Bioinformaticians to the rescue

Elena Sügis elena.sugis@.ut.ee

Have you ever thought of making the world a better

place with computer science?

http://www.scifiwright.com/2015/06/tomorrowland/

Slide credit: D.Fishman, Introduction to ML in bioinformatics

Bioinformatics

How we do science

lots of experiments

v

analysis

Science

knowledge

hypothesis

v v

The Wellcome Human Genome Library in London (Left CC: Russ London, Right Source: Wellcome Collection)

What’s in the bookcase?

The Wellcome Human Genome Library in London (Left CC: Russ London, Right Source: Wellcome Collection)

A single human genome

~3GB

Big Data

ATGCTCGTAC = 1mm

Tallinn - Jõgeva - Misso: 320 km

Slide image credit: P.Adler. Bioinformaatika, põnev väljakutse

Labs that produce data

Research groups that can analyse data

Labs that produce data

Experts to analyse data

Motivation

Labs that produce data

Experts to analyse data

MotivationLabs that produce data

Research groups that can analyse data

YOU?

Because Excel can’t help anymore

What kind of problems can we solve using bioinformatics?

Finding the right treatment

Illustration by Zhou Tao (ShanghaiDaily.com)

VS

ACCTTGCTTACC

Medical records

Slide image credit: D.Fishman, ML in bioinformatics

ACCTTGCTTACC

Medical records

How does The Perfect Bioinformatician look like?

ComputerScience

ComputerScience Biology

ComputerScience Biology

Statistics

ComputerScience Biology

Statistics

Bioinformatics is a broad field

Proteomics

Black magic

Machine learningModeling

AlgorithmsSequences

Perks of being a bioinformatician

BIIT 2016BIIT 2016

MEM

Working with smart colleagues

Learning something new everyday

http://boingboing.net/2015/05/11/the-only-technique-to-learn-so.html

Travelling

You can make an impact

http://www.scifiwright.com/2015/06/tomorrowland/

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

Genes are us…

and them.SOURCE:,JAVIER,HERRERO,,EUROPEAN,MOLECULAR,BIOLOGY,LABORATORY—EUROPEAN,BIOINFORMAT,ICS,INSTITUTE

50%

Illustration by Mari-Liis Allikivi