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Effective Transportation and Translocation of Therapeutic
Molecules Using Suitably Functionalized Carbon Nanotubes
AISWARYA.N School of Chemical Sciences,
Mahatma Gandhi University, Kottayam, Kerala, India.
Introduction Deliverables Why carbon nanotubes? Functionalized CNTs as Innovative Tool. How the Drug Delivery…? Future Applications Concluding Remarks References
CONTENTS
IntroductionIn 1991, Iijima discovered carbon nanotubes (CNTs) that are elongated fullerenes where the walls of the tubes are hexagonal carbon and often capped at each end.
Carbon Nanotubes
Micro-crystals with high aspect ratios of 1000 or more, although their diameter is close to molecular dimensions
Single-Walled Carbon Nanotubes (SWCNTs).
Multi-Walled Carbon Nanotubes (MWCNTs)
Deliverables
Future aspects.
Importance of Carbon nanotubes as a ‘microshuttle’ for drug delivery.
The effect of functionalization for the therapeutic applications
Advantages and challenges in the field of drug delivery using the functionally modified carbon nanotubes.
Why Carbon Nanotubes…?
CNTs – the pitt version
Bionano materials such as liposomes
Nanotubes over nanospheres….?
Polymer or lipid based conjugate system.
A new entity with novel therapeutic or diagnostic properties
Functionalized CNTs as Innovative Tool
Solubility
Biocompatible natureNeed for Functionalization
........ . . .... . ... . . . .
X % X %
Functionalization of CNTs
Step 1 :
Step 2 :
Step 3:
Step 4:
sidewall tip
Molecular Structures of the Carbon Nanotube Conjugated
with Different Therapeutic Agents
Ultrathin transverse section of a HeLa cell treated with ammonium-functionalized CNT
Plasmid DNA delivery Cell internalisation
Antibiotic delivery Anticancer delivery
Impact of f-CNTs in immune system
Dendritic CellMacrophages T Lymphocyte
Two aspects of cell functionality studied Potential activation of immune cells
The capacity of immune cells that have previously encountered f-CNTs to respond to a physiological stimulus
Immune Cells- ‘True Soldiers’ of human body
Advantages of Using f-CNT as Vector Drug Delivery Offer multimodel options (Diagnosis, transport and targeted delivery to always) Specificity
Nano needle mechanism Solubility
Controlled drug release
Disadvantages Toxicity
Selectivity for functionalisation
How the Drug Delivery?
..
.
.
.......
Challenges Selection of the functionalizing agents. Translocation of the therapeutic molecule.
Biodistribution of f-CNTs.
Future Applications Microshuttle.
A new tool for the development of non-toxic drugs through cost effective routes.
Concluding Remarks
●The functionalization of CNT is still a subject of intense research, which generates continuous advances as well as novel materials.
●Offers “rediscovering” of old drug molecules and also offer new discovery and design options for new molecules.
●Anticancer and antibiotic carbon nanotube conjugates as well as antigen- presenting conjugates for the potential fabrication of vaccines and plasmid DNA complexes for construction of gene therapeutics.
References1.H.J.BWu,Dumortier,S.Lacotten,G.Pastorin,R.Marega,W.D.Bonifazi,J.Br
iad,M.Prato,S.Muller and A. Bianco,Nano letters,2006,6(7),1522.
2.A. Bianco,K.Kostarelos and M.Prato,Current Opinion in Chemical Biology,2005,9,674.3. CR Martin, P Kohli : The emerging field of nanotube biotechnology. Nat Rev Drug Discov 2003, 2:294. A.Bianco, K.Kostarelos, C.D Partidos, M.Prato. Biomedical applications of functionalised carbon nanotubes. Chem. Commun. 2005, 571.5. Y. Lin ,S.Taylor, H.Li , SKA.Fernando ,L. Qu ,W. Wang , et al. Advances towards bioapplications of carbon nanotubes. J Mater Chem 2004;14(4):527.
Sincere Thanks ToDr.P.K.RadhakrishnanDr.Sabu ThomasDr.Suresh MathewSchool of Chemical SciencesIrshad.K
Muhammed Ashik U P
Special Thanks ToChemistry Alumni AssociationStaff and Students of M.E.S Ponnani College