6 120
5
10
15
20
25
age in months
IR a
rea
[%
]
ntg
TMHT
*
6 120
5
10
15
20
25
age in months
IR a
rea
[%
]
******
###
6 120
5
10
15
20
25
age in months
IR a
rea
[%
]
*** *
##
6 120
5
10
15
20
25
age in months
IR a
rea
[%
]
* ***
6 120
5
10
15
20
25
age in months
IR a
rea
[%
]
6 120
5
10
15
20
25
age in months
IR a
rea
[%
]
*
#
Untangling Alzheimer´s Disease Hallmarks
in Sensory Systems of Rodent Models
´
β β
MATERIALS and METHODS
SUMMARY and CONCLUSION
BACKGROUND RESULTS
Joerg Neddens1, Magdalena Temmel1, Meritxell Aguilo Garcia1,2, Tina Loeffler1, Irati Aiestaran Zelaia1,
Vera Niederkofler1, Stefanie Flunkert1 and Birgit Hutter-Paier1
1QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria2Institute of Molecular Biosciences, University of Graz, Graz, Austria
A BChAT GAD67
CTH
GFAP Iba1
ptau Thr231D
FE
ChATGAD67
TH DAPI
ChATGAD67
TH DAPI
A TMHT – 6 months
ChATGAD67
TH DAPI
ntg – 12 months TMHT – 12 months
ChATGAD67
TH DAPI
GFAPIba1
pTau (PH-6)DAPI
GFAPIba1
pTau (PH-6)DAPI
GFAPIba1
pTau (PH-6)DAPI
GFAPIba1
pTau (PH-6)DAPI
GCL
NFL
IPL
OPL
IPL
ntg – 6 months
TMHT – 6 months
ntg – 12 months TMHT – 12 months
ntg – 6 months
B
C D
A B
C D
RESULTS