Transcript
Page 1: Review of muscle cell structure and phenotype plasticity

Review of muscle cell structure and phenotype plasticity.

LEARNING OBJECTIVES

1. Review the structure of skeletal muscle.

BS277 Biology of Muscle

Page 2: Review of muscle cell structure and phenotype plasticity

Review of muscle structure.Organism to cell.

1

2

3

4 56

7

8

86

79

8

4

10

6

10

10

12

14

11

13

15

16

18

10

17

Page 3: Review of muscle cell structure and phenotype plasticity

1. Brachium2. Tendon3. Skeletal muscle / biceps4. Epimysium5. Blood vessels and nerves6. Perimysium7. Muscle fascicle8. Muscle fibre / myocyte/muscle cell9. Blood vessels10. Endomysium11. Capillary12. Sarcolemma13. Sarcoplasm14. Nucleus15. Mitochondria16. Nerve17. Satellite cell

Page 4: Review of muscle cell structure and phenotype plasticity
Page 5: Review of muscle cell structure and phenotype plasticity

Overview of Muscle Development.

Page 6: Review of muscle cell structure and phenotype plasticity

Review of muscle structure. Cell to organelle. 1

1

2

2

3

4

4

67

1

8

910

11

5

Page 7: Review of muscle cell structure and phenotype plasticity

1. Sarcolemma2. Sarcoplasm3. Nucleus4. Myofibril5. Sarcoplasmic reticulum6. Terminal cisterna7. Mitochondrion8. T-tubule9. Triad10.Thick myofilament11.Thin myofilament

Page 8: Review of muscle cell structure and phenotype plasticity

Review of muscle structure. Cell to organelle.

Page 9: Review of muscle cell structure and phenotype plasticity

Review of muscle structure. Myofibril banding pattern.

Sarcomere

A bandI band

H zone

M line

Z line

Zone of overlap

Thin myofilament

Thick myofilament

Titin

Page 10: Review of muscle cell structure and phenotype plasticity

Review of muscle structure. Myofibril banding pattern.

Page 11: Review of muscle cell structure and phenotype plasticity

The molecular basis of the sarcomere banding pattern

Sarcomere

Thin myofilamentThick

myofilamentα-actinin

Titin

Titin

Page 12: Review of muscle cell structure and phenotype plasticity

The molecular basis of myofilament structure

Page 13: Review of muscle cell structure and phenotype plasticity

The molecular basis of myofilament structure

Page 14: Review of muscle cell structure and phenotype plasticity

Sliding filaments and muscle contraction

Page 15: Review of muscle cell structure and phenotype plasticity

Overview of the regulation of muscle contraction

Page 16: Review of muscle cell structure and phenotype plasticity

The active state. Initiation of cross bridge cycling.

Page 17: Review of muscle cell structure and phenotype plasticity

The cross bridge cycle. Step 1.

Page 18: Review of muscle cell structure and phenotype plasticity

Recommended