTo Plants C N N C C CCarbonic Anhydrase(dehydrates HCO3)Lungs Erythrocytes(Red Blood Cells)TissuesNo nucleus (no DNA)stems from bone marrow Chlorine ion(for electroneutrality)CarbonCarbonic Dioxide Bicarbonate To LungsAnhydrase(from cells) (hydrates CO2) WaterHydrogen ionTo Cells~7m 49. Life Loves Looping the Loop Two Haploid Gametes23 Sperm & Ovum: 46/2 Chromosomes each 23Meiosis(germ cell division) Fertilization (chromosome addition)23 46 46One Diploid Zygote23+23 Shuffled ChromosomesConsenting Adults13 ~5 10 (50 trillion!) cells, 2*23 Chromosomes each Mitosis (body cell multiplication)Cell Growth, Differentiation Local Entropy? (subtraction!) 50. Some Really Close Relatives Homo sapiens sapiens0 1 Pan troglodyte (Chimp) 2 3 Gorilla gorilla 4 Sivapithecus5 Ramapithecus 6 7 Pongo pygmaeus (Orang) Earlier 8Ancestors Hylobates lar (Gibbon)9 Old World Monkeys103025 2015 10 5 0 % DNAMillion years agodifferences 51. Text,Concept, Artwork,Graphics, Animations:Henry NormanMicroTech ConsultingTagaytay City Philippine Islandsgoogleplus/henry.ko.normanCopyright 2011 Henry Norman