Año 7, N° 8, agosto 2021
TEMA: KION
Imagen: Zingiber officinale , Zingiberaceae, jengibre, rizoma
Extraído de: https://upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Zingiber_officinale_002.JPG/800px-Zingiber_officinale_002.JPG
Comentarios: licencia Creative Commons Attribution-Share Alike 3.0 Unported, no se realizó modificaciones a la imagen, solo está acorde al diagrama del marco
Autor: H. Zell
I. INTRODUCCIÓN
El jengibre (Zingiber officinale) es una especie medicinal, aromática y condimentaria que se
cultiva en regiones tropicales y subtropicales del mundo citado en [Zambrano, 2015].
Zingiber officinale es la planta más conocida de las 1200 especies pertenecientes a la
familia Zingiberaceae, muchas se reconocen por sus aromas, sabores y lo atractivo de sus
flores. En el caso del jengibre la parte más usada es el rizoma (tallo subterráneo
horizontal), apreciado por su aroma y sabor picante, citado en [Inecol].
Por tratarse de una especie de propagación vegetativa, su variabilidad genética tiende a ser
baja; sin embargo es posible hallar una amplia variabilidad genética principalmente en la
China e India, considerándose actualmente como el principal centro de origen y diversidad de
esta especie, citado en [Zambrano, 2015].
Se utiliza como un potente estimulante circulatorio y vasodilatador. Activa la digestión,
aumenta la motilidad intestinal. Acciones antiemético [MINAGRI].
Zingiber officinale
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I INTRODUCCIÓN 1-04
II COMPOSICIÓN QUÍMICA 05-06
III
ESTADÍSTICAS SOBRE SOLICITUDES DE
PATENTES RELACIONADAS Y ARTÍCULOS
CIENTÍFICOS
07-12
IV PUBLICACIONES CIENTÍFICAS 13-107
V TECNOLOGÍA ASOCIADA 108- 117
VI BIBLIOGRAFÍA 118
TABLA DE CONTENIDOS
Jengibre, autor: Filo gèn '
licencia Creative Commons Attribution-Share Alike 4.0 International
Extraído de: https://upload.wikimedia.org/wikipedia/commons/thumb/5/5f/Zingiber_officinale_%28Zingiberaceae%29.jpg/800px-Zingiber_officinale_%28Zingiberaceae%29.jpg
Taxonomía de Zingiber officinale
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La planta alcanza 1.5 metros de altura, con hojas largas de 20 cm; las flores están agrupadas en
una inflorescencia que sale de la base de la planta, tienen distintos colores según la variedad
tratada; generalmente son flores de tres sépalos amarillentos y tres pétalos de color guinda
con manchas claras, citado en [Inecol].
Botánica de Zingiber officinale
Extraído de: http://legacy.tropicos.org/Image/100165148.
Autor: S. Hameed . No se realizaron cambios
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La importancia nutricional del jengibre reside en su amplísimo espectro de aceites esenciales
(2,5-3%) y sustancias picantes no volátiles. Los principales componentes de la fracción de
sustancias picantes son los gingeroles, con un 25%. Un contenido elevado de gingeroles y un
sabor picante intenso son señal de frescura y calidad. Por su estructura química y acción, los
gingeroles son semejantes al ácido acetilsalicílico, por lo que presentan un efecto analgésico.
Como antagonistas de la serotonina, un neurotransmisor, los gingeroles actúan en el estómago
y el intestino contra la flatulencia, los espasmos y las náuseas. Junto con los shogaoles, los
gingeroles figuran entre las sustancias picantes que incluso durante la cocción experimentan
poca evaporación. Estimulan el flujo de saliva y la secreción de jugos gástricos. Al excitar los
receptores térmicos del estómago generan en él una sensación ardiente y cálida muy intensa.
Los principales componentes de los aceites esenciales son los sesquiterpenos como el
curcumeno y el alfafarneseno [Wichtl M., 1989; pharmakobotanik , 2007] citados en [U.
Siedentopp, 2008]. Su aroma característico se debe a la mezcla de isómeros cis y trans del
betaeudesmol y a los alcoholes sesquiterpénicos betasesquifelandrol y zingiberol. El olor a
limón es debido al neral y el geranial [Ärztezeitschrift für Naturheilverfahren, 2001] citado
en [U. Siedentopp, 2008]. Al analizar los nutrientes destaca el elevado contenido en agua
(81%) y los hidratos de carbono (11%). En cuanto a los minerales, posee cantidades apreciables
de potasio, fósforo, magnesio y hierro [Elmadfa I., et al, 2004] citado en [U. Siedentopp,
2008]. Además, el jengibre contiene numerosas sustancias vegetales secundarias con efectos
antioxidantes.
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Distribución mundial de Zingiber officinale
Extraído de: http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:798372-1
Es nativa de Assam, centro-sur de China, Himalaya oriental, India e introducida en Islas
Andamán, Bangladesh, Borneo, Camboya, Sudeste de China, Comoras, Costa Rica, Cuba,
República Dominicana, Islas del Golfo de Guinea, Hainan, Haití, Honduras, Islas de
Sotavento, Islas Menores de Sunda, Madagascar, Malaya, Mauricio, Suroeste de México,
Myanmar, isla Nicobar, Filipinas, Puerto Rico, Queensland, Rodrigues, Reunión, Sri Lanka,
Taiwán, Tailandia, Trinidad-Tobago, Vietnam, Windward, Tailandia, Trinidad-Tobago,
Vietnam, Islas de Barlovento, Tailandia, Trinidad-Tobago, Vietnam, Islas de Barlovento.
[Plants of the world online]
II. COMPOSICIÓN QUÍMICA
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6-gingerol 8-gingerol
10-gingerol quercetina
zingerona gingerenona-A
6-dehidrogingerdiona β-bisaboleno
α-curcumeno β-sesquifelandreno
zingibereno α-farneseno
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III. SOLICITUDES DE PATENTES RELACIONADAS Y
ARTÍCULOS
A. Publicaciones de patentes por año
Fuente: Clarivate analytics
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Este gráfico muestra las solicitudes publicadas a lo largo de los años, siendo la mayor cantidad en 2019 y
2020 con 282 y 221 publicaciones, respectivamente, además desde enero hasta inicios de agosto del año
2021, la cantidad de publicaciones relacionadas con Zingiber officinale ha sido de 148. Se observa
también que existe una fluctuación de publicaciones en todos los años, sin embargo se observa que
dichas cantidades son iguales o superiores a 200 solicitudes desde el 2016.
B. Solicitudes de patentes por año
Este gráfico muestra las solicitudes presentadas a lo largo de los años, siendo la mayor cantidad en 2010,
2014 y 2017 con 225 y 232 y 237 publicaciones, respectivamente, además desde enero hasta inicios de
agosto del año 2020, la cantidad de solicitudes relacionadas con Zingiber officinale ha sido de 98. Se
observa también que existe una fluctuación de solicitudes en todos los años, sin embargo se observa que
dichas cantidades son iguales o superiores a 200 solicitudes desde el 2016.
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C. Tendencias tecnológicas relacionadas a papaya
Este gráfico muestra las tendencias tecnológicas relacionadas a kion desde el 2002 hasta el 2021,
evidenciando picos de tecnologías entre el 2018 al 2020. Se observa también que existe una fluctuación
de las tecnologías involucradas de los campos biotecnológico, farmacéutico, alimentario, cosmético en la
siguiente leyenda:
Cáncer, tratamiento, administración, desorden, enfermedad, inhibidor, farmacéutico
Cáncer , tratamiento, administración, inhibidor, enfermedad, desorden, farmacéutico
Nutricional, extracto, suplemento, dietario, Lactobacillus, probiótico, sabor
Cosmético, cabello, piel, cuidado oral, surfactante, extracto, limpieza
Antimicrobiano, hongos, biofilm, crecimiento, nocivo, microbiano, compuesto
Grano de café, té, tostado, cafeína, clorogénico, expreso
Ácido nucleico, ARN, cáncer, proteína, ingeniería, enfermedad, tratamiento
Aditivo para alimento, alimento para mascota, rumiante, suplemento, Lactobacillus, bacilo,
probiótico
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Fuente: Clarivate analytics
D. Clasificación Internacional de Patentes
Las clasificaciones que se observan en la mayor cantidad de solicitudes corresponden a A61K y A61Q:
A61K 8/00 Cosméticos o preparaciones similares para el aseo [2006.01].
A61K 8/97 •••a partir de algas, hongos, líquenes o plantas; a partir de sus derivados [2017.01]
A61K 36/00 Preparaciones medicinales de constitución indeterminada que contienen sustancias
procedentes de algas, líquenes, hongos o plantas o sus derivados, p. ej. medicinas
tradicionales basadas en plantas [2006.01]
A61K 36/906 •••Zingiberaceae (familia del jengibre) [2006.01]
A61K 36/18 •Magnoliophyta (angiospermas) [2006.01]
A61K 36/185 ••Magnoliopsida (dicotiledóneas) [2006.01]
A61K 36/56 •••Loganiaceae (familia de la logania), p. ej. Spigelia [2006.01]
A61K 36/28 •••Asteraceae o Compositae (familia del áster o del girasol) p. ej. margarita, crisantemo,
aquilea o equinácea [2006.01]
A61K 36/9068 ••••Zingiber, p. ej. jengibre [2006.01]
A61Q 19/00 Preparaciones para el cuidado de la piel [2006.01]
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Fuente: Clarivate analytics
E. Los mayores solicitantes de invenciones por regiones
La mayor cantidad de solicitudes presentadas se encuentran en China, con 430 solicitudes, India con
329 solicitudes, Estados Unidos, con 326 solicitudes, seguido de la República de Corea con 285, por vía
PCT con 232 solicitudes, Australia con 104, Canadá con 85 solicitudes cada una, respectivamente. Entre
los países sudamericanos, se observan solicitudes de Brasil con 75 y México con 67.
F. Estado de las solicitudes
Como se observa en el gráfico, 1080 solicitudes se encuentran denegadas por algún paso administrativo
incompleto, fallido o caduco en trámite, 1234 solicitudes se encuentran en trámite u otorgadas y 409
solicitudes figuran como indeterminadas.
Página 11
Fuente: Clarivate analytics
Fuente: Clarivate analytics
G. Tendencias de uso
En el siguiente mapa cartográfico sobre Zingiber officinale, se observa que algunas islas describen
actividades en la investigación relacionadas a este recurso, por ejemplo, su uso en medicina tradicional,
investigaciones botánicas, formulaciones herbarias, crecimiento del cabello, formas de preparación así
como otras actividades fitoquímicas.
En el siguiente mapa cartográfico sobre Zingiber officinale, algunas islas contienen información en
los campos agrícola, conocimientos tradicionales, químico, alimentario y farmacéutico, dentro de los
cuales destacan los procedimientos de obtención de aceite, extractos que se encuentran relacionadas
entre ellas. En otras islas se muestran las áreas relacionadas donde se localizan terapias contra
enfermedades contra el cáncer, diabetes, colitis, entre otras.
Página 12
Fuente: Clarivate analytics
Fuente: Clarivate analytics
Fuente: https://www.mdpi.com/2304-8158/8/6/185/htm
IV. PUBLICACIONES CIENTÍFICAS
Página 13
Fuente: https://www.tandfonline.com/doi/abs/10.1080/09064710.2019.1606930
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Fuente: https://www.sciencedirect.com/science/article/abs/pii/S0959652619332688
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Fuente: https://clinphytoscience.springeropen.com/articles/10.1186/s40816-018-0097-4
Página 16
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Fuente: https://www.researchgate.net/profile/Augustine-Airaodion/
publication/331438134_Investigation_of_Aqueous_Extract_of_Zingiberofficinale_Root_Potential_in_the_Prevention_of_Peptic_Ulcer_in_Albino_Rats/
links/5c7926a4299bf1268d2e52e3/Investigation-of-Aqueous-Extract-of-Zingiberofficinale-Root-Potential-in-the-Prevention-of-Peptic-Ulcer-in-Albino-Rats.pdf
Fuente: https://www.researchgate.net/profile/Fang-Chen-56/
publication/316975019_Beneficial_effects_of_ginger_Zingiber_officinale_Roscoe_on_obesity_and_metabolic_syndrome_A_review/
links/5a2562280f7e9b71dd078b10/Beneficial-effects-of-ginger-Zingiber-officinale-Roscoe-on-obesity-and-metabolic-syndrome-A-review.pdf
Página 18
Fuente: https://www.sciencedirect.com/science/article/abs/pii/S1043466620302404
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Fuente: https://www.sciencedirect.com/science/article/abs/pii/S0044848618325249
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Fuente: https://link.springer.com/article/10.1007/s13337-020-00584-0
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Fuente: https://www.tandfonline.com/doi/abs/10.1080/87559129.2019.1573829
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Source: APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 180 (8): 1482-1496 DEC 2016
Title: Protective Effect of Zingiber officinale Against Dalton's Lymphoma Ascites Tumour by
Regulating Inflammatory Mediator and Cytokines
Author(s): Rubila, S | Ranganathan, TV | Sakthivel, KM
Date: DEC 2016
Author keywords: Zingiber officinale paste | Antitumour | GC-MS | Antioxidant enzymes |
Cytokines | 6-gingerol
Keywords plus: ANTIOXIDANT PROPERTIES | LIPID-PEROXIDATION | CANCER | GINGER |
EXTRACT | SYSTEM | ANTICANCER | METABOLISM | NUT
Publication year: 2016
Volume: 180
Abstract:
The aim of the present investigation was to evaluate Zingiber officinale paste against Dalton's
lymphoma ascites (DLA)-induced tumours in Swiss albino mice. Experimental animals received Z.
officinale paste (low dose 100 mg/kg bw and high dose 500 mg/kg bw) orally for eight alternative days.
Treatment with Z. officinale paste showed significant increase in haemoglobin level and decrease in
aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and
gamma glutamyl transferase (gamma-GT) level. Z. officinale paste reduced the inflammatory
mediators and cytokine levels, such as inducible nitric oxide (iNOS), tumour necrosis factor level (TNF-
alpha) and interleukin-1 beta (IL-1 beta). Treatment with Z. officinale paste also significantly increased
the antioxidant enzyme level, such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione
(GSH) and glutathione transferase (GST), and decreased the lipid peroxidation. Treatment also
increased the vitamin C and E levels in treated animals compared with the DLA-bearing host.
Histopathological studies also confirmed the protective influence of Z. officinale paste against DLA. The
present study suggested that Z. officinale paste could be used as natural spice and a potent antitumour
agent.
Source: PLANTS-BASEL | 8 (8): - AUG 2019
Title: Comparative and Phylogenetic Analyses of Ginger (Zingiber officinale) in the Family
Zingiberaceae Based on the Complete Chloroplast Genome
Author(s): Cui, YX | Nie, LP | Sun, W | Xu, ZC | Wang, Y | Yu, J | Song, JY | Yao, H
Date: AUG 2019
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Author keywords: Zingiber officinale | Zingiberaceae | complete chloroplast genome |
comparative analysis | phylogenetic analysis
Keywords plus: SEQUENCE | MITOCHONDRIAL | RATES
Publication year: 2019
Volume: 8
Abstract:
Zingiber officinale, commonly known as ginger, is an important plant of the family Zingiberaceae
and is widely used as an herbal medicine and condiment. The lack of chloroplast genomic information
hinders molecular research and phylogenetic analysis on ginger. We introduced the complete
chloroplast genome of Z. officinale and identified its phylogenetic position in Zingiberaceae. The
chloroplast genome of Z. officinale is 162,621 bp with a four-part circular structure and 36.1% GC
content. All 113 unique genes were annotated. A total of 78 simple sequence repeats (SSRs) and 42 long
repeat sequences, which are potential areas for species authentication, were found. Comparative
analysis revealed some highly variable regions, including rps16-trnQ-UUG, atpH-atpI, trnT-UGU-trnL-
UAA, ycf1, and psaC-ndhE. Moreover, the small single-copy (SSC) region was the most variable region
in all four shared regions, indicating that it may be undergoing rapid nucleotide substitution in the
family Zingiberaceae. Phylogenetic analysis based on all available chloroplasts of Zingiberales in the
National Center for Biotechnology Information indicated that Zingiber is a sister branch to Kaempferia
species. The availability of the Z. officinale chloroplast genome provided invaluable data for species-
level authentication and phylogenetic analysis and can thus benefit further investigations on species in
the family Zingiberaceae.
Source: FASEB JOURNAL | 34: - Suppl. S1 APR 2020
Title: Vaso-relaxant Effect of <it>Zingiber officinale</it> Extract Involves Release of Nitric Oxide
from the Endothelium
Author(s): Adebisi, IM | Bello, SO | Ugwah-Oguejiofor, CJ | Umaru, ML | Abubakar, K
Date: APR 2020
Author keywords:
Keywords plus:
Publication year: 2020
Volume: 34
Abstract:
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PLANT SCIENCES
Source: FASEB JOURNAL | 31: - Suppl. 1 APR 2017
Title: Ginger (Zingiber officinale) extract inhibits the lipid droplet accumulation and expression of
adipogenic transcription factors in 3T3-L1 preadipocytes
Author(s): Kim, HJ | Mun, EG | Oh, JH | Cha, YS
Date: APR 2017
Author keywords:
Keywords plus:
Publication year: 2017
Volume: 31
Abstract:
Abubakar, Kabiru
Source: JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 22 (2): 526-534 MAR 4 2019
Title: Molluscicidal Activity of the Essential Oil of Zingiber officinale Roscoe Rhizomes
Author(s): Gomes, PRB | Fernandes, RP | Reis, JB | Fontenele, MA | de Freitas, AC | da Silva, JC | de
Oliveira, RWS | Lyra, WD | de Paula, MD | Louzeiro, HC | Mouchrek, VE
Date: MAR 4 2019
Author keywords: Volatile constituents | Zingiber officinale Roscoe | hydrodistillation |
Biomphalaria glabrata | Schistosomiasis | alpha-Zingiberene
Keywords plus: GINGER | SCHISTOSOMIASIS | ANTIFUNGAL | PLANTS
Publication year: 2019
Volume: 22
Abstract:
This work evaluated the molluscicidal activity of the essential oil of the Zingiber officinale Roscoe
rhizomes in with of the Biomphalaria glabrata species. The essential oil was isolated quantitatively
by hydrodistillation and the oil was characterized analytically by gas chromatography coupled to mass
spectrometry and the LC50 of the oil was calculated from the methods of Reed-Muench & Pizzi,
respectively. From this, 18 components were identified, the main ones being A-zingiberene, geranial and
nerolidol. The essential oil obtained LC50 of 56.23 mg.L-1 and mortality of the snails in the
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concentration of 75 mg.L-1 in 72 hours. It was concluded that this essential oil has molluscicidal activity.
Source: INORGANIC AND NANO-METAL CHEMISTRY | 48 (2): 139-145 2018
Title: Sunlight mediated rapid synthesis of small size range silver nanoparticles using Zingiber
officinale rhizome extract and its antibacterial activity analysis
Author(s): Mathew, S | Prakash, A | Radhakrishnan, EK
Date: 2018
Author keywords: Silver nanoparticles | green synthesis | sunlight | small sized nanoparticles |
antibacterial | Zingiber officinale
Keywords plus: GREEN SYNTHESIS | ANTIMICROBIAL ACTIVITY | ROOT EXTRACT | LEAF
EXTRACT | LINN.
Publication year: 2018
Volume: 48
Abstract:
Herein we report the green synthesis of silver nanoparticles (AgNPs) completed within a rapid time of 2
hrs using Zingiber officinale rhizome extract in presence of sunlight. Characterization of
nanoparticles was carried out by UV-Vis spectroscopy, HR-TEM, XRD and FTIR. Under TEM analysis,
the size of the biosynthesized AgNPs was found to be remarkably small with size range of 4 to 15 nm.
The AgNPs also exhibited excellent antibacterial activity against Staphylococcus aureus and
Escherichia coli. MIC and MBC was found to be 62.5 mu g/mL and 500 mu g/mL for S. aureus, 125
mu g/mL and 250 mu g/mL for E. coli respectively.
Source: BIOLOGICAL TRACE ELEMENT RESEARCH | 170 (2): 330-330 APR 2016
Title: Genetic and Histopathological Responses to Cadmium Toxicity in Rabbit's Kidney and Liver:
Protection by Ginger (Zingiber officinale) (vol 170, pg 320, 2016)
Author(s): Baiomy, AA | Mansour, AA
Date: APR 2016
Author keywords:
Keywords plus:
Publication year: 2016
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Volume: 170
Abstract:
Source: HOLISTIC NURSING PRACTICE | 33 (1): 60-65 JAN-FEB 2019
Title: Natural Health Strategies for Pain Care, Part I: A Phytomedicine Compendium
Author(s): Ross, SM
Date: JAN-FEB 2019
Author keywords:
Keywords plus: GINGER ZINGIBER-OFFICINALE | TOPICAL CAPSAICIN | DOUBLE-BLIND | TNF
-ALPHA | CURCUMIN | EFFICACY | OSTEOARTHRITIS | METAANALYSIS | EXTRACTS | ARNICA
Publication year: 2019
Volume: 33
Abstract:
Source: INTERNATIONAL FOOD RESEARCH JOURNAL | 23 (2): 837-841 2016
Title: Chemical constituents and antibacterial activities of crude extract and essential oils of Alpinia
galanga and Zingiber officinale
Author(s): Hamad, A | Alifah, A | Permadi, A | Hartanti, D
Date: 2016
Author keywords: Crude extract | Essential oils | Alpinia galanga | Zingiber officinale | Chemical
constituents | Antimicrobial activity
Keywords plus: ANTIOXIDANT ACTIVITY | COMBINATION | LINN.
Publication year: 2016
Volume: 23
Abstract:
Crude extract and essential oils from dried rhizome of two Zingiberaceae family plants, Alpinia
galanga and Zingiber officinale, were evaluated for their chemical constituents and antimicrobial
activity. The essential oils were analyzed by Gas Chromatography - Mass Spectroscopy (GCMS). The
abundant constituents for A. galanga were cineole, 4-allylphenyl acetate, alpha-farnesene, (2,6-
dimethylphenyl) borate and alpha-pinene; and for Z. officinale were cineole, 2,2-dimethyl-3-
Página 27
methylenenorbornane, alpha-curcumenene, beta-sesquiphellandrene and rosefuran epoxide. Alpha-
pinene, 2,2-dimethyl-3-methylenenorbornane, beta-pinene, beta-mircene, cineole, beta-citral, alpha-
citral, bornyl acetate, alpha-curcumene, alpha-zingiberene, beta-sesquiphellandrene, and hexadecanoic
acid are detected in both galangal and ginger rhizomes. Minimum Inhibitory Concentration (MIC) of
essential oils and crude extracts were evaluated by broth dillution method against foodborne bacteria
Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Salmonella typhymurium and
Vibrio cholera. MIC of crude extract and essential oils of galangal and ginger against all tested
microogranisms were relatively high. (c) All Rights Reserved
Source: EUROPEAN PSYCHIATRY | 33: S593-S594 Suppl. S MAR 2016
Title: Post menopausal women's sexual satisfaction: Effect of oral capsule of mixed Tribulus
Terrestris, Zingiber Officinale, Crocus Sativus and Cinnamomum Verum: A randomized
controlled clinical trial
Author(s): Taavoni, S | Ekbatani, NN | Gooshegir, SA | Haghani, H
Date: MAR 2016
Author keywords:
Keywords plus:
Publication year: 2016
Volume: 33
Abstract:
Source: PLANTA MEDICA | 82: - Suppl. 1 DEC 2016
Title: Ginger oil and its active ingredient, citral, relax rat airway smooth muscle by calcium channel
blockade
Author(s): Mangprayool, T | Chudapongse, N
Date: DEC 2016
Author keywords: Ginger oil | Zingiber officinale | citral; bronchodilation | calcium channel
Keywords plus: EXTRACT | NAUSEA
Publication year: 2016
Volume: 82
Abstract:
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Source: NANOMATERIALS | 9 (9): - SEP 2019
Title: Zingiber officinale Extract (ZOE) Incorporated with Layered Double Hydroxide Hybrid
through Reconstruction to Preserve Antioxidant Activity of ZOE against Ultrasound and Microwave
Irradiation
Author(s): Kim, HJ | Lee, SB | Choi, AJ | Oh, JM
Date: SEP 2019
Author keywords: layered double hydroxide | Zingiber officinale extract | antioxidant activity |
ultrasound | microwave irradiation | protection
Keywords plus: INTRACRYSTALLINE STRUCTURE | CONTROLLED-RELEASE | GINGER
EXTRACT | INTERCALATION | CALCINATION | CHEMISTRY | DELIVERY | MG | CO
Publication year: 2019
Volume: 9
Abstract:
We prepared Zingiber officinale extract (ZOE) incorporated in a layered double hydroxide (LDH)
hybrid through a reconstruction method in order to preserve the antioxidant activity of ZOE from
ultrasound and microwave irradiation. X-ray patterns, infrared spectroscopy, and scanning electron
microscopy suggested that ZOE moieties were encapsulated in the interparticle space of reconstructed
LDH, thus preserving its intact structure. Dynamic light scattering and zeta-potential measurement also
supported the hypothesis that ZOE moieties were located in the interparticle pore of LDH rather than at
the surface of LDH particles. Thermogravimetry analysis revealed that thermal stability of encapsulated
ZOE could be enhanced by LDH encapsulation. Radical scavenging assay showed that antioxidant
activity of ZOE-LDH hybrid was increased after ultrasound and microwave irradiation, while ZOE itself
dramatically lost its antioxidant activity upon ultrasound and microwave treatment.
Source: JOURNAL OF FOOD BIOCHEMISTRY | 44 (7): - JUL 2020
Title: The role of mTOR and oral intervention of combined Zingiber officinale-Terminalia
chebula extract in type 2 diabetes rat models
Author(s): Mathiyazhagan, J | Muthukaliannan, GK
Date: JUL 2020
Author keywords: mTOR | RIN-5F | Terminalia chebula | type 2 diabetes | Zingiber officinale
Keywords plus: INSULIN-RESISTANCE | CHOLESTEROL | CANCER | GROWTH | RETZ. | ASSAY
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Publication year: 2020
Volume: 44
Abstract:
The present study examined the potential of Zingiber officinale-Terminalia chebula extract alone
(ZO and TC) and in combination (ZOTC) against type 2 diabetes via downregulation of mechanistic
target of rapamycin (mTOR). The 1:4 (ZOTC) ratio showed high cell survival percentage against the rat
insulinoma cell line (RIN-5F) when compared to other possible ratios of ZOTC. Oral administration of
ZO alone, TC alone, combined ZOTC (1:4), and the positive control metformin (Met) in fructose-
streptozotocin (STZ) -induced diabetic rats showed reduced blood glucose levels, reduced insulin
resistance (HOMA-IR), increased insulin levels, and increased pancreatic beta cell function (HOMA-
beta). ZOTC treatment in diabetic rats ameliorated the antioxidant status without affecting liver and
serum parameters. Histological evaluation of the pancreas was performed to find pathological changes;
the transcriptional and immunohistochemistry results showed reduced mTOR expression in the
pancreas during ZOTC treatment. Conclusively, the results obtained suggest that ZOTC treatment
against fructose-STZ-induced type 2 diabetes rat models can help regulate blood glucose, insulin levels,
and normalize pancreatic beta cell damage. Practical applications Type 2 diabetes is a chronic metabolic
disorder that affects a large number of populations worldwide. Zingiber officinale (ZO) and
Terminalia chebula (TC) has been used in traditional medicine since ancient times against various
ailments, including diabetes. In this study, we reported the effect of the combined ZOTC that showed
significant blood glucose reduction and increased insulin levels via mTOR when compared to individual
treatments. This finding is valuable for food technologists and alternative medicine practitioners to
know the antidiabetic effect of the ZOTC combination.
Source: INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE | 16 (2): 256-262 APR 2017
Title: Development of chewable tablet of Trikatu churna and standardization by densitometry
Author(s): Tripathi, SM | Sharma, RJ | Bansal, AK | Bhutani, KK | Singh, IP
Date: APR 2017
Author keywords: Piper longum | Piper nigrum | Zingiber officinale | Trikatu | Densitometry
| HPTLC
Keywords plus: AYURVEDIC FORMULATION
Publication year: 2017
Volume: 16
Abstract:
Página 30
Trikatu is a well known polyherbal powder form formulation in Ayurveda consisting of Piper longum
L. fruit, Piper nigrum L. fruit and Zingiber officinale Rosc. rhizome in equal amounts, i.e., 1:1:1
ratio. It is prescribed for cold, fever, asthma, cough, respiratory problems and treatment of digestive
disorders. The aim of the present study was to develop and validate a densitometric method for the
identification and quantification of piperine and 6-gingerol in the crude drug Trikatu as the markers for
quality of raw materials and to develop a well characterized formulation of Trikatu as a chewable tablet.
Source: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 31 (2): 491-498 MAR 2018
Title: Synergistic potential of Zingiber officinale and Curcuma longa to ameliorate diabetic-
dyslipidemia
Author(s): Hussain, N | Hashimi, AS | Wasim, M | Akhtar, T | Saeed, S | Ahmad, T
Date: MAR 2018
Author keywords: Diabetic-dyslipidemia | Phytomedicine | Zingiber officinale | Curcuma longa | 6-
Gingerol | Curcumin | HPLC
Keywords plus: EXTRACT | METABOLISM
Publication year: 2018
Volume: 31
Abstract:
To find the cure of world's one of the leading morbid and mortal disorders; diabetes mellitus and its
most prevalent complication, 'diabetic-dyslipidemia', is one of the leading health challenges of 21st
century. The use of phytomedicine is a glimmer of hope in this scenario. Studies of current decade have
shown that methanolic extracts of Zingiber officinale and Curcuma longa have highly effective
therapeutic potentials against the aforesaid disorders, however, which of the extracts has more potential
is still unclear. Furthermore, synergistic effect of the extracts has never been studied. Forty-eight Albino
adult rats of either sex were randomly divided into eight groups. A-D groups were containing healthy
rats while E-H groups were of induced diabetic-dyslipidemic rats. For forty-two days, rats of each group
were given either distilled water or Zingiber officinale methanolic extract (ZOME) or Curcuma
longa methanolic extract (CLME) or ZOME+CLME therapies at dose rate of 300mg/100 mL dist.
H2O/kg body wt/day. FPG and lipid profiles were estimated before and after the trial, and were
statistically analyzed by one-way ANOVA along with Post hoc Tukey's multiple comparison tests.
Although, ZOME and CLME significantly (P<0.05) lowered fasting plasma glucose (FPG) levels and
controlled lipid profiles in diabetic-dyslipidemic rats; yet, synergistic therapy of both extracts
(ZOME+CLME) most significantly (P<0.05) controlled all parameters of diabetic-dyslipidemia (78.00
+/- 1.06mg/dL FPG, 62.00 +/- 0.58mg/dL TG, 66.50 +/- 0.76mg/dL cholesterol, 32.00 +/- 0.36mg/dL
Página 31
HDL, 22.43 +/- 0.64 mg/dL LDL, and 12.40 +/- 0.12mg/dL VLDL). Our findings may be useful to
formulate new medicines having multiple potentials to control diabetes mellitus, dyslipidemia, and
diabetic-dyslipidemia.
Source: NATIONAL ACADEMY SCIENCE LETTERS-INDIA | 41 (6): 341-343 DEC 2018
Title: Invasive Hypogeic Mealybug, Formicococcus polysperes Williams (Hemiptera:
Pseudococcidae) on Turmeric (Curcuma longa Linnaeus): A New Host Record
Author(s): Firake, DM | Joshi, S | Rajappa, JJ | Behere, GT
Date: DEC 2018
Author keywords: Zingiber officinale | Northeast India | Meghalaya | Biology
Keywords plus: INDIA
Publication year: 2018
Volume: 41
Abstract:
The turmeric, Cucurma longa Linnaeus (Zingiberaceae) is one of the most important commercial
spice crop grown in different parts of India including Meghalaya state. Invasive hypogeic mealybug,
Formicococcus polysperes Williams (Hemiptera: Pseudococcidae) is reported for the first time
infesting rhizomes of turmeric under field conditions. Information on basic biological attributes on two
important hosts and field infestation of F. polysperes on turmeric is reported and discussed. In
laboratory conditions, female F. polysperes completed life cycle in 56.33 +/- 6.64 and 50.67 +/-
4.91days on ginger (Zingiber officinale Roscoe) and Cucurma longa Linnaeus, respectively. Although,
considerable yield losses were not observed due to infestation of F. polysperes on turmeric, studies on
chemical composition especially curcumin content' of infested and healthy turmeric rhizomes would be
essential in future to know the indirect losses due to F. polysperes.
Source: ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 91 (4): - 2019
Title: Zingiber officinale formulation reduces hepatic injury and weight gain in rats fed an unhealthy
diet
Author(s): Leal, DT | Fontes, GG | Villa, JKD | Freitas, RB | Campos, MG | Carvalho, CA | Pizziolo, VR
| Diaz, MAN
Date: 2019
Author keywords: cafeteria diet | gingerol | nonalcoholic fatty liver disease | oxidative stress | shogaol
Página 32
| Zingiber officinale
Keywords plus: FATTY LIVER-DISEASE | ANTIOXIDANT CAPACITY | LIPID-PEROXIDATION |
METABOLIC SYNDROME | ETHANOLIC EXTRACT | INDUCED OBESITY | GINGER | 6-GINGEROL |
INSULIN | ACCUMULATION
Publication year: 2019
Volume: 91
Abstract:
This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse
health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and
three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals
were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight,
hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic
glutathione S-transferase concentration, compared to the control group, which received commercial
chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body
weight and 66% of the total area of lipid droplets deposited, compared to the group that received the
cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in
malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver.
The cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile,
liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial
effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative
stress and hepatic injury.
Source: JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 21 (6): 1542-1549 NOV 2 2018
Title: Chemical Composition and Skin Protective Effects of Essential Oil Obtained from Ginger (Zingiber
officinale Roscoe)
Author(s): Feng, J | Du, ZY | Zhang, LY | Luo, WQ | Zheng, YT | Chen, DK | Pan, WY | Yang, ZW | Lin,
L | Xi, LY
Date: NOV 2 2018
Author keywords: Ginger | essential oils | nude mice | UVB | anti-wrinkle
Keywords plus: TECHNOLOGY | CHEMISTRY
Publication year: 2018
Volume: 21
Página 33
Abstract:
This study aimed to determine the chemical composition and skin protective effects of essential oil from
ginger (Zingiber officinale Roscoe), a traditional Chinese medicine, spice, and food. Essential oil was
extracted from ginger by hydrodistillation. Forty-three compounds were identified in ginger essential oil
(GEO) by using gas chromatography-mass spectrometry. GEO comprised alpha-zingiberene (26.00 %),
beta-sesquiphyllandrene (8.10 %), alpha-curcumene (7.99 %), alpha-bergamotene (7.99 %), beta-
bisabolene (7.47 %), and ar-turmerone (3.86 %). Skin damage induced by eight-week Ultraviolet B
(UVB) irradiation, including erythema, wrinkles, and skin inflammation in nude mice. GEO treatment at
three different concentrations ameliorated UVB-induced skin inflammation and inhibited interleukin-1
beta and tumour necrosis factor-alpha expression in skin tissues. Therefore, GEO adequately protected
the skin from UVB irradiation and photoaging.
Source: JOURNAL OF PEST SCIENCE | 91 (2): 887-895 MAR 2018
Title: Essential oils cause detrimental effects on biological parameters of Trichogramma galloi
immatures
Author(s): Parreira, DS | Alcantara-de la Cruz, R | Zanuncio, JC | Lemes, PG | Rolim, GD | Barbosa,
LR | Leite, GLD | Serrao, JE
Date: MAR 2018
Author keywords: Immature stages | Natural products | Parasitoids | Reproductive performance |
Selectivity
Keywords plus: FRUGIPERDA LEPIDOPTERA-NOCTUIDAE | PRETIOSUM HYMENOPTERA
TRICHOGRAMMATIDAE | BOTANICAL INSECTICIDES | HEMIPTERA-PENTATOMIDAE |
AZADIRACHTA-INDICA | NATURAL-PRODUCTS | EGG PARASITOIDS | MELIA-AZEDARACH |
NEEM OIL | TOXICITY
Publication year: 2018
Volume: 91
Abstract:
Essential oils from botanical extracts used for insect pest control should be both effective and have low
impact on natural enemies. The objective was to evaluate the effects of ten essential oils on the biological
and reproductive parameters in two Trichogramma galloi Zucchi (Hymenoptera:
Trichogrammatidae) generations. The emergence F-1 generation of T. galloi was reduced by more than
30% with Allium sativum, Carapa guianensis, Citrus sinensis, Neem and Syzygium
aromaticum. Zingiber officinale reduced the T. galloi emergence of the F-1 and F-2 generations by
Página 34
between 30 and 99%. The longevity of the F-1 generation was reduced by more than 50% with Z.
officinale at the pre-pupae and pupae stages. All oils reduced the parasitism rate of the F-1 generation in
the egg-larva and pre-pupa stages. Allium sativum, C. guianensis and C. sinensis, Neem and
Origanum vulgare reduced parasitism by between 30 and 79%. Zingiber officinale was slightly and
moderately harmful to the F-1 and F-2 generations, respectively, for the T. galloi parasitism. The sex
ratio of the two T. galloi generations was not affected by the essential oils. The low side effects of the
oils on the F-2 generation, except for Z. officinale (the most harmful oil), suggest that T. galloi
developed some post-transgenerational tolerance/resistance mechanisms to these oils and/or their
components. The A. sativum, C. guianensis, C. sinensis, Neem, O. vulgare, S. aromaticum and
Z. officinale oils were not selective for T. galloi. Mentha piperita, Piper nigrum and Thymus
vulgaris essential oils can be included in integrated pest management programs for this parasitoid.
Source: CHEMICO-BIOLOGICAL INTERACTIONS | 270: 15-23 MAY 25 2017
Title: Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on
chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats
Author(s): Abolaji, AO | Ojo, M | Afolabi, TT | Arowoogun, MD | Nwawolor, D | Farombi, EO
Date: MAY 25 2017
Author keywords: Chlorpyrifos | Zingiber officinale | Female reprotoxicity | Neurotoxicity |
Oxidative damage | Inflammation
Keywords plus: GLUTATHIONE S-TRANSFERASES | INDUCED TOXICITY | NITRIC-OXIDE |
DROSOPHILA-MELANOGASTER | REPRODUCTIVE TOXICITY | SUPEROXIDE-DISMUTASE |
ANTIOXIDANT ENZYMES | LIPID-PEROXIDATION | ULCERATIVE-COLITIS | EXPRESSION
Publication year: 2017
Volume: 270
Abstract:
Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and
household environments. 6-Gingerol-rich fraction from Zingiber officinale (Ginger, 6-GRF) has been
reported to possess potent anti-oxidative, anti-inflammatory and anti-apoptotic properties. Here, we
investigated the protective properties of 6-GRF on CPF-induced oxidative damage and inflammation in
the brain, ovary and uterus of rats. Five groups of rats containing 14 rats/group received corn oil
(control), CPF (5 mg/kg), 6-GRF (100 mg/Kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg)
+ 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively. The results showed that 6-
GRF protected against CPF-induced increases in oxidative stress ((hydrogen peroxide (H2O2) and
malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) and tumour
Página 35
necrosis factor-alpha (TNF- alpha)), and apoptotic (caspase-3) markers. Also, 6-GRF improved the
activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx),
and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary and uterus of
rats exposed to CPF (p < 0.05). Overall, the protective effects of 6-GRF on CPF-induced toxicity in the
brain and reproductive organs of rats may be due to its potent antioxidative, anti-inflammatory and
antiapoptotic properties. (C) 2017 Elsevier B.V. All rights reserved.
Source: FOODS | 7 (4): - APR 2018
Title: How Safe Is Ginger Rhizome for Decreasing Nausea and Vomiting in Women during Early
Pregnancy?
Author(s): Stanisiere, J | Mousset, PY | Lafay, S
Date: APR 2018
Author keywords: pregnancy | Zingiber officinale R | ginger | NVP | toxicity | safety | adverse
effects | food supplement | CAM
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | ALTERNATIVE MEDICINE USE |
POSTPARTUM PERIOD | COMPLEMENTARY | EXTRACT | TOXICITY | PHARMACOKINETICS |
CLASSIFICATION | 6-GINGEROL | VITAMIN-B6
Publication year: 2018
Volume: 7
Abstract:
Ginger, Zingiber officinale Roscoe, is increasingly consumed as a food or in food supplements. It is
also recognized as a popular nonpharmacological treatment for nausea and vomiting of pregnancy
(NVP). However, its consumption is not recommended by all countries for pregnant women. Study
results are heterogeneous and conclusions are not persuasive enough to permit heath care professionals
to recommend ginger safely. Some drugs are also contraindicated, leaving pregnant women with NVP
with few solutions. We conducted a review to assess effectiveness and safety of ginger consumption
during early pregnancy. Systematic literature searches were conducted on Medline (via Pubmed) until
the end of December 2017. For the evaluation of efficacy, only double-blind, randomized, controlled
trials were included. For the evaluation of the safety, controlled, uncontrolled, and pre-clinical studies
were included in the review. Concerning toxicity, none can be extrapolated to humans from in vitro
results. In vivo studies do not identify any major toxicities. Concerning efficacy and safety, a total of 15
studies and 3 prospective clinical studies have been studied. For 1 g of fresh ginger root per day for four
days, results show a significant decrease in nausea and vomiting and no risk for the mother or her future
baby. The available evidence suggests that ginger is a safe and effective treatment for NVP. However,
Página 36
beyond the ginger quantity needed to be effective, ginger quality is important from the perspective of
safety.
Source: JOURNAL OF NATURAL MEDICINES | 72 (2): 530-536 MAR 2018
Title: Inhibitory effect of bofutsushosan (fang feng tong sheng san) on glucose transporter 5 function in
vitro
Author(s): Gao, SL | Satsu, H | Makino, T
Date: MAR 2018
Author keywords: Glucose transporter 5 | Fructose | Bofutsushosan | Zingiber officinale | 6-gingerol
Keywords plus: HEALTH
Publication year: 2018
Volume: 72
Abstract:
Bofutsushosan (BTS; fang feng tong sheng san in Chinese) is a formula in traditional Japanese Kampo
medicine and Chinese medicine comprising eighteen crude drugs, and is used to treat obesity and
metabolic syndrome. Fructose is contained in refreshing beverages as high-fructose corn syrup, and is
associated with obesity. Fructose is absorbed via glucose transporter 5 (GLUT5) in the intestine.
Therefore, the inhibition of GLUT5 is considered to be a target of obesity drugs. We evaluated the
inhibitory effects of BTS extract and its constituents on fructose uptake using Chinese hamster ovary K1
cells, i.e., cells stably expressing GLUT5. Boiled water extract of BTS significantly suppressed GLUT5
function in a concentration-dependent manner without cytotoxicities. Among 18 components of BTS,
the boiled water extracts of the rhizome of Zingiber officinale, the root and rhizome of
Saposhnikovia divaricata, and the root of Platycodon grandiflorum exhibited significant inhibitory
effects on fructose uptake with IC50 values of 314, 119 and 475 A mu g/ml, respectively. Among the
constituents of the rhizome of Z. officinale extract, 6-gingerol significantly inhibited GLUT5 with an
IC50 value of 39 A mu M, while 6-shogaol exhibited a significant but weak inhibition on GLUT5 at 100
A mu M. One of the mechanisms of action of BTS may be the inhibition of fructose absorption in the
intestine, and one of the active components of BTS is the rhizome of Z. officinale and 6-gingerol.
Source: JOM | 70 (6): 982-987 JUN 2018
Title: Insights into Comparative Antimicrobial Efficacies of Synthetic and Organic Agents: The Case of
ZnS Nanoparticles and Zingiber officinale Rosc.
Author(s): Obidi, OF | Nejo, AO | Ayeni, RA | Revaprasadu, N
Página 37
Date: JUN 2018
Author keywords:
Keywords plus: MEDICINAL-PLANTS | SAFETY | GINGER
Publication year: 2018
Volume: 70
Abstract:
The differences among the antimicrobial activities of synthetic nanoparticles (NPs), organic agents and
conventional antibiotics against human pathogens are little known. We compared the antimicrobial
activities of aqueous, ethanol and ethyl acetate extracts of Zingiber officinale rhizomes with ZnS NPs
and tetracycline/nystatin using agar-diffusion techniques. Transmission electron microscopy (TEM),
Fourier transform infrared (FTIR) and ultraviolet spectroscopy were used to characterize ZnS NPs. At
100 mg/ml, ethanol and ethyl acetate extract inhibited Acinetobacter baumannii, Salmonella
typhimurium, Enterococcus faecium, Shigella flexneri, Klebsiella pneumoniae,
Staphylococcus epidermidis and Candida albicans with zones of inhibition (ZOI) ranging
between 0-42 mm and 0-39 mm, respectively. Candida albicans had a remarkable ZOI of 42 mm and
22 mm from ethanol and ZnS NPs compared with 20 mm from conventional nystatin. TEM and FTIR
revealed spherically shaped polydispersed NPs with particle size of 12.5 nm and the role of banana peel
extracts in ZnS NPs synthesis. Organic and synthetic NPs proved potential alternatives to conventional
antimicrobial agents.
Source: SCIENTIA HORTICULTURAE | 256: - OCT 15 2019
Title: Methyl jasmonate maintained antioxidative ability of ginger rhizomes by regulating antioxidant
enzymes and energy metabolism
Author(s): Li, CY | Zhang, JH | Wei, ML | Ge, YH | Hou, JB | Cheng, Y | Chen, JX
Date: OCT 15 2019
Author keywords: Reactive oxygen species | Zingiber officinale | Energy charge | Antioxidative
ability
Keywords plus: CHILLING INJURY | ZINGIBER-OFFICINALE | OXIDATIVE STRESS | COLD-
STORAGE | LONGAN FRUIT | NITRIC-OXIDE | SENESCENCE | ACID | L. | ACCUMULATION
Publication year: 2019
Volume: 256
Abstract:
Página 38
Antioxidant capacity and energy status are closely related to postharvest senescence and stress tolerance
of fruits and vegetables. In this study, ginger rhizomes were treated with 100 mu M methyl jasmonate
(MeJA) solution for 10 min and stored at 20 degrees C with 30%-40% relative humidity for 18 d to
investigate the changes of hydrogen peroxide (H2O2) content, the activity of antioxidant enzymes in
reactive oxygen species and energy metabolism. The results indicated that MeJA treatment increased
H2O2 content and the activity of superoxide dismutase, peroxidase, ascorbate peroxidase and
glutathione reductase in ginger rhizomes. The activity of succinate dehydrogenase, cytochrome C
oxidase, H+-ATPase and Ca2+-ATPase, the content of ATP, ADP and energy charge were also enhanced
by MeJA treatinent in ginger rhizomes. All these results suggest that MeJA could maintain antioxidative
capacity of ginger rhizomes by regulating antioxidant enzymes and energy metabolism during room
temperature storage.
Source: IET NANOBIOTECHNOLOGY | 13 (3): 262-268 MAY 2019
Title: Autoclave-assisted synthesis of AgNPs in Z. officinale extract and assessment of their
cytotoxicity, antibacterial and antioxidant activities
Author(s): Kalantari, K | Afifi, AM | Moniri, M | Moghaddam, AB | Kalantari, A | Izadiyan, Z
Date: MAY 2019
Author keywords: nanoparticles | cancer | organic compounds | antibacterial activity | particle size |
microorganisms | silver | visible spectra | ultraviolet spectra | biomedical materials | biochemistry |
nanofabrication | free radicals | nanomedicine | toxicology | cellular biophysics | transmission electron
microscopy | unique approach | eco-friendly approach | Zingiber officinale | reducing agent |
stabiliser agent | transmission electron microscopy results | antibacterial agents | free radical
scavenging activity | synthesised AgNPs | 1-diphenyl-2-picryl-hydrazyl free radical scavenging | strong
bactericidal activity | antimicrobial AgNPs | autoclave-assisted synthesis | antioxidant activities |
cytotoxic effect | silver nanoparticles | autoclave | time 24 | 0 hour
Keywords plus: MEDIATED SILVER NANOPARTICLES | GREEN SYNTHESIS | GOLD
NANOPARTICLES | NANOCRYSTALLINE SILVER | SEED EXTRACT | BIOSYNTHESIS | AG |
STRAIN | WOUNDS | SHAPE
Publication year: 2019
Volume: 13
Abstract:
In this study, the authors synthesised silver nanoparticles (AgNPs) using autoclave as a simple, unique
and eco-friendly approach. The effect of Zingiber officinale extract was evaluated as a reducing and
stabiliser agent. According to transmission electron microscopy results, the AgNPs were in the spherical
Página 39
shape with a particle size of similar to 17 nm. The biomedical properties of AgNPs as antibacterial agents
and free radical scavenging activity were estimated. Synthesised AgNPs showed significant 1,1-diphenyl-2
-picryl-hydrazyl free radical scavenging. Strong bactericidal activity was shown by the AgNPs on Gram-
positive and Gram-negative bacteria. A maximum inhibition zone of similar to 14 mm was obtained for
epidermidis at a concentration of 60 mu g/ml for sample fabricated at 24 h. The AgNPs also showed a
significant cytotoxic effect against MCF-7 breast cancer cell lines with an half maximal inhibitory
concentration value of 62 mu g/ml in 24 h by the MTT assay. It could be concluded that Z. officinale
extract can be used effectively in the production of potential antioxidant and antimicrobial AgNPs for
commercial application.
Source: AGRONOMY-BASEL | 11 (2): - FEB 2021
Title: Alterations in Microrhizome Induction, Shoot Multiplication and Rooting of Ginger (Zingiber
officinale Roscoe) var. Bentong with Regards to Sucrose and Plant Growth Regulators Application
Author(s): Zahid, NA | Jaafar, HZE | Hakiman, M
Date: FEB 2021
Author keywords: Zingiber officinale Rosc | var Bentong | microrhizome | sucrose | cytokinin | 1-
naphthaleneacetic acid
Keywords plus:
Publication year: 2021
Volume: 11
Abstract:
Ginger (Zingiber officinale Roscoe) var. Bentong is a monocotyledon plant that belongs to the
Zingiberaceae family. Bentong ginger is the most popular cultivar of ginger in Malaysia, which is
conventionally propagated by its rhizome. As its rhizomes are the economic part of the plant, the
allocation of a large amount of rhizomes as planting materials increases agricultural input cost.
Simultaneously, the rhizomes' availability as planting materials is restricted due to the high demand for
fresh rhizomes in the market. Moreover, ginger propagation using its rhizome is accompanied by several
types of soil-borne diseases. Plant tissue culture techniques have been applied to produce disease-free
planting materials of ginger to overcome these problems. Hence, the in vitro-induced microrhizomes are
considered as alternative disease-free planting materials for ginger cultivation. On the other hand,
Bentong ginger has not been studied for its microrhizome induction. Therefore, this study was conducted
to optimize sucrose and plant growth regulators (PGRs) for its microrhizome induction. Microrhizomes
were successfully induced in Murashige and Skoog (MS) medium supplemented with a high sucrose
concentration (>45 g L-1). In addition, zeatin at 5-10 mu M was found more effective for microrhizome
Página 40
induction than 6-benzylaminopurine (BAP) at a similar concentration. The addition of 7.5 mu M 1-
naphthaleneacetic acid (NAA) further enhanced microrhizome formation and reduced sucrose's required
dose that needs to be supplied for efficient microrhizome formation. MS medium supplemented with 60
g L-1 sucrose, 10 mu M zeatin and 7.5 mu M NAA was the optimum combination for the microrhizome
induction of Bentong ginger. The in vitro-induced microrhizomes sprouted indoors in moist sand and all
the sprouted microrhizomes were successfully established in field conditions. In conclusion, in vitro
microrhizomes can be used as disease-free planting materials for the commercial cultivation of Bentong
ginger.
Source: SOUTH AFRICAN JOURNAL OF ANIMAL SCIENCE | 48 (6): 997-1008 2018
Title: Influence of dietary supplementation of ginger powder at different levels on growth performance,
haematological profiles, slaughter traits and gut morphometry of broiler chickens
Author(s): Shewita, RS | Taha, AE
Date: 2018
Author keywords: Zingiber officinale | chicken | growth | immunity | serum parameters | carcass
Keywords plus: ZINGIBER-OFFICINALE | ANTIOXIDANT STATUS | SERUM METABOLITES |
ESSENTIAL OIL | BLOOD
Publication year: 2018
Volume: 48
Abstract:
The present investigation was performed to determine the impact of the dietary inclusion of ginger
powder (Zingiber officinale) on the growth performance, immune response, slaughter traits, blood
biochemistry and gut morphology of broiler chickens. One hundred and eighty unsexed broiler chicks
(Avian 48) were randomly allocated to four equal groups (45 birds each) (G1, G2, G3 and G4), and each
treatment had three replicates (15 birds/replicate). The G1 group was fed with basal diet, G2, G3 and G4
were received the basal diet plus 2 g/kg, 4 g/kg and 6 g/kg ginger powder, respectively. The trial lasted
for six weeks. The results demonstrated a significant decrease in the final bodyweight of G4 compared
with those of G2 and G3. However, total feed intake improved in G2 and G3 and decreased in G4. The
lowest feed conversion ratio (FCR) was observed in chicks of G3, followed by that of G2. At 42 days old,
the ginger-supplemented groups showed significant increases in hemagglutination inhibition (HI) titre
against Newcastle Disease virus. Significant increases in the leucocyte count (WBCs) and serum total
protein were noticed only in G4, and cholesterol and high-density lipoprotein (HDL) levels decreased
significantly in G4. In addition, the serum very-low-density lipoprotein (VLDL) and triglyceride levels
Página 41
decreased significantly in the ginger-supplemented groups compared with G1, and the abdominal fat
percentage significantly decreased in the G3 and G4 groups. Additionally, the ginger-supplemented
groups showed higher villus lengths and greater crypt depths than the control group. Supplementation
with ginger powder at a moderate level up to 4 g/kg diet has beneficial effects on growth performance,
and up to level 6 g/kg diet improves histological gut parameters and hypolipidemic properties of
broilers.
Source: NATURAL PRODUCT COMMUNICATIONS | 13 (6): 763-766 JUN 2018
Title: Zingiber vuquangensis and Z. castaneum: Two Newly Discovered Species from Vietnam
and Their Essential Oil Constituents
Author(s): Huong, LT | Huong, TT | Huong, NTT | Chau, DTM | Sam, LN | Ogunwande, IA
Date: JUN 2018
Author keywords: Zingiber vuquangensis | Zingiber castaneum | Essential oil | Monoterpenes |
Sesquiterpenes
Keywords plus: RICH ESSENTIAL OIL | OFFICINALE ROSCOE | RHIZOME OIL | INDIA | LEAVES
Publication year: 2018
Volume: 13
Abstract:
The chemical constituents of essential oils obtained by hydrodistillation from Zingiber vuquangensis
Ly N.S., Le T.H., Trinh T. H., Nguyen V.H., Do N.D. and Zingiber castaneum Skorniek. & Q.B.
Nguyen collected from Vu Quang National Park, Ha Tinh Province, Vietnam were analysed by GC and
GC-MS. beta-Pinene (24.7% and 26.1%) and beta-caryophyllene (12.3% and 13.9%) were the main
constituents in the leaf oil and stem oil of Zingiber vuquangensis. On the other hand the root oil
contained bornyl acetate (20.9%), zerumbone (14.1%) and alpha-humulene (9.6%) while beta-pinene
(19.6%), 1,8-cineole (15.6%), alpha-pinene (10.3%) and beta-caryophyllene (10.4%) were the significant
compounds of the fruit oil. The leaf oil Zingiber castaneum was dominated by beta-pinene (30.6%),
alpha-pinene (9.5%), beta-caryophyllene (9.4%) and bicycloelemene (9.1%). The compounds occurring
in higher quantity in the stem oil were beta-caryophyllene (14.7%), delta-cadinene (9.8%),
bicycloelemene (8.4%) and alpha-cubebene (7.8%). However, camphene (15.1%), 1,8-cineole (13.6%),
linalool (11.3%) and delta-3-carene (8.5%) were the main compounds of the root oil while (E)-nerolidol
(23.2%), (Z)-9-octadecenamide (17.3%) and beta-caryophyllene (10.8%) were the main constituents of
the fruit oil. The essential oil did not exhibit noticeable antimicrobial effects. This is the first report on
the volatile compositions of Z. vuquangensis and Z. castaneum.
Página 42
Source: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 33 (4): 1641-1657 JUL 2020
Title: Authentication of various commercially available crude drugs using different quality control
testing parameters
Author(s): Fatima, K | Mahmud, S | Yasin, H | Asif, R | Qadeer, K | Ahmad, I
Date: JUL 2020
Author keywords: Plant materials | Powder microscopy | TLC | FTIR | Quality control tests
Keywords plus: GINGER ZINGIBER-OFFICINALE | STANDARDIZATION | CRITERIA | EFFICACY
| MEDICINE | SAFETY
Publication year: 2020
Volume: 33
Abstract:
The object of this study is to investigate the quality of various plant materials used in the preparation of
herbal formulations using different methods of standardization to confirm their purity, safety and
efficacy. However, it is uncertain whether these raw materials comply with the standards prescribed in
the pharmacopeias. In the present study six raw materials' i.e. Foeniculum vulgarae, Curcuma
longa, Aloe barbadensis, Plantago ovata, Zingiber officinale and Glycyrrhiza glabra have
been obtained from the market and various quality control tests including microscopic evaluation,
physico-chemical characteristics, thin layer chromatography (TLC), spectrophotometric assay (British
Pharmacopoeia) and Fourier transform infrared spectroscopy (FTIR) have been performed to determine
their compliance with the standards. The TLC has been used for the identification of the active
ingredients on comparison of their R-f values with the reference standard FTIR Spectra of these
materials have been obtained to assign the functional groups present in the components of a particular
material. Although these findings provide a significant data to herbal drug manufacturers for
authentication of commercially available plant materials used in various herbal formulation.
Source: JOURNAL OF FUNCTIONAL FOODS | 31: 304-310 APR 2017
Title: Neuroprotective effect of 6-paradol enriched ginger extract by fermentation using
Schizosaccharomyces pombe
Author(s): Choi, JW | Park, HY | Oh, MS | Yoo, HH | Lee, SH | Ha, SK
Date: APR 2017
Author keywords: 6-paradol | Zingiber officinale Roscoe | Schizosaccaromyces pombe |
Página 43
Biotransformation | 6-shogaol | Fermentation
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | ASPERGILLUS-NIGER | PUNGENT
CONSTITUENTS | ALZHEIMERS-DISEASE | BIOTRANSFORMATION | 6-SHOGAOL | SHOGAOL |
PARADOLS | CHROMATOGRAPHY | REEXAMINATION
Publication year: 2017
Volume: 31
Abstract:
6-paradol is a non-pungent and biotransformed metabolite of 6-shogaol. It has recently been shown to
exhibit a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative
activities. This study was designed to investigate biotransformation of 6-shogaol to 6-paradol from 6-
shogaol-enriched ginger extracts (SGE) by Schizosaccharomyces pombe and evaluate the
neuroprotective effect of fermented ginger extract (FGE). During fermentation of SGE by S. pombe, 6-
gingerol content was maintained, whereas 6-shogaol was efficiently biotransformed to 6-paradol. FGE
was evaluated for its neuroprotective effect against amyloid-beta (A beta)-induced neurotoxicity in rat
primary hippocampal cells. Cell viability was reduced to 68%, and to 65% when exposed to A beta
oligomer and A beta plaque for 18 h, and 50 mu g/mL of FGE increased cell viability (92% and 89.6%,
respectively). These results indicate that fermentation of SGE can provide an efficient method of 6-
pradol formation and that FGE has potential as a neuroprotective agent. (C) 2017 Elsevier Ltd. All rights
reserved.
Source: LWT-FOOD SCIENCE AND TECHNOLOGY | 126: - MAY 2020
Title: Total phenolics, total carotenoids, individual phenolics and antioxidant activity of ginger
(Zingiber officinale) rhizome as affected by drying methods
Author(s): Ghafoor, K | Al Juhaimi, F | Ozcan, MM | Uslu, N | Babiker, EE | Ahmed, IAM
Date: MAY 2020
Author keywords: Ginger | Drying | Total phenolics | Total carotenoids | Antioxidant activity |
Phenolic compounds
Keywords plus: CHEMICAL-COMPOSITION | ROSCOE SLICES | CAPACITY | OPTIMIZATION |
ACID
Publication year: 2020
Volume: 126
Abstract:
Página 44
This study was conducted to evaluate total phenolic content, antioxidant activity, total carotenoids and
phenolic compounds of ginger (Zingiber officinale) rhizomes dried using different drying methods
(oven, microwave, freeze and room-air drying). Freeze-dried ginger rhizomes exhibited significantly (p <
0.05) higher total phenolics (931.94 mgGAE/100 g), antioxidant activity (82.00%) and total carotenoids
(13.17 mu g/g) than those dried using other techniques. Oven-dried ginger showed higher values for all
individual phenolic compounds detected in this study as compared to those dried using other methods.
The dominant phenolic compounds of dried ginger included (+)-catechin (250.02 mg/100 g), gallic acid
(197.03 mg/100 g) and 3, 4-dihydroxybenzoic acid (116.07 mg/100 g). Drying of ginger rhizome using
oven and freeze-drying methods my result in improved contents of bioactive compounds and higher
antioxidant activity. Correlation analyses for biochemical composition of ginger rhizomes showed that
total phenolics were positively correlated with antioxidant activity (r(2) = 0.973, p < 0.001).
Source: MOLECULES | 23 (8): - AUG 2018
Title: Beneficial Effect of Herbal Formulation KM1608 on Inflammatory Bowl Diseases: A Preliminary
Experimental Study
Author(s): Shin, MS | Kim, SB | Lee, J | Choi, HS | Park, J | Park, JY | Lee, S | Hwang, GS | Koo, BA |
Kang, KS
Date: AUG 2018
Author keywords: anti-inflammatory | Aucklandia lappa DC | ulcerative colitis | Terminalia chebula
Retz | Zingiber officinale Roscoe
Keywords plus: ULCERATIVE-COLITIS | ACID | GASTROENTEROLOGY | MECHANISMS | MICE
Publication year: 2018
Volume: 23
Abstract:
Aucklandia lappa DC., Terminalia chebula Retz and Zingiber officinale Roscoe have been
traditionally used in east Asia to treat chronic diarrhea and abdominal pain. This study aimed to
evaluated the anti-inflammatory activity of KM1608, which is composed of three natural herbs in a mouse
model of dextran sodium sulfate (DSS)-induced ulcerative colitis. The anti-inflammatory activity and
underlying mechanism were assessed in vitro using LPS-treated RAW264.7 cells. The in vivo effect of
KM1608 on DSS-induced colitis was examined after oral administration in mice. KM1608 significantly
inhibited the inflammatory mediators such as nitric oxide, interleukin (IL)-6, monocyte chemotactic
protein 1 (MCP-1) and tumor necrosis factor (TNF)- in LPS-treated RAW264.7 cells. The inhibitory effect
of KM1608 was attributed to the reduction of Akt phosphorylation in the LPS-treated cells. In the mouse
model, oral administration of KM1608 significantly improved DSS-induced colitis symptoms, such as
Página 45
disease activity index (DAI), colon length, and colon weight, as well as suppressed the expression of IL-6,
TNF-, and myeloperoxidase (MPO) in the DSS-induced colitis tissues. Taken together, KM1608
improved colitis through the regulation of inflammatory responses, suggesting that KM1608 has
potential therapeutic use in the treatment of inflammatory diseases.
Source: ACS OMEGA | 3 (12): 18572-18581 DEC 2018
Title: Ginger Extract Promotes Telomere Shortening and Cellular Senescence in A549 Lung Cancer Cells
Author(s): Kaewtunjai, N | Wongpoomchai, R | Imsumran, A | Pompimon, W | Athipornchai, A |
Suksamrarn, A | Lee, TR | Tuntiwechapikul, W
Date: DEC 2018
Author keywords:
Keywords plus: DIETARY PHYTOCHEMICALS | ZINGIBER-OFFICINALE | CHEMOPREVENTION |
APOPTOSIS | INHIBITION | ANTICANCER | 6-SHOGAOL | CURCUMIN | PATHWAY
Publication year: 2018
Volume: 3
Abstract:
Replicative senescence, which is caused by telomere shortening from the end replication problem, is
considered one of the tumor-suppressor mechanisms in eukaryotes. However, most cancers escape this
replicative senescence by reactivating telomerase, an enzyme that extends the 3'-ends of the telomeres.
Previously, we reported the telomerase inhibitory effect of a crude Zingiber officinale extract (ZOE),
which suppressed hTERT expression, leading to a reduction in hTERT protein and telomerase activity in
A549 lung cancer cells. In the present study, we found that ZOE-induced telomere shortening and
cellular senescence during the period of 60 days when these A549 cells were treated with subcytotoxic
doses of ZOE. Using assay-guided fractionation and gas chromatography/mass spectrometry analysis, we
found that the major compounds in the active subfractions were paradols and shogaols of various chain
lengths. The results from studies of pure 6-paradol and 6-shogaol confirmed that these two compounds
could suppress hTERT expression as well as telomerase activity in A549 cells. These results suggest that
these paradols and shogaols are likely the active compounds in ZOE that suppress hTERT expression and
telomerase activity in these cells. Furthermore, ZOE was found to be nontoxic and had an anticlastogenic
effect against diethylnitrosamine-induced liver micronucleus formation in rats. These findings suggest
that ginger extract can potentially be useful in dietary cancer prevention.
Source: FRONTIERS IN PLANT SCIENCE | 9: - OCT 4 2018
Title: The Fight Against Panax notoginseng Root-Rot Disease Using Zingiberaceae Essential Oils as
Página 46
Potential Weapons
Author(s): Yin, YJ | Chen, CJ | Guo, SW | Li, KM | Ma, YN | Sun, WM | Xu, FR | Cheng, YX | Dong, X
Date: OCT 4 2018
Author keywords: Panax notoginseng | root-rot disease | Zingiberaceae | EOs | fungi
Keywords plus: INHIBITORY CONCENTRATION | LIPID-PEROXIDATION | STRESS |
PHOTOSYNTHESIS | FUSARIUM | PHOTORESPIRATION | ANTIOXIDANT | ANTIFUNGAL |
GENOTYPES | DEPLETION
Publication year: 2018
Volume: 9
Abstract:
The root of Panax notoginseng (P. notoginseng) is one of the most highly valuable medicinal herbs
in China owing to its pronounced hemostatic and restorative properties. Despite this important fact,
growing P. notoginseng is seriously limited by root-rot diseases. In studies aimed at developing a
solution to this problem, environment-friendly essential oils (EOs) of five medicinal plants of the family
Zingiberaceae were tested for their inhibitory effects on the growth of three main soil pathogens
associated with the root-rot diseases of P. notoginseng. The results showed that the EOs of Alpinia
katsumadai Hayata and Zingiber officinale Roscoe promote significant reductions in the mycelium
growth of the pathogen in vitro at a concentration of 50 mg mL(-1), which is much higher than that
needed (5 mg mL(-1)) to reduce growth by the positive control, flutriafol. Furthermore, the chemical
components of the two EOs were determined by using GC-MS analysis. Eucalyptol was found to account
for more than 30% of the oils of the two plants, with the second major components being geranyl acetate
and alpha-terpineol. These substances display different degrees of fungistasis in vitro. To further
determine the effects of the EO of Zingiber officinale (Z. officinale) in vivo, soilless cultivation of P.
notoginseng with pathogen inoculation was conducted in a greenhouse. Addition of the petroleum
ether extract (approximately equal to EO) of Z. officinale to the culture matrix causes a large decrease
in both the occurrence and severity of the P. notoginseng root-rot disease. The decreasing trend of net
photosynthetic rate (P-n), stomatal conductance (g(s)), intercellular CO2 concentration (C-i), and
transpiration rate (T-r) were all alleviated. In addition, the activities of catalase (CAT), peroxidase
(POD), and the malondialdehyde (MDA) content were also largely reduced after pathogen infection, with
the root activity being higher than that of the control. Taken together, the findings reveal that the EOs
from plants might serve as promising sources of eco-friendly natural pesticides with less chemical
resistance.
Source: BIOMOLECULES | 10 (2): - FEB 2020
Página 47
Title: Solid gamma-Cyclodextrin Inclusion Compound with Gingerols, a Multi-Component Guest:
Preparation, Properties and Application in Yogurt
Author(s): Pais, JM | Pereira, B | Paz, FAA | Cardoso, SM | Braga, SS
Date: FEB 2020
Author keywords: fresh ginger rhizome | molecular encapsulation | antioxidant | food fortification |
nutraceutics
Keywords plus: ZINGIBER-OFFICINALE | ANTIOXIDANT PROPERTIES | ALLYL
ISOTHIOCYANATE | BETA-CYCLODEXTRIN | IN-VITRO | 6-GINGEROL | EXPRESSION |
COMPLEXES | NMR | BIOAVAILABILITY
Publication year: 2020
Volume: 10
Abstract:
Gingerols from the rhizome of fresh ginger (Zingiber officinale) were obtained by a simple extraction,
followed by purification. The gingerols extract was composed of 6-gingerol (54%), 8-gingerol (20%), and
10-gingerol (26%). It was included into gamma-cyclodextrin by classic co-dissolution procedures. Solid-
state characterisation of gamma-cyclodextrin center dot gingerols shows that this inclusion compound
features 1:1 host-to-guest stoichiometry and that it is a microcrystalline powder with a crystalline cell
that belongs to the tetragonal space group 42(1)2, having the host molecules stacked in infinite channels
where the gingerols are accommodated. In chimico studies with ABTS(center dot+) scavenging, NO
center dot scavenging, beta-carotene peroxidation, and 5-LOX inhibition show that gamma-cyclodextrin
is a suitable carrier for gingerols, because it does not alter their reactivity towards these substances.
Yogurt was tested as a matrix for the incorporation of gingerols and gamma-cyclodextrin center dot
gingerols into foodstuff. The colour of the fortified yogurt suffered little alterations. In the case of yogurt
with the inclusion compound, gamma-cyclodextrin center dot gingerols, as fortificant, these alterations
were not perceptible to the naked eye. Moreover, yogurt with gamma-cyclodextrin center dot gingerols
showed a good antioxidant activity, thus being suitable for use in nutraceutical applications.
Source: AQUACULTURE | 543: - OCT 15 2021
Title: Inclusion of essential oil from ginger in the diet improves physiological parameters of tambaqui
juveniles (Colossoma macropomum)
Author(s): Chung, S | Ribeiro, K | Teixeira, DV | Copatti, CE
Date: OCT 15 2021
Author keywords: Hepatocytes | Histological parameters | Leukocytes | Intestinal villi | Zingibereno
Página 48
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | GROWTH-PERFORMANCE |
HEMATOLOGICAL PARAMETERS | IMMUNE-RESPONSE | CLOVE BASIL | IMMUNOSTIMULANT |
HOMEOSTASIS | STRESS | PLANTS | SERUM
Publication year: 2021
Volume: 543
Abstract:
The aim of this study was to investigate the effect of essential oil of ginger (Zingiber officinale)
(EOZO) on the growth performance and hematological, biochemical and histological parameters of
tambaqui (Colossoma macropomum) juveniles. The fish were randomly distributed in 20 tanks (15
fish per tank), in five treatments containing different concentrations of EOZO (0.0 (control); 0.50; 1.0;
1.5; and 2.0 mL kg diet-1) for 60 days. The main chemical compounds were zingiberene (31.8%),
sesquiphellandrene (13.0%) and ar-curcumene (12.4%). The addition of EOZO to the diet did not
improve growth performance. Treatments with the highest levels of EOZO reduced plasma albumin,
alanine aminotransferase and aspartate aminotransferase levels and increased leukocytes, hemoglobin
and thrombocytes, blood glucose and plasma cholesterol levels. The control group had high villus height,
epithelial thickness and goblet cell number in the intestinal villi. Hepatocyte area and the number of
hepatocytes with necrosis were higher in fish supplemented with the highest levels of EOZO. To sum up,
it seems that the addition of 0.5 mL EOZO kg diet- 1 can improve some physiological parameters
(leukocytes, hemoglobin and thrombocytes, and plasma ALT and AST levels) without causing liver
damage or negatively affecting the intestinal villi of tambaqui juveniles.
Source: PHYTOTHERAPY RESEARCH | 30 (7): 1156-1163 JUL 2016
Title: Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase
and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats
Author(s): Akinyemi, AJ | Thome, GR | Morsch, VM | Bottari, NB | Baldissarelli, J | de Oliveira, LS |
Goularte, JF | Bello-Klein, A | Oboh, G | Schetinger, MRC
Date: JUL 2016
Author keywords: Zingiber officinale | Curcuma longa | hypertension | platelet |
ectonucleotidases | ADA
Keywords plus: ANGIOTENSIN-1 CONVERTING-ENZYME | 5'-NUCLEOTIDASE ACTIVITIES |
BLOOD-PRESSURE | ANTIPLATELET | INHIBITION | CONSTITUENTS | RESVERATROL |
ANTIOXIDANT | REACTIVITY | NTPDASE
Publication year: 2016
Página 49
Volume: 30
Abstract:
Hypertension is associated with platelet alterations that could contribute to the development of
cardiovascular complications. Several studies have reported antiplatelet aggregation properties of ginger
(Zingiber officinale) and turmeric (Curcuma longa) with limited scientific basis. Hence, this study
assessed the effect of dietary supplementation of these rhizomes on platelet ectonucleotidase and
adenosine deaminase (ADA) activities in N-nitro-l-arginine methyl ester hydrochloride (l-NAME)
induced hypertensive rats. Animals were divided into seven groups (n=10): normotensive control rats;
induced (l-NAME hypertensive) rats; hypertensive rats treated with atenolol (10mg/kg/day);
normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.
After 14days of pre-treatment, the animals were induced with hypertension by oral administration of l-
NAME (40mg/kg/day). The results revealed a significant (p<0.05) increase in platelet ADA activity and
ATP hydrolysis with a concomitant decrease in ADP and AMP hydrolysis of l-NAME hypertensive rats
when compared with the control. However, dietary supplementation with turmeric or ginger efficiently
prevented these alterations by modulating the hydrolysis of ATP, ADP and AMP with a concomitant
decrease in ADA activity. Thus, these activities could suggest some possible mechanism of the rhizomes
against hypertension-derived complications associated to platelet hyperactivity. Copyright (c) 2016 John
Wiley & Sons, Ltd.
Source: GENE | 692: 217-222 APR 15 2019
Title: Biological effects of whole Z. Officinale extract on chronic myeloid leukemia cell line K562
Author(s): Tiber, PM | Sevinc, SK | Kilinc, O | Orun, O
Date: APR 15 2019
Author keywords: Z.officinale | Peripheral blood mononuclear cells | Apoptosis | K562 |
Proliferation | ROS
Keywords plus: 6-SHOGAOL INDUCES APOPTOSIS | BAD PHOSPHORYLATION | CANCER CELLS
| INHIBITS PROLIFERATION | CYCLE ARREST | ACTIVATION | GINGER | 10-GINGEROL |
CONSTITUENT | INDUCTION
Publication year: 2019
Volume: 692
Abstract:
The anticancer activity of Zingiber officinalis (ginger) is an area of active research. However, data is
quite limited regarding its action and mechanism, especially in hematologic cancer types. Here,
Página 50
antiproliferative and apoptotic effects of whole extract of the rhizome of Zingiber officinalis (ZOWE),
was investigated in K562 cell line derived from a chronic myeloid leukemia (CML) patient. Various
concentrations of whole extract (0, 10, 25, 50 and 100 mu M) were tested in K562 cultures. Cytotoxicity
and apoptosis was assessed with appropriate methods, as well as cellular ROS levels. In this study, we
showed that ZOWE inhibited proliferation of K562 cells substantially, when compared to peripheral
blood mononuclear cells (PBMCs) isolated from healthy donor. Increased Bax/Bcl-2 ratio, reduced
mitochondrial membrane potential and increased PARP cleavage demonstrated that ZOWE inhibited
proliferation by induction of apoptosis. These changes were coupled with an increase of reactive oxygen
species (ROS) production. Furthermore, ZOWE addition to the culture also reduced expression levels of
survival proteins pAkt and survivin, in a concentration dependent manner. Our results clearly mark that
ZOWE causes to a reduction in cell viability, an induction of apoptosis and elevation in ROS levels in
chronic myeloid leukemia cells and effects are significantly different from healthy peripheral blood
mononuclear cells, further supporting its potential therapeutic value.
Source: INDUSTRIAL CROPS AND PRODUCTS | 127: 11-15 JAN 2019
Title: Bioactivity of ten essential oils on the biological parameters of Trichogramma pretiosum
(Hymenoptera: Trichogrammatidae) adults
Author(s): Parreira, DS | Alcantara-de La Cruz, R | Dimate, FAR | Batista, LD | Ribeiro, RC | Ferreira,
GAR | Zanuncio, JC
Date: JAN 2019
Author keywords: Biological control | Egg parasitoids | Essential oils | IPM | T. pretiosum
Keywords plus: BOTANICAL INSECTICIDES | ANTICARSIA-GEMMATALIS | LEPIDOPTERA-
NOCTUIDAE | CARAPA GUIANENSIS | COPAIFERA SP | TOXICITY | AZADIRACHTIN |
PESTICIDES | EXTRACTS | PESTS
Publication year: 2019
Volume: 127
Abstract:
Trichogrammatidae are biological control agents of agricultural and forest pests. However, chemicals
can affect their biological aspects. Essential oils (EOs) are an alternative for pest control, but their effect
on biological control agents are not fully known. The objective was to evaluate the effects of EOs of
Allium sativum, Carapa guianensis, Citrus sinensis, Mentha piperita, Origanum vulgare,
Piper nigrum, Syzygium aromarticum, Thymus vulgaris, Zingiber officinale and Azadirachta
indica on the female longevity, parasitism and emergence rates and sex ratio of Trichogramma
pretiosum (Riley) (Hymenoptera: Trichogrammatidae) adults of parental, F-1 and F-2 generations.
Página 51
The longevity of T. pretiosum females in the parental and F-1 generations was reduced similar to 50%
by the EOs of A. sativum and M. piperita in comparison to controls (similar to 10 days). Eggs of
Anagasta kuehniella (Zeller) (Lepidoptera: Pyralidae) treated with Z. officinale were not
parasitized, evidencing a strong repellent activity of this EO. Allium sativum and C. guianensis
EOs reduced the parasitism rate in 33 and 70%, respectively, of females from the parental T.
pretiosum generation. These EOs were classified as slightly harmful (class 2) in relation to
parasitism. Carapa guianensis caused the greatest reduction in the emergence rate of the F-1
generation (27%); however, this EO continued to be classified as innocuous to T. pretiosum. Sex ratio
of the F-1 and F-2 T. pretiosum generations was no affect by these ten EOs. Zingiber officinale was
not compatible for T. pretiosum; and A. sativum, C. guianensis and M. piperita are poorly
compatible with this parasitoid. The EOs of the other six plant species are promising for integrated pest
management with T. pretiosum.
Source: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 177: 62-68 DEC
2017
Title: Bioreduction potentials of dried root of Zingiber officinale for a simple green synthesis of
silver nanoparticles: Antibacterial studies
Author(s): Vijaya, JJ | Jayaprakash, N | Kombaiah, K | Kaviyarasu, K | Kennedy, LJ | Ramalingam,
RJ | Al-Lohedan, HA | Mansoor-Ali, VM | Maaza, M
Date: DEC 2017
Author keywords: Microwave processing | Silver nanoparticles | Electron microscopy | Cyclic
voltammetry | Antibacterial studies
Keywords plus: FRUIT EXTRACT | ESCHERICHIA-COLI | GOLD | BIOSYNTHESIS | AG |
POLYMER | ETHANOL | AU
Publication year: 2017
Volume: 177
Abstract:
Green synthesis of silver nanoparticles (Ag NPs) using an extract of dried Zingiber officinale
(ginger) root as a reducing and capping agent in the presence of microwave irradiation was herein
reported for the first time. The formation of symmetrical spheres is confirmed from the UV-Visible
spectrum of Ag NPs. Fourier transform infrared spectroscopy confirms the formation of the Ag NPs. X-
ray diffraction analysis was utilized to calculate the crystallite size of Ag NPs and the value was found to
be 10 nm. High-resolution transmission electron microscopy and high-resolution scanning electron
microscopy were used to investigate the morphology and size of the synthesized samples. The sphere
Página 52
like morphology is confirmed from the images. The purity and crystallinity of Ag NPs is confirmed by
energy-dispersive X-Ray analysis and selected area electron diffraction respectively. The electrochemical
behavior of the synthesized Ag NPs was assessed by cyclic voltammetry (CV) and shows the redox peaks
in the potential range of -1.1 to + 1.1 V. Agar diffusion method is used to examine the antibacterial
activity of Ag NPs. For this purpose, two gram positive and two gram negative bacteria were studied.
This single step approach was found to be simple, short time, cost-effective, reproducible, and eco-
friendly.
Source: 3 BIOTECH | 9 (2): - FEB 2019
Title: The healing property of a bioactive wound dressing prepared by the combination of bacterial
cellulose (BC) and Zingiber officinale root aqueous extract in rats
Author(s): Pourali, P | Yahyaei, B
Date: FEB 2019
Author keywords: Bacterial cellulose (BC) | Zingiber officinale root | Aqueous extract | Wound-
healing assay
Keywords plus: SOIL ISOLATED-BACTERIA | SILVER NANOPARTICLES | IN-VITRO | GINGER |
BIOSYNTHESIS | IMPREGNATION | CYTOTOXICITY | RHIZOMES
Publication year: 2019
Volume: 9
Abstract:
Gluconacetobacter xylinus was used for production of bacterial cellulose (BC). The obtained BC was
washed and floated in the nontoxic dose of the herb aqueous extract that was obtained from the methyl
thiazol tetrazolium (MTT) assay. Twenty-four Wistar rats were divided into four separated groups and
after inducing the wounds (15mm in diameter), each group was treated with honey, BC, herb aqueous
extract, and the combination of BC-herb aqueous extract. Each day the contraction percentages of the
wound sites were measured. On days 3, 7, and 14, two rats from each group were euthanized, the skin
samples from the wound regions were achieved and their paraffin blocks were prepared. Finally after
trichrome staining, the microscopic examinations were done. MTT assay results indicated that the herb
aqueous extract had dose-dependent toxic effects and the nontoxic dose of the extract was prepared and
utilized for in vivo assay. Although the macroscopic analysis revealed that the BC and the herb aqueous
extract had better activity in the wound contraction percentages than their combination, microscopic
analysis indicated that the combination of BC-herb aqueous extract revealed all the characteristics that
each material induced in the wound site alone. In conclusion, the speed of the wound healing should not
be solely considered and its quality should be considered as well.
Página 53
Source: CARBOHYDRATE POLYMERS | 228: - JAN 15 2020
Title: Investigating the properties of electrospun nanofibers made of hybride polymer containing
anticoagulant drugs
Author(s): Amand, FK | Esmaeili, A
Date: JAN 15 2020
Author keywords: Heart valve | Electrospinning | Anticoagulant | Scaffolds | Zingiber officinale
Keywords plus: IN-VITRO RELEASE | NANOPARTICLES | DELIVERY | CHITOSAN |
OPTIMIZATION | DOXORUBICIN
Publication year: 2020
Volume: 228
Abstract:
The aim of this study is to provide a scaffold made of chitosan/polyvinylalcohol/Polyurethane/
polyaniline/Zingiber officinal (CS//PVA/PU/PANI/Zin) and heparin (CS//PVA/PU/PANI/HEP)
with double-needle electrospinning that contains anticoagulant drugs. The medicine that was loaded on
the nanofibers was measured with FT-IR, SEM, XRD, ZPS, and RSM, TST and AFM. In vitro release of
loading drugs was measured at room temperature and at pH = 5.3 and pH = 7.4. The kinetic release of
the drugs was studied and their cytotoxicity was assessed with MTT assay, HT, coagulation[(PT), PTT,
and INR test], and TST. Based on the in vitro release studies, about 73.62% and 73.40%, respectively, of
Zin and heparin were put in a medium with pH = 7.4. The results indicated that a heart valve with high
tensile strength and anticoagulant properties had been developed. Clinically, due to the structural
similarity of the polyurethane, biocompatibility and blood compatibility were improved in the presence
of Zin extract.
Source: PLANT GENOME | 11 (3): - NOV 2018
Title: Transcriptome Analysis Provides Insights into Gingerol Biosynthesis in Ginger (Zingiber
officinale)
Author(s): Jiang, YS | Huang, MJ | Wisniewski, M | Li, HL | Zhang, MX | Tao, X | Liu, YQ | Zou, Y
Date: NOV 2018
Author keywords:
Keywords plus: EXPRESSION ANALYSIS | GENE ONTOLOGY | 6-GINGEROL | ANNOTATION |
APOPTOSIS | ANTIOXIDANT | PLATFORM | COLITIS | GENOME | MICE
Página 54
Publication year: 2018
Volume: 11
Abstract:
Ginger (Zingiber officinale Roscoe), a perennial herb, is one of the most economically valuable plants
in the Zingiberaceae family. Gingerol, as the major constituents of ginger essential oil, contributes to the
unique flavor and pharmaceutical value of ginger. However, the pathway of gingerol biosynthesis has
not been verified and described in ginger to help understand the biosynthesis of secondary metabolites
in nonmodel species. In this study, the concentrations of gingerols were quantified at different stages of
rhizome development and in different tissues. The results confirmed that rhizomes are the major source
of gingerols and that accumulation of gingerols in the rhizome starts at an early developmental stage.
We also assembled a reference ginger transcriptome, which is composed of 219,479 unigenes consisting
of 330,568 transcripts and provides a high-quality genetic resource for further research. An analysis of
differentially expressed genes (DEGs) identified 12,935 DEGs among several different comparisons. Five
genes [ curcumin synthase (CURS), cinnamate 4-hydroxylase (CYP73A), p-coumaroyl quinate/
shikimate 3'-hydroxylase (CYP98A), caffeoyl-coenzyme A O-methyl transferase (CCoAOMT), and
hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyl transferase (HCT)] associated
with gingerol biosynthesis were identified as being significantly differentially expressed in the rhizome
at an early developmental stage and all five genes were upregulated. Expression analysis revealed that
different loci of these genes have become functionally specialized in different tissues and different
developmental stages of the rhizome (subfunctionalization). Among the DEGs, CCoAOMT and HCT may
act as gatekeepers and rate-limiting enzymes in the gingerol biosynthesis pathway and thus play an
important role in regulating the biosynthesis of gingerol.
Source: JOURNAL OF ETHNOPHARMACOLOGY | 244: - NOV 15 2019
Title: Ginger essential oil and fractions against Mycobacterium spp.
Author(s): Baldin, VP | Scodro, RBD | Fernandez, CMM | Ieque, AL | Caleffi-Ferracioli, KR | Siqueira,
VLD | de Almeida, AL | Goncalves, JE | Cortez, DAG | Cardoso, RF
Date: NOV 15 2019
Author keywords: Mycobacteria | Essential oil | Ginger | Cytotoxicity | Terpenoids
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | NONTUBERCULOUS MYCOBACTERIA |
ANTIMYCOBACTERIAL ACTIVITY | TUBERCULOSIS | SUSCEPTIBILITY | ANTIOXIDANT |
TOXICITY | DRUGS | ASSAY
Publication year: 2019
Página 55
Volume: 244
Abstract:
Ethnopharmacological relevance: Zingiber officinale (ginger) is a perennial herbaceous plant native
in tropical Asia and generally cultivated in most American tropical countries with widespread use in
popular medicine. Ginger essential oil (GEO) has been reported to exhibit several biological activities,
such as antimicrobial. Aims of the study: The aim of this study was to determine the composition and
the property of GEO and related fractions against Mtb and NTM, as well as their cytotoxicity. Methods
and materials: GEO was obtained by hydrodistillation and fractionation was performed. Chemical
characterization of GEO and fractions were carried out by gas chromatography/mass spectrometry. The
anti-mycobacterial activity was evaluated by resazurin microtiter assay plate and broth microdilution
method for Mtb and NTM, respectively. The cytotoxicity in Vero cells was assessed by MTT colorimetric
assay. Results: The analyses showed 63 compounds in the GEO sample, characterized by a high number
of monoterpenes and sesquiterpenes. GEO fractionation rendered 11 fractions (FR1 to FR11). GEO and
fractions minimum inhibitory concentration ranged from 31.25 to > 250 mu g/mL against Mtb and from
15.6 to > 250 mu g/mL against NTM. GEO showed better activity against NTM, M. chelonae, and M.
abscessus sub. massiliense, than the semi-pure fractions. One fraction (FR5), containing gamma-
eudesmol as the main compound, was the most active against Mtb and NTM. The GEO and semi-pure
fractions cytotoxicity assay showed CC50 63.3 mu g/mL, and 36.3-312.5 mu g/mL, respectively.
Conclusions: In general, GEO showed a mix of monoterpenes and sesquiterpenes and a better
antimycobacterial activity than the semi-pure fractions. Cytotoxic effects of GEO and its fractions
should be better investigated.
Source: JOURNAL OF COSMETIC DERMATOLOGY | 19 (7): 1794-1803 JUL 2020
Title: Phytochemical screening and cytotoxicity evaluation of crude extracts: Toxicity comparison of
crude extracts and its ethosomal formulations
Author(s): Sasindran, S | Easwaran, M | Shyamala, G | Karuppaiah, A | Siram, K | Veintramuthu, S
Date: JUL 2020
Author keywords: Croton tiglium | ethosomes | minoxidil | Phyllanthus niruri | Zingiber
officinale
Keywords plus:
Publication year: 2020
Volume: 19
Abstract:
Página 56
Background Combined plant extracts of Phyllanthus niruri, Croton tiglium, and Zingiber
officinale are reported to have potential pharmacological applications. Ethosomes have a unique ability
of encapsulating drugs or plant extracts with varying hydrophobicities in the phospholipid bilayer. Aim
To explore cytotoxicity of the combined plant extracts and ethosome loaded combined plant extracts for
topical delivery. To study effect of ethosomes loaded combined plant extracts using HaCaT cells model
treated with testosterone. Methods Dried powder of plant was extracted with ethanol using Soxhlet and
cold macerations. Total phenolic and flavonoid contents were also determined using established
methods. The combined extract loaded ethosome formulation was prepared by solvent dispersion
method. Results The plant extracts loaded ethosomes formulation with a vesicle size range 1524.6-167.7
nm was prepared. HaCaT cells treated with testosterone negative control showed an IC50 value of 27 +/-
1.0. Thw standard marketed topical minoxidil (1% solution) treated cells with testosterone showed an
IC50 value 33 +/- 1.0 and the combined plant extracts loaded ethosomes with testosterone showed an
IC50 value 30 +/- 1.0. Morphological alterations of rat skin exposed to the combined plant extract
loaded ethosomes solution were assessed and compared with untreated skin and negative control.
Conclusion The preclinical safety was investigated employing an in vitro cytotoxicity and
histopathological study. The cell line study results confirmed that the combined plant extracts loaded
ethosomes inhibits testosterone and increase cell viability closer to that of standard drug minoxidil.
According to our histopathological study, the combined plant extract loaded ethosomal formulations did
not cause any damage to the rat skin layer.
Source: EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE | 10: 19-24 FEB 2017
Title: Determination of the concentration of major active anti-emetic constituents within commercial
ginger food products and dietary supplements
Author(s): Marx, W | Isenring, EA | Lohning, AE
Date: FEB 2017
Author keywords: HPLC | Chemotherapy-induced nausea and | vomiting | CINV | Gingerol | Ginger
Keywords plus: ZINGIBER-OFFICINALE | NAUSEA | METAANALYSIS | PREGNANCY
Publication year: 2017
Volume: 10
Abstract:
Introduction: Studies suggest that the bioactive compounds contained within the rhizome of ginger
(Zingiber officinale) could exert a beneficial effect on the symptoms of several chronic conditions
(e.g. diabetes, arthritis) and in the reduction of nausea. However, it is unknown if ginger supplements
Página 57
and food products contain sufficient quantities of the necessary active ingredients to achieve a
therapeutic effect. This study analyzed twenty commercially available ginger products including ginger
dietary supplements, ginger spices (ground dried ginger), and ginger-containing drinks and food
products and determined the concentration of [6]-, [8]-and [10]-gingerol and [6]-and [10]-shogaol.
Methods: The samples were extracted prior to separation by Reversed Phase-High Performance Liquid
Chromatography (RP-HPLC) and detected by ultraviolet (UV) spectrophotometry. Results: Considerable
variation between individual items within each food type was observed. Per gram, ginger supplements,
particularly the standardized extracts, contained the greatest concentration of measured compounds
(10.08 +/- 7.92 mg, mean +/- standard deviation), while the concentration of compounds within spices
(9.29 +/- 6.73 mg), beverages (1.77 +/- 1.06 mg), confectionery (0.43 +/- 0.32 mg), and teas (0.13 +/-
0.00 mg) was considerably lower. When the concentration of compounds was measured per standardized
serve, four ginger confectionery and beverage products contained total gingerol and shogaol
concentrations that were similar to the analyzed dietary supplement. Conclusion: Of the twenty
commercially available ginger products examined, those with the highest content of active, antiemetic
constituents were the standardized ginger extracts and supplements although ginger spices also showed
high levels of active constituents per serve. In addition, standard deviation reveals a large variation
within each product type. (C) 2017 Elsevier GmbH. All rights reserved.
Source: INDIAN JOURNAL OF AGRICULTURAL SCIENCES | 87 (7): 878-882 JUL 2017
Title: Standardization of novel technique for preparation of ginger (Zingiber officinale)-blended wine
from different cultivars of pear (Pyrus communis)
Author(s): Attri, BL | Kumar, A | Mer, MS | Kishor, A
Date: JUL 2017
Author keywords: Pear cultivars | Pear-ginger wine | Physico-chemical characters | Sensory
evaluation
Keywords plus:
Publication year: 2017
Volume: 87
Abstract:
In North-West Himalayas including Kumaon region of Uttarakhand pear (Pyrus communis L.)
cultivars like Jagner, Sand Pear and Kakria are being grown with very high yield and productivity but due
to poor market the growers are reluctant to harvest the crop because of which the nutritious fruits are
spoiled in the orchards. Except for Jagner which is soft and used for table purpose, there are very few
takers for other cultivars like Sand Pear and Kakria. All the cultivars are rich in various phyto-chemical
Página 58
characters including anti-oxidants. Hence, for reducing the huge spoilage of nutritious fruits, an attempt
was made to standardize a novel technique for pear wine from three cultivars after blending their juice
with 2.5% ginger (Zingiber officinale Roc) juice, 0.1% DAHP and 0.2% pectinol. After complete
fermentation with yeast, Saccharomyces cerevisiae var. ellipsoideus, the prepared base wines were
siphoned/filtered at regular intervals and stored at ambient conditions. A significant difference was
recorded in bio-chemical and sensory quality attributes of the wines after preparation and 6 months
storage. Among all the treatments ginger-blended Sand Pear wine prepared by raising the TSS to 22 B
and having 2.5% ginger juice had an edge over other treatments in overall quality. A significant
reduction in all the parameters was recorded irrespective of the cultivars used for wine preparation. On
the basis of the study the cost of production of ginger-blended pear wine was found quite reasonable
((sic) 93.10, 73.10 and 73.10/650 ml bottle for Jagner-ginger, Sand Pear-ginger and Kakria-ginger wines
respectively) with good profit margin comparable with low alcoholic beverages available in the market.
Source: BIOMOLECULES | 10 (2): - FEB 2020
Title: Chemical Composition of Essential Oils from Different Parts of Zingiber kerrii Craib and Their
Antibacterial, Antioxidant, and Tyrosinase Inhibitory Activities
Author(s): Pintatum, A | Laphookhieo, S | Logie, E | Vanden Berghe, W | Maneerat, W
Date: FEB 2020
Author keywords: Zingiber kerrii | chemical composition | biological activity | anti-tyrosinase |
cytotoxicity
Keywords plus: VOLATILE CONSTITUENTS | GINGER | OFFICINALE | EXTRACTS |
HYDRODISTILLATION | IDENTIFICATION | RHIZOMES | LEAVES | PLANTS | ASSAY
Publication year: 2020
Volume: 10
Abstract:
The essential oils of the fresh rhizomes; flowers; and leaves of Zingiber kerrii Craib were investigated
using different extraction techniques; including solid-phase microextraction (SPME), hydrodistillation
(HD), and organic solvent (OS), and characterized by gas chromatography-mass spectrometry (GC-MS).
A total of 37 SPME; 19 HD; and 36 OS compounds were identified from the rhizome extract of Z. kerrii;
with the major components being alpha-pinene; beta-pinene; and terpinen-4-ol; respectively. From the
flower extract; 16 SPME; 2 HD; and 10 OS compounds were identified; (E)-caryophyllene was found as a
major compound by these techniques. The leaf extract exhibited 20 SPME; 13 HD; and 14 OS
compounds; with alpha-pinene; (E)-caryophyllene; and n-hexadecanoic acid being the major
compounds; respectively. The rhizome extract showed tyrosinase inhibitory activity of 71.60% and a total
Página 59
phenolic content of 22.4 mg gallic acid/g. The IC50 values of the 2,2-diphenyl-1-picrylhydrazyl (DPPH)
and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays were 25.2
mu g/mL and 153.6 mu g/mL; respectively; and the ferric ion reducing antioxidant power (FRAP) assay
value was 318.5 mu M ascorbic acid equivalent (AAE)/g extract. The rhizome extract showed weak
antibacterial activity. This extract showed no adverse toxicity in human keratinocyte (HaCaT) cell lines
at concentrations below 200 mu g/mL.
Source: FARMACIA | 68 (4): 740-744 JUL-AUG 2020
Title: MERCURY EXPOSURE: NOVEL THERAPEUTIC APPROACHES
Author(s): Tincu, RC | Cobilinschi, C | Coman, OA | Coman, L | Tincu, IF | Macovei, RA
Date: JUL-AUG 2020
Author keywords: mercury | toxicity | low level exposure
Keywords plus:
Publication year: 2020
Volume: 68
Abstract:
In the past decade, it has been a focus on chronic, low or moderate exposure to methylmercury and
some randomized control trials draw the attention on health implications of low-grade mercury toxicity.
This study was aimed to evaluate efficacy of a combined treatment in mercury exposed patients.
Subjects were randomized to receive chelation therapy alone or chelation therapy associated with a
combination of Silybum marianum (172 mg), N-Acetyl-Cysteine (200 mg), L-Glutathione (25 mg),
Vitamin C (120 mg), Selenium (100 mu g), Helianthus tuberosus, Taraxacum officinale,
Schisandra chinensis, Zingiber officinale, Citrus paradise (an already on use formula),
respectively. A total of 300 patients were equally randomized in 2 groups. Patients in the intervention
group had significantly lower levels of mercury after 30 days of treatment, as well as after 30 days since
the treatment has stopped (6.1 +/- 4.4 vs. 7.6 +/- 4.0, p = 0.002 and 3.8 +/- 3.0 vs. 5.5 +/- 3.3, p =
0.000, respectively). This study provides evidence regarding some herbal extracts that may play a
protective role against mercury toxicity, improving clinical scores when compared to standard
treatment. More trials are needed to establish an integrative approach against mercury poisoning.
Source: CROP PROTECTION | 137: - NOV 2020
Title: Bioecological attributes and physiological indices of invasive fall armyworm, Spodoptera
frugiperda (J. E. Smith) infesting ginger (Zingiber officinale Roscoe) plants in India
Author(s): Firake, DM | Behere, GT
Página 60
Date: NOV 2020
Author keywords: Nutritional indices | ECI | ECD | Eocanthecona furcellata | Chelonus |
Mermithid | SfMNPV | SpfrNPV and Nomuraea rileyi
Keywords plus: ARMIGERA HUBNER LEPIDOPTERA | HOST STRAINS | NOCTUIDAE |
PATHOGENS | BIOLOGY | LARVAE | PEST | PARASITOIDS | POPULATIONS | RESISTANCE
Publication year: 2020
Volume: 137
Abstract:
Invasive fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) of
American origin, has recently arrived in Asian countries, found damaging maize and other host plants
including ginger (Zingiber officinale Roscoe) in India and China. The ginger is an economically
important spice and a medicinal cash crop of Asia. However, apart from just an occurrence, no other
information is available hitherto on interaction of FAW and ginger plants. This is the first
comprehensive report unfolding the FAW infestation to the ginger crop, including its bioecological and
physiological aspects. FAW identity was confirmed at the molecular level by comparing the sequences of
the CO I gene of mitochondrial DNA. FAW infestation was higher during mid-July (0.2 larvae/m(2)),
when ginger plants were in rhizome initiation stage (critical stage of growth). Besides generalist
predators, four natural enemies were found causing a total of 74.03% fortuitous biocontrol of FAW
larvae. Biological attributes and nutritional indices of FAW were studied on ginger for 3 consecutive
generations. The larval duration has significantly extended; however the body weight and lifetime
fecundity were considerably reduced in ginger fed larvae than maize. The Consumption Index (CI),
Relative Growth Rate (RGR) and Approximate Digestibility (AD) were significantly lower (Mann-
Whitney U Test, P < 0.001) in ginger fed FAW larvae compared to its regular host `maize'.
Nevertheless, the higher tissue growth (ECI) and more assimilation (ECD) of FAW on ginger indicate it
as a suitable alternate host plant and FAW may cause economic damage under certain circumstances.
Insights on ginger plants as a new host of FAW and fortuitous biocontrol aspects of FAW are discussed.
Source: PROGRESS IN NUTRITION | 18 (4): 421-428 DEC 2016
Title: Antioxidant effects of ginger, cinnamon and combination on Streptozotocin-induced
hyperglycemia associated oxidative stress in rats
Author(s): ElSadek, MF | Almajwal, AM | Abulmeaty, MMA
Date: DEC 2016
Author keywords: ginger | cinnamon | combined formula | Streptozotocin | antioxidant biomarkers
Página 61
Keywords plus: ZINGIBER-OFFICINALE | CHOLESTEROL | EXTRACT | INSULIN | EXPRESSION |
PLASMA | ENZYME | FOODS
Publication year: 2016
Volume: 18
Abstract:
Background and Aim: The aim of the present study was to investigate the antioxidant effects of ginger
(Zingiber officinale), cinnamon (Cinnamomum cassia) and combined formula of both powders on
the oxidative status on Streptozotocin (STZ)-induced diabetic rats. Methodology: Fifty male wistar
Albino rats were randomly divided into five groups (n=10). Group (1) Normal control rats received basal
diet. Group (2) Diabetic control, which injected intraperitoneally with a single dose of 50 mg/kg STZ and
received basal diet. Group (3) received basal diet with 15% of ginger. Group (4) received basal diet with
15% of cinnamon. Group (5) received basal diet with 15% of combined formula (50/50). Herbal powders
and combination were placed in rats' diet by 15% of dried materials for 30 days for STZ rats. Oxidative
status was investigated by measuring the total antioxidant capacity and the level of antioxidant
biomarkers such as malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase
(GPx) in the serum, in addition to, catalase (CAT), MDA, GPx and SOD in the liver tissue. Results:
Changes in body weight, food intake and food efficiency ratio were significantly observed between STZ
and control groups. Administration of 15% combined formula was the most significantly (P<0.05)
effective in reduction of plasma glucose, triglyceride, total cholesterol, LDL-C, VLDL-C, and liver
enzymes, in addition to an elevation in FER, insulin, and HDL-C compared to diabetic control group.
Furthermore, CAT, GPx, and SOD were significantly (P<0.05) elevated in liver tissue in combined
formula-treated group. Conclusion: Administration of ginger and cinnamon powder with 15% showed
amelioration of all investigated parameters with synergistic effects than each single herb on
hypoglycemic, hypolipidemic effects with a remarkable decrease in both serum and tissue lipid
peroxidation with enhancing antioxidant status for diabetic rats.
Source: ANIMALS | 9 (11): - NOV 2019
Title: Effects of Ginger Extract on Laying Performance, Egg Quality, and Antioxidant Status of Laying
Hens
Author(s): Wen, C | Gu, YF | Tao, ZG | Cheng, ZJ | Wang, T | Zhou, YM
Date: NOV 2019
Author keywords: antioxidant status | egg quality | ginger extract | laying hen
Keywords plus: ROOT ZINGIBER-OFFICINALE | SERUM METABOLITES | OXIDATIVE STRESS |
Página 62
BLOOD PARAMETERS | FEED ADDITIVES | FATTY-ACID | CHOLESTEROL | POWDER | ROSCOE |
SUMAC
Publication year: 2019
Volume: 9
Abstract:
Simple Summary: The application of in-feed antibiotic growth promoters was banned in many countries
due to their negative effects, and several kinds of feed additives were widely investigated as antibiotic
alternatives, in which natural plant-derived products received much attention due to their
environmentally friendly properties and numerous biological activities. Ginger (Zingiber officinale
Roscoe), a widely used herbal medicine and spice, was proven to have potential as an antibiotic
alternative in poultry feed, but there is little literature on the efficacy of ginger extract (GE), which has
concentrated bioactive compounds with high bioavailability. Our results showed that dietary GE
supplementation increased egg weight, improved egg quality, and reduced the yolk cholesterol content of
laying hens. Decreased serum activities of alanine transaminase and aspartate transaminase and
improved antioxidant status were observed in the GE group. Our study demonstrated the potential
benefits of GE in laying hens. Abstract: The objective of this study was to investigate the effects of ginger
extract (GE) as a dietary supplement for laying hens. A total of 40-week-old 288 Hyline Brown laying
hens were randomly divided into two groups with six replicates, and fed a basal diet with or without 100
g/t GE for eight weeks. Dietary GE supplementation increased egg weight, albumin height, and Haugh
unit of eggs, and decreased yolk cholesterol content and activities of alanine transaminase and aspartate
transaminase in serum at eight weeks. Moreover, GE resulted in higher total superoxide dismutase (T-
SOD) activity and lower malondialdehyde (MDA) content in yolk at four and eight weeks and in serum.
It was concluded that GE was effective in increasing egg weight and improving the egg quality and
antioxidant status of laying hens.
Source: ACTA CHROMATOGRAPHICA | 30 (3): 164-168 SEP 2018
Title: Simultaneous Determination of Eight Kinds of Gingerols in Zingiberis Rhizome Collected From
Different Areas of China
Author(s): Wang, Y | Chen, JH | Li, YT | Li, PL | Iqbal, J | Chen, Y | Ma, YL | Zhang, C
Date: SEP 2018
Author keywords: Zingiber offcinale Rosc | gingerol | high-performance liquid chromatography |
quantitative analysis
Keywords plus: ZINGIBER-OFFICINALE ROSC. | MASS-SPECTROMETRY | PGE(2) PRODUCTION
| RATS
Página 63
Publication year: 2018
Volume: 30
Abstract:
A reliable and rapid high-performance liquid chromatography coupled with diode array detector
method (HPLC-DAD) was established and validated to determine eight gingerol simultaneously in the
rhizomes of Zingiber offcinale Rosc. The separation of eight compounds (4-hydroxy-3-methoxy-
benzenebutanol,3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl) decane, 3,5-dihydroxy-1-(3,4-
dimethoxyphenyl) decane, 6-gingerol, 8-gingerol, 6-shogaol, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)
-1,4-decadien-3-one, and 10-gingerol) were performed on an Agilent TC(2) C-18 (250 mm x 4.6 mm, 5
mu m) at 30 degrees C using acetonitrile (A) and 1% formic acid aqueous solution (B) as the mobile
phase with gradient elution (0-10 min, 20%-35% A; 10-28 min, 35%-55% A; 28-35 min, 55%-60% A; 35-
55 min, 60%-70% A; 55.01-60 min, 100%-100% A). The detection wavelength was set at 280 nm, and
the flow rate was 0.8 mL/min. Validation of the analytical method was performed by linearity,
precision, and accuracy test. All compounds were quantified with good linear calibration curves
(coefficient of determination R-2, >0.9999). The method showed good precision with overall
coefficients of variation between 0.56% and 0.84%. The range of recovery was from 95.50% to 104.14%
for the analytes. This method was successfully applied to quantify eight gingerols in Z. offcinale Rosc
from different regions in China, so it can provide quality assessment for this medicine.
Source: FISH & SHELLFISH IMMUNOLOGY | 74: 444-449 MAR 2018
Title: Blood biochemical parameters and melanomacrophage centers in Nile tilapia fed essential oils of
clove basil and ginger
Author(s): Brum, A | Pereira, SA | Cardoso, L | Chagas, EC | Chaves, FCM | Mourino, JLP | Martins,
ML
Date: MAR 2018
Author keywords: Fish | Triglycerides | Cholesterol | Lysozyme | Immunoglobulins | Spleen
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | FED SUPPLEMENTED DIET | GROWTH-
PERFORMANCE | IMMUNE-RESPONSE | OREOCHROMIS-MOSSAMBICUS | DISEASE
RESISTANCE | MEDICINAL-PLANTS | CHEMISTRY | EXTRACTS | HEMATOLOGY
Publication year: 2018
Volume: 74
Abstract:
Página 64
Nile tilapia (Oreochromis niloticus) is the most farmed freshwater fish in the world, however,
disease outbreaks are the main cause of losses in production. Due to this, there is an increasing interest
in natural products for enhancing disease resistance, without causing physiological impairment. The
aim of this study was to verify the effect of the essential oils of clove basil (Ocimum gratissimum)
and ginger (Zingiber officinale) on physiological and immunological parameters of nile tilapia. After
35 and 55 days of supplementation (0.5%, 1.0% and 1.5%), blood collection was performed for
determination of metabolites (glucose, cholesterol, triglycerides, serum total protein and
immunoglobulins) and lysozyme activity. Spleen tissue was also collected at 55 days for analyzing
melanomacrophages centers. At 35 days, cholesterol showed significant reduction in the treatments
0.5% and 1.5 ginger and 1.5% clove basil. The serum triglycerides showed significant reduction in these
same treatments, in addition to 1.0% clove basil. At 55 days all the supplemented groups showed
significant reduction for both parameters. The lysozyme activity at 35 days was significantly higher in
fish supplemented with 1.0% ginger and showed no difference among the treatments at 55 days.
Regarding the melanomacrophage centers, at 35 days increased number in fish supplemented with
0.5% clove basil was observed but with no significant difference in the total percent area of spleen
occupied by centers. The levels of glucose, total serum protein and immunoglobulins did not show
significant differences in both sampling times. The addition of essential oils showed to be useful for
improving physiological status of the fish, without excessive activation of defense mechanisms.
Source: EUROPEAN JOURNAL OF NUTRITION | 60 (5): 2781-2793 AUG 2021
Title: 6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR
pathway
Author(s): Pei, XD | He, ZL | Yao, HL | Xiao, JS | Li, L | Gu, JZ | Shi, PZ | Wang, JH | Jiang, LH
Date: AUG 2021
Author keywords: 6-Shogaol | Apoptosis | Cell migration | Autophagy | PI3K/Akt/mTOR pathway
Keywords plus: EPITHELIAL-MESENCHYMAL TRANSITIONS | ZINGIBER-OFFICINALE | CELL-
PROLIFERATION | INHIBITS BREAST | AUTOPHAGY | APOPTOSIS | ACTIVATION | INVASION |
ARREST | DEATH
Publication year: 2021
Volume: 60
Abstract:
Purpose 6-Shogaol, an active phenolic compound from ginger (Zingiber officinale), can inhibit the
growth of a variety of human cancer cells. Nevertheless, its underlying molecular mechanisms in
cervical cancer remain unclear. In this study, we systematically examine the inhibitory effect of 6-
Página 65
shogaol on cervical cancer in vitro and in vivo. Methods Cell proliferation was assessed by CCK8 assay
and colony formation assay in HeLa and SiHa cells. We analyzed cell cycle and apoptosis through flow
cytometry. GFP-LC3 puncta and transmission electron microscopy were used to observe autophagic
bodies. Wound-healing assay and transwell assay were used for evaluating the migration of cells.
Western blot was applied to detect protein expression levels. Results 6-Shogaol could suppress cell
proliferation and migration, cause cell cycle arrest in the G2/M phase in HeLa and SiHa cells. Moreover,
6-shogaol triggered the apoptosis process through the mitochondrial pathway by downregulating the
expression levels of p-PI3K, p-Akt and p-mTOR. Further research indicated that the induction of
apoptosis by 6-shogaol was remarkably decreased after the treatment of ROS scavenger and PI3K
agonist. Additionally, 6-shogaol increased the number of LC3-positive puncta and autophagic bodies per
cell in both HeLa and SiHa cells. Pretreatment of cells with Bafilomycin A1, an autophagy inhibitor,
accelerated 6-shogaol mediated cell apoptosis, suggesting that induction of autophagy by 6-shogaol is
suppressive to apoptosis. Furthermore, in vivo data revealed that 6-shogaol significantly inhibited
tumor growth and cell proliferation in tumor tissues. Conclusion These findings suggested that 6-
shogaol could be developed as a functional food ingredient, which is potentially used as therapeutic
agents for patients with cervical cancer.
Source: DRYING TECHNOLOGY | 36 (9): 1107-1116 2018
Title: Effect of high pressure pretreatment on drying kinetics and oleoresin extraction from ginger
Author(s): George, JM | Sowbhagya, HB | Rastogi, NK
Date: 2018
Author keywords: 6-gingerol | diffusion coefficient | drying | extraction | high pressure processing |
oleoresin
Keywords plus: HIGH HYDROSTATIC-PRESSURE | ZINGIBER-OFFICINALE | OSMOTIC
DEHYDRATION | NATURAL-PRODUCTS | BIOACTIVE COMPOUNDS | GREEN EXTRACTION |
MASS-TRANSFER | BEHAVIOR | QUALITY | CARROT
Publication year: 2018
Volume: 36
Abstract:
The present study reports for the first time the effect of high pressure pretreatment (100-400MPa,
10min) on drying kinetics of ginger and its oleoresin extraction. High pressure pretreated samples were
dried, powdered and solvent extracted. The increase in drying temperature (55-85 degrees C) increased
the moisture diffusivity (2.03-4.87x10(-9)m(2)/s) but resulted in decrease in 6-gingerol (53.98%) and
oleoresin yield (57.31%). However, high pressure pretreatment followed by dehydration (55 degrees C)
Página 66
resulted in higher moisture diffusivity (2.84-6.09x10(-9)m(2)/s) as well as enhanced extraction yield of 6
-gingerol (34.05%) and oleoresin (28.29%).
Source: ANTIOXIDANTS | 6 (3): - SEP 2017
Title: Antioxidant Activity of Spices and Their Impact on Human Health: A Review
Author(s): Yashin, A | Yashin, Y | Xia, XY | Nemzer, B
Date: SEP 2017
Author keywords: antioxidants | spices | herbs | flavonoids | polyphenols
Keywords plus: GINGER ZINGIBER-OFFICINALE | TRANSFORM INFRARED-SPECTROSCOPY |
OREGANO ORIGANUM-VULGARE | PEPPER PIPER-NIGRUM | IN-VITRO | PLANT-EXTRACTS |
BLACK PEPPER | PHENOLIC-COMPOUNDS | WATER EXTRACTS | LIPID PROFILE
Publication year: 2017
Volume: 6
Abstract:
Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices
and herbs are rich sources of antioxidants. They have been used in food and beverages to enhance flavor,
aroma and color. Due to their excellent antioxidant activity, spices and herbs have also been used to treat
some diseases. In this review article, the chemical composition and antioxidant activity of spices and
culinary herbs are presented. The content of flavonoids and total polyphenols in different spices and
herbs are summarized. The applications of spices and their impacts on human health are briefly
described. The extraction and analytical methods for determination of antioxidant capacity are concisely
reviewed.
Source: ITALIAN JOURNAL OF ANIMAL SCIENCE | 17 (4): 867-872 2018
Title: Ginner (Zingiher officinale Roscoe) powder as dietary supplementation in rabbit: lite
performances, carcass characteristics and meat quality
Author(s): Mancini, S | Secci, G | Preziuso, G | Parisi, G | Paci, G
Date: 2018
Author keywords: Rabbit | ginger | meat quality | antioxidant | diet
Keywords plus: SPIRULINA ARTHROSPIRA-PLATENSIS | THYME THYMUS-VULGARIS |
CURCUMA-LONGA L. | OXIDATIVE STATUS | ANTIOXIDANT CAPACITY | LONGISSIMUS-DORSI |
Página 67
ASCORBIC-ACID | BURGERS | PROFILE | STABILITY
Publication year: 2018
Volume: 17
Abstract:
The aim of this study was to evaluate the effect of dietary Zingiber officinale Roscoe (ginger) powder
on rabbit productive performances, meat quality and shelf-life of raw and cooked meat. Ninety hybrid
rabbits of 60 days old were fed three different diets: basal diet (control, C), basal diet supplemented by 4
g of ginger powder on 100 g of feed (G4) and basal diet supplemented by 8 g of ginger powder on 100 g of
feed (G8) (3.6 and 7.2 9/100 g of dry matter for G4 and G8, respectively). Live weight, average daily gain
and feed intake were recorded. Ten rabbits of each group were slaughtered at 90 days of age and meat
quality was assessed during seven days of storage at 4 degrees C. Live performance and slaughter traits
did not show any significant differences. Dietary ginger powder induced modification in pH of raw
samples and in colour indexes of both raw and cooked meat. Lipid oxidation of raw samples was delayed
in time by ginger feed addition even if no modification was highlighted in antioxidant capacity. Ginger
powder could be a potential supplementation in diet of rabbits for increasing meat shelf-life.
Source: JOURNAL OF FOOD BIOCHEMISTRY | 45 (2): - FEB 2021
Title: Effect of ginger (Zingiber officinale) supplementation on oxidative stress parameters: A systematic
review and meta-analysis
Author(s): Morvaridzadeh, M | Sadeghi, E | Agah, S | Fazelian, S | Rahimlou, M | Kern, FG | Heshmati,
S | Omidi, A | Persad, E | Heshmati, J
Date: FEB 2021
Author keywords: ginger | glutathione peroxidase | malondialdehyde | oxidative stress | total
antioxidant capacity
Keywords plus:
Publication year: 2021
Volume: 45
Abstract:
A wide variety of antioxidant properties are attributed to ginger (Zingiber officinale) and several
randomized controlled trials (RCTs) have investigated the effect of ginger intake on major oxidative
stress (OS) parameters. We conducted a systematic review and meta-analysis to evaluate the effects of
using ginger to improve OS levels. Medline, Scopus, ISI Web of Science, EMBASE, and the Cochrane
Página 68
Central Register of Controlled Trials were systematically searched up until March 2020 to gather RCTs
that evaluated the impact of ginger intake on the levels and activity of OS parameters in adult subjects.
Means and standard deviations for relevant OS variables were extracted and evaluated to assess the
quality of the trials based on the Cochrane risk-of-bias tool for randomized trials. The gathered data were
pooled and expressed as standardized mean difference (SMD) with 95% Confidence Intervals (95% CI).
Twelve trials were included in this review. Ginger intake was shown to significantly increase glutathione
peroxidase (GPx) activity (SMD: 1.64; 95% CI: 0.43, 2.85; I-2 = 86.8%) and total antioxidant capacity
(TAC) (SMD: 0.40; 95% CI: 0.06, 0.73; I-2 = 42.8%) and significantly decrease malondialdehyde (MDA)
levels (SMD: -0.69; 95% CI: -1.26, -0.12; I-2 = 85.8%) compared to control groups. Ginger
supplementation also non-significantly associated with an increase in CAT activity (SMD: 1.09; 95% CI: -
0.07, 2.25; I-2 = 87.6%). This systematic review and meta-analysis presents convincing evidence
supporting the efficacy of ginger supplementation on improving OS levels. Practical implications: In
health sciences, OS, due to its pivotal role in the pathophysiology of several chronic diseases, is a subject
with a long history. Recent research strives for a safe, ideal, and effective antioxidant. Ginger is herbal
medicine, which has been widely used in traditional and complementary medicine. Proving the
antioxidant effect and potential benefit of ginger has positive clinical implications for the application of
this practical herb.
Source: GREEN PROCESSING AND SYNTHESIS | 8 (1): 895-900 JAN 2019
Title: Photocatalytic activity of Ag/Ni bi-metallic nanoparticles on textile dye removal
Author(s): Mohan, S | Devan, MV
Date: JAN 2019
Author keywords: Z. root extract | Ag/Ni NPs | textile dye | SEM | UV and redox
Keywords plus: GREEN SYNTHESIS | CATALYTIC-ACTIVITY | ROOM-TEMPERATURE | SILVER |
REDUCTION
Publication year: 2019
Volume: 8
Abstract:
The photocatalysis of Ag/Ni bi-metallic nanoparticles on safranin O dye degradation was evaluated by UV
light irradiations. Ag/Ni bi-metallic nanoparticles were synthesized by the green approach using
Zingiber officinale root (Zinger) extract. The average particles size of Ag/Ni bi-metallic nanoparticles
was found to be 70-88 nm from SEM image and from XRD patterns it was confirmed that the existence of
Ag/Ni bi-metallic nanoparticles. 8 mg of Ag/Ni bi-metallic nanoparticles present in 40 mL of 10 ppm dye,
degraded completely in presence of UV light irradiations within 30 min time durations. The effect of dye
Página 69
degradation within a short period of time (30 min) was due to wide band gap energy and photo-chemical
redox reactions.
Source: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC
BIOMATERIALS | 67 (9): 581-588 2018
Title: Turmeric nanofiber-encapsulated natural product formulation act as a phytogenic feed additiveA
study in broilers on growth performance, biochemical indices of blood, and E-coli in cecum
Author(s): Gopi, S | Amalraj, A | Varma, K | Jude, S | Reddy, PB | Divya, C | Haponiuk, JT | Thomas, S
Date: 2018
Author keywords: Bioactive compounds | broiler chicken | growth performance | phytogenic feed
additive | turmeric nanofiber
Keywords plus: GINGER ZINGIBER-OFFICINALE | SEED NIGELLA-SATIVA | ESSENTIAL OILS |
ANTIOXIDANT STATUS | CAMELLIA-OLEIFERA | MEAT QUALITY | NUTRIENT DIGESTIBILITY |
DIETARY FIBER | CHICKENS | SUPPLEMENTATION
Publication year: 2018
Volume: 67
Abstract:
A phytogenic feed additive (PFA) formulation was prepared with bioactive moleculescurcuminoids,
gingerol, and carvacrol by encapsulating in nanofiber isolated from turmeric spent (turmeric nanofiber,
TNF). This formulation was completely characterized by scanning electron microscope, ultra
performance liquid chromatography, and gas chromatography and evaluated for its efficacy. PFA-
encapsulated TNF (PFA@TNF) considerably increased mean body weight, decreased cholesterol level,
mortality rate, and reduced Escherichia coli content of broilers than antibiotic growth promoter
(AGP). The depth of crypts in the ileum of broilers was considerably reduced by the inclusion of
PFA@TNF in diets compared with the AGP. [GRAPHICS]
Source: CURRENT MICROBIOLOGY | 75 (4): 505-511 APR 2018
Title: Culturable Endophytic Bacteria of Ginger Rhizome and their Remarkable Multi-trait Plant
Growth-Promoting Features
Author(s): Rohini, S | Aswani, R | Kannan, M | Sylas, VP | Radhakrishnan, EK
Date: APR 2018
Author keywords:
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Keywords plus: ZEA-MAYS L. | ACID
Publication year: 2018
Volume: 75
Abstract:
Functional contribution of endophytic bacteria towards plant growth is highly impressive due to their
species diversity and array of probiotic mechanisms. In the study, 96 endophytic bacteria isolated from
rhizome of ginger (Zingiber officinale) were screened for phosphate solubilisation, 1-amino
cyclopropane-1-carboxylate (ACC) deaminase activity, nitrogen fixation, ammonia and IAA production.
Among these, sixteen endophytes with multiple plant growth-promoting activities were identified by 16S
rDNA sequencing and all of them showed growth enhancement in Vigna unguiculata var Lola which
make the study remarkably significant. The result was a clear indication of consistent, reliable and broad
spectrum plant probiotic features of all the selected isolates. However, strain-specific effects on soil
parameters represent the unique and distinguishable role of each of the selected isolates in the
chemobiology of ginger rhizome. The study provided deeper insight into microbiomics of ginger rhizome
with its agricultural promises.
Source: STARCH-STARKE | : - JUN 9 2021
Title: Antioxidant and Immunomodulatory Activities In Vitro of a Neutral Polysaccharide from Ginger
(Zingiber Officinale)
Author(s): Hou, MD | Jun, G | Liu, ZQ | Yu, S | Liu, SY
Date:
Author keywords: antioxidant activity | ginger | immunomodulatory activity | polysaccharides |
structures
Keywords plus: STRUCTURAL-CHARACTERIZATION | INHIBITORY-ACTIVITIES | EXTRACTION
| CARBOHYDRATE | OPTIMIZATION | PECTIN | FRUIT
Publication year:
Volume:
Abstract:
In this study, crude polysaccharides from ginger are obtained by ultrasonic-assisted enzymatic
extraction. After deproteinization using Sevag method, dialysis, and isolation on a DEAE52-cellulose
column and a Sephadex G-100 column, a neutral heteropolysaccharide purified ginger polysaccharide
(pGP) with the molecular weight of 62 500 Da is obtained. Four sugar residues are confirmed in pGP,
Página 71
including -> 3)-alpha-L-Araf-(1 ->, -> 2)-alpha-L-Rhap, -> 3)-beta-D-Galp-(1 ->, -> 6)-alpha-D-Glcp-(1
->. Antioxidant activities analysis confirms that pGP possess good scavenging effects on DPPH, 2,2-
azino-bis-3-ethylbenzthiazoline-6-sulphonic acid, and hydroxyl radicals. In addition, pGP significantly
stimulates the phagocytic activity of RAW264.7 cells and has strong protection effect against H2O2-
induced damage. These results show that pGP can be used as a potential antioxidant agent in medicine
or functional food.
Source: CURRENT SCIENCE | 110 (4): 579-583 FEB 25 2016
Title: Chemopreventive prospective of dietary spices against hepatocellular carcinoma
Author(s): Akhtar, T | Sheikh, N
Date: FEB 25 2016
Author keywords: Apoptosis | carcinogenesis | chemoprevention | hepatocellular carcinoma |
inflammation
Keywords plus: CELL-CYCLE ARREST | FACTOR-KAPPA-B | CYTOCHROME-C | ZINGIBER-
OFFICINALE | LIPID-PEROXIDATION | DIALLYL SULFIDE | HEPATOMA-CELLS | CURCUMA-
LONGA | LIVER-CANCER | GARLIC OIL
Publication year: 2016
Volume: 110
Abstract:
Hepatocellular carcinoma (HCC), a primary liver cancer, is one of the most fatal cancers having
universal prevalence. Developing countries of Asia and Africa are reported with more HCC cases
compared to the United States and Europe. Surgical resection and liver transplantation present limited
treatment choices for HCC. It is need of the hour to investigate promising alternative chemopreventive
and therapeutic strategies to control the disease. In most cases HCC develops and progresses in an
environment of inflammation and oxidative stress. Phytochemicals such as dietary spices and their
active components gifted with potent anti-inflammatory and antioxidant properties, offer an
appropriate alternative mitigation of HCC. Ginger, turmeric and garlic are the commonly used spices.
Studies suggest that these have anti-inflammatory, antioxidant and antitumour activities. This article
reviews their apoptotic, anti-inflammatory and antioxidant effects as well as involvement of various
molecular signalling pathways.
Source: CHEMICAL & PHARMACEUTICAL BULLETIN | 64 (1): 21-26 JAN 2016
Title: Microeneapsulation of Ginger Volatile Oil Based on Gelatin/Sodium Alginate Polyelectrolyte
Complex
Página 72
Author(s): Wang, LX | Yang, SW | Cao, JL | Zhao, SH | Wane, WW
Date: JAN 2016
Author keywords: polyelectrolyte complexation | ginger volatile oil (GVO) | microcapsule | gelatin |
sodium alginate
Keywords plus: ZINGIBER-OFFICINALE | ANTIOXIDANT ACTIVITY | IN-VITRO |
MICROENCAPSULATION | MICROCAPSULES | COACERVATION | CHITOSAN | MICROSPHERES |
KINETICS | RELEASE
Publication year: 2016
Volume: 64
Abstract:
The coacervation between gelatin and sodium alginate for ginger volatile oil (GVO) microencapsulation
as functions of mass ratio, pH and concentration of wall material and core material load was evaluated.
The microencapsulation was characterized by scanning electron microscopy (SEM), Fourier transform
infrared (FT-IR), and thermal gravimetric analysis (TGA). SEM and FT-IR studies indicated the
formation of polyelectrolyte complexation between gelatin and sodium alginate and successful
encapsulation of GVO into the microcapsules. Thermal property study showed that the crosslinked
microparticles exhibited higher thermal stability than the neat GVO, gelatin, and sodium alginate. The
stability of microencapsulation of GVO in a simulated gastric and an intestinal situation in vitro was also
studied. The stability results indicated that the release of GVO from microcapsules was much higher in
simulated intestinal fluid, compared with that in simulated-gastric fluid.
Source: JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE | 55 (8): 3001-3007 AUG
2018
Title: Inhibitory effect of chemical and natural anti-browning agents on polyphenol oxidase from ginger
(Zingiber officinale Roscoe)
Author(s): Lim, WY | Wong, CW
Date: AUG 2018
Author keywords: Polyphenol oxidase | Ginger | Anti-browning agents | Inhibition
Keywords plus: PURIFICATION | PREVENTION | POTATO | BANANA | JUICE
Publication year: 2018
Volume: 55
Abstract:
Página 73
Food browning is undesirable as it causes deterioration in food quality and appearance. This
phenomenon was related to polyphenol oxidase (PPO), which catalyzes conversion of phenolic
compounds into o-quinones. The present work evaluated the use of chemical and natural anti-browning
agents to prevent the browning of ginger PPO. Sodium metabisulfite (5 mM) is a better chemical
inhibitor compared to l-cysteine and sodium chloride as 55.00% of ginger PPO inhibition was achieved.
The percentage of inhibition increased as the concentration of anti-browning agents increases. The
addition of heated onion, chili pepper and pineapple extracts exhibited a stronger inhibitory effect on
ginger PPO than unheated extracts. Heated chili pepper extract was the best natural inhibitor found in
this study and it inhibited the ginger PPO (47.97%) mixed-competitively. Natural anti-browning agents
have potential to be used to control the browning of ginger as well as other vegetables and fruits.
Source: SEMINARS IN CANCER BIOLOGY | 69: 140-149 FEB 2021
Title: Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic
applications
Author(s): Mahomoodally, MF | Aumeeruddy, MZ | Rengasamy, KRR | Roshan, S | Hammad, S |
Pandohee, J | Hu, XB | Zengin, G
Date: FEB 2021
Author keywords: Zingiber officinale | Microbiome | Gingerol | Shogaol | Enzyme inhibition |
Combination therapy | Nanoformulation
Keywords plus:
Publication year: 2021
Volume: 69
Abstract:
Ginger is a spice that is renowned for its characteristic aromatic fragrance and pungent taste, with
documented healing properties. Field studies conducted in several Asian and African countries revealed
that ginger is used traditionally in the management of cancer. The scientific community has probed into
the biological validation of its extracts and isolated compounds including the gingerols, shogaols,
zingiberene, and zingerone, through in -vitro and in-vivo studies. Nonetheless, an updated compilation
of these data together with a deep mechanistic approach is yet to be provided. Accordingly, this review
highlights the mechanisms and therapeutics of ginger and its bioactive compounds focused on a cancer
context and these evidence are based on the (i) cytotoxic effect against cancer cell lines, (ii) enzyme
inhibitory action, (iii) combination therapy with chemotherapeutic and phenolic compounds, (iv)
possible links to the microbiome and (v) the use of nano-formulations of ginger bioactive compounds as
a more effective drug delivery strategy in cancer therapy.
Página 74
Source: JCI INSIGHT | 6 (3): - FEB 8 2021
Title: Antineutrophil properties of natural gingerols in models of lupus
Author(s): Ali, RA | Gandhi, AA | Dai, LP | Weiner, J | Estes, SK | Yalavarthi, S | Gockman, K | Sun,
DX | Knight, JS
Date: FEB 8 2021
Author keywords:
Keywords plus: NEUTROPHIL EXTRACELLULAR TRAPS | ZINGIBER-OFFICINALE |
ANTIPHOSPHOLIPID SYNDROME | THROMBOSIS | EXPRESSION | METABOLITES | 6-GINGEROL
| APREMILAST | ANTIBODIES | CONTRIBUTE
Publication year: 2021
Volume: 6
Abstract:
Ginger is known to have antiinflammatory and antioxidative effects and has traditionally been used as
an herbal supplement in the treatment of various chronic diseases. Here, we report antineutrophil
properties of 6-gingerol, the most abundant bioactive compound of ginger root, in models of lupus and
antiphospholipid syndrome (APS). Specifically, we demonstrate that 6-gingerol attenuates neutrophil
extracellular trap (NET) release in response to lupus- and APS-relevant stimuli through a mechanism
that is at least partially dependent on inhibition of phosphodiesterases. At the same time, administration
of 6-gingerol to mice reduces NET release in various models of lupus and APS, while also improving
other disease-relevant endpoints, such as autoantibody formation and large-vein thrombosis. In
summary, this study is the first to our knowledge to demonstrate a protective role for ginger-derived
compounds in the context of lupus. Importantly, it provides a potential mechanism for these effects via
phosphodiestera se inhibition and attenuation of neutrophil hyperactivity.
Source: JOURNAL OF FOOD QUALITY | : - 2017
Title: The Aroma Composition of Baby Ginger Paocai
Author(s): Luo, SM | Li, Q | Chen, AJ | Liu, XY | Pu, B
Date: 2017
Author keywords:
Keywords plus: GC-MS | ZINGIBER-OFFICINALE | FERMENTATION | OLFACTOMETRY |
FLAVOR | SAFETY | FOOD
Página 75
Publication year: 2017
Volume:
Abstract:
The purpose of this study was to analyze the volatile compounds in baby ginger paocai and the fresh
baby ginger and identify the key aroma components that contribute to the flavor of baby ginger paocai. A
total of 86 volatile compounds from the two baby ginger samples were quantified; these compounds
were extracted by headspace solid-phase microextraction (HS-SPME) and analyzed by gas
chromatography-mass spectrometry (GC-MS). The aroma composition of baby ginger paocai was
different from that of fresh baby ginger. Baby ginger paocai was characterized by the presence of aroma-
active compounds which varied in concentration from 0.03 to 28.14%. Geranyl acetate was the aroma
component with the highest relative content in baby ginger paocai. beta-myrcene, eucalyptol, trans-beta-
ocimene, Z-ocimene, linalool, decanal, cis-citral, geraniol, geranyl acetate, curcumene, and beta-
bisabolene contributed to the overall aroma of the product of baby ginger paocai which had gone
through a moderate fermentation process.
Source: FRONTIERS IN PHARMACOLOGY | 11: - SEP 23 2020
Title: COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
Author(s): Silveira, D | Prieto-Garcia, JM | Boylan, F | Estrada, O | Fonseca-Bazzo, YM | Jamal, CM |
Magalhaes, PO | Pereira, EO | Tomczyk, M | Heinrich, M
Date: SEP 23 2020
Author keywords: herbal medicine | coronavirus (2019-nCoV) | COVID-19 | benefit | risk assessment
| respiratory diseases
Keywords plus: MIKANIA-GLOMERATA SPRENGEL | PERFORMANCE LIQUID-
CHROMATOGRAPHY | ZINGIBER-OFFICINALE ROSCOE | PREGNANCY-INDUCED NAUSEA |
PLANTAGO-LANCEOLATA L. | WILLOW BARK EXTRACT | POLYGALA-TENUIFOLIA WILLDENOW
| OREGANO LIPPIA-GRAVEOLENS | ESSENTIAL OIL COMPOSITION | THISTLE SILYBUM-
MARIANUM
Publication year: 2020
Volume: 11
Abstract:
Background Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19)
include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that
many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims To
Página 76
provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory
diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method The
plant selection was primarily based on species listed by the WHO and EMA, but some other herbal
remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical
data on their efficacy and safety were collected from authoritative sources. The target population were
adults with early and mild flu symptoms without underlying conditions. These were evaluated according
to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The
benefits/risks balance of the treatments was classified aspositive,promising,negative, andunknown.
Results A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient.
According to our method, the benefits/risks assessment of the herbal medicines was found to be positive
in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix,
andSambucus nigra), promising in 12 cases (Allium sativum,Andrographis
paniculata,Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulusessential oil,
Justicia pectoralis, Magnolia officinalis,Mikania glomerata,Pelargonium
sidoides,Pimpinella anisum,Salixsp,Zingiber officinale), and unknown for the rest. On the same
grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the
use of paracetamol and/or codeine. Conclusions Our work suggests that several herbal medicines have
safety margins superior to those of reference drugs and enough levels of evidence to start a clinical
discussion about their potential use as adjuvants in the treatment of early/mild common flu in otherwise
healthy adults within the context of COVID-19. While these herbal medicines will not cure or prevent the
flu, they may both improve general patient well-being and offer them an opportunity to personalize the
therapeutic approaches.
Source: AFRICAN JOURNAL OF AQUATIC SCIENCE | : - NOV 14 2019
Title: Effects of Chromolaena odorata leaf extract on behaviour and haematology of Clarias gariepinus
juveniles (Burchell, 1822)
Author(s): Okoro, N | Iheanacho, SC | Nwakpa, J | Eze, K
Date:
Author keywords: behaviour | Chromolaena odorata | plant leaf extract | haematology
Keywords plus: ZINGIBER-OFFICINALE | DISEASE RESISTANCE | FISH | GROWTH | PLANTS
Publication year:
Volume:
Abstract:
The current study investigated the effect of Chromolaena odorata leaf extract on the behaviour and
Página 77
haematology of Clarias gariepinus juveniles. One hundred and fifty (150) juveniles of C. gariepinus
(46.02 +/- 1.20 g) were exposed to a range of concentrations of C. odorata leaf extract: 10 mg l(-1), 20 mg
l(-1), 30 mg l(-1) and 40 mg l(-1) at 24 h, 48 h, 72 h and 96 h exposure duration. Dose- and time-
dependent behavioural changes, such as loss of equilibrium, hyperactivity and jerky movement, were
observed in fish exposed to C. odorata leaf extract. There was a progressive and dose-dependent
decrease in response to stimulus with time, until a state of calmness, which was subsequently followed by
death. Haematological analyses revealed significant and dose-dependent decreases in pack cell volume,
haemoglobin and erythrocytes, and elevated white blood cells, in exposed fish relative to control fish.
Source: FOOD CHEMISTRY | 350: - JUL 15 2021
Title: The effect of borage, ginger and fennel extracts on acrylamide formation in French fries in deep
and electric air frying
Author(s): Haddarah, A | Naim, E | Dankar, I | Sepulcre, F | Pujola, M | Chkeir, M
Date: JUL 15 2021
Author keywords: Acrylamide | Borago officinalis | Foeniculum vulgare | Natural extracts | Scavenging
activity | Zingiber officinale
Keywords plus:
Publication year: 2021
Volume: 350
Abstract:
The aim of this study was to evaluate the effect of three Lebanese wild plant extracts on acrylamide (AA)
content in French fries, and to investigate the impact of air frying (AF) and deep frying (DF) techniques
against AA formation. HPLC showed higher level of AA in DF (1384.79 ng/g) than in AF (163.1 ng/g).
Indeed, the plant extracts of ginger, borage and fennel succeeded to decrease AA (59.67, 67.99, and
73.36% in (AF) and 21.91, 66.29 and 29.15% in (DF) respectively) in both fryers. Accordingly, borage
fennel and ginger with their high scavenging activity (86.09%, 89.11% 93.67% respectively) and total
phenolic contents (298.61, 117.79 and 97.36 of GAE respectively) can act as healthy beneficial pre-
treatment, overall reducing AA in potato fries particularly in AF. This study was the first to reveal the
importance of using plant extract in reducing AA in potato fries, a staple Lebanese food.
Source: FRONTIERS IN PHARMACOLOGY | 9: - FEB 27 2018
Title: 6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol
Efflux-Related Genes in HepG2 Cells
Página 78
Author(s): Li, X | Guo, JT | Liang, N | Jiang, XW | Song, Y | Ou, SY | Hu, YF | Jiao, R | Bai, WB
Date: FEB 27 2018
Author keywords: 6-gingerol | cholesterol metabolism | LDLR | cholesterol efflux | ABCA1
Keywords plus: HIGH-FAT DIET | PLASMA-CHOLESTEROL | FAMILIAL
HYPERCHOLESTEROLEMIA | ZINGIBER-OFFICINALE | MESSENGER-RNA | X-RECEPTOR |
LIVER | ABCA1 | MICE | GINGER
Publication year: 2018
Volume: 9
Abstract:
Gingerols, the pungent ingredients in ginger, are reported to possess a cholesterol-lowering activity.
However, the underlying mechanism remains unclear. The present study was to investigate how 6-
gingerol (6-GN), the most abundant gingerol in fresh ginger, regulates hepatic cholesterol metabolism.
HepG2 cells were incubated with various concentrations of 6-GN ranging from 50 to 200 mu M for 24 h.
Results showed that both cellular total cholesterol and free cholesterol decreased in a dose-dependent
manner. Besides, 6-GN ranging from 100 to 200 mu M increased the LDLR protein and uptake of
fluorescent-labeled LDL. Moreover, the mRNA and protein expressions of cholesterol metabolism-
related genes were also examined. It was found that 6-GN regulated cholesterol metabolism via up-
regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related
genes LXR alpha and ABCA1.
Source: JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY | 94 (6): 753-760 NOV 2
2019
Title: Indirect somatic embryogenesis and Agrobacterium-mediated transient transformation of ginger
(Zingiber officinale Rosc.) using leaf sheath explants
Author(s): Mehaboob, VM | Faizal, K | Thilip, C | Raja, P | Thiagu, G | Aslam, A | Shajahan, A
Date: NOV 2 2019
Author keywords: Ginger | Agrobacterium | transformation | somatic embryos | hygromycin
Keywords plus: PLANT-REGENERATION | EFFICIENT REGENERATION | COCULTIVATION
MEDIUM | EXPRESSION | SYSTEM | TISSUE | SPP.
Publication year: 2019
Volume: 94
Abstract:
Página 79
This study has established an efficient and simple Agrobacterium-mediated transient transformation
method for a valuable spice crop 'ginger' via indirect somatic embryogenesis. Leaf sheath explants were
transformed using Agrobacterium tumefaciens strains EHA105 and LBA4404 harbouring vector
pGFPGUSPlus containing beta-glucuronidase (gus) reporter and hygromycin phosphotransferase (hptII)
selection marker. Different parameters enhancing agro-infection were investigated to optimise
transformation efficiency. High transformation frequency was achieved when explants were co-
cultivated with bacterial cell density of 0.6 OD600 on medium containing 150 mu M acetosyringone for
2 days, followed by selection regime of 40 mg/l hygromycin. Histochemical GUS analysis confirmed the
transient expression of gus gene, which was further confirmed by PCR analysis of hptII and nptII genes
specific primers. The origin and developmental stages of somatic embryos from leaf sheath explants
were investigated with the help of scanning electron micrographs. This newly developed transient
transformation system provides a basis for quick expression of marker genes in regenerated plantlets.
Source: FRONTIERS IN PHYSIOLOGY | 11: - JUL 21 2020
Title: Effect of a Blend of Zingiber officinale Roscoe and Bixa orellana L. Herbal Supplement on
the Recovery of Delayed-Onset Muscle Soreness Induced by Unaccustomed Eccentric Resistance
Training: A Randomized, Triple-Blind, Placebo-Controlled Trial
Author(s): Dominguez-Balmaseda, D | Diez-Vega, I | Larrosa, M | San Juan, AF | Issaly, N | Moreno-
Perez, D | Burgos, S | Sillero-Quintana, M | Gonzalez, C | Bas, A | Roller, M | Perez-Ruiz, M
Date: JUL 21 2020
Author keywords: annatto | ginger | young athletes | pain | sport performance | recovery | ReWin(d) |
heart rate variability
Keywords plus: HEART-RATE-VARIABILITY | ARONIA-CITRUS JUICE | INFLAMMATORY
RESPONSE | OXIDATIVE STRESS | GINGER | PAIN | ENDURANCE | DAMAGE
Publication year: 2020
Volume: 11
Abstract:
Background: There is an increasing interest in the use of eccentric muscle exercise to improve physical
condition, especially with regards to its health-related benefits. However, it is known that unaccustomed
eccentric exercise causes muscle damage and delayed pain, commonly defined as "delayed onset muscle
soreness" (DOMS). The efficacy of herbal preparations in subjects suffering from DOMS has been
reported in a few previous studies with small or moderate outcome measures related to muscle recovery.
The present study aimed to evaluate the effects of a polyherbal mixture containing whole Zingiber
officinale Roscoe and Bixa orellana L., powders called ReWin(d), in young male athletes suffering
Página 80
from DOMS induced by a 1 h session of plyometric exercises. Methods: Thirty-three young male athletes
participated in this randomized, Triple-blind, placebo-controlled trial: 17 of them assigned to the ReWin
(d) group and 16 of them to the placebo group. Creatine kinase (CK) was measured as a muscle damage
marker, pain was assessed using the Visual Analog Scale (VAS), muscle performance was measured
through half-squat exercise (HS) monitored with an accelerometer (Encoder), and heart rate variability
(HRV) was monitored for 5 min with the subjects in the supine position. All determinations were
performed before and after the eccentric session and 24, 48, and 72 h after the session. Results: The
eccentric exercise session caused an increase in CK at 24 and 48 h after exercise intervention in both
groups (p< 0.001). There was no interaction between groups regarding muscle damage. The pain
increased after the training session in both groups (p< 0.001), and a significant interaction was observed
between groups at 48 h after exercise (p= 0.004). Lower limb muscular power showed a significant
interaction between groups 24 h after exercise (p= 0.049); the placebo group showed a reduction in
muscle power compared to the ReWin(d) group. The LF/HF ratio decreased significantly at 72 h after
exercise in the herbal group but not in the placebo group. Conclusion: The herbal supplement maintained
the maximum power of the lower limbs and attenuated muscle pain.
Source: FOOD ANALYTICAL METHODS | 10 (4): 1016-1023 APR 2017
Title: Novel Dispersed Sorbent Sorptive Extraction Method for the Chromatography Profiling of Active
Substances in Ginger
Author(s): Havlikova, LC | Urbanova, M | Chocholou, P | Solich, P
Date: APR 2017
Author keywords: Dispersive SPE | Dispersed sorbent sorptive extraction (DSSE) | Gingerols | Fused-
core particles | Phenyl-hexyl
Keywords plus: SOLID-PHASE EXTRACTION | LIQUID-CHROMATOGRAPHY | MASS-
SPECTROMETRY | SAMPLE PREPARATION | ZINGIBER-OFFICINALE | GAS-CHROMATOGRAPHY |
BIOLOGICAL-FLUIDS | PESTICIDES | RESIDUES | TRENDS
Publication year: 2017
Volume: 10
Abstract:
One of the important aspects of sample pretreatment is the pre-concentration step. In a sample, analytes
are often present in trace levels and pretreatment procedures with high enrichment factor are needed.
This work describes the practical aspects of novel dispersed sorbent sorptive extraction (DSSE) method
that uses dispersed sorbent for analyte extraction and not for matrix suppression as is typical in
QuEChERS. The DSSE was used for the extraction of gingerols, family of active substances in ginger
Página 81
samples, before fast HPLC separation. Using presented extraction method, a high pre-concentration
factor (up to 50) of analytes was reached. The separation method using fused-core phenyl-hexyl
stationary phase and mobile phase composed of 50 % acetonitrile in water in isocratic mode was
developed and validated. Advantages and disadvantages of DSSE and pitfalls during the method
development and optimization will be discussed.
Source: MOLECULES | 24 (6): - MAR 2 2019
Title: Antibacterial and Biofilm Inhibitory Activity of Medicinal Plant Essential Oils Against
Escherichia coli Isolated from UTI Patients
Author(s): Lagha, R | Ben Abdallah, F | AL-Sarhan, BO | Al-Sodany, Y
Date: MAR 2 2019
Author keywords: Escherichia coli | UTI | essential oils | Origanum majorana | Thymus zygis
| Rosmarinus officinalis | Juniperus communis | Zengiber officinale | antibacterial |
antibiofilm
Keywords plus: URINARY-TRACT-INFECTIONS | ANTIMICROBIAL ACTIVITY | CHEMICAL-
COMPOSITION | CHLORHEXIDINE DIGLUCONATE | STAPHYLOCOCCUS-AUREUS | ANTIBIOTIC-
RESISTANCE | EUCALYPTUS OIL | L. | THYMOL | CONSTITUENTS
Publication year: 2019
Volume: 24
Abstract:
Urinary tract infections (UTIs), caused by Escherichia coli 80% to 85% of the time, are one of the
most important causes of morbidity and health care spending affecting persons of all ages. These
infections lead to many difficult problems, especially increasing resistance to antibiotic drugs. Bacterial
biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and
relapses. In this study, we have investigated the antibacterial activity of five medicinal plant essential
oils against UTIs caused by E. coli using disc diffusion and minimal inhibition concentration (MIC)
methods. In addition, biofilm inhibitory action of oils was realized by crystal violet. Gas chromatography
-mass spectrometry (GC-MS) analysis showed a variability between oils in terms of compound numbers
as well as their percentages. Antibacterial activity was observed only in cases of Origanum majorana,
Thymus zygis and Rosmarinus officinalis, while Juniperus communis and Zingiber
officinale did not showed any effect towards E. coli isolates. T. zygis essential oil demonstrated the
highest antibacterial activity against E. coli isolates, followed by O. majorana and R. officinalis.
Further, oils showed high biofilm inhibitory action with a percentage of inhibition that ranged from
14.94% to 94.75%. R. officinalis oil had the highest antibiofilm activity followed by T. zygis and O.
Página 82
majorana. Accordingly, tested oils showed very effective antibacterial and antibiofilm activities against E.
coli UTIs and can be considered as good alternative for antibiotics substitution.
Source: JOURNAL OF NATURAL PRODUCTS | 82 (6): 1412-1423 JUN 2019
Title: Indole Diterpenoids from an Endophytic Penicillium sp.
Author(s): Ariantari, NP | Ancheeva, E | Wang, CY | Mandi, A | Knedel, TO | Kurtan, T | Chaidir, C |
Muller, WEG | Kassack, MU | Janiak, C | Daletos, G | Proksch, P
Date: JUN 2019
Author keywords:
Keywords plus: CLAVICEPS-PASPALI STEVENS | TREMORGENIC METABOLITE | NATURAL-
PRODUCTS | JANTHITREM-B | FUNGUS | BIOSYNTHESIS | PAXILLINE | ALKALOIDS |
JANTHINELLUM | INDOLOSESQUITERPENE
Publication year: 2019
Volume: 82
Abstract:
A chemical investigation of the endophyte Penicillium sp. (strain ZO-R1-1), isolated from roots of the
medicinal plant Zingiber officinale, yielded nine new indole diterpenoids (1-9), together with 13
known congeners (10-22). The structures of the new compounds were elucidated by 1D and 2D NMR
analysis in combination with HRESIMS data. The absolute configuration of the new natural products 1, 3,
and 7 was determined using the TDDFT-ECD approach and confirmed for 1 by single-crystal X-ray
determination through anomalous dispersion. The isolated compounds were tested for cytotoxicity
against L5178Y, A2780, J82, and HEK-293 cell lines. Compound 1 was the most active metabolite toward
L5178Y cells, with an IC50 value of 3.6 mu M, and an IC50 against A2780 cells of 8.7 mu M. Interestingly,
1 features a new type of indole diterpenoid scaffold with a rare 6/5/6/6/6/6/5 heterocyclic system
bearing an aromatic ring C, which is suggested to be important for the cytotoxic activity of this natural
product aga inst L5278Y and A2780 cells.
Source: FOOD SCIENCE AND BIOTECHNOLOGY | 29 (3): 379-385 MAR 2020
Title: Optimizing extraction conditions for functional compounds from ginger (Zingiber officinale
Roscoe) using response surface methodology
Author(s): Cha, J | Kim, CT | Cho, YJ
Date: MAR 2020
Página 83
Author keywords: Extraction | Ginger | Optimization | Response surface methodology | Regression
equation
Keywords plus: PRESSURE EXTRACTION | ASSISTED EXTRACTION | OPTIMIZATION |
CAROTENOIDS | ULTRASOUND | COMPONENTS | SOLVENT
Publication year: 2020
Volume: 29
Abstract:
Extraction process was optimized for maximizing the contents of functional compounds from ginger
using response surface methodology which applied Box-Behnken design. Ginger extracts were obtained
at 3 levels of ethanol concentration (0-70%) of solvent, extraction time (30-90 min), and extraction
temperature (50-70 degrees C) as independent variables. The 6-shogaol and 6-gingerol of the extracts
were analyzed through HPLC. The significance of each term in polynomial regression equations was
evaluated on functional compound contents and extraction yield in extraction process. It was verified
that the regression equations were accurate with high determination coefficients over 0.892. The
optimum ethanol concentration, extraction time, and extraction temperature for extraction yield were
determined as 41.38%, 78.16 min, and 70 degrees C, respectively. The functional compound contents
predicted at optimal conditions were as follows: 39.55 mg/g at 70%, 70 min, and 70 degrees C for 6-
gingerol, 2.44 mg/g at 70%, 51.90 min, and 62.29 degrees C for 6-shogaol.
Source: JOURNAL OF FUNCTIONAL FOODS | 81: - JUN 2021
Title: Effects of culinary herbs and spices on obesity: A systematic literature review of clinical trials
Author(s): Deekshith, C | Jois, M | Radcliffe, J | Thomas, J
Date: JUN 2021
Author keywords: Body mass index | Body weight | Body composition | Obesity | Herb | Spice
Keywords plus: ZINGIBER-OFFICINALE SUPPLEMENTATION | TYPE-2 DIABETES-MELLITUS |
Y GASTRIC BYPASS | LIPID PROFILE | DOUBLE-BLIND | BODY-COMPOSITION | GLYCEMIC
STATUS | BLOOD-PRESSURE | CHICORY SEED | CINNAMON
Publication year: 2021
Volume: 81
Abstract:
The aim of this article was to systematically review literature on clinical trials investigating the effects of
culinary herbs and spices on obesity in adults. Relevant articles were searched through the electronic
Página 84
databases using predefined search terms. Thirty commonly used herbs and spices for weight loss were
selected based on the literature. Out of 33 intervention studies that were eligible for inclusion in the
review, 24 studies reported statistically significant (P < 0.05) reductions in obesity indices either
compared to baseline or to the placebo. Overall, eight herbs/spices were reported to be beneficial in
regards to obesity in the eligible literature including basil (on BW and BMI), cardamom (on BW, BMI
and WC), cinnamon (on BW, BMI, BFP and WC), coriander (on BMI), garlic (on BMI and WC), ginger
(on BW, BMI, WC and HC), nigella (on BW, BMI, WC, BFP and HC) and turmeric (on BW, BMI, BFP
and WC).
Source: POLYMERS | 12 (9): - SEP 2020
Title: Development of Polyvinylidene Fluoride Membrane by Incorporating Bio-Based Ginger Extract
as Additive
Author(s): Fahrina, A | Arahman, N | Mulyati, S | Aprilia, S | Nawi, NIM | Aqsha, A | Bilad, MR |
Takagi, R | Matsuyama, H
Date: SEP 2020
Author keywords: antibiofouling | antimicrobial additive | bio-based membrane | ginger extract |
membrane fouling
Keywords plus: ULTRAFILTRATION MEMBRANE | ZINGIBER-OFFICINALE | PERFORMANCE |
COMPOSITE | NANOPARTICLES | FABRICATION
Publication year: 2020
Volume: 12
Abstract:
Biofouling on the membrane surface leads to performance deficiencies in membrane filtration. In this
study, the application of ginger extract as a bio-based additive to enhance membrane antibiofouling
properties was investigated. The extract was dispersed in a dimethyl acetamide (DMAc) solvent together
with polyvinylidene fluoride (PVDF) to enhance biofouling resistance of the resulting membrane due to
its antibiotic property. The concentrations of the ginger extract in the dope solution were varied in the
range of 0-0.1 wt %. The antibacterial property of the resulting membranes was assessed using the Kirby
Bauer disc diffusion method. The results show an inhibition zone formed around the PVDF/ginger
membrane against Escherichia coli and Staphylococcus aureus demonstrating the efficacy of the
residual ginger extract in the membrane matrix to impose the antibiofouling property. The addition of
the ginger extract also enhanced the hydrophilicity in the membrane surface by lowering the contact
angle from 93 degrees to 85 degrees, which was in good agreement with the increase in the pure water
flux of up to 62%.
Página 85
Source: PLANT CELL TISSUE AND ORGAN CULTURE | 128 (3): 715-721 MAR 2017
Title: Nitric oxide as a bioactive molecule in the regulation of chalcone synthase during jasmonic acid
mediated defense signaling in ginger
Author(s): Girija, A | Devakumar, LJPS | Vijayanathan, M | Vasudevan, SE
Date: MAR 2017
Author keywords: Chalcone synthase | Jasmonic acid | Nitric oxide | Zingiber officinale
Keywords plus: SECONDARY METABOLISM | ARABIDOPSIS-THALIANA | STRESS RESPONSES
| PLANTS | INVOLVEMENT | RESISTANCE | CULTURES | CELLS
Publication year: 2017
Volume: 128
Abstract:
Nitric oxide (NO) and elicitors have been found to enhance the defense responses in plants. In this
study, the role of NO in the regulation of chalcone synthase (CHS) gene during jasmonic acid (JA)-
mediated defense response under wound stress in ginger were investigated. It was observed that NO is
responsible for the up-regulation of CHS during wound stress, which further stimulates the JA-
mediated stress responses. Confocal microscopy and qRT-PCR were used to study the accumulation of
NO and CHS (ZoCHS) transcript levels, respectively, at the wound site. Relative expression of ZoCHS
was found to increase by double fold in wounded plants upon treatment with NO and JA. Confocal
studies confirmed the accumulation of NO at the wound sites which further triggered the JA-mediated
stress responses. Overall results in this work implicate the role of NO in positive modulation of JA
defense signaling responses and expression of CHS in ginger during wounding. These findings will help
in the development of plants with improved metabolic and defense traits.
Source: PLANTA MEDICA | 86 (18): 1375-1388 DEC 2020
Title: Effects of a Multicomponent Herbal Extract on the Course of Subclinical Ketosis in Dairy Cows -
a Blinded Placebo-controlled Field-study
Author(s): Durrer, M | Mevissen, M | Holinger, M | Hamburger, M | Graf-Schiller, S | Mayer, P |
Potterat, O | Bruckmaier, R | Walkenhorst, M
Date: DEC 2020
Author keywords: subclinical ketosis | herbal extract | sodium propionate | dairy cow
Página 86
Keywords plus: EARLY-LACTATION HYPERKETONEMIA | BLOOD BETA-HYDROXYBUTYRATE |
NONESTERIFIED FATTY-ACIDS | PROPYLENE-GLYCOL | OXIDATIVE STRESS | KETONE-BODIES |
MILK-YIELD | LIVER | TRIAL | PREVALENCE
Publication year: 2020
Volume: 86
Abstract:
A blinded placebo-controlled multi-center on-farm trial was conducted in dairy cows with subclinical
ketosis to investigate effects of a multicomponent herbal extract. Blood ketone levels were measured
weekly in early lactating cows from 16 Swiss herds. Cows were subclassified based on their initial blood-
beta -hydroxybutyrate levels (>= 1.0 [KET-low, 84 cows] and >1.2mmol/L [KET-high, 39 cows]) and
randomly distributed to 3 groups treated orally with herbal extract containing Camellia sinensis,
Cichcorium intybus, Gentiana lutea, Glycyrrhiza glabra, Taraxacum officinale, Trigonella
foenum-graecum , and Zingiber officinale , sodium propionate, or placebo twice a day for 5 days.
Milk yield, milk acetone, blood- beta -hydroxybutyrate, glucose, nonesterified fatty acids, gamma-
glutamyl transferase, and glutamate dehydrogenase were analyzed over 2wk. Linear mixed effect models
were used for data analysis. No effects were found for nonesterifed fatty acids, gamma-glutamyl
transferase, and glucose. Significantly higher glutamate dehydrogenase (29.71U/L) values were found in
herbal extract-treated animals compared to sodium propionate on day 7 (22.33U/L). By trend, higher
blood- beta -hydroxybutyrate levels (1.36mmol/L) were found in the placebo group of KET-high-cows on
day 14 compared to the sodium propionate group (0.91mmol/L). Milk yields of all treatment groups
increased. Milking time and treatment showed a significant interaction for milk acetone: sodium
propionate led to an immediate decrease, whereas herbal extracts resulted in a milk acetone decrease
from day 7 on, reaching significantly lower milk acetone on day 14 (3.17mg/L) when compared to placebo
(4.89mg/L). In conclusion, herbal extracts and sodium propionate are both likely to improve subclinical
ketosis in dairy cows, however, by different modes of action.
Source: INTERNATIONAL JOURNAL OF FOOD PROPERTIES | 19 (6): 1303-1316 JUN 2 2016
Title: Optimization of Phenolic Content, Antioxidant, and Inhibitory Activities of alpha-Glucosidase and
Angiotensin Converting (AC) Enzymes from Zingiber officinale Z.
Author(s): Alu'datt, MH | Rababah, T | Alhamad, MN | Gammoh, S | Ereifej, K | Johargy, A | Kubow, S
| Almajwal, AM | Rawashdeh, M
Date: JUN 2 2016
Author keywords: Free and bound phenolics | Angiotensin converting enzyme | Extraction |
Antioxidant activity | alpha-Glucosidase | Ginger
Página 87
Keywords plus: MEDICINAL-PLANTS | CHEMICAL-COMPOSITION | GINGER |
QUANTIFICATION | POLYPHENOLS | EXTRACTION | PRINCIPLES | AMYLASE | HERBS | ROSC
Publication year: 2016
Volume: 19
Abstract:
The optimum extraction conditions of phenolic compounds from ginger were evaluated with respect to
antioxidant activity and angiotensin converting enzyme and alpha-glucosidase inhibitory activities. Free
phenolics were extracted under conditions that varied according to extraction time, temperature, and
solvent type (water, acetone, and methanol). Acid and base hydrolysis reactions were used to obtain
bound phenolic compounds from ginger. The results showed that the type of solvent used and the
temperature and time of extraction needed for maximal total phenolic content, antioxidant activity, and
angiotensin converting enzyme inhibitory activity differed greatly from solvent conditions and showed
the greatest alpha-glucosidase inhibitory activity. The predominant free phenolics in the methanol
extracts included diosmin, thymol, and carvacrol, which varied greatly according to solvent extraction
conditions (i.e., time and temperature). Diosmin was the predominant bound phenolic compound of the
methanol extracts. The present study findings indicate that differing solvent extraction protocols
involving extraction time and temperature for ginger need to be explored to generate specific optimal
bioactivities of the extracts, which are related to the pattern of predominant phenolics in those extracts.
Source: DRYING TECHNOLOGY | : - NOV 21 2020
Title: Microparticles obtained by spray-drying technique containing ginger essential oil with the
addition of cellulose nanofibrils extracted from the ginger vegetable fiber
Author(s): de Souza, HB | Dessimoni, ALD | Ferreira, MLA | Botrel, DA | Borges, SV | Viana, LC | de
Oliveira, CR | Lago, AMT | Fernandes, RVD
Date:
Author keywords: Ginger fiber | gum Arabic | inulin | cellulose | spray drying
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | ENCAPSULATION EFFICIENCY | D-
LIMONENE | MICROENCAPSULATION | GUM | INULIN | STABILITY | EMULSIONS | PROTEIN |
MALTODEXTRIN
Publication year:
Volume:
Abstract:
Página 88
The encapsulation capacity and the polymer blends containing gum Arabic (GA), inulin (IN), and
cellulose nanofibrils ginger (CNFG), extracted from the fibrous ginger residues, for the
microencapsulation of ginger essential oil by spray-drying technique were evaluated in this study. The
addition of CNFG improved the emulsifying properties of the formulations, with an increase in
Newtonian viscosity (mu); however, the partial substitution of GA by IN decreased the viscosity. The
higher IN levels increased the emulsion droplets in the formulations with and without the addition of
CNFG. In addition, the emulsion droplets with smaller size resulted in the formation of pulverized
droplets with smaller diameter. The presence of CNFG in the polymer blends exhibited similar
instantaneization times and provided greater oil retention of ginger essential oil by spray drying. The oil
retention in the formulation containing GA and CNFG was 12.23% higher than the formulation
containing only GA. Changes in the retention of the compounds of pure and microencapsulated ginger
essential oil were observed by GC-MS, all six major components remained in the final product, however
with some variations on the encapsulated essential oil profile.
Source: JOURNAL OF APPLIED ANIMAL RESEARCH | 46 (1): 691-695 2018
Title: The effect of phytogenics on growth traits, blood biochemical and intestinal histology in broiler
chickens exposed to Clostridium perfringens challenge
Author(s): Abudabos, AM | Alyemni, AH | Dafalla, YM | Khan, RU
Date: 2018
Author keywords: Antibiotic | broiler | Clostridium perfringens | phytobiotics
Keywords plus: EXPERIMENTALLY-INDUCED COCCIDIOSIS | GINGER ZINGIBER-OFFICINALE |
RELATIVE ORGAN WEIGHT | GASTROINTESTINAL-TRACT | ANTIOXIDANT STATUS | CECAL
MICROFLORA | PERFORMANCE | MEAT | SALMONELLA | SANGUINARINE
Publication year: 2018
Volume: 46
Abstract:
A total 560 day-old broiler chicks (Ross 308) was randomly allocated to seven treatments (eight
replicates). Control (basal diet), T1, infected with Clostridium perfringens, T2, infected + Avilamycin
at the rate of 0.2 g/kg T3, infected + essential oil of thyme, T4, infected + Sanguinarine, T5, infected +
Anti-Salmonella phytobiotic, T6., infected + essential oils of thyme, anise and others (oregano, carvacol,
yucca extract and cinnamaldehyde). Feed conversion ratio (FCR) were significantly (P< 0.05) high in the
T2 during the third week. The dressing percentage decreased significantly (P< 0.05) and intestinal
weight increased (P< 0.05) in T1. Blood protein, and globulin increased significantly (P< 0.05) in birds in
T6 during fourth weeks, while blood alanine transaminase (ALT) increased significantly (P< 0.05) in T5.
Página 89
Thiobarbituric acid reactive substances (TBARS) increased significantly (P< 0.05) in T5 and T6.
Similarly, villus height and width increased significantly (P< 0.05) in T5 and T6. From the results of
the present study, it was concluded that different feed additives could be substituted with antibiotics in
the feed of broiler exposed to Clostridium perfringens challenge.
Source: BIOMED RESEARCH INTERNATIONAL | 2016: - 2016
Title: Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ
Fibroblasts and HaCaT Keratinocytes
Author(s): Schadich, E | Hlavac, J | Volna, T | Varanasi, L | Hajduch, M | Dzubak, P
Date: 2016
Author keywords:
Keywords plus: S-TRANSFERASE P1-1 | ZINGIBER-OFFICINALE | SIGNALING PATHWAYS |
SKIN | EXPRESSION | ACTIVATION | GSTP1 | IDENTIFICATION | MECHANISMS | RADIATION
Publication year: 2016
Volume: 2016
Abstract:
Quercetin and phenylpropanoids are well known chemoprotective compounds identified in many
plants. This study was aimed at determining their effects on activation of Nuclear factor erythroid 2-
related factor 2 (Nrf2) antioxidant response element (Nrf2-ARE) signalling pathway and expression of
its important downstream effector phase II detoxification enzyme glutathione S-transferase P1 (GSTP1)
in BJ foreskin fibroblasts and skin HaCaT keratinocytes. Cell lines and their corresponding Nrf2-ARE
luciferase reporter cells were treated by ginger phenylpropanoids and quercetin for 10 h and the level of
Nrf2 activity was subsequently determined. Both, ginger phenylpropanoids and quercetin, significantly
increased the level of Nrf2 activity. Subsequent western blot analyses of proteins showed the increased
expression level of glutathione-S-transferase P1 (GSTP1) in BJ cells but not in HaCaT cells. Such
phenomenon of unresponsive downstream target expression in HaCaT cells was consistent with
previous studies showing a constitutive expression of their GSTP1. Thus, while both ginger
phenylpropanoids and quercetin have the property of increasing the level of Nrf2 both in HaCaT and in
BJ cells, their effects on its downstream signalling were mediated only in BJ cells.
Source: SOLAR ENERGY | 136: 428-436 OCT 15 2016
Title: A salient reduction of energy consumption and drying time in a novel PV-solar collector-assisted
intermittent infrared dryer
Página 90
Author(s): Ziaforoughi, A | Esfahani, JA
Date: OCT 15 2016
Author keywords: Solar dryer | Intermittent infrared | Photovoltaic system | Energy reduction |
Drying time
Keywords plus: HEAT-PUMP DRYER | ZINGIBER-OFFICINALE | TEMPERATURE |
PERFORMANCE | RADIATION | PRODUCTS | KINETICS
Publication year: 2016
Volume: 136
Abstract:
Drier systems, as one of the high energy consumption systems, undertake a considerable amount of the
energy consumption due to its wide applications in different industries such as agricultural process
industries. In the present study, a solar assisted intermittent infrared dryer powered with a photovoltaic
system has been built to investigate the effective parameters of dryer systems. Hence, the drying kinetic
and temperature history of potato slices are studied in the thicknesses of 3, 5 and 7 mm at temperatures
of 50, 60 and 70 degrees C. The obtained results are compared with the similar experiments of an
infrared intermittent dryer. The results reveal that there is a reduction in the electrical energy
consumption which is provided by a photovoltaic system in the range of minimum 40% to maximum
69%. In addition, a minimum 31% to maximum 52% salient reduction of the drying time has been
observed with respect to infrared intermittent dryer. Finally, it is suggested using an assisted dryer for
drying potatoes at the temperature of 50 degrees C. (C) 2016 Elsevier Ltd. All rights reserved.
Source: JOURNAL OF ARTHROPOD-BORNE DISEASES | 11 (2): 278-285 MAY 2017
Title: Bio-Pesticides: New Tool for the Control of Aedes (Stegomyia) albopictus (Culicidae: Diptera)
in Pakistan
Author(s): Bilal, H | Sahar, S | Din, S
Date: MAY 2017
Author keywords: Mosquitoes | Plant extracts | Larvicide
Keywords plus: PETROLEUM ETHER EXTRACT | DENGUE VECTOR | MALARIAL VECTOR |
PLANT-EXTRACTS | MOSQUITO | FEVER
Publication year: 2017
Volume: 11
Abstract:
Página 91
Background: Application of plant extracts as mosquito control strategy was practiced from centuries.
These are easily available, non-toxic, biodegradable and exhibit broad-spectrum target specific activities
against larval stages of mosquitoes. Method: Different potential parts of locally grown plants, seeds of
nutmeg (Myristica fragrans), peel of musambi (Citrus sinensis), leaves of babuna (Matricaria
chamomilla), mint (Mentha spicata) and ginger rhizome (Zingiber officinale) selected and
evaluated for their larvicidal properties against Aedes (Stegomyis) albopictus. Oils were extracted
through steam distillation process and extracts were evaluated as per WHO 2005 guidelines for testing of
insecticides against larvae of mosquitoes. Result: Among the five plant extracts, C. sinensis had the
lowest LC50 (400.81ppm) while M. fragrans had the highest LC50 value (710.30ppm) respectively after
24h of exposure. In terms of % age mortality, a series of concentrations (300-800ppm) gave high %
mortality in case of C. sinensis while M. fragrans gave low % age mortality. Conclusion: All the five
plant species have larvicidal effects to certain extant and C. sinensis had great potential. Further small-
scale field trials with the extracts of the most promising one (C. sinensis) shall be conducted to
determine operational feasibility.
Source: PHYTOCHEMISTRY REVIEWS | 18 (4): 1211-1222 Sp. Iss. SI AUG 2019
Title: Drugs of plant origin from the "Carlo Erba" collection of the Botanical Museum in Portici "Orazio
Comes"
Author(s): Monaco, A | Chianese, G | Idolo, M
Date: AUG 2019
Author keywords: Anticancer effect | Chemical composition | Medicinal plants | Plant drugs
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | ANTICANCER ACTIVITY | CANCER |
ANTIOXIDANT | APOPTOSIS | PHARMACOLOGY | EXTRACT
Publication year: 2019
Volume: 18
Abstract:
The aim of this paper is to illustrate the origin and composition of a collection of 192 plant drugs, based
on archival documents from 1932 to 1940. This unique collection was produced in 1937 by the
pharmaceutical company "Carlo Erba" of Milan at the request of prof. Giuseppe Catalano, director of the
Botanical Institute in Portici. The 192 plant drugs, coming from almost all continents, belong to 78
botanical families among which the Asteraceae with 17 species and the Fabaceae with 15 species are the
most represented. Twenty-eight of them are classified as poisonous even if used for a long time in the
Italian and European pharmacopoeia. One hundred eleven plant samples from the collection were
already known as plant remedies and described in two ancient books in the Historical Library of the
Página 92
Orazio Comes Botanical Museum, dedicated to medicinal plants: the first dated 1585 and the second
dated 1712. Among the many plant species that make it up, 13 of them have been selected for their
anticancer effect which has either been known since long or is currently being studied.
Source: FOOD AND CHEMICAL TOXICOLOGY | 109: 910-922 Part 2 NOV 2017
Title: Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with
drugs on human cervical adenocarcinoma cells
Author(s): Zhang, F | Zhang, JG | Qu, J | Zhang, Q | Prasad, C | Wei, ZJ
Date: NOV 2017
Author keywords: Tangling White Ginger | 6-Gingerol | Anti-cancerous activities | Combination
Keywords plus: ZINGIBER-OFFICINALE | CYCLE ARREST | IN-VITRO | ANTIINFLAMMATORY
ACTIVITIES | CHEMICAL-CONSTITUENTS | OXIDATIVE STRESS | APOPTOSIS | ANTIOXIDANT |
EXTRACTS | LINES
Publication year: 2017
Volume: 109
Abstract:
The anti-cancerous activity of 6-gingerol extracted from Tongling White Ginger was investigated. 6-
Gingerol inhibited the growth of HeLa cells with IC50 (96.32 mu M) and IC80 (133.01 mu M) and led to
morphological changes, induced the cell cycle arrest in GO/G1-phase and ultimately resulted into
apoptosis. Among cell cycle-related genes and proteins, the expression of cyclin (A, D1, El) reduced, while
of CDK-1, p21 and p27 showed slight decrease, except cyclin B1 and El (protein). Western blotting
reported the induction of apoptosis with an increased Bax/Bcl-2 ratio, release of cytochrome c, cleavage
of caspase-3,-8,-9 and PRPP in treated cells. 6-Gingerol activated AMPK, but inhibited PI3K/AKT
phosphorylation with reduced P70S6K expression and also suppressed the mTOR phosphorylation. 6-
Gingerol with 5-FU and Ptx resulted in 83.2% and 52% inhibition respectively, this synergy have
stimulated apoptosis proteins more efficiently as compared to 6-Gingerol alone (10.75%) under in vitro
conditions. (C) 2017 Elsevier Ltd. All rights reserved.
Source: JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH | : - FEB 25 2021
Title: The effect of rue (Ruta graveolens) and ginger (Zingiber officinale) extracts as antifouling
agents in silicone matrix coatings
Author(s): Zmozinski, AV | Peres, RS | Brust, FR | Macedo, AJ | Becker, EM | Napp, AP | de Brito, HA |
Página 93
Vainstein, MH | Schrank, A | Ferreira, CA
Date:
Author keywords: Antifouling | Silicone matrix | Rue | Ginger
Keywords plus:
Publication year:
Volume:
Abstract:
The use of rue extract and ginger oleoresin as natural antifouling agents in a silicone matrix was verified
in this work. C-13 nuclear magnetic resonance (C-13 NMR) analysis identified a series of compounds
with bactericidal properties in the two investigated natural products. Thermogravimetric analyses
showed that the addition of rue extract and ginger oleoresin in the silicone matrix increased the thermal
stability of the formed films. Electrochemical impedance spectroscopy analysis showed that the presence
of both antifouling agents increases the velocity of water diffusion into the film, improving contact
between marine water and the two products. Fourier transform infrared spectroscopy confirms that both
antifouling agents were trapped inside the silicone matrix. Bacterial adhesion tests showed that rue
extract reduced the adhesion of gram-negative bacteria, Escherichia coli, while ginger oleoresin did
not show any significant effect. Optical microscopy images demonstrated that the presence of rue extract
slightly increased the film's porosity without impairing the silicone hydrophobicity, while ginger
oleoresin significantly altered the film's morphology (reducing the water contact angle). Finally, the
sample containing rue extract showed excellent results against marine fouling after 6 months of
immersion in a real marine environment. The polymer containing ginger oleoresin showed satisfactory
results against marine fouling; however, the film showed adhesion failures after 6 months. [GRAPHICS] .
Source: PHYTOTHERAPY RESEARCH | 30 (10): 1584-1591 OCT 2016
Title: Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review
Author(s): Javan, R | Yousefi, M | Nazari, SM | Amiri, P | Mosavi-Jarrahi, A | Modiramani, P | Naghedi
-Baghdar, H
Date: OCT 2016
Author keywords: menorrhagia | idiopathic heavy menstrual bleeding | complementary therapies |
phytotherapy | herbal medicine
Keywords plus: GINGER ZINGIBER-OFFICINALE | ANTIOXIDANT | CLASSIFICATION |
POMEGRANATE | MANAGEMENT | CELLS | WOMEN | ACID
Página 94
Publication year: 2016
Volume: 30
Abstract:
Idiopathic heavy menstrual bleeding (HMB; IHMB) is a common gynecological problem with no pelvic
pathology or general bleeding disorder. Herbal remedies are commonly used to treat HMB. This
systematic review aimed to assess the effectiveness and safety of herbal preparations for the treatment
of IHMB. MEDLINE, Ovid, and the Cochrane Central Register of Controlled Trials were searched from
inception to 23 August 2015. Only randomized controlled trials were considered. Three randomized
controlled trials were included in this systematic review. Different herbal preparations were used in the
included trials. In two studies, Ginger capsules and myrtle fruit syrup significantly reduced the
menstrual duration and blood loss compared with placebo based on the pictorial blood loss assessment
chart score (p<0.001, p=0.01). In another trial, Punica granatum flower capsules were as effective as
tranexamic acid capsules in reducing the mean (SD) pictorial blood loss assessment chart score, with no
significant difference between the two treatments (p=0.3). The results show that the methods used in
these trials may reduce menstrual bleeding in women with IHMB. Additional well-designed trials are
needed to investigate the safety and efficacy of herbs for the treatment of women with IHMB or other
forms of HMB.
Source: AGRONOMY JOURNAL | 113 (3): 2832-2845 MAY 2021
Title: Bamboo-based agroforestry system effects on soil fertility: Ginger performance in the bamboo
subcanopy in the Himalayas (India)
Author(s): Garima | Bhardwaj, DR | Thakur, CL | Kaushal, R | Sharma, P | Kumar, D | Kumari, Y
Date: MAY 2021
Author keywords:
Keywords plus: PHYSICAL-PROPERTIES | FARMYARD MANURE | CHEMICAL-PROPERTIES |
QUALITY | GROWTH | KERALA | YIELD
Publication year: 2021
Volume: 113
Abstract:
An on-farm bamboo intercropping study was conducted near Solan, Himachal Pradesh, India. It uses a
split-plot design with two bamboo species (Dendrocalamus asper and Dendrocalamus
hamiltonii) and an open field condition as main plots, under which ginger (Zingiber officinale) was
grown at five nutrient levels supplied through chemical fertilizers and organic sources (subplots). In the
Página 95
intercropping with bamboo species, ginger yield increased by 10.5-15.6% in comparison to the open field
condition. Application of farmyard manure (FYM) based on N equivalent ratio showed the best (P
<= .05) yield response of ginger (rhizome length, 7.65 cm; yield, 4,028 kg ha(-1)). Photoactive radiation
was reduced by 60% under the bamboo canopy. Simultaneously, higher soil moisture (%) content was
noticed for D. asper. Various soil physico-chemical properties (top 0-15 cm) were significantly higher in
the FYM treatment under D. asper than under D. hamiltonii or sole ginger cropping. Maximum
returns (3,595.67 US$ ha(-1) yr(-1)) were realized when the ginger crop was raised under the canopy of
D. asper and supplied with FYM on N equivalent ratio + plant growth-promoting rhizobacteria. Overall,
the results establish that ginger production in the northwest Himalayan region of India is a viable use of
land resources for improved economic returns.
Source: PHYTOTHERAPY RESEARCH | 35 (2): 864-876 FEB 2021
Title: Natural products forCOVID-19 prevention and treatment regarding to previous coronavirus
infections and novel studies
Author(s): Boozari, M | Hosseinzadeh, H
Date: FEB 2021
Author keywords: 3CL(pro)inhibitors | ACE2 | coronavirus | COVID-19 | natural products | PL(pro)
inhibitors
Keywords plus: RESPIRATORY SYNDROME CORONAVIRUS | PAPAIN-LIKE PROTEASE | SARS-
COV 3CL(PRO) | ANTIVIRAL ACTIVITIES | ISATIN DERIVATIVES | INHIBITION |
IDENTIFICATION | BIFLAVONOIDS | SILVESTROL | VIRUS
Publication year: 2021
Volume: 35
Abstract:
Recently, the novel life-threatening coronavirus infection (COVID-19) was reported at the end of 2019 in
Wuhan, China, and spread throughout the world in little time. The effective antiviral activities of natural
products have been proved in different studies. In this review, regarding the effective herbal treatments
on other coronavirus infections, promising natural products for COVID-19 treatment are suggested. An
extensive search in Google Scholar, Science Direct, PubMed, ISI, and Scopus was done with search
words include coronavirus, COVID-19, SARS, MERS, natural product, herb, plant, and extract. The
consumption of herbal medicine such as Allium sativum, Camellia sinensis, Zingiber officinale,
Nigella sativa, Echinacea spp. Hypericum perforatum, and Glycyrrhiza glabra, Scutellaria
baicalensis can improve the immune response. It seems that different types of terpenoids have
promising effects in viral replication inhibition and could be introduced for future studies. Additionally,
Página 96
some alkaloid structures such as homoharringtonine, lycorine, and emetine have strong anti-coronavirus
effects. Natural products can inhibit different coronavirus targets such as S protein (emodin, baicalin)
and viral enzymes replication such as 3CL(pro)(Iguesterin), PLpro(Cryptotanshinone), helicase
(Silvestrol), and RdRp (Sotetsuflavone). Based on previous studies, natural products can be introduced
as preventive and therapeutic agents in the fight against coronavirus.
Source: FOOD CONTROL | 84: 312-320 FEB 2018
Title: Antimicrobial and antioxidant efficiency of nanoemulsion-based edible coating containing ginger
(Zingiber officinale) essential oil and its effect on safety and quality attributes of chicken breast fillets
Author(s): Noori, S | Zeynali, F | Almasi, H
Date: FEB 2018
Author keywords: Chicken breast | Edible coating | Ginger essential oil | Nanoemulsion | Shelf life
extension
Keywords plus: SODIUM CASEINATE | SHELF-LIFE | PHYSICOCHEMICAL CHARACTERIZATION
| CHITOSAN FILMS | MEAT-PRODUCTS | GREEN BEANS | FORMULATION | SYSTEMS |
OPTIMIZATION | PRESERVATION
Publication year: 2018
Volume: 84
Abstract:
Nanoemulsion-based edible sodium caseinate coating containing ginger essential oil (GEO) (3 and 6%
wt) was applied onto chicken breast fillet to extend its shelf life. GC-MS analysis showed that the most
components of GEO were alpha-zingiberene (24.96%) and then beta-sesquiphellandrene (12.74%).
Comparison between conventional emulsion and nanoemulsion-based coatings was applied by particle
size, polydispersity index and zeta-potential analyses. Antibacterial potential of active coatings was more
than their antioxidant activity and it was significantly (p < 0.05) increased when nanoemulsion was
fabricated. Nanoemulsion based edible coatings with 6% of GEO nanoemulsion caused to significant
decrease. of total aerobic psychrophilic bacteria of refrigerated chicken fillets during 12 days. The effect
of GEO on TBARS levels of fillets was not significant. The lowest color difference and cooking loss were
obtained for nanoemulsion coated samples. The highest total acceptance was recorded for coated fillets
with 6% of GEO nanoemulsion during storage. Generally the GEO nanoemulsion was more effective than
its conventional emulsion in extending the durability of chicken breast fillets. (C) 2017 Elsevier Ltd. All
rights reserved.
Source: ANDROLOGIA | 52 (7): - AUG 2020
Página 97
Title: The protective effect of cinnamon and ginger hydro-alcoholic extract on carbon tetrachloride-
induced testicular damage in rats
Author(s): Mazani, M | Ojarudi, M | Banaei, S | Salimnejad, R | Latifi, M | Azizi, H | Rezagholizadeh, L
Date: AUG 2020
Author keywords: CCl4 | cinnamon | ginger | oxidative stress | testis
Keywords plus: ZINGIBER-OFFICINALE | STRESS | INJURY
Publication year: 2020
Volume: 52
Abstract:
Sexual dysfunction of men is one of the most serious problems in human society. This study aimed to
evaluate the protective effect of cinnamon and ginger extract on testicular damages induced by carbon
tetrachloride (CCl4). Thirty-six male Wistar rats were randomly divided into 6 groups (n = 6): 1. Normal
control; 2. Carbon tetrachloride (CCl4); 3. CCl4 + Cinnamon; 4. CCl4 + Ginger; 5. CCl4 + Cinnamon and
Ginger; and 6. Cinnamon + Ginger. CCl4 (1 ml/kg) was injected intraperitoneally on the 14th day, and
cinnamon (50 mg/kg, orally) and ginger (250 mg/kg, orally) were administered daily for 14 days. Fifty
hours after the CCl4 injection, the testicles and epididymis were separated and examined as to
histological alterations and oxidative stress markers. CCl4 significantly increased malondialdehyde level
and decreased total antioxidant capacity when compared to the normal control group (p < .05). In
addition, degenerative alterations in the testicular and epididymal tissue were observed in CCl4 group.
The pre-treatment with ginger and cinnamon extract significantly improved these parameters when
compared to the CCl4 group (p < .05). The results of this study indicated that co-treatment of ginger and
cinnamon reduces the damages induced by CCl4 in testicular tissue by increasing antioxidant capacity
and reducing lipid peroxidation.
Source: PARASITOLOGY | 147 (14): 1689-1699 DEC 2020
Title: Antiparasitic effects of ethanolic extracts of Piper arboreum and Jatropha gossypiifolia
leaves on cercariae and adult worms of Schistosoma mansoni
Author(s): Alves, RRD | Rodrigues, JGM | Teles-Reis, A | Nogueira, RA | Lica, ICL | Lira, MGS | Alves,
RD | Silva-Souza, N | Andrade, TDAD | Miranda, GS
Date: DEC 2020
Author keywords: Morphological damage | plant extracts | schistosomiasis | secondary metabolites |
treatment
Keywords plus: IN-VITRO | ESSENTIAL OIL | ANTILEISHMANIAL ACTIVITIES |
Página 98
ANTHELMINTIC ACTIVITY | ZINGIBER-OFFICINALE | NATURAL-PRODUCTS | GOSSYPIFOLIA L. |
PRAZIQUANTEL | VIVO | PLANTS
Publication year: 2020
Volume: 147
Abstract:
New treatment strategies for schistosomiasis should be evaluated, since resistant strains to the only
available drug, Praziquantel, have already been described. Thus, we demonstrated antiparasitic effects of
ethanolic extracts of Jatropha gossypiifolia and Piper arboreum on cercariae and adult worms of
Schistosoma mansoni. The bioassays were performed at 0-10 000 mu g mL(-1) concentration for 0-
72 h. Adult worms were stained with carmine to assess external and internal damage. The chemical
screening was performed using high-performance liquid chromatography. P. arboreum displayed the
best cercaricidal effect, with a 100% reduction in viability in just 60 min. The extract of J. gossypiifolia
was more effective against adult worms, with 100% viability reduction of male and female worms after 12
and 24 h, respectively. P. arboreum and J. gossypiifolia were equally effective in inhibiting the
oviposition of S. mansoni (93% reduction) and causing damage to internal and external structures in
adult worms. Flavonoids were identified in both the extracts and phenolic compounds and amides only
in P. arboreum. Thus, for the first time, it was proven that ethanolic extracts of P. arboreum and J.
gossypiifolia leaves are biologically active against cercariae and adult worms of S. mansoni in vitro.
Source: JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 98 (15): 5632-5638 DEC 2018
Title: Biochemical composition and antioxidant activity affected by spraying potassium sulfate in black
grape (Vitis vinifera L. cv. Rasha)
Author(s): Zareei, E | Javadi, T | Aryal, R
Date: DEC 2018
Author keywords: TAA | potassium sulfate | phenol | PPO | grape
Keywords plus: ZINGIBER-OFFICINALE ROSCOE | PHENOLIC-COMPOUNDS | FRUIT-QUALITY |
DNA-DAMAGE | FERTILIZATION | ANTHOCYANINS | FLAVONOIDS | CULTIVARS | PLANTS |
VARIETIES
Publication year: 2018
Volume: 98
Abstract:
BACKGROUND The physiological and metabolic processes involved with grapevine growth and
Página 99
production are influenced by key macro- and micronutrients. Potassium is an essential plant nutrient
that affects growth and fruit quality. In this study, the impact of foliar spraying of potassium sulfate
(K2SO4) on qualitative characteristics of grape berries was evaluated in the cultivar 'Rasha', a commonly
cultivated cultivar in Kurdistan province of Iran. Leaves of the fully grown vines were sprayed with each
of the 1.5 and 3 g L-1 K2SO4 solutions once (1 month after petal senescence) and twice (15 days after first
spraying). The control plants were sprayed with distilled water. Various biochemical contents and
enzyme activities on the ripe berries were analyzed. RESULTS CONCLUSION Significant increases in
anthocyanin, total protein content, and antioxidant enzyme activities were observed in the berries
treated twice with 3 g L-1 K2SO4. Concentrations of total carbohydrate, phenol, and antioxidant activity
in berries sprayed with K2SO4 were higher than in the controls. We observed a strong correlation
between antioxidant activity and different phenolic compounds. These findings suggest that K2SO4
treatment influences biosynthesis of phenolic compounds and antioxidant enzymes. Thus, treatment by
K2SO4 could improve nutritional and qualitative attributes of grape. (c) 2018 Society of Chemical
Industry
Source: ONCOTARGET | 8 (42): 72260-72271 SEP 22 2017
Title: [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast
cancer in vivo
Author(s): Martin, ACBM | Fuzer, AM | Becceneri, AB | da Silva, JA | Tomasin, R | Denoyer, D | Kim,
SH | McIntyre, KA | Pearson, HB | Yeo, B | Nagpal, A | Ling, XW | Selistre-de-Araujo, HS | Vieira, PC |
Cominetti, MR | Pouliot, N
Date: SEP 22 2017
Author keywords: gingerol | breast cancer | cell cycle | apoptosis | animal models
Keywords plus: BRAIN METASTASES | RISK-FACTORS | GINGER ROOT | CELLS | TUMOR |
CHEMOTHERAPY | 10-GINGEROL | DISEASE | SURVIVAL | BONE
Publication year: 2017
Volume: 8
Abstract:
There is increasing interest in the use of non-toxic natural products for the treatment of various
pathologies, including cancer. In particular, biologically active constituents of the ginger oleoresin
(Zingiber officinale Roscoe) have been shown to mediate anti-tumour activity and to contribute to the
anti-inflammatory, antioxidant, antimicrobial, and antiemetic properties of ginger. Here we report on
the inhibitory properties of [10]-gingerol against metastatic triple negative breast cancer (TNBC) in vitro
and in vivo. We show that [10]-gingerol concentration-dependently induces apoptotic death in mouse
Página 100
and human TNBC cell lines in vitro. In addition, [10]-gingerol is well tolerated in vivo, induces a marked
increase in caspase-3 activation and inhibits orthotopic tumour growth in a syngeneic mouse model of
spontaneous breast cancer metastasis. Importantly, using both spontaneous and experimental
metastasis assays, we show for the first time that [10]-gingerol significantly inhibits metastasis to
multiple organs including lung, bone and brain. Remarkably, inhibition of brain metastasis was observed
even when treatment was initiated after surgical removal of the primary tumour. Taken together, these
results indicate that [10]-gingerol may be a safe and useful complementary therapy for the treatment of
metastatic breast cancer and warrant further investigation of its efficacy, either alone or in combination
with standard systemic therapies, in pre-clinical models of metastatic breast cancer and in patients.
Source: FOOD BIOSCIENCE | 37: - OCT 2020
Title: Encapsulation of ginger oil in alginate-based shell materials
Author(s): Atencio, S | Maestro, A | Santamaria, E | Gutierrez, JM | Gonzalez, C
Date: OCT 2020
Author keywords: Ginger oil | Zingiber officinale | Encapsulation | Alginate | Kappa-carrageenan |
Chitosan
Keywords plus: KENAF SEED OIL | MICROENCAPSULATION | CARRAGEENAN | GELATION |
CALCIUM | MICROSPHERES | SURVIVAL | EXTRACT | STORAGE | SODIUM
Publication year: 2020
Volume: 37
Abstract:
Hydrogels consisting of a blend of sodium alginate and kappa-carrageenan aqueous solutions were
prepared using Ca2+ as the gelling agent in a shell material formulation for encapsulation of food-grade
ginger oil. A preliminary study on the rheological and textural behavior of two hydrogels prepared from
(1) alginate water solution and (2) alginate blended with kappa-carrageenan in water showed that the
latter produced gels with higher values of elastic and viscous moduli and gel strength, related to added
mechanical rigidity. In the encapsulation of ginger oil, 4 formulations of shell material were prepared
from 1% w/w alginate solution and from the blend of 1% w/w alginate solution with 1.5% w/w kappa-
carrageenan (at 80:20 v/v ratio) with and without incubation in a 0.1 w/w chitosan solution as a final
coating in a two-stage capsule hardening procedure. The ability of the formulated shell materials to
protect the encapsulated ginger oil from oxidative degradation was measured using both primary and
secondary oxidation products using peroxide value, p-anisidine value, and thiobarbituric acid reactive
substances. Encapsulated ginger oil gave lower values of the oxidation products compared to
unencapsulated. Moreover, the ginger oil extracted from capsules with alginate and kappa-carrageenan,
Página 101
along with chitosan as the final coating, showed the lowest content of oxidation products throughout the
storage period, suggesting a better protection of ginger oil.
Source: ANDROLOGIA | 49 (10): - DEC 2017
Title: 6-Gingerol-rich fraction prevents disruption of histomorphometry and marker enzymes of
testicular function in carbendazim-treated rats
Author(s): Salihu, M | Ajayi, BO | Adedara, IA | Farombi, EO
Date: DEC 2017
Author keywords: 6-gingerol-rich fraction | carbendazim | histomorphometry | marker enzymes |
reproductive toxicity
Keywords plus: ZINGIBER-OFFICINALE | DEVELOPMENTAL TOXICITY | TESTIS
MORPHOMETRY | OXIDATIVE DAMAGE | SPERMATOGENESIS | CELLS | SUPPLEMENTATION |
FERTILITY | KOLAVIRON | COLITIS
Publication year: 2017
Volume: 49
Abstract:
Previous investigations demonstrated that 6-gingerol-rich fraction (6-GRF) prevented testicular toxicity
via inhibition of oxidative stress and endocrine disruption in CBZ-treated rats. The influence of 6-GRF
on alterations in histomorphometry and marker enzymes of testicular function in CBZ-treated rats which
hitherto has not been reported was investigated in this study. The animals were orally administered
either CBZ (50mg/kg) alone or in combination with 6-GRF (50, 100 and 200mg/kg) for 14 consecutive
days. Histomorphormetric analysis demonstrated that 6-GRF significantly prevented CBZ-mediated
increase in the organo-somatic index of the testes and seminiferous tubular diameter as well as the
reduction in epithelium height and tubular length of testes in the rats. Similarly, 6-GRF ameliorated CBZ
-induced disruption in the epithelium height as well as in the proportion of tubule and interstitium of the
epididymis the treated rats. Furthermore, 6-GRF prevented CBZ-mediated increase in testicular acid
phosphatase activity and the decrease in testicular alkaline phosphatase, aminotransferases, glucose-6-
phosphate dehydrogenase and lactate dehydrogenase activities. Moreover, 6-GRF ameliorated CBZ-
induced reduction in the testicular and epididymal sperm count and sperm motility in the treated rats.
Conclusively, 6-GRF enhances key functional enzymes involve in spermatogenesis and maintains histo-
architecture of testes and epididymis in CBZ-treated rats.
Source: FOOD & FUNCTION | 12 (2): 519-542 JAN 21 2021
Página 102
Title: A recent update on the multifaceted health benefits associated with ginger and its bioactive
components
Author(s): Ma, RH | Ni, ZJ | Zhu, YY | Thakur, K | Zhang, F | Zhang, YY | Hu, F | Zhang, JG | Wei, ZJ
Date: JAN 21 2021
Author keywords:
Keywords plus:
Publication year: 2021
Volume: 12
Abstract:
Due to recent lifestyle shifts and health discernments among consumers, synthetic drugs are facing the
challenge of controlling disease development and progression. Various medicinal plants and their
constituents are recognized for their imminent role in disease management via modulation of biological
activities. At present, research scholars have diverted their attention on natural bioactive entities with
health-boosting perception to combat the lifestyle-related disarrays. In particular, Zingiber officinale
is a medicinal herb that has been commonly used in food and pharmaceutical products. Its detailed
chemical composition and high value-added active components have been extensively studied. In this
review, we have summarized the pharmacological potential of this well-endowed chemo preventive
agent. It was revealed that its functionalities are attributed to several inherent chemical constituents,
including 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, 6-hydroshogaol, and oleoresin, which were
established through many studies (in vitro, in vivo, and cell lines). In this review, we also focused on the
therapeutic effects of ginger and its constituents for their effective antioxidant properties. Their
consumption may reduce or delay the progression of related diseases, such as cancer, diabetes, and
obesity, via modulation of genetic and metabolic activities. The updated data could elucidate the
relationship of the extraction processes with the constituents and biological manifestations. We have
collated the current knowledge (including the latest clinical data) about the bioactive compounds and
bioactivities of ginger. Their detailed mechanisms, which can lay foundation for their food and medical
applications are also discussed.
Source: INTERNATIONAL JOURNAL OF NANOMEDICINE | 16: 3293-3315 2021
Title: Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular
Diseases
Author(s): Hesari, M | Mohammadi, P | Khademi, F | Shackebaei, D | Momtaz, S | Moasefi, N | Farzaei,
MH | Abdollahi, M
Página 103
Date: 2021
Author keywords: cardiovascular diseases | medicinal plants | natural products | nanoformulation |
nanoparticles
Keywords plus: SOLID LIPID NANOPARTICLES | ACUTE MYOCARDIAL-ISCHEMIA | INDUCED
OXIDATIVE STRESS | INDUCED CARDIAC TOXICITY | DOXORUBICIN-INDUCED
CARDIOTOXICITY | GINGER ZINGIBER-OFFICINALE | DRACOCEPHALUM-MOLDAVICA L. |
GINKGO-BILOBA EXTRACT | IN-VITRO | NATURAL-PRODUCTS
Publication year: 2021
Volume: 16
Abstract:
Considering the high prevalence of cardiovascular diseases (CVDs), the primary cause of death during
the last several decades, it is necessary to develop proper strategies for the prevention and treatment of
CVDs. Given the excessive side effects of current therapies, alternative therapeutic approaches like
medicinal plants and natural products are preferred. Lower toxicity, chemical diversity, cost-
effectiveness, and proven therapeutic potentials make natural products superior compared to other
products. Nanoformulation methods improve the solubility, bioavailability, circulation time, surface area
-to-volume ratio, systemic adverse side effects, and drug delivery efficiency of these medications. This
study intended to review the functionality of the most recent nanoformulated medicinal plants and/ or
natural products against various cardiovascular conditions such as hypertension, atherosclerosis,
thrombosis, and myocardial infarction. Literature review revealed that curcumin, quercetin, and
resveratrol were the most applied natural products, respectively. Combination therapy, conjugation, or
fabrication of nanoparticles and nanocarriers improved the applications and therapeutic efficacy of
herbal- or natural-based nanoformulations. In the context of CVDs prevention and/or treatment,
available data suggest that natural-based nanoformulations are considerably efficient, alone or in blend
with other herbal/synthetic medicines. However, clinical trials are mandatory to elucidate the safety,
cardioprotective effect, and mechanism of actions of nanophytomedicines.
Source: ANIMAL NUTRITION | 5 (4): 407-409 DEC 2019
Title: Ginger extract enhances antioxidant ability and immunity of layers
Author(s): An, SY | Liu, GZ | Guo, X | An, YH | Wang, RY
Date: DEC 2019
Author keywords: Antioxidant ability | Immunity | Ginger extract | Layers | Prostaglandin E-2
Keywords plus: ROOT ZINGIBER-OFFICINALE | GROWTH-PERFORMANCE | SERUM
Página 104
METABOLITES
Publication year: 2019
Volume: 5
Abstract:
This experiment was to investigate ginger extract on production performance, antioxidant ability and
immunity of laying hens. A total of 600 Hy-Line brown laying hens aged at 25 wk old were randomly
divided into 2 treatments, 4 replicates per treatment, 75 layers each replicate. The control group hens
were fed a basal diet; the experimental group hens were fed basal diets with 0.1% ginger extract. The
results were shown as follows: 1) ginger extract significantly enhanced laying rates (P < 0.05) and daily
egg weight (P < 0.05), substantially reduced the ratio of feed to egg (P < 0.05) of the hens; 2) ginger
extract did not change the activities of glutathione peroxidase (GSH-PX) and total antioxidant capacity
(TAOC) but significantly improved plasma superoxide dismutase (SOD) activity (P < 0.05), reduced
malondialdehyde (MDA) content (P < 0.05) of the birds; 3) ginger extract did not affect the contents of
serum total protein (TP), albumin (ALB), globulin (GLB), but significantly increased lysozyme (LZM)
activity (P < 0.05); 4) ginger extract also significantly reduced plasma prostaglandin E-2 (PGE(2))
content (P < 0.05). This study shows that ginger extract not only can improve the birds' antioxidant
capacity, enhance immune function, but also has a potential of reducing inflammatory response. (C)
2019, Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by
Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
Source: IET NANOBIOTECHNOLOGY | 12 (8): 1084-1089 DEC 2018
Title: Biogenically engineered nanoparticles inhibit Fusarium oxysporum causing soft-rot of ginger
Author(s): Athawale, V | Paralikar, P | Ingle, AP | Rai, M
Date: DEC 2018
Author keywords: nanoparticles | biotechnology | microorganisms | toxicology | mass spectroscopic
chemical analysis | antibacterial activity | plant diseases | fusarium oxysporum | sulphur nanoparticles | f
| oxysporum | soil samples | bavistin demonstrated maximum inhibition | biogenically engineered
nanoparticles | ginger soft-rot | chitosan nanoparticles | ridomil gold
Keywords plus: SULFUR NANOPARTICLES | COPPER NANOPARTICLES
Publication year: 2018
Volume: 12
Abstract:
Página 105
Soft-rot of ginger (Zingiber officinale) is the most important disease usually caused by Fusarium
oxysporum (F. oxysporum) leading to significant yield loss. In this study, chitosan, copper and
sulphur nanoparticles synthesised from leaf extract of selected plants were screened against two isolates
of F. oxysporum recovered from the infected rhizome of ginger and soil samples. Moreover, among
these, sulphur nanoparticles showed maximum inhibition of F. oxysporum isolated from soil samples
(ZOI=12.33mm) followed by copper (ZOI=>12mm) and chitosan nanoparticles (ZOI=>9mm). Similarly,
in the case of F. oxysporum isolated from infected ginger, sulphur nanoparticles showed maximum
inhibition (ZOI=13.33) as compared to copper (ZOI=>11mm) and chitosan nanoparticles (ZOI=>9mm).
Considering the high efficacy, sulphur nanoparticles were further evaluated in combination with
commercial fungicides, viz., bavistin, ridomil gold, sunflex and streptocycline. The combination of
sulphur nanoparticles with bavistin demonstrated maximum inhibition (ZOI=45.16mm, MIC -20 mu g/
ml), whereas the minimum inhibition was shown by its combination with ridomil gold (ZOI=10.5mm,
MIC -40 mu g/ml). Therefore, it can be concluded that the combination of sulphur nanoparticles with
bavistin can be used for effective and eco-friendly management of F. oxysporum causing soft-rot of
ginger.
Source: PHARMACEUTICAL BIOLOGY | 57 (1): 498-506 JAN 1 2019
Title: A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect
Author(s): Chen, Z | Ye, SY | Yang, Y | Li, ZY
Date: JAN 1 2019
Author keywords: Charcoal drug | carbon dots | traditional Chinese medicine
Keywords plus: GINGER ZINGIBER-OFFICINALE | GRAPHENE QUANTUM DOTS | CARBON
DOTS | POLLEN-TYPHAE | NANODOTS | BIOACTIVITY | EXPRESSION | FLAVONOIDS |
PRODUCTS
Publication year: 2019
Volume: 57
Abstract:
Context: Charcoal of Chinese drugs is a kind of special processing product in Chinese medicine and used
for treatment of haemoptysis, hematemesis and haemorrhage in the clinic during ancient times. During
carbonizing, significant changes occur in chemical constituents and the efficacy of haemostasis will be
enhanced. But the quality control standard of 'carbonizing retains characteristics' should be followed.
Objective: This review introduces the typical methods of carbonizing, which highlight current research
progress on haemostatic substances of charcoal drugs so as to provide a reasonable explanation for the
theory of haemostasis treated by charcoal medicine. Methods: English and Chinese literature from 2004
Página 106
to 2019 was collected from databases including Web of Science, PubMed, Elsevier and CNKI (Chinese).
Charcoal drug, chemical constituents, processing, haemostasis and carbon dots were used as the key
words. Results: Charcoal drugs mainly play a haemostatic role and the effect can be classified into four
types to stop bleeding: removing blood stasis, cooling blood, warming meridians and astringing. Changes
in composition lead to changes in pharmacodynamics. Carbonizing methods and basic research on
haemostasis material in charcoal drugs have also been summarized. Conclusions: This review
summarizes the classification of charcoal drugs and highlights the possible material bases for the
haemostatic effect of charcoal drugs in recent years, providing new insights to future research.
Source: RENEWABLE ENERGY | 168: 815-828 MAY 2021
Title: Techno-economical and energy analysis of sunflower oil biodiesel synthesis assisted with waste
ginger leaves derived catalysts
Author(s): John, M | Abdullah, MO | Hua, TY | Nolasco-Hipolito, C
Date: MAY 2021
Author keywords: Biodiesel | Heterogeneous catalyst | Ginger leaves | Sunflower oil | Renewable
energy-yield ratio | Sustainable economy
Keywords plus:
Publication year: 2021
Volume: 168
Abstract:
The present study was carried out to investigate biodiesel production via transesterification of sunflower
oil employing heterogeneous catalyst derived from indigenous ginger (Zingiber Officinale) leaves. It
also aims to compare the techno-economy performance of the ginger-based catalysts in 3 different forms
viz. calcinated (CGL), activated by KOH (KGL) and NaOH (NGL). The plant-based catalysts were
characterised by Scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) and Fourier
transform infrared spectroscopy (FTIR). The parametric effects on the biodiesel production such as
reaction time, methanol to oil ratio and catalyst loading were investigated. The experimental result shows
that 1.6 wt % catalyst, 6:1 M ratio of alcohol to oil, 1 h 30 min of reaction time with a speed of 200 rpm
gave the best results. It was found that the KGL obtained highest biodiesel yield of 93.83% under
optimum conditions. Subsequently, the specific energy and energy productivity of KGL catalyst was
found to be 1.2728, 26.1544 MJ/ kg and 0.0382 kg/MJ, respectively, per 1 L of biodiesel. Meanwhile, the
renewable energy to nonrenewable energy ratio for CGL, KGL and NGL is found to be 3.17, 4.01 and 3.67,
respectively. A higher sustainable renewable energy-yield ratio and overall economical profit cost ratio
are preferable for the biodiesel production process. (c) 2020 Elsevier Ltd. All rights reserved.
Página 107
COMPOSICIÓN FARMACÉUTICA A BASE DE MATERIAS PRIMAS VEGETALES
RESUMEN
Una composición farmacéutica que contiene polvo seco de agujas de pino (Pinus) y cáscaras y
huesos secos de extracto de uva y aditivo farmacéuticamente aceptable, extractos secos de
jengibre ( Zingiber officinale ), té verde (Camellia sinensis), jengibre amarillo
(Curcuma longa), mostaza amarilla (Brassica hirta) semillas, pimienta blanca, corteza de
granada (Punica granatum) y polvo seco de jugo de granada (Punica granatum).
N° DE PUBLICACIÓN US11083764
FECHA DE PUBLICACIÓN 10/08/2021
INVENTORES OREN BABRY
SOLICITANTE OREN BABRY
Página 108
V. TECNOLOGÍA ASOCIADA
COMPOSICIONES DE BIOPESTICIDAS QUE COMPRENDEN EXTRACTOS
VEGETALES Y SU USO FITOSANITARIO
RESUMEN
Una composición de bioplaguicida que comprende un núcleo bioactivo sinérgico que consta de
aceite esencial, oleorresina, extracto acuoso, alcohólico o hidroalcohólico de raíz o rizomas
de Zingiber officinale Roscoe y cinamaldehído o fuente de cinamaldehído. Dicha
composición puede contener al menos un componente secundario y / o sustancias inertes. La
presente invención también se refiere al método para su obtención, así como a su uso en
agricultura, parques e instalaciones deportivas contra plagas pertenecientes al grupo de la
mosca blanca.
N° DE PUBLICACIÓN WO2021148684 (A1)
FECHA DE PUBLICACIÓN 29/07/2021
INVENTORES
GARCIA MORENO FÉLIX [ES]; REMESAL
GONZÁLEZ EFRÉN [ES]; JULIO TORRES LUIS
FERNANDO [ES]; SANTANA MÉRIDAS OMAR
[ES]; MARTÍN BEJERANO MARÍA
[ES]; GIMÉNEZ GARCÍA SALVADOR [ES]
SOLICITANTE KIMITEC BIOGROUP SL [ES]
Página 109
COMPOSICIÓN HERBARIA PARA INHIBIR LA METÁSTASIS CELULAR DE
MELANOMA Y SU MÉTODO DE FABRICACIÓN
RESUMEN
La presente invención se refiere a una composición de medicina herbal china que se prepara a
partir de una materia prima que comprende la siguiente proporción: 1 parte en peso de Lilium
brownii var. viridulum, 5 partes en peso de Houttuynia cordata, 2 partes en peso de
Atractylodes macrocephala, 2 partes en peso de Poria cocos (Schw.) Wolf., 1 parte en
peso de Ziziphi Spinosae Semen, 3 partes en peso de Adenophora morrisonensis, 2 partes
en peso de Semen Astragali Complanati, 0,5 partes en peso de Zingiber officinale, 5
partes en peso de Tribulus terrestris, 3 partes en peso de Pogostemon cablin, 0,5 partes
en peso de Ziziphus jujuba y 0,1 partes en peso de Dimocarpus longan. La invención
también se refiere a un método para usar la composición de hierbas para inhibir la metástasis
de células de melanoma. La invención también se refiere a un proceso para la preparación de la
composición de hierbas.
N° DE PUBLICACIÓN US2021205402 (A1)
FECHA DE PUBLICACIÓN 08/07/2021
INVENTORES LEE CHIH-CHEN [TW]
SOLICITANTE ST LOTUS BIOTECH CORP [TW]
Página 110
MÉTODOS Y COMPOSICIONES PARA EL TRATAMIENTO DEL CÁNCER DE
PULMÓN DE CÉLULAS NO PEQUEÑAS
RESUMEN
La presente invención está dirigida a métodos y composiciones terapéuticas para tratar el
cáncer de pulmón de células no pequeñas en un sujeto, que comprenden administrar una
cantidad eficaz de un extracto o polvo de una mezcla de hierbas, opcionalmente con un agente
anticanceroso a dicho sujeto. La mezcla de hierbas comprende un componente de al menos una
especie de cada género Astragalus, Cimicifuga foetida rhizoma, Ophiopogon radix,
Atractylodes lancea rhizoma, Panax ginseng-Red, Atractylodes rhizoma-White, Massa
medicata fermentata, Citrus reticulata-Viride, Citrus reticulata , Glycyrrhiza radix,
Schisandra fructus, Angelica sinensis radix, Phellodendron cortex, Alisma rhizoma,
Pueraria radix, Ziziphus fructus-Red y Zingiber officinale radix.
N° DE PUBLICACIÓN US2021205389 (A1)
FECHA DE PUBLICACIÓN 08/07/2021
INVENTOR HUANG TSE-HUNG [TW]; HUANG CHI-YING [TW]; HSU
HSUAN-MIN [TW]; LIN KUAN-TING [TW]
SOLICITANTE CHANG GUNG MEDICAL ENCONTRÓ KEELUNG CHANG
GUNG MEMORIAL HOSPITAL [TW]
Página 111
COMPOSICIONES ÚTILES EN LA PREVENCIÓN Y / O TRATAMIENTO DE
INFLAMACIONES Y DOLORES
RESUMEN
Se describen composiciones que comprenden: a) un extracto de Curcuma longa, curcumina
o curcumina complejada con fosfolípidos; b) un extracto lipofílico de Zingiber officinale ; y
c) un extracto lipofílico obtenido de plantas que contienen isobutilamidas de ácidos grasos
poliinsaturados seleccionados del grupo que consiste en Echinacea spp. extracto,
Zanthoxylum spp. extracto y extracto de Acmella oleracea (Spilanthes oleracea)
N° DE PUBLICACIÓN US2021205388 (A1)
FECHA DE PUBLICACIÓN 08/07/2021
INVENTORES BOMBARDELLI EZIO [IT]
SOLICITANTE INDENA SPA [IT]
Página 112
PRODUCTO BIOLÓGICAMENTE ACTIVO CON COMPLEJO PROBIÓTICO
COMBINADO CON PREBIÓTICOS, PECTINAS Y COMPLEJO VITAMINICO
RESUMEN
Producto biológicamente activo con complejo probiótico, combinado con prebiótico, pectina y
complejo vitamínico, que contiene los siguientes componentes: 1. Complejo probiótico:
realización 1: Lactobacillus delbrueckii subespecie bulgaricus, Streptococcus salivarius
ssp. Thermophilus, Lactobacillus casei subsp. Casei, Lactobacillus reuteri, 2. Inulina
prebiótica - 4.16-10.45 3. Fructosa - 42.4-58.4 4. Pectina pura de manzana - pectina altamente
esterificada - 12.5-13.9 5. Pectina cítrica - 16.6-17.6; 6. Vitamina C (ácido L-ascórbico) - 0.69-
0.83 7. Vitamina D3 (Vitamina D3 - 0.00004-0.000052 8. Vitamina K2 - 0.0006-0.00004 9.
Zinc - 0.08 - 0.07 10. Selenio - 0.00029-0.00024 11. extracto de Jengibre (Extraer Zingiber
officinale ) - 0.83-1.39 12. Extracto de cúrcuma (Extracto de Curcuma longa) - también
llamado curcumina - 0.83-1.04 13. Extracto de equinácea (Extracto de equinácea) - 1.66-2.09
14. Sabor - Aroma natural de manzana - 0.000005-0.000015. .
N° DE PUBLICACIÓN BG4020 (U1)
FECHA DE PUBLICACIÓN 31/03/2021
INVENTORES KIRCHEV DIMITAR
SOLICITANTE MEDIKOFARM K EOOD [BG]
Página 113
COMPOSICIONES DE UNA MEDICINA HERBARIA PARA EL TRATAMIENTO DEL
DENGUE Y SU PRODUCCIÓN
RESUMEN
Esta invención se refiere a composiciones de medicamentos a base de hierbas para el
tratamiento del dengue y su producción. Las composiciones de hierbas medicinales consisten
en hojas secas y finamente pulverizadas de Lagerstroemia speciosa; partes aéreas secas y
finamente pulverizadas de Euphorbia hirta; rizoma de Zingiber officinale seco y
finamente pulverizado ; y una combinación de dosis fija de los tres. En otra versión de la
formulación, se utilizó en su lugar el extracto acuoso, etanólico, metanólico o hidroalcohólico
secado por aspersión de las plantas mencionadas.
N° DE PUBLICACIÓN PH12019000387 (A1)
FECHA DE PUBLICACIÓN 07/06/2021
INVENTORES ALVERO RITA GRACE Y [PH]
SOLICITANTE DE LA SALLE CIENCIAS MÉDICAS Y DE LA SALUD
INST DLSMHSI [PH]; PHARMALYTICS CORP [PH]
Página 114
PREPARACIÓN DE PLANTAS DE PROTECCIÓN DEL CORAZÓN PARA PREVENIR Y
MEJORAR LA ENFERMEDAD CORONARIA DEL CORAZÓN
RESUMEN
La presente divulgación proporciona una preparación de planta natural, que incluye extractos
de las siguientes partes de plantas: raíces de Salvia miltiorrhiza Bunge, Juglans regia,
Aesculus hippocastanum L. y Zingiber officinale Rosc., Cortezas de Cinnamomum
cassia Presl, semillas de Sesamum indicum, Carica papaya L., Nigella damascena L. y
Punica granatum L., hojas de Centaurea cyanus L., resina de Pistacia Lentiscus,
drupas de Cocos nucifera L., frijoles de Theobroma cacao L., pulpa y granos secos de
Phoenix dactylifera L., secos pulpa de Olea europaea, Ficus carica Linn., Nogal y
Vaccinium Spp, clavo de Allium sativum y pétalos de Rosa sp. La presente divulgación
proporciona además un método para preparar una preparación de plantas, que incluye el
tratamiento de las partes anteriores de las plantas con etanol
N° DE PUBLICACIÓN US2021093688 (A1)
FECHA DE PUBLICACIÓN 01/04/2021
INVENTORES SONG YUANDA [CN]; AMMAR SYED
[CN]; LI SHAOQI [CN]; YANG WU [CN]
SOLICITANTE TECNOLOGÍA UNIV SHANDONG [CN]
Página 115
COMPOSICIÓN FARMACÉUTICA PARA PREVENIR O TRATAR EL CÁNCER QUE
COMPRENDE Angelica gigas, Aconitum carmichaeli Debeaux y Zingiber
officinale Roscoe
RESUMEN
La presente invención se refiere a una composición para prevenir o tratar el cáncer que
comprende un extracto de Angelica gigas, Aconitum carmichaeli Debeaux y Zingiber
officinale Roscoe como ingrediente activo y, más específicamente, a una composición
farmacéutica, una composición alimentaria y una composición de pienso para prevenir o el
tratamiento del cáncer, que comprende extractos de Angelica gigas, Aconitum
carmichaeli Debeaux y Zingiber officinale Roscoe como ingredientes activos; un método
para prevenir o tratar el cáncer que comprende un paso de administrar la composición
farmacéutica; y un uso para prevenir o tratar el cáncer. Angelica gigas, Aconitum
carmichaeli Debeaux o Zingiber officinale Roscoe de la presente invención exhiben un
excelente efecto de tratamiento del cáncer,
N° DE PUBLICACIÓN KR20210025955 (A)
FECHA DE PUBLICACIÓN 10/03/2021
INVENTORES KO SEONG GYU
SOLICITANTE UNIV GRUPO DE COOPERACIÓN INDUSTRIAL
KYUNG HEE UNIV [KR]
Página 116
MÉTODO DE EXTRACCIÓN DE POLIFENOLES DE LAS RAÍCES DE JENGIBRE
RESUMEN
Dicho resultado técnico se logra mediante la adición a los rizomas desmotadoras, solución
acuosa de etanol al 40% en proporción 1: 7 en peso, agitando a fondo, hirviendo en baño
maría por 15 minutos, luego se infunden 10 días a temperatura ambiente, centrifugado a
10,000 rpm durante 30 minutos y producido en un extracto sobrenadante de
polifenoles; luego se pasa la centrifugadora a través de polvo de celulosa microcristalina de la
misma masa, que los portainjertos de jengibre molidos, y la pasta enriquecida con polifenoles
se seca al aire durante tres días; El concentrado obtenido contiene 2,50 ± 0,098 mg de
compuestos polifenólicos por 1 g de masa seca.
N° DE PUBLICACIÓN RU2740997 (C1)
FECHA DE PUBLICACIÓN 22/01/2021
INVENTORES LOGINOV PAVEL VADIMOVICH [RU]; NIKOLAEV ALEKSANDR
ARKADEVICH [RU]; MAVLYUTOVA ELENA BORISOVNA
SOLICITANTE
FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE
OBRAZOVA TELNO E UCHREZHDEN IE VYSSHEGO
OBRAZOVANIYA «ASTRAKHANS [RU]
Página 117
VI. BIBLIOGRAFÍA
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(2019). Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe).
Foods, 8(6), 185.
2. ZAMBRANO-BLANCO, Eleonora. Diversidad genética del jengibre (Zingiber officinale
Roscoe.) A nivel molecular: Avances de la última década. En: Entramado. Julio - Diciembre,
2015 vol. 11, no. 2, p. 190-199, http://dx.doi.org/10.18041/entramado.2015v11n2.22239
3. Ministerio de Agricultura. Ficha sobre jengibre. Disponible en: https://
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lineasdecultivosemergentes/JENGIBRE.pdf
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mes/37-planta-del-mes/499-jengibre-zingiber-officinale
5. U. Siedentopp. Ginger - effective as drug, spice and tea. Revista Internacional de
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revista-internacional-acupuntura-279-pdf-13125914
6. Ingwerwurzelstock. Internetauftritt., www.pharmakobotanik.de/systematik/6droge-f/
zingib-r.htm, 05.12.2007
7. Wichtl M. Teedrogen. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH;1989. p. 249-51
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München: Gräfe und Unzer Verlag;2004/05:22-3.
10. Búsqueda de Zingiber officinale en Espacenet.
11. Búsqueda en base de datos Clarivate web of sciences sobre Zingiber officinale
12. Búsqueda en base de datos Derwent Innovation sobre Zingiber officinale
13. Zingiber officinale. Plants of the world online Powo Science. [visitado el 20.08.2021].
Url: http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:798372-1
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Para comentarios o sugerencias, en relación con el boletín, por favor comuníquese con:
[email protected] / [email protected]
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Dirección de Invenciones y Nuevas Tecnologías
Comisión Nacional contra la Biopiratería
Copyright © 2021 Instituto Nacional de Defensa de la Competencia y de la Protección
de la Propiedad Intelectual (Indecopi)
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Imagen: Zingiber officinale Roscoe
Autor: Franz Eugen Köhler, Köhler's Medizinal-Pflanzen
Extraído de: https://upload.wikimedia.org/wikipedia/commons/thumb/1/18/Koeh-146-no_text.jpg/800px-Koeh-146-no_text.jpg
Licencia: Dominio público . No se realizaron cambios