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BRANCHES: CHENNAI (HO) / BANGALORE / HYDERABAD / PUNE
COMPANY PROFILE
CORPORATE PRESENTATION
Dr Yellapragada Subbarow
(1895-1948)
Because he lived you may be alive and well today; because he
lived you may live longer He Transformed Science; Changed
Lives
Divisions of Dr Yellapragada Lifesciences
• Bio-Fugue (Inoculating Knowledge)
Training in Lifesciences / Biological / Basic & Analytical Sciences.
• Sherwood-HR (Soar Beyond The Horizon)
Retained search firm & Refined Recruitment solutions (All verticals)
• Laasya Advertising ( Complete Outdoor Branding)
Complete Outdoor Solutions – Online Promotion - Branding
Biological / Bio Pharmaceutical Services
Clinical Research
Clinical Data management
Drug Discovery services
Waste management
Microbiological studies(Basic & Clinical)
Biochemical & Phytochemical studies
Bio-Technology studies
Molecular biology studies
Molecular genetic studies.
Cell biology studies.
Nano-biotechnology studies.
Biological / Bio Pharmaceutical Services
Bio-remediation.
Immunological studies
R-DNA Technology studies
Cell line studies/Animal tissue culture studies.
Invitro anti-cancer studies.
Plant tissue culture studies.
MYCO-Technology studies.
Anti-Oxidant studies.
Anti – Inflammatory studies (Invitro/In vivo).
Biological / Bio Pharmaceutical Services
Anti-Diabetic Studies (Invitro/In vivo).
Anti – Proliferative studies (Invitro/In vivo).
Custom Assay Development Services (CADS).
Biologics/Biosimilars/Bio Pharma CMC Support Assays.
Bio- Analytical Services (PK/TK/Immunogenicity/ Invitro Assays).
Final Product Characterization
Efficacy.
Toxicology
Antibody Production, Purification, Labeling, and Characterization.
Host – Cell Contamination.
Biological / Bio Pharmaceutical Services
Animal Model Development.
Stability Services.
Microbial Gene Analysis.
Invitro Laboratory Testing Services
Proximate analysis.
Pesticide analysis.
Heavy metal analysis.
Toxic element analysis.
Additive analysis.
Extraneous Material analysis.
Food Dyes analysis.
Animal Feed analysis.
Fatty acid analysis.
Invitro Laboratory Testing Services
Preservatives analysis.
Trace elements analysis.
Minerals analysis
Myco-Toxin analysis.
Hazardous sludge analysis.
BOD/COD analysis.
Emission analysis.
Water/Waste water/Air/Soil/Pharma/Cosmetic product analysis.
Invitro Laboratory Testing Services
Rancidity
Nutritional labeling.
Cereals/Pulses/Nuts/Oils/Fats/Milk/Egg/Fruit/Vegetables/Beverages/Sea-Food analysis/Poultry/Meat/dairy products analysis.
Specialized Instrumentation / Facilities
AFM
HR-TEM
SEM
FT-IR
UV-SPEC
NMR
XRD
GC-MS
Chromatography (HPLC, HPTLC, TLC, Column & Ion exchange).
Specialized Instrumentation / Facilities
Soxhlet Apparatus
Flow Cytometer
Confocal Microscopy
DNA Sequencer
FPLC
RT-PCR
ICPMS
Atomic Absorption Spectrophotometer
Chemidoc
Specialized Instrumentation / Facilities
Fluorescence Microscope
GC-MS
LC-MS/MS
Multi Mod Micro plate reader
Electrophoresis –Blotting – (Southern, Northern & Western).
Radiobiology
Ultra centrifuge
Tissue culture Facility
Fermentor
Nanodrop-Spetrophotometer
PRODUCTS
Nanoparticles (E.g. Silver, Gold, CDS, Zns etc Synthetic and Green chemistry)
(For academic and research purposes only.)
Custom Formulations
Research & Development Bio- Pharmaceuticals
API’s (Pipeline) • Anti-Diabetic Agents. • Anti – Oxidants. • Anti-Inflammatory
Agents. • Anti-Obesity Agents. • Anti-Proliferate Agents.
Research & Development Biologicals (pipeline)
Monoclonal Antibodies.
Therapeutic Proteins.
Oncology & Retroviral
Drugs
Vaccines
Pre-Clinicals
Test Batch Production
Process development
Potency Testing
Immunogenicity
Toxicology
Batch Release Test
Dose Stability
Pre-Clinicals
Efficacy
Endotoxins
Exotoxins
Outer- membrane
Toxins
Physchem studies
Pyrogens
Enzymes
Catalases
Oxidases
Peroxidases
Amylase
Lactase
Aspartase
Protease
Nitrilase
Fumerase
Aminoacyclase
Cellulase
Amino-Acids
L- Glutamic acid
L- Glutamine
L- Lysine
L-Threonine
L-Serine
L-Isoleucine
L-Leucine
L-Valine
Amino-Acids
L-Arginine
L-Histidine
L-Alanine
Aspartic acid
Proline
Cysteine
Methionine
Tryptophan
Phenylalanine
Tyrosine
Bio - Nanotechnology
Nano-Particles (Silver, Gold, Carbon,
ZNS etc.) Nano-powders Nanowires
Bio - Informatics
Tools, Software’s and Databases:
Sequence Analysis
Structure Analysis
Molecular Modeling
Molecular Docking
Molecular Dynamics and
Simulation
Insilco Drug Designing
Bio – Agricultural (Pipeline)
Bio-Composting
Molasses storage
Mushroom cultivation
Animal Feed
Clinical Research
• Acute Oral Toxicity
• Acute Dermal Toxicity
• Acute Inhalation Toxicity
• Acute Dermal Irritation / Corrosion
• Acute Eye Irritation / Corrosion
• Skin Sensitization
ACUTE
• Repeated Dose 14/28 Days Oral / Dermal
Toxicity Studies SUB ACUTE
• Repeated Dose 90 / 180 Days Toxicity Studies
• Carcinogenicity Studies
SUBCHRONIC &
CHRONIC
KPO Services
We offer “Quality Service” in IP and Market Analytic Sectors strengthening biological science, Pharma, business, law-IT sectors.
SWOT Analysis.
Trend Analysis.
Six Sigma.
IDEAL.
Ice-berg Studies.
KOL Assessment.
Process Optimization.
Study design & data management.
Licensing assessment.
Analysis & Interpretation.
Literature Review.
Patent, Non-Patent preparation.
LPO Services
IPR Services.
Research & Drafting Services.
Patent Drafting &
Filing Services.
Litigation Support.
CRO Services
We are committed to provide quality central laboratory services
for clinical trials, understanding fully that the reliability of
clinical laboratory data is crucial for the success of each trial.
We maintain the integrity and confidentiality of your research
which is critical to the well being of each study subject and
overall success of the trial. The lab provides services that meet
the required regulatory standards of the pharmaceutical industry.
PHARMACOKINETICS
ADME PK / In – vivo & In – Vitro
Efficacy
Physchem Studies
Batch Release Testing
In-Vitro
ADME (Absorption, Distribution, Metabolism, Excretion)
In vitro ADME studies help in optimization of
pharmacokinetic characteristics of a drug candidate identify
the metabolic pathways and provide valuable inputs for the
design of in vivo studies. We offer both standardized as
well as customized assays.
In-Vitro
• Permeability (Caco2, MDCK and PAMPA) • Aqueous Solubility • Metabolic stability and biotransformation • Test systems (microsomes, hepatocytes, S9, recombinant enzymes) • Species (rodent, guinea pig, rabbit, canine, non-human primate, human) • Protein binding (Equilibrium Dialysis and Ultrafiltration) • CYP Induction • CYP Isozyme Mapping • CYP Inhibition • Metabolite ID and profiling • Mass balance and drug disposition
Molecular Biology
DNA sequencing to DNA services have become routine tools in
drug discovery research, preclinical and clinical development. Both
basic and advanced DNA technologies are used on a daily basis in
most research laboratories. Dr Yellapragada Lifesciences Network
offers you a wide range of services have follows
Gene Regulation
• RNA interference, siRNA, shRNA,
• Micro RNA, miR RNA interference
• Immunoassays • Gene expression analysis
Nucleic Acid Analysis
• DNA isolation and purification • RNA isolation and purification • cDNA synthesis • DNA sequencing • Cloning • PCR analysis • Quantitative real time PCR
• DNA Library Creation • DNA Library Screening
Nucleic Acid Analysis
•Cloning of target genes into vectors • Gene Amplification and optimization (PCR) • Site directed mutagenesis • DNA Sequencing
• Microbial identification • Fragment analysis • DNA Sub-cloning • DNA and RNA Isolation • Northern blotting • Gene expression analysis by Real Time PCR
Proteomics
• Protein expression profiling (Array based) • SDS-PAGE • Immunoblotting
Immuno-Phenotyping
• Acute myeloid leukaemia characterization
• Acute lymphoblastic leukaemia characterization
• T-ALL diagnosis • B-ALL diagnosis
• Chronic lymph proliferative disorder diagnosis
• Hairy cell leukaemia • Multiple myeloma
Cell biology
Cell based assays
Cell-based assays are a vital early step in the testing of your
compounds and drug candidates for activity.
• Proprietary Cell-Based Assays
• High-throughput Fluorescence based assays
• Primary Cells and Proprietary Cell based assays
Cell Assays
• Angiogenesis • Apoptosis • Cell Migration • Cell Cycle analysis (Flow cytometer) • Cell Viability (MTT, SRB, CyQuant, 3H) • Inflammation and Cytokines assays • Reporter Gene assays (Luciferase) • Glucose Uptake
Cell and Diagnostic Applications
• Cell cycle analysis • Cell proliferation assays
• Apoptosis assays • Mitochondrial membrane potential analysis
• Oxidative burst assay • Reactive oxygen species analysis
• Autophagy assay • Immunofluorescence (confocal microscopy)
• Cell isolation and expansion • Cell immortalization • Cell sorting services
• Hematopoietic stem cell analysis
Pharmacology
In-Vivo
•We offer wide range of preclinical in vivo pharmacology efficacy studies in the
therapeutic areas of inflammation, pain, metabolic diseases etc. In-house bred and
imported animals would be used in the studies.
Inflammation and Pyrogen
• LPS induced sepsis model in mice.
• Adjuvant induced arthritis model in rats
• Collagen induced arthritis model in mice
• Carrageenan induced paw oedema model
• Rat air pouch model
Pharmacology
In-Vivo
Metabolic disorders
• Diabetic Neuropathy models
• STZ and nSTZ induced Diabetes modelslHFD + STZ induced Diabetes Models
• Genetically Modified mice (Lepr db/db mice)
Pain
• Formalin induced pain in rats
• Acetic acid induced writhing model in Swiss albino mice
• Evaluation of analgesic activity by Tail flick
• Apparatus and Eddy's hot plate methods.
Pharmacology
In-Vivo
Oncology
• Subcutaneous xenograft models
• Orthotopic tumor models
• Metastatic models
• Syngeneic models
• Hollow fibre assay
Infective
• LD50 determination (Systemic infection or Mouse protection model)
• Thigh infection model
• Lung infection model
Safety Pharmacology
CENTRAL NERVOUS SYSTEM
• Motor activity
• Behavior
• Body Temperature
• Sensory/ Motor reflexes
CARDIO VASCULAR SYSTEM
• Systolic & Diastolic BP
• Mean Arterial Pressure
• Heart Rate
Toxicology
Dr Yellapragada Lifesciences Drug discovery Network has facilities and expertise to
perform all aspects of health and environmental safety testing with animals. We
continue to develop new techniques in line with SOP based system with advances in
regulatory requirements and also constantly working towards 3R principle.
• GUIDELINES FOLLOWED
• OECD, OCSPP (OPPTS), EC, ICH, Schedule Y, ISO and custom design
Toxicology - In vivo
• Acute oral Toxicity – Up an d Down procedure (UDP)
• Acute oral Toxicity –Toxic Class method
• Acute Dermal Toxicity (Rat/Rabbit)
• Acute Dermal irritation in Rabbit
• Acute Eye irritation in Rabbit
• Skin sensitization in Guinea pig: Buehler test, Magnusson & Kligman
• Repeated Dose 28-Day Toxicity Study in Rodents
• 90-Day Oral Toxicity in Rodents
ROUTE OF ADMINISTRATION
Oral, Dermal, Intra dermal, Subcutaneous, Intravenous, Intra peritoneal and
Intramuscular
Geno-Toxicity Studies
The impact of any chemical on DNA is genotoxic ability of given test item. Effects
of chemicals on the genetic material form an integral part of research and regulatory
requirement.
• Ames Test
• Chromosomal aberration test
• In vivo Micronucleus test
Eco-Toxicology Studies
The impact of chemicals in Eco-system is regulatory requirement. The following
studies are conducted to draw the eco-toxic effect of given test item.
• Algae Growth Inhibition Test
• Acute Immobilization Test (Daphnia Sp.,)
• Acute Toxicity in Fish
• Earthworm, Acute Toxicity Test
• Acute Oral Toxicity Test – Japanese quail
Analytical Chemistry
Dr Yellapragada Lifesciences Drug discovery Network is equipped with advanced
instruments to cater the needs of chemists /researcher in the area of structural
elucidation, mass characterization, determination of true elements, separation science
etc. The following are the list of equipment's completely operational by experts in
analytical chemistry. In addition our chemists would offer on need basis, suggestion,
help and inputs for any of our client needs / problems etc.
High performance Liquid Chromatography (HPLC)
• HPLC Method Development (Analytical/Bio-analytical)
• Method Validation (Analytical / Bio-analytical)
• Qualitative analysis
• Quantitative analysis
• Routine sample analysis or Subject sample analysis
• Pharmacokinetics studies using HPLC
High performance Thin Layer Chromatography (HPTLC)
• HPTLC Method Development
• Method Validation
• Qualitative analysis (Profiling / finger printing)
• Quantitative analysis
• Stability Sample analysis
• Routine sample analysis or Subject sample analysis
Nuclear Magnetic Resonance Spectroscopy (NMR)
• 1H -Proton NMR • 13C NMR • Cosy • Nosy • DEBT 135 • HMQC • HSQC • HMBC • APT
Gas Chromatography coupled with Mass Spectrometry
(GCMS)
• GCMS Method Development (Analytical/Bio-analytical)
• Method Validation (Analytical/Bio-analytical)
• Qualitative analysis
• Quantitative analysis
• Routine sample analysis or Subject sample analysis
• Pharmacokinetics studies using GCMS
Inductive coupled plasma Mass Spectrometry (ICPMS)
ICPMS techniques are robust and suitable methods of trace metals analysis amenable
to a wide array of sample types. Metals, plastics, proteins, ceramics many others can
be successfully analyzed using ICPMS methods.
• Total sulphur and sulphur species in hydrocarbon fuels
• Organotin species in marine sediments and biota, consumer goods, and drinking
water
• Mercury species in fish, industrial discharges, and petroleum processing
• Arsenic species in marine algae, food products, and drinking water
Inductive coupled plasma Mass Spectrometry (ICPMS)
• Brominated and phosphorus-based flame retardants in consumer goods
• Phosphorus and sulphur in biological samples
• Protein- and peptide-bound metals
• Pesticides and herbicides
• Chemical warfare agents
• Volatile organo halides in air samples
Other Services
• Bio-Analytical
• On-going Projects
• Patent Works: New Molecule Identification, Drug Discovery-ADEMT TOX
Studies
• Medicinal / Phyto Chemistry Lab work Studies
• Structural Interpretation, X-ray Crystallography, Structure Identification, Docking
Studies
Value Added Services
As a part of value added services we offer solutions and services to
B.Tech, M.Tech, M.Sc., M.Phil, and PhD, in Lifesciences / Biological /
Basic & Analytical Sciences.
– Project guidance for Life sciences/ Biological/ Basic & Analytical
sciences.
– Wet lab/invitro facilities available.
– Career counseling.
– Protocol designing
Contact Us @
Vishnu Kiran.M || Head – Research & Marketing
Dr Yellapragada Lifesciences
No 8916, LIG -1, TNHB, Ayappakkam,
Ambattur, (OPP ICMR), Chennai - 600017 INDIA
Mob: +91.7299697960, +91.9962192013.
Email: [email protected] / [email protected]
