FAT SOLUBLE FAT SOLUBLE VITAMINSVITAMINS

Dr Ayyub Patel, PhD CChem MRSC FRSC

Assistant Professor, Medicine KKU KSA

Lipid (FAT) solubleLipid (FAT) soluble Vitamins Vitamins

Retinoic acid -Vitamin ARetinoic acid -Vitamin A

Retinoic acid (Vitamin A)Retinoic acid (Vitamin A)• Active forms: Retinol, Retinal & Retinoic acid • Functions: Maintenance of reproduction Vision Promotion of growth Differentiation & maintenance of epithelial tissues Gene expression • Deficiency: impotence, night blindness, retardation of

growth, xerophthalmia • Signs & Symptoms: Dryness of cornea

Vitamin A- FunctionsVitamin A- Functions

Retinoic acid (Vitamin A)Retinoic acid (Vitamin A)

• Source: Liver, kidney, cream, butter, and egg yolk. Yellow and dark green vegetables are good source of the carotenes ( precursor of vitamin A )

• RDA: 800 – 1000 RE (retinol equivalents)

1 RE = 1 mg of retinol or

= 6 mg of β carotene

Cholecalciferol - Vitamin DCholecalciferol - Vitamin D

Cholecalciferol - Vitamin DCholecalciferol - Vitamin D

• Other Names: Ergocalciferol, cholecalciferol• Active form: 1,25-Dihydroxy-cholecalciferol• Function: Calcium uptake• Deficiency: Rickets in children Osteomalacia in adults

Sign and symptom: Soft, pliable bones

Cholecalciferol - Vitamin Cholecalciferol - Vitamin DD

• Source: Fatty fish, liver egg yolk, milk

• RDA: 5 mg cholecalciferol OR 200 IU of vitamin D

αα Tocopherol - Vitamin E Tocopherol - Vitamin E

αα Tocopherol - Vitamin E Tocopherol - Vitamin E• Active form: several derivatives of tocopherols • Function: Antioxidant• Deficiency: Rare

• Sign and symptom: red cell fragility leads to hemolytic anemia

• Source: Vegetable oils,(good source) liver, eggs

• RDA: 8 – 10 mg/day

Vitamin KVitamin K

Phylloquinone –Vitamin KPhylloquinone –Vitamin K• Active forms: Menadione, menaquinone, &

phylloquinone• Function: γ-Carboxylation of glutamate residue in clotting

and other proteins

• Deficiency: Rare in adults

• Sign and symptom: bleeding in children

• Source: Cabbage, cauliflower, spinch, egg yolk and liver• RDA: 70 – 140 mg/day