Name /bks_52233_bing/52233_ch03_a pg 57 # 3

Acetaminophen

57

Ace

tam

inop

hena

Stor

age

Con

ditio

ns

Tem

pera

ture

Post

-tha

wTe

mp

Dru

gM

anuf

actu

rer

Con

cent

ratio

nD

iluen

tsO

smol

ality

(mO

sm/k

g)pH

Room

Refr

igFr

ozen

Room

Refr

igBo

dyTe

mp

Refe

r.

CO

NTA

INER

Bags

,Pla

stic

CA

D10

mg/

mL

undi

lute

dc

b6

hn/

an/

an/

an/

an/

a1

Poly

olef

inC

AD

10m

g/m

Lun

dilu

ted

cb

6h

n/a

n/a

n/a

n/a

n/a

2

Poly

viny

lC

hlor

ide

(PVC

)C

AD

10m

g/m

Lun

dilu

ted

cb

6h

n/a

n/a

n/a

n/a

n/a

2

Syri

nges

,Pla

stic

(BD

)C

AD

10m

g/m

Lun

dilu

ted

cb

6h

n/a

n/a

n/a

n/a

n/a

1,2

Syri

nges

,Po

lypr

opyl

ene

CA

D10

mg/

mL

undi

lute

dc

b84

hn/

an/

an/

an/

an/

a4,

5

OTH

ERIN

FUSI

ON

CO

NTA

INER

S

Gla

ssC

AD

10m

g/m

Lun

dilu

tedd

cb

6h

n/a

n/a

n/a

n/a

n/a

1

BMS

10m

g/m

Lun

dilu

tedd,

en/

a3.

7–6.

648

hn/

an/

an/

an/

an/

a3

CA

D10

mg/

mL

undi

lute

ddc

b84

hn/

an/

an/

an/

an/

a4,

5

Flus

hC

ompa

tibili

ty:

Hep

arin

sodi

uman

dno

rmal

salin

e.2

Spec

ial

Con

side

ratio

ns:

Stor

eat

room

tem

pera

ture

;do

not

refri

gera

teor

freez

e.1

Not

esa A

ceta

min

ophe

nis

know

nin

tern

atio

nally

aspa

race

tam

ol.1

b pH

ofun

dilu

ted

solu

tion

isap

prox

imat

ely

5.5.

1

c Osm

olal

ityof

undi

lute

dso

lutio

nis

appr

oxim

atel

y29

0m

Osm

/kg.

1

d Und

ilute

d,af

ter

open

ing

and

with

inor

igin

algl

ass

vial

.e W

ithke

topr

ofen

(Pro

feni

d,SA

V)10

0m

gad

ded

topa

race

tam

ola

(Per

falg

an,

BMS)

10m

g/m

Lin

orig

inal

glas

svi

al.

Refe

renc

es1.

Ofir

mev

�[p

acka

gein

sert]

.San

Die

go,C

A:

Cad

ence

Phar

mac

eutic

als,

Inc.

;N

ovem

ber

2010

.2.

Nav

arre

teT,

Med

ical

Info

rmat

ion

Serv

ices

[per

sona

lcom

mun

icat

ion]

.San

Die

goC

A:

Cad

ence

Phar

mac

eutic

als;

Sept

embe

r27

,201

2.3.

Kam

bia

NK,

Lyuc

kxM

,Din

eT,

etal

.Sta

bilit

yan

dco

mpa

tibili

tyof

para

ceta

mol

inje

ctio

nad

mix

edw

ithke

topr

ofen

.Eu

rJ

Hos

pPh

arm

.20

06;

12:8

1–4.

4.Kw

iatk

owsk

iJL.

Exte

nded

stab

ility

ofin

trave

nous

acet

amin

ophe

nin

syrin

ges

and

open

edgl

ass

bottl

es.I

CH

PA

nnua

lMee

ting,

Sept

embe

r20

12.

5.Kw

iatk

owsk

iJL,

John

son

CE,

Wag

ner

DS.

Exte

nded

stab

ility

ofin

trave

nous

acet

amin

ophe

nin

syrin

ges

and

open

edvi

als.

AmJ

Hea

lth-S

yst

Phar

m.

2012

;69

:199

9–20

01.