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Evaluation of the Cosmetic Power of a Product in Reducing Cellulite and Local Adiposity
Introduction
Cellulite is a cosmetic term used for areas of the skin that appear like an
orange peel or cottage cheese due to abnormal accumulation of lipocytes
just under the skin surface. This accumultion of lipids usually occurs on
the thighs, buttocks, and hips of both slim and overweight women.
Formation can begin as early as puberty but it is most evident in women
over 30. Men usually have no cellulite because the lipocytes are located
deeper and their disposition is such that the adipose tissue is more
connective and flat resulting to less pressure on the skin surface. In
women, lypocytes are located under the skin in groups separated by
collagen fibers. When the lipocytes swell due to increased lipid
biosynthesis, the groups swell while the connective tissue (collagen)
fibers stay the same, thereby causing the dimpling of the skin, the well
known characteristic of cellulite.
REGENESIS BioComplex
ANTICELLULITE CREME GEL
Causes of Cellulite
GENETIC CAUSES :heredity, vascular diseases, atherosclerosis, varicose veins.
ENVIRONMENTAL CAUSES: diet, aerobic and anaerobic exercise, oral contraceptives, sedentary life.
REGENESIS BioComplex
ANTICELLULITE CREME GEL
Instrumental Evaluation
Thermographic measurements are taken with ELC plates.
VIDEOCAP: epiluminescence polarized light immersion videodermoscopy.
REGENESIS BioComplex
ANTICELLULITE CREME GEL
Aim
• Through the test one can evaluate if the tested cosmetic product has got a cosmetic anti-cellulite effect, in particular if its daily use can significantly change the skin parameters of compactness, smoothness, complexion, orange peel, nodules, microcirculation and the impendance values.
Test Subjects
• 30 females with cellulite, with an age between 18 and 70 years of age, have been selected for the test, following the undermentioned inclusion criteria:
1. good state of general health2. no dermatopathies3. no pharmacological treatment in progress4. promise not to change the usual daily routine5. no atopy in the anamnesis
REGENESIS BioComplex
ANTICELLULITE CREME GEL
HISTOLOGY
NORMAL ASPECT
Network of Pre-CollagenReticular Fibrils
Blood Vessel
Adipocytes
Interstice between Adipocytes
Under normal conditions, the adipose tissue is well
sprinkled: the capillary vessels are very close to the
adipocytes’ cytoplasmatic membrane.
REGENESIS BioComplex
ANTICELLULITE CREME GEL
HISTOLOGY
PATHOLOGICAL ASPECT-1st and 2nd stage
The first consequence of the venular stasis is the
abnormal endhothelial permeability followed by the
transudation of plasma into the interstitial tissue.
Ectasia-microaneurisms ofblood transudate
Dissociation ofAdipocytes
Edematous
Transudate
Flooding of Interstices
REGENESIS BioComplex
ANTICELLULITE CREME GEL
HISTOLOGY
PATHOLOGICAL ASPECT -3rd stage PATHOLOGICAL ASPECT -4th stage
Representa t ion o f a m icronodu le : a
considerable number of altered adipocytes is
surrounded by a full-fledged capsule of
collagenous fibrils and consequently isolated
from the tissue.
The merging of several micronodules, having
microscopic dimension, give rise to so-called
macronodule, that can be detected through
digital palpation.
Capsule of thick-scleroialinotic
connetive fibrils
Adipocytes altered by
abiotrophic regressive
processes
Macronodule’s capsule
Micronodules forming
macronodule
Vol. 01
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/v
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Vol. 02
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
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Vol. 03
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
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Vol. 04
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 05
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
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Vol. 06
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 07
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
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Vol. 08
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 09
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 10
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 11
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 12
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 13
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 14
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 15
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 16
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 17
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 18
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 19
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
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Vol. 20
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 21
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 22
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 23
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 24
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 25
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 26
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 27
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
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Vol. 28
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 29
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v
Vol. 30
After 60 days of treatment
the structure of the capillaries improved and
the microhaemorrhages decreased
T= 0
T= 60 days
T= 60 days
Gens 01/p
Gens 01/v