- 1.GUIDED BY:PRESENTED BY:Dr.R.K.Parikh AHALGAMA JIGNESH
VDEPARTMENT OF PHARMACEUTICS ANDPHARMACEUTICAL TECHNOLOGY M.Pharm
-1 (2011-12)L.M.COLLEGE OF PHARMACY Roll no :-
09AHMEDABAD-380009
2. Thermal analysis Classification of thermal analysis
Differential thermal analysis(DTA) Principle
InstrumentationAdvantage and Disadvantage Application References
Ahalgama Jignesh V. , M-Pharm-1(paper code- 2/25 910102),
DTA,LMCP,GTU(2011-12)) 3. Thermal analysis incorporates those
techniques inwhich some physical parameter of the system is
derivedand/or recorded as a function of temperature. Matter is
heated it undergoes physical and chemicalchanges occur. physical
change: melting or boiling ,weight loss,gasevolution. chemical
change:decomposition or reaction take place. Ahalgama Jignesh V. ,
M-Pharm-1(paper code- 910102), DTA,LMCP,GTU(2011-12))3/25 4. Sr no
TechniqueParameterInstrumentGraph measured used1 Thermogravimetry
mass thermobalance Mass vs.temp or time2 Derivative
dm/dtthermobalance dm/dt vs.thermogravimetrytemp.3 Differential
thermal Delta TDTA apparatus Delta T vs.analysistemp.4 Differential
dH.dtcalorimeter dh/dt vs.scanningtemp.calorimetry5 Thermometric
temperaturecalorimeter Temp vs.titrimetrytitrant
volume(Cont..)Ahalgama Jignesh V. , M-Pharm-1(paper
code-4/25910102), DTA,LMCP,GTU(2011-12)) 5. 6
DynamicReflectanceSpectrophot%Reflectance ometer
reflectancespectroscopy and temp7 Evolved gas Thermal ThermalT.C
vs.detectionconductivity conductivity temp.cell8 ThermoVolume or
dilatometerVolume ormechanicallength length vs.analysis temp.9
ElectricalCurrent orelectrometer I or R vs.conductivityresistance
temp.10 EmanationRadioactivity ETAE vs. temp. thermalapparatus
analysisAhalgama Jignesh V. , M-Pharm-1(paper code-910102),
DTA,LMCP,GTU(2011-12)) 5/25 6. Combination withthermogravimetry
1)for better interpretation a) TG DTAb) TG DSC 2)for identification
of gas involved inthermal analysisa) TG MS b) TG GC MSAhalgama
Jignesh V. , M-Pharm-1(paper code-6/25910102),
DTA,LMCP,GTU(2011-12)) 7. TG/DTA Simultaneous Measuring
InstrumentSimultaneousTG/DTAimproves easeof operation,sensitivity
andanalyticalaccuracy . Ahalgama Jignesh V. , M-Pharm-1(paper code-
910102), DTA,LMCP,GTU(2011-12)) 7/25 8. Principle:A technique in
which the temperature differencebetween a substance and a
reference(Al2o3) materialis measured as a function of temperature
while thesubstance and reference are subjected to a
controlledtemperature program. endothermic and exothermic peak.
endothermic and exothermic reaction.Ahalgama Jignesh V. ,
M-Pharm-1(paper code-910102), DTA,LMCP,GTU(2011-12)) 8/25 9. T vs.
temperatureT Temp.Ahalgama Jignesh V. , M-Pharm-1(paper
code-9/25910102), DTA,LMCP,GTU(2011-12)) 10. Ahalgama Jignesh V. ,
M-Pharm-1(Pharmaceutical technology & Pharmaceutics,
10/25DTA,LMCP(2011-12)) 11. a) METALIC : nickel,stainless
steel,platinum sharp endothermic peak.a) NON METALIC :
glass,silica,sintered alumina sharp exothermic peak.For heating the
sample.Material used wire or ribbon wound on refrectorytube.
Ahalgama Jignesh V. , M-Pharm-1(paper code- 11/25 910102),
DTA,LMCP,GTU(2011-12)) 12. 1) SENSOR2) CONTROL ELEMENT3)
HEATERAhalgama Jignesh V. , M-Pharm-1(paper code-12/25910102),
DTA,LMCP,GTU(2011-12)) 13. 1) DEFLECTION TYPE: Recording pen is
moved directly by the input signal.2) NULL TYPE: Input signal is
compared with a reference or standard signal and difference is
amplified.Ahalgama Jignesh V. , M-Pharm-1(paper code-13/25910102),
DTA,LMCP,GTU(2011-12)) 14. Ahalgama Jignesh V. , M-Pharm-1(paper
code-14/25910102), DTA,LMCP,GTU(2011-12)) 15. High resolution and a
robust easy to use. Less satisfactory than dsc with regard to
resolution of thermal traces and quantitative data. Unable to
measure the energy associated with each event.Ahalgama Jignesh V. ,
M-Pharm-1(paper code-910102), DTA,LMCP,GTU(2011-12))15/25 16. 1)
Identification of substance: DTA curve of two substance is not
identical.2) Identification of product:substance is react with
another substance product is identified by their specific DTA
curve.3) Melting point: It is an endothermic process in which heat
is absorbed by analyte.4)Detection of impuritycurves could be
compared with the curve of referencestandard. Ahalgama Jignesh V. ,
M-Pharm-1(paper code- 16/25 910102), DTA,LMCP,GTU(2011-12)) 17. 5)
Studying and characterizing polymersThermochimica acta
,vol,4,Aug-1972,page-249-255.thermal transition for a polymer often
take place over a extended temp. range because even a pure polymer
is a mixture of homologues and not a single chemical. species.
Ahalgama Jignesh V. , M-Pharm-1(paper code- 17/25 910102),
DTA,LMCP,GTU(2011-12)) 18. 6) Detection of eutectic mixture: binary
mixture :two endotherm eutectic mixture : single major endotherm.7)
generation of phase diagram andphase transitions In which the peak
at 113 c corresponds to the solid phase change from the rhombic to
monoclinic form.the peak at 124 c corresponds to the melting point
of the element. The peak at 446 c corresponds to the boiling point
of sulfur.Ahalgama Jignesh V. , M-Pharm-1(paper code- 18/25910102),
DTA,LMCP,GTU(2011-12)) 19. Ahalgama Jignesh V. , M-Pharm-1(paper
code-19/25910102), DTA,LMCP,GTU(2011-12)) 20. 8) Application of DTA
to compatibility and stability problems in penicillin stearic acid
mixturejournal of pharmaceutical science,vol-5,page
631-633,may-1969 Identify stearic acid as the inactivating
component in unstable formulation containing sodium dicloxacin and
other excipients. Stearic acid + k.penicilin=incompatible Stearic
acid+ sodium dicloxacin =incompatible Stearic acid+ ampicilin
trihydrates=compatibleAhalgama Jignesh V. , M-Pharm-1(paper
code-20/25910102), DTA,LMCP,GTU(2011-12)) 21. (9) Comparative
physical-chemical charecterizationof encapsulated lipid based
ISOTRETINOINproduct by thermal behavior analysisThermochimica acta
505 ,(2010),73-78. Use in nodular acne. Study the three
encapsulated product (1 reference and 2generic).measure thermal
behavior of that product no specificchange and more thermostable
than isotretinoin.Ahalgama Jignesh V. , M-Pharm-1(paper
code-21/25910102), DTA,LMCP,GTU(2011-12)) 22. (10) Physiochemical
charecterization of edaravonewith hydroxy propyl
B-cyclodextrin.carbohydrate polymer 83(2011),1101-1105. novel free
radical scavenger. that preparation for the improve solubility and
stability. inclusion complex charecterized by DTA-TG method.
inclusion complex more stable than edaravone. Ahalgama Jignesh V. ,
M-Pharm-1(paper code- 22/25 910102), DTA,LMCP,GTU(2011-12)) 23.
Remingtons Pharmaceutical Science,21st edition,2005. Theory and
Practice of Industrial Pharmacy by Lachman &Lieberman,third
edition. Physical pharmacy, Alfred martin, fourth edition The
Science of Dosage form Design M.E Aulton Thermochimica acta
,vol,4,Aug-1972,page-249-255. journal of pharmaceutical
science,vol-5,page 631-633,may-1969. Thermochimica acta 505
,(2010),73-78. carbohydrate polymer 83(2011),1101-1105.Ahalgama
Jignesh V. , M-Pharm-1(paper code- 23/25910102),
DTA,LMCP,GTU(2011-12)) 24. Principle and Instrumental analysis,
skoog-hollar-nieman, 5th editio.Chemical Abstract vol:146,
No:25,June 18 :2007,507180Instrumental methods of chemical
analysis,gurdeep r.chatwal,2008. www.linseis.net
www.nd.eduwww.shimadzu.lacerta-technology.comwww.wikipedia.com
www.ijpsonline.com/article.asp Encyclopedia of pharmaceutical
Technology ,Swarbrick & Boylan vol-06 Encyclopedia of
pharmaceutical Technology ,Swarbrick & Boylan vol-02 Ahalgama
Jignesh V. , M-Pharm-1(paper code- 24/25 910102),
DTA,LMCP,GTU(2011-12)) 25. Ahalgama Jignesh V. , M-Pharm-1(paper
code-25/25910102), DTA,LMCP,GTU(2011-12))
