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Defense Against Infectious Disease (Core)

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For the IB Biology course

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Page 1: Defense Against Infectious Disease (Core)

Assessment Statements Obj

631 Define pathogen 1

632 Explain why antibiotics are effective against bacteria but not viruses 3

633 Outline the role of skin and mucous membranes in defense against pathogens 2

634 Outline how phagocytic leucocytes ingest pathogens in the blood and body tissues 2

635 Distinguish between antibodies and antigens 2

636 Explain antibody production 3

637 Outline the effects of HIV on the immune system 2

638 Discuss the cause transmission and social implications of AIDS 3

Assessment statements from Online IB Biology Subject GuideCommand terms httpi-biologynetibdpbiocommand-terms

Bacteriabull Prokaryotes (no real nucleus)bull Divide by binary fission

Can causebull Food poisoning (eg Salmonella)bull Ear and eye infectionsbull Cholera diarrhea

httpenwikipediaorgwikiFileEricson_Type_II_ConjunctivitisJPG

The 1918 flu epidemic killed between 50 and 130 million people httpenwikipediaorgwiki1918_flu_pandemic

Virusesbull Acellular (non-living)bull Need a lsquohostrsquo cell to carry out functions of life including reproductionbull Can have DNA or RNAbull Mutate evolve and recombine quickly

Causebull Flu HIVAIDS smallpox measles common cold herpes ebola

Fungibull Eukaryotes reproduce with spores

Cause bull Athletersquos foot mould ringwormbull Allergic reactions and respiratory

problemsImage from httpenwikipediaorgwikiAthletes_foot

Protozoabull Simple parasites

Causebull Malariabull Leishmaniasisbull Toxoplasmosis

Leishmaniasis image from httpenwikipediaorgwikiLeishmaniasis

Antibiotics are ineffective against viruses

httpwwwyoutubecomwatchv=RedO6rLNQ2o

Over-use of antibiotics is accelerating the evolution of more harmful bacteria We are running out of antibiotics that work and are selecting for diseases such as MRSA

Antibiotics are designed to disrupt structures or metabolic pathways in bacteria and fungibull cell walls and membranesbull DNA synthesis (replication)bull RNA polymerasebull Translation

These do not exist or are very different in viruses so the antibiotic will have no effect

Bacterial drug resisance from Wiley Essential Biochemistry Find out more herehttpwwwwileycomcollegepratt0471393878studentactivitiesbacterial_drug_resistanceindexhtml

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 2: Defense Against Infectious Disease (Core)

Bacteriabull Prokaryotes (no real nucleus)bull Divide by binary fission

Can causebull Food poisoning (eg Salmonella)bull Ear and eye infectionsbull Cholera diarrhea

httpenwikipediaorgwikiFileEricson_Type_II_ConjunctivitisJPG

The 1918 flu epidemic killed between 50 and 130 million people httpenwikipediaorgwiki1918_flu_pandemic

Virusesbull Acellular (non-living)bull Need a lsquohostrsquo cell to carry out functions of life including reproductionbull Can have DNA or RNAbull Mutate evolve and recombine quickly

Causebull Flu HIVAIDS smallpox measles common cold herpes ebola

Fungibull Eukaryotes reproduce with spores

Cause bull Athletersquos foot mould ringwormbull Allergic reactions and respiratory

problemsImage from httpenwikipediaorgwikiAthletes_foot

Protozoabull Simple parasites

Causebull Malariabull Leishmaniasisbull Toxoplasmosis

Leishmaniasis image from httpenwikipediaorgwikiLeishmaniasis

Antibiotics are ineffective against viruses

httpwwwyoutubecomwatchv=RedO6rLNQ2o

Over-use of antibiotics is accelerating the evolution of more harmful bacteria We are running out of antibiotics that work and are selecting for diseases such as MRSA

Antibiotics are designed to disrupt structures or metabolic pathways in bacteria and fungibull cell walls and membranesbull DNA synthesis (replication)bull RNA polymerasebull Translation

These do not exist or are very different in viruses so the antibiotic will have no effect

Bacterial drug resisance from Wiley Essential Biochemistry Find out more herehttpwwwwileycomcollegepratt0471393878studentactivitiesbacterial_drug_resistanceindexhtml

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 3: Defense Against Infectious Disease (Core)

The 1918 flu epidemic killed between 50 and 130 million people httpenwikipediaorgwiki1918_flu_pandemic

Virusesbull Acellular (non-living)bull Need a lsquohostrsquo cell to carry out functions of life including reproductionbull Can have DNA or RNAbull Mutate evolve and recombine quickly

Causebull Flu HIVAIDS smallpox measles common cold herpes ebola

Fungibull Eukaryotes reproduce with spores

Cause bull Athletersquos foot mould ringwormbull Allergic reactions and respiratory

problemsImage from httpenwikipediaorgwikiAthletes_foot

Protozoabull Simple parasites

Causebull Malariabull Leishmaniasisbull Toxoplasmosis

Leishmaniasis image from httpenwikipediaorgwikiLeishmaniasis

Antibiotics are ineffective against viruses

httpwwwyoutubecomwatchv=RedO6rLNQ2o

Over-use of antibiotics is accelerating the evolution of more harmful bacteria We are running out of antibiotics that work and are selecting for diseases such as MRSA

Antibiotics are designed to disrupt structures or metabolic pathways in bacteria and fungibull cell walls and membranesbull DNA synthesis (replication)bull RNA polymerasebull Translation

These do not exist or are very different in viruses so the antibiotic will have no effect

Bacterial drug resisance from Wiley Essential Biochemistry Find out more herehttpwwwwileycomcollegepratt0471393878studentactivitiesbacterial_drug_resistanceindexhtml

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 4: Defense Against Infectious Disease (Core)

Fungibull Eukaryotes reproduce with spores

Cause bull Athletersquos foot mould ringwormbull Allergic reactions and respiratory

problemsImage from httpenwikipediaorgwikiAthletes_foot

Protozoabull Simple parasites

Causebull Malariabull Leishmaniasisbull Toxoplasmosis

Leishmaniasis image from httpenwikipediaorgwikiLeishmaniasis

Antibiotics are ineffective against viruses

httpwwwyoutubecomwatchv=RedO6rLNQ2o

Over-use of antibiotics is accelerating the evolution of more harmful bacteria We are running out of antibiotics that work and are selecting for diseases such as MRSA

Antibiotics are designed to disrupt structures or metabolic pathways in bacteria and fungibull cell walls and membranesbull DNA synthesis (replication)bull RNA polymerasebull Translation

These do not exist or are very different in viruses so the antibiotic will have no effect

Bacterial drug resisance from Wiley Essential Biochemistry Find out more herehttpwwwwileycomcollegepratt0471393878studentactivitiesbacterial_drug_resistanceindexhtml

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 5: Defense Against Infectious Disease (Core)

Protozoabull Simple parasites

Causebull Malariabull Leishmaniasisbull Toxoplasmosis

Leishmaniasis image from httpenwikipediaorgwikiLeishmaniasis

Antibiotics are ineffective against viruses

httpwwwyoutubecomwatchv=RedO6rLNQ2o

Over-use of antibiotics is accelerating the evolution of more harmful bacteria We are running out of antibiotics that work and are selecting for diseases such as MRSA

Antibiotics are designed to disrupt structures or metabolic pathways in bacteria and fungibull cell walls and membranesbull DNA synthesis (replication)bull RNA polymerasebull Translation

These do not exist or are very different in viruses so the antibiotic will have no effect

Bacterial drug resisance from Wiley Essential Biochemistry Find out more herehttpwwwwileycomcollegepratt0471393878studentactivitiesbacterial_drug_resistanceindexhtml

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 6: Defense Against Infectious Disease (Core)

Antibiotics are ineffective against viruses

httpwwwyoutubecomwatchv=RedO6rLNQ2o

Over-use of antibiotics is accelerating the evolution of more harmful bacteria We are running out of antibiotics that work and are selecting for diseases such as MRSA

Antibiotics are designed to disrupt structures or metabolic pathways in bacteria and fungibull cell walls and membranesbull DNA synthesis (replication)bull RNA polymerasebull Translation

These do not exist or are very different in viruses so the antibiotic will have no effect

Bacterial drug resisance from Wiley Essential Biochemistry Find out more herehttpwwwwileycomcollegepratt0471393878studentactivitiesbacterial_drug_resistanceindexhtml

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 7: Defense Against Infectious Disease (Core)

Antibiotics are ineffective against viruses

Chlamydia trachomatis bacteria Are you ready for the end of antibiotics Guardian httpgucomp2jxgj

Analyse the graph below Over time outline what has happened tobull The number of new approved antibioticsbull The diversity of new approved antibiotics

Suggest reasons for your answers Use the graph to write your own DBQ practice questions

The scariest graph yoursquoll ever see Read the article by Maryn McKennahttpwwwwiredcomwiredscience201102not-many-antibiotics

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

  • Slide 1
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Page 8: Defense Against Infectious Disease (Core)

httpapchutecomlymphaticinflamhtml

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

  • Slide 1
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Page 9: Defense Against Infectious Disease (Core)

Phagocytic Leucocytesldquoeating cellrdquo ldquowhite blood cellsrdquo

Chemotaxis (movement in response to chemicals) attracts the phagocytes to the area of invasion as response to bull proteins produced by the pathogenbull phospholipids released by damaged cells

The phagocyte attaches to the pathogenrsquos cell surface proteins and then engulfs it The fluid nature of the plasma membrane allows this to happen

A phagosome forms This is a vesicle that contains the pathogen Lysosomes ndash vesicles of digestive enzymes ndash deposit the enzymes into the phagosome

The digestive enzymes break down the pathogen and the waste products are expelled from the cell by exocytosis

Review opportunity bull Plasma membranes and vesiclesbull Membrane fluidity and fusionbull Endo- and exo-cytosis

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

  • Slide 1
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Page 10: Defense Against Infectious Disease (Core)

Phagocytic Leucocytes card sort game order the images amp outline the processes

Images from httphigheredmcgraw-hillcomsites0072495855student_view0chapter2animation__phagocytosishtml

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Page 11: Defense Against Infectious Disease (Core)
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